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Items: 1 to 20 of 110

1.
Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH
Deqiang Zhang, Yuee Zhao, Gary Zhang, Daniel Lank, Sarah Cooke, Sujuan Wang, Alli Nuotio-Antar, Xin Tong, Lei Yin
Mol Metab. 2024 Jul; 85: 101957. Published online 2024 May 11. doi: 10.1016/j.molmet.2024.101957
PMCID:
PMC11145360
AbstractArticlePDF–4.8M
2.
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring
Jiaqi Li, Shuang Zhang, Yuyao Sun, Jian Li, Zian Feng, Huaxin Li, Mengxue Zhang, Tengteng Yan, Jihong Han, Yajun Duan
EMBO Rep. 2024 Apr; 25(4): 2097–2117. Published online 2024 Mar 26. doi: 10.1038/s44319-024-00121-w
PMCID:
PMC11014959
AbstractArticlePDF–6.0M
3.
Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use
Anna Worthmann, Julius Ridder, Sharlaine Y. L. Piel, Ioannis Evangelakos, Melina Musfeldt, Hannah Voß, Marie O’Farrell, Alexander W. Fischer, Sangeeta Adak, Monica Sundd, Hasibullah Siffeti, Friederike Haumann, Katja Kloth, Tatjana Bierhals, Markus Heine, Paul Pertzborn, Mira Pauly, Julia-Josefine Scholz, Suman Kundu, Marceline M. Fuh, Axel Neu, Klaus Tödter, Maja Hempel, Uwe Knippschild, Clay F. Semenkovich, Hartmut Schlüter, Joerg Heeren, Ludger Scheja, Christian Kubisch, Christian Schlein
Nat Commun. 2024; 15: 45. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44364-y
PMCID:
PMC10762034
AbstractArticlePDF–1.0M
4.
Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib
K.A. Krishnamurthy, M.G.S. Rutten, J.A. Hoogerland, T.H. van Dijk, T. Bos, M. Koehorst, M.P. de Vries, N.J. Kloosterhuis, H. Havinga, B.V. Schomakers, M. van Weeghel, J.C. Wolters, B.M. Bakker, M.H. Oosterveer
Mol Metab. 2024 Jan; 79: 101838. Published online 2023 Nov 22. doi: 10.1016/j.molmet.2023.101838
PMCID:
PMC10716006
AbstractArticlePDF–929K
5.
The transcription factor ChREBP links mitochondrial lipidomes to mitochondrial morphology and progression of diabetic kidney disease
Li Li, Jianyin Long, Koki Mise, Naravat Poungavrin, Philip L. Lorenzi, Iqbal Mahmud, Lin Tan, Pradip K. Saha, Yashpal S. Kanwar, Benny H. Chang, Farhad R. Danesh
J Biol Chem. 2023 Sep; 299(9): 105185. Published online 2023 Aug 21. doi: 10.1016/j.jbc.2023.105185
PMCID:
PMC10506103
AbstractArticlePDF–3.1M
6.
HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis
Ashot Sargsyan, Ludivine Doridot, Sarah A. Hannou, Wenxin Tong, Harini Srinivasan, Rachael Ivison, Ruby Monn, Henry H. Kou, Jonathan M. Haldeman, Michelle Arlotto, Phillip J. White, Paul A. Grimsrud, Inna Astapova, Linus T. Tsai, Mark A. Herman
JCI Insight. 2023 Jan 10; 8(1): e153740. Published online 2023 Jan 10. doi: 10.1172/jci.insight.153740
PMCID:
PMC9870088
AbstractArticlePDF–5.4M
7.
Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation
Prashanth Thevkar-Nagesh, Justine Habault, Maud Voisin, Sophie E. Ruff, Susan Ha, Rachel Ruoff, Xi Chen, Shruti Rawal, Tarik Zahr, Gyongyi Szabo, Inez Rogatsky, Edward A. Fisher, Michael J. Garabedian
PLoS One. 2022; 17(9): e0272986. Published online 2022 Sep 2. doi: 10.1371/journal.pone.0272986
PMCID:
PMC9439225
AbstractArticlePDF–1.7M
8.
The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation
Ziyi Song, Alus M. Xiaoli, Youlei Li, Gerile Siqin, Tian Wu, Randy Strich, Jeffrey E. Pessin, Fajun Yang
Mol Metab. 2022 Oct; 64: 101548. Published online 2022 Jul 19. doi: 10.1016/j.molmet.2022.101548
PMCID:
PMC9386464
AbstractArticlePDF–6.6M
9.
Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure
Liora S. Katz, Gabriel Brill, Pili Zhang, Anil Kumar, Sharon Baumel-Alterzon, Lee B. Honig, Nicolás Gómez-Banoy, Esra Karakose, Marius Tanase, Ludivine Doridot, Alexandra Alvarsson, Bennett Davenport, Peng Wang, Luca Lambertini, Sarah A. Stanley, Dirk Homann, Andrew F. Stewart, James C. Lo, Mark A. Herman, Adolfo Garcia-Ocaña, Donald K. Scott
Nat Commun. 2022; 13: 4423. Published online 2022 Jul 30. doi: 10.1038/s41467-022-32162-x
Correction in:
Nat Commun. 2022; 13: 5681.
PMCID:
PMC9339008
AbstractArticlePDF–8.0M
10.
Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells
Donghee Kim, Ga-Young Nam, Eunhui Seo, Hee-Sook Jun
J Biomed Sci. 2022; 29: 31. Published online 2022 May 10. doi: 10.1186/s12929-022-00814-1
PMCID:
PMC9092836
AbstractArticlePDF–3.7M
11.
Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia
Huabo Wang, Jie Lu, Frances Alencastro, Alexander Roberts, Julia Fiedor, Patrick Carroll, Robert N. Eisenman, Sarangarajan Ranganathan, Michael Torbenson, Andrew W. Duncan, Edward V. Prochownik
Cell Mol Gastroenterol Hepatol. 2022; 13(6): 1785–1804. Published online 2022 Mar 5. doi: 10.1016/j.jcmgh.2022.02.018
PMCID:
PMC9046243
AbstractArticlePDF–3.8M
12.
ChREBPβ is dispensable for the control of glucose homeostasis and energy balance
Emeline Recazens, Geneviève Tavernier, Jérémy Dufau, Camille Bergoglio, Fadila Benhamed, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Alice Brion, Laurent Monbrun, Renaud Dentin, Clara Ferrier, Mélanie Leroux, Pierre-Damien Denechaud, Cedric Moro, Jean-Paul Concordet, Catherine Postic, Etienne Mouisel, Dominique Langin
JCI Insight. 2022 Feb 22; 7(4): e153431. Published online 2022 Feb 22. doi: 10.1172/jci.insight.153431
PMCID:
PMC8876429
AbstractArticlePDF–4.1M
13.
Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP
Arturo Mendoza, Catherine Tang, Jinyoung Choi, Mariana Acuña, Maya Logan, Adriana G. Martin, Lujain Al-Sowaimel, Bhavna N. Desai, Danielle E. Tenen, Christopher Jacobs, Anna Lyubetskaya, Yulong Fu, Hong Liu, Linus Tsai, David E. Cohen, Douglas Forrest, Andrew A. Wilson, Anthony N. Hollenberg
Sci Signal. Author manuscript; available in PMC 2022 Feb 17.
Published in final edited form as: Sci Signal. 2021 Nov 16; 14(709): eabh3839. Published online 2021 Nov 16. doi: 10.1126/scisignal.abh3839
PMCID:
PMC8853622
AbstractArticlePDF–1.1M
14.
The Roles of Carbohydrate Response Element Binding Protein in the Relationship between Carbohydrate Intake and Diseases
Katsumi Iizuka
Int J Mol Sci. 2021 Nov; 22(21): 12058. Published online 2021 Nov 8. doi: 10.3390/ijms222112058
PMCID:
PMC8584459
AbstractArticlePDF–5.4M
15.
Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Protein Knockout Mice
Vincent Nuernberger, Sharif Mortoga, Christoph Metzendorf, Christian Burkert, Katrina Ehricke, Elisa Knuth, Jenny Zimmer, Stephan Singer, Neetika Nath, Majedul Karim, Mohd Yasser, Diego F. Calvisi, Frank Dombrowski, Silvia Ribback
Cells. 2021 Oct; 10(10): 2787. Published online 2021 Oct 18. doi: 10.3390/cells10102787
PMCID:
PMC8534692
AbstractArticlePDF–6.0M
16.
The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis
Patrick A. Carroll, Brian W. Freie, Pei Feng Cheng, Sivakanthan Kasinathan, Haiwei Gu, Theresa Hedrich, James A. Dowdle, Vivek Venkataramani, Vijay Ramani, Xiaoying Wu, Daniel Raftery, Jay Shendure, Donald E. Ayer, Charles H. Muller, Robert N. Eisenman
PLoS Biol. 2021 Oct; 19(10): e3001085. Published online 2021 Oct 20. doi: 10.1371/journal.pbio.3001085
PMCID:
PMC8528285
AbstractArticlePDF–7.1M
17.
SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1
Chaoyu Zhu, Menghao Huang, Hyeong-Geug Kim, Kushan Chowdhury, Jing Gao, Sheng Liu, Jun Wan, Li Wei, X. Charlie Dong
Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2022 Dec 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1; 1867(12): 166249. Published online 2021 Aug 21. doi: 10.1016/j.bbadis.2021.166249
PMCID:
PMC8488016
AbstractArticlePDF–1.4M
18.
Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
Christian Schlein, Alexander W. Fischer, Frederike Sass, Anna Worthmann, Klaus Tödter, Michelle Y. Jaeckstein, Janina Behrens, Matthew D. Lynes, Michael A. Kiebish, Niven R. Narain, Val Bussberg, Abena Darkwah, Naja Zenius Jespersen, Søren Nielsen, Camilla Scheele, Michaela Schweizer, Ingke Braren, Alexander Bartelt, Yu-Hua Tseng, Joerg Heeren, Ludger Scheja
Cell Rep. Author manuscript; available in PMC 2021 Jun 29.
Published in final edited form as: Cell Rep. 2021 Jan 12; 34(2): 108624. doi: 10.1016/j.celrep.2020.108624
PMCID:
PMC8240962
AbstractArticlePDF–1.0M
19.
The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation
Steffi Heidenreich, Pamela Weber, Heike Stephanowitz, Konstantin M. Petricek, Till Schütte, Moritz Oster, Antti M. Salo, Miriam Knauer, Isabel Goehring, Na Yang, Nicole Witte, Anne Schumann, Manuela Sommerfeld, Matthias Muenzner, Johanna Myllyharju, Eberhard Krause, Michael Schupp
J Biol Chem. 2020 Dec 11; 295(50): 17158–17168. Published online 2020 Oct 6. doi: 10.1074/jbc.RA120.014402
PMCID:
PMC7863887
AbstractArticlePDF–2.8M
20.
Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a
Yu Lei, Joanne A. Hoogerland, Vincent W. Bloks, Trijnie Bos, Aycha Bleeker, Henk Wolters, Justina C. Wolters, Brenda S. Hijmans, Theo H. van Dijk, Rachel Thomas, Michel van Weeghel, Gilles Mithieux, Riekelt H. Houtkooper, Alain de Bruin, Fabienne Rajas, Folkert Kuipers, Maaike H. Oosterveer
Hepatology. 2020 Nov; 72(5): 1638–1653. Published online 2020 Oct 30. doi: 10.1002/hep.31198
PMCID:
PMC7702155
AbstractArticlePDF–887K

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