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Select item 111597481.

Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel‐induced leukopenia

Kazuma Kiyotani, Taisei Mushiroda, Michiaki Kubo, Hitoshi Zembutsu, Yuichi Sugiyama, Yusuke Nakamura

Cancer Sci. 2008 May; 99(5): 967–972. Published online 2008 Feb 20. doi: 10.1111/j.1349-7006.2008.00765.x

PMCID:: PMC11159748

Abstract Article PDF–101K

Select item 90521532.

Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling

Zhihui Li, So Mee Kwon, Daochuan Li, Linhao Li, Xiwei Peng, Junran Zhang, Tatsuya Sueyoshi, Jean-Pierre Raufman, Masahiko Negishi, Xin Wei Wang, Hongbing Wang

J Biol Chem. 2022 May; 298(5): 101885. Published online 2022 Mar 30. doi: 10.1016/j.jbc.2022.101885

PMCID:: PMC9052153

Abstract Article PDF–3.8M

Select item 89895233.

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

Monicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, Boer Xie, Shirish Chodankar, Andrew D Huber, Jing Wu, Kavya Annu, William C Wright, Hyeong-Min Lee, Jayaraman Seetharaman, Jingheng Wang, Cameron D Buchman, Junmin Peng, Taosheng Chen

Nucleic Acids Res. 2022 Apr 8; 50(6): 3254–3275. Published online 2022 Feb 25. doi: 10.1093/nar/gkac133

PMCID:: PMC8989523

Abstract Article PDF–2.8M

Select item 84316494.

Activation of the Constitutive Androstane Receptor Inhibits Leukocyte Adhesiveness to Dysfunctional Endothelium

Mireia López-Riera, Rebeca Ortega, Luisa Hueso, María Carmen Montesinos, Mari Carmen Gomez-Cabrera, María Jesús Sanz, José T. Real, Laura Piqueras

Int J Mol Sci. 2021 Sep; 22(17): 9267. Published online 2021 Aug 27. doi: 10.3390/ijms22179267

PMCID:: PMC8431649

Abstract Article PDF–4.6M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80090486.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 76926477.

Regulation of CAR and PXR Expression in Health and Disease

Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin

Cells. 2020 Nov; 9(11): 2395. Published online 2020 Oct 31. doi: 10.3390/cells9112395

PMCID:: PMC7692647

Abstract Article PDF–614K

Select item 76423278.

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner

Nat Commun. 2020; 11: 5559. Published online 2020 Nov 3. doi: 10.1038/s41467-020-19032-0

PMCID:: PMC7642327

Abstract Article PDF–12M

Select item 76026459.

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

Jenni Küblbeck, Jonna Niskanen, Paavo Honkakoski

Cells. 2020 Oct; 9(10): 2306. Published online 2020 Oct 15. doi: 10.3390/cells9102306

PMCID:: PMC7602645

Abstract Article PDF–887K

Select item 699164610.

Long non‐coding RNA F11‐AS1 inhibits HBV‐related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA‐211‐5p

Yibin Deng, Zhongheng Wei, Meijin Huang, Guidan Xu, Wujun Wei, Bin Peng, Shunqiang Nong, Houji Qin

J Cell Mol Med. 2020 Jan; 24(2): 1848–1865. Published online 2019 Dec 27. doi: 10.1111/jcmm.14881

PMCID:: PMC6991646

Abstract Article PDF–2.6M

Select item 674682211.

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei

Giovanni Nassa, Giorgio Giurato, Annamaria Salvati, Valerio Gigantino, Giovanni Pecoraro, Jessica Lamberti, Francesca Rizzo, Tuula A. Nyman, Roberta Tarallo, Alessandro Weisz

Sci Data. 2019; 6: 173. Published online 2019 Sep 16. doi: 10.1038/s41597-019-0179-2

PMCID:: PMC6746822

Abstract Article PDF–2.0M

Select item 650411912.

Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer‐related pathways in breast cancer

Yan Liu, Jian Li, Zhifang Ma, Jun Zhang, Yuzhi Wang, Zhenghong Yu, Xue Lin, Zhi Xu, Qian Su, Li An, Yehui Zhou, Xinxing Ma, Yiwen Yang, Feifei Wang, Qingfei Chen, Yunchao Zhang, Jilinlin Wang, Huilin Zheng, Aihua Shi, Shuang Yu, Jingzhong Zhang, Weiyong Zhao, Liming Chen

Cancer Med. 2019 Feb; 8(2): 729–741. Published online 2019 Jan 16. doi: 10.1002/cam4.1938

PMCID:: PMC6504119

Abstract Article PDF–1.3M

Select item 637944113.

Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity

Yu Wang, Xi Xiang, Wei-Wei Huang, Andrew J Sandford, Shou-Quan Wu, Miao-Miao Zhang, Ming-Gui Wang, Guo Chen, Jian-Qing He

Sci Rep. 2019; 9: 2217. Published online 2019 Feb 18. doi: 10.1038/s41598-018-38452-z

PMCID:: PMC6379441

Abstract Article PDF–1.1M

Select item 614479914.

In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets

Ben Niu, Denise M Coslo, Alain R Bataille, Istvan Albert, B Franklin Pugh, Curtis J Omiecinski

Nucleic Acids Res. 2018 Sep 19; 46(16): 8385–8403. Published online 2018 Aug 8. doi: 10.1093/nar/gky692

PMCID:: PMC6144799

Abstract Article PDF–7.7M

Select item 582271015.

Multiple analyses indicate the specific association of NR1I3, C6 and TNN with low hip BMD risk

Ying-Ying Han, Lan-Juan Zhao, Yong Lin, Hao He, Qing Tian, Wei Zhu, Hui Shen, Xiang-Ding Chen, Hong-Wen Deng

J Genet Genomics. Author manuscript; available in PMC 2018 Feb 22.

Published in final edited form as: J Genet Genomics. 2017 Jun 20; 44(6): 327–330. Published online 2017 May 8. doi: 10.1016/j.jgg.2017.05.004

PMCID:: PMC5822710

Article PDF–1.0M

Select item 576692316.

Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation

Ryota Shizu, Jungki Min, Mack Sobhany, Lars C. Pedersen, Shingo Mutoh, Masahiko Negishi

J Biol Chem. 2018 Jan 5; 293(1): 333–344. Published online 2017 Nov 13. doi: 10.1074/jbc.M117.806604

PMCID:: PMC5766923

Abstract Article PDF–2.2M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 464794118.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 462760319.

CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α

Jie Gao, Jiong Yan, Meishu Xu, Songrong Ren, Wen Xie

Mol Endocrinol. 2015 Nov; 29(11): 1558–1570. Published online 2015 Sep 25. doi: 10.1210/me.2015-1145

PMCID:: PMC4627603

Abstract Article

Select item 461721120.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

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