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Select item 115361191.

eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations

Barbora Valcikova, Natalia Vadovicova, Karolina Smolkova, Magdalena Zacpalova, Pavel Krejci, Shannon Lee, Jens Rauch, Walter Kolch, Alexander von Kriegsheim, Anna Dorotikova, Zdenek Andrysik, Rachel Vichova, Ondrej Vacek, Karel Soucek, Stjepan Uldrijan

Proc Natl Acad Sci U S A. 2024 Oct 29; 121(44): e2321305121. Published online 2024 Oct 22. doi: 10.1073/pnas.2321305121

PMCID:: PMC11536119

Abstract Article PDF–5.7M

Select item 115118942.

The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations

Ming Yi, Daniel Soppet, Frank McCormick, Dwight V. Nissley

Sci Rep. 2024; 14: 25452. Published online 2024 Oct 26. doi: 10.1038/s41598-024-76591-8

PMCID:: PMC11511894

Abstract Article PDF–3.0M

Select item 114106593.

Titration of RAS alters senescent state and influences tumour initiation

Adelyne S. L. Chan, Haoran Zhu, Masako Narita, Liam D. Cassidy, Andrew R. J. Young, Camino Bermejo-Rodriguez, Aleksandra T. Janowska, Hung-Chang Chen, Sarah Gough, Naoki Oshimori, Lars Zender, Sarah J. Aitken, Matthew Hoare, Masashi Narita

Nature. 2024; 633(8030): 678–685. Published online 2024 Aug 7. doi: 10.1038/s41586-024-07797-z

PMCID:: PMC11410659

Abstract Article PDF–25M

Select item 113948824.

Loss of Heterozygosity and Mutations in the RAS-ERK Pathway Genes in Tumor Cells of Various Loci in Multiple Myeloma

Maiia Soloveva, Maksim Solovev, Natalya Risinskaya, Elena Nikulina, Igor Yakutik, Bella Biderman, Tatiana Obukhova, Yulia Chabaeva, Sergej Kulikov, Andrey Sudarikov, Larisa Mendeleeva

Int J Mol Sci. 2024 Sep; 25(17): 9426. Published online 2024 Aug 30. doi: 10.3390/ijms25179426

PMCID:: PMC11394882

Abstract Article PDF–2.6M

Select item 113819225.

Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia

Robyn Lints, Christina A. Walker, Omid Delfi, Matthew Prouse, Mandy PohLui De Silva, Stefan K. Bohlander, Andrew C. Wood

Biol Open. 2024 Sep 15; 13(9): bio060523. Published online 2024 Aug 30. doi: 10.1242/bio.060523

PMCID:: PMC11381922

Abstract Article PDF–2.1M

Select item 112099356.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111795077.

KRAS, NRAS and BRAF Mutational Profile of Colorectal Cancer in a Series of Moroccan Patients

Sara El Zaitouni, Abdelilah Laraqui, Meriem Ghaouti, Asmae Benzekri, Fouad Kettani, Tahar Bajjou, Yassine Sekhsokh, Soukaina Benmokhtar, Meryem Jafari, Walid Baba, Mohamed Oukabli, Hicham El Annaz, Rachid Abi, Mohamed Rida Tagajdid, Safae El Kochri, Idriss Amine Lahlou, Rabii Ameziane El Hassani, Khalid Ennibi

Cancer Control. 2024 Jan-Dec; 31: 10732748241262179. Published online 2024 Jun 14. doi: 10.1177/10732748241262179

PMCID:: PMC11179507

Abstract Article PDF–582K

Select item 111769478.

Organ involvement in adults with BPDCN is associated with sun exposure history, TET2 and RAS mutations, and survival

Shai Shimony, Julia Keating, Christopher J. Fay, Marlise R. Luskin, Donna S. Neuberg, Nicole R. LeBoeuf, Andrew A. Lane

Blood Adv. 2024 Jun 11; 8(11): 2803–2812. Published online 2024 Apr 16. doi: 10.1182/bloodadvances.2024012797

PMCID:: PMC11176947

Abstract Article PDF–1.9M

Select item 111416449.

Mechanism of co-operation of mutant IL-7Rα and mutant NRAS in acute lymphoblastic leukemia: role of MYC

Hila Winer, Wenqing Li, Gisele Rodrigues, Tim Gower, Thomas Joshua Meyer, Julie Hixon, Scott K. Durum

Haematologica. 2024 Jun 1; 109(6): 1726–1740. Published online 2023 Nov 30. doi: 10.3324/haematol.2023.283559

PMCID:: PMC11141644

Abstract Article PDF–4.7M

Select item 1113573310.

Changes in cell morphology and function induced by the NRAS Q61R mutation in lymphatic endothelial cells

Shiho Yasue, Michio Ozeki, Akifumi Nozawa, Saori Endo, Hidenori Ohnishi

PLoS One. 2024; 19(5): e0289187. Published online 2024 May 29. doi: 10.1371/journal.pone.0289187

PMCID:: PMC11135733

Abstract Article PDF–2.1M

Select item 1099458711.

Epidemiological and clinicopathological features of KRAS, NRAS, BRAF mutations and MSI in Chinese patients with stage I–III colorectal cancer

Weicheng Wang, Rui Wang, Xiao Han, Wei Zhang, Lijun Zhu, Yanhong Gu

Medicine (Baltimore) 2024 Apr 5; 103(14): e37693. Published online 2024 Apr 5. doi: 10.1097/MD.0000000000037693

PMCID:: PMC10994587

Abstract Article PDF–581K

Select item 1098726512.

NRAS mutant dictates AHCYL1-governed ER calcium homeostasis for melanoma tumor growth

Chufan Cai, Jiayi Tu, Jeronimo Najarro, Rukang Zhang, Hao Fan, Freya Q. Zhang, Jiacheng Li, Zhicheng Xie, Rui Su, Lei Dong, Nicole Arellano, Michele Ciboddo, Shannon E. Elf, Xue Gao, Jing Chen, Rong Wu

Mol Cancer Res. Author manuscript; available in PMC 2024 Oct 2.

Published in final edited form as: Mol Cancer Res. 2024 Apr 2; 22(4): 386–401. doi: 10.1158/1541-7786.MCR-23-0445

PMCID:: PMC10987265

Abstract Article PDF–2.7M

Select item 1080448313.

Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis

Haruhiko Takahashi, Manabu Natsumeda, Norikazu Hara, Akihide Koyama, Hiroshi Shimizu, Akinori Miyashita, Daiken Satake, Yoshihiro Mouri, Jun Tsukano, Keita Kawabe, Yoshihiro Tsukamoto, Masayasu Okada, Ryosuke Ogura, Akihiko Yuki, Hajime Umezu, Akiyoshi Kakita, Takeshi Ikeuchi, Makoto Oishi

Acta Neuropathol Commun. 2024; 12: 14. Published online 2024 Jan 22. doi: 10.1186/s40478-024-01723-0

PMCID:: PMC10804483

Abstract Article PDF–6.0M

Select item 1061767314.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 1058395915.

Anatomical resection improves relapse-free survival in colorectal liver metastases in patients with KRAS/NRAS/BRAF mutations or right-sided colon cancer: a retrospective cohort study

Wenju Chang, Yijiao Chen, Shizhao Zhou, Li Ren, Yuqiu Xu, Dexiang Zhu, Wentao Tang, Qinghai Ye, Xiaoying Wang, Jia Fan, Ye Wei, Jianmin Xu

Int J Surg. 2023 Oct; 109(10): 3070–3077. Published online 2023 Aug 1. doi: 10.1097/JS9.0000000000000562

PMCID:: PMC10583959

Abstract Article PDF–741K

Select item 1045428716.

Clinical, Pathological and Molecular Insights on KRAS, NRAS, BRAF, PIK3CA and TP53 Mutations in Metastatic Colorectal Cancer Patients from Northeastern Romania

Vlad-Adrian Afrăsânie, Mihai-Vasile Marinca, Bogdan Gafton, Teodora Alexa-Stratulat, Alexandra Rusu, Eliza-Maria Froicu, Daniel Sur, Cristian Virgil Lungulescu, Larisa Popovici, Andrei-Vlad Lefter, Irina Afrăsânie, Anca-Viorica Ivanov, Lucian Miron, Cristina Rusu

Int J Mol Sci. 2023 Aug; 24(16): 12679. Published online 2023 Aug 11. doi: 10.3390/ijms241612679

PMCID:: PMC10454287

Abstract Article PDF–497K

Select item 1044047517.

Some aspects of the life of SARS-CoV-2 ORF3a protein in mammalian cells

Song Jiao, Pablo Miranda, Yan Li, Dragan Maric, Miguel Holmgren

Heliyon. 2023 Aug; 9(8): e18754. Published online 2023 Aug 1. doi: 10.1016/j.heliyon.2023.e18754

PMCID:: PMC10440475

Abstract Article PDF–8.9M

Select item 1039866018.

C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains

Julia Jülg, Dieter Edbauer, Christian Behrends

EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895

PMCID:: PMC10398660

Abstract Article PDF–2.4M

Select item 1026678219.

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

Jian-Gang Ren, Bowen Xing, Kaosheng Lv, Rachel A. O’Keefe, Mengfang Wu, Ruoxing Wang, Kaylyn M. Bauer, Arevik Ghazaryan, George M. Burslem, Jing Zhang, Ryan M. O’Connell, Vinodh Pillai, Elizabeth O. Hexner, Mark R. Philips, Wei Tong

J Clin Invest. 2023 Jun 15; 133(12): e165510. Published online 2023 Jun 15. doi: 10.1172/JCI165510

PMCID:: PMC10266782

Abstract Article PDF–2.8M

Select item 1024078220.

Correlation between KRAS and NRAS mutational status and clinicopathological features in 414 cases of metastatic colorectal cancer in Morocco: the largest North African case series

Youssef Mahdi, Mouna Khmou, Amine Souadka, Hajar El Agouri, Soumaya Ech-charif, Chaimaa Mounjid, Basma El Khannoussi

BMC Gastroenterol. 2023; 23: 193. Published online 2023 Jun 5. doi: 10.1186/s12876-023-02694-7

PMCID:: PMC10240782

Abstract Article PDF–910K

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