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Select item 108658461.

The E3 ligase TRIM22 restricts SARS-CoV-2 replication by promoting proteasomal degradation of NSP8

Lujie Fan, Yuzheng Zhou, Xiafei Wei, Wei Feng, Huimin Guo, Yunfei Li, Xiang Gao, Jian Zhou, Yanling Wen, Yezi Wu, Xiaotong Shen, Lei Liu, Gang Xu, Zheng Zhang

mBio. 2024 Feb; 15(2): e02320-23. Published online 2024 Jan 26. doi: 10.1128/mbio.02320-23

PMCID:: PMC10865846

Abstract Article PDF–1.6M

Select item 107816802.

TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma

Donghee Kang, Hyun Jung Hwang, Yurim Baek, Jee Young Sung, KyeongJin Kim, Heon Joo Park, Young-Gyu Ko, Yong-Nyun Kim, Jae-Seon Lee

Cell Death Dis. 2024 Jan; 15(1): 26. Published online 2024 Jan 10. doi: 10.1038/s41419-024-06427-w

PMCID:: PMC10781680

Abstract Article PDF–2.7M

Select item 104998213.

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets

Filip Mihalič, Caroline Benz, Eszter Kassa, Richard Lindqvist, Leandro Simonetti, Raviteja Inturi, Hanna Aronsson, Eva Andersson, Celestine N. Chi, Norman E. Davey, Anna K. Överby, Per Jemth, Ylva Ivarsson

Nat Commun. 2023; 14: 5636. Published online 2023 Sep 13. doi: 10.1038/s41467-023-41312-8

PMCID:: PMC10499821

Abstract Article PDF–2.6M

Select item 103241604.

Aberrant KAT2A accumulations render TRIM22-low melanoma sensitive to Notch1 inhibitors via epigenetic reprogramming

Xiaoli Gu, Wei Min, Yibin Zeng, Ni Fan, Qihong Qian

J Transl Med. 2023; 21: 443. Published online 2023 Jul 6. doi: 10.1186/s12967-023-04305-1

PMCID:: PMC10324160

Abstract Article PDF–11M

Select item 103180695.

TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1

Xiaowei Fei, Ya-nan Dou, Kai Sun, Jialiang Wei, Qingdong Guo, Li Wang, Xiuquan Wu, Weihao Lv, Xiaofan Jiang, Zhou Fei

Exp Mol Med. 2023 Jun; 55(6): 1203–1217. Published online 2023 Jun 1. doi: 10.1038/s12276-023-01007-y

PMCID:: PMC10318069

Abstract Article PDF–7.6M

Select item 100058986.

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay

J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027

PMCID:: PMC10005898

Abstract Article PDF–6.7M

Select item 97696987.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 94650288.

TRIM22 orchestrates the proliferation of GBMs and the benefits of TMZ by coordinating the modification and degradation of RIG-I

Xiaowei Fei, Xiuquan Wu, Ya-Nan Dou, Kai Sun, Qingdong Guo, Lei Zhang, Sanzhong Li, Jialiang Wei, Yu Huan, Xin He, Zhou Fei

Mol Ther Oncolytics. 2022 Sep 15; 26: 413–428. Published online 2022 Aug 25. doi: 10.1016/j.omto.2022.08.007

PMCID:: PMC9465028

Abstract Article PDF–7.2M

Select item 94349879.

FOXC1-mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis via NF-κB signaling pathway

Yazhi Wei, Xinmin Huang, Yanmei Ma, Liping Dai

Mol Med Rep. 2022 Oct; 26(4): 304. Published online 2022 Aug 9. doi: 10.3892/mmr.2022.12820

PMCID:: PMC9434987

Abstract Article PDF–6.2M

Select item 941277810.

On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity

Nidhal Raheem Juhi Al-Kaabi, Sepideh Chodari Khameneh, Mohadeseh Montazeri, Mahsa Mardasi, Jalal Mosayebi Amroabadi, Fatemeh Sakhaee, Abolfazl Fateh

Hum Genomics. 2022; 16: 33. Published online 2022 Aug 26. doi: 10.1186/s40246-022-00394-z

PMCID:: PMC9412778

Abstract Article PDF–778K

Select item 921872311.

Role of TRIM22 in ulcerative colitis and its underlying mechanisms

Bin Ye, Zhongkai Lu

Mol Med Rep. 2022 Aug; 26(2): 249. Published online 2022 Jun 7. doi: 10.3892/mmr.2022.12765

PMCID:: PMC9218723

Abstract Article PDF–5.8M

Select item 914404912.

TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling

Wei Liu, Yuechao Zhao, Guangfu Wang, Shuang Feng, Xuhui Ge, Wu Ye, Zhuanghui Wang, Yufeng Zhu, Weihua Cai, Jianling Bai, Xuhui Zhou

Redox Biol. 2022 Jul; 53: 102344. Published online 2022 May 18. doi: 10.1016/j.redox.2022.102344

PMCID:: PMC9144049

Abstract Article PDF–17M

Select item 880641713.

Knockdown of Tripartite motif-containing 22 (TRIM22)relieved the apoptosis of lens epithelial cells by suppressing the expression of TNF receptor-associated factor 6 (TRAF6)

Kai Meng, Chengbo Fang

Bioengineered. 2021; 12(1): 7213–7222. Published online 2021 Sep 24. doi: 10.1080/21655979.2021.1980645

PMCID:: PMC8806417

Abstract Article PDF–2.4M

Select item 860245114.

Identification of proximal SUMO-dependent interactors using SUMO-ID

Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M. Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland

Nat Commun. 2021; 12: 6671. Published online 2021 Nov 18. doi: 10.1038/s41467-021-26807-6

PMCID:: PMC8602451

Abstract Article PDF–11M

Select item 849086915.

Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection

Matthew Charman, Steven McFarlane, Joanna K. Wojtus, Elizabeth Sloan, Rebecca Dewar, Gail Leeming, Mohammed Al-Saadi, Laura Hunter, Miles W. Carroll, James P. Stewart, Paul Digard, Edward Hutchinson, Chris Boutell

Front Cell Infect Microbiol. 2021; 11: 689707. Published online 2021 Sep 21. doi: 10.3389/fcimb.2021.689707

PMCID:: PMC8490869

Abstract Article PDF–12M

Select item 820841116.

TRIM22 inhibits the TRAF6-stimulated NF-κB pathway by targeting TAB2 for degradation

Hui Qiu, Fang Huang, Han Xiao, Binlian Sun, Rongge Yang

Virol Sin. 2013 Aug; 28(4): 209–215. Published online 2013 Jun 26. doi: 10.1007/s12250-013-3343-4

PMCID:: PMC8208411

Abstract Article PDF–632K

Select item 810809317.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 785315018.

TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα

Jianxiong Ji, Kaikai Ding, Tao Luo, Xin Zhang, Anjing Chen, Di Zhang, Gang Li, Frits Thorsen, Bin Huang, Xingang Li, Jian Wang

Cell Death Differ. 2021 Jan; 28(1): 367–381. Published online 2020 Aug 19. doi: 10.1038/s41418-020-00606-w

PMCID:: PMC7853150

Abstract Article PDF–7.7M

Select item 770413319.

Long Noncoding RNA LINC01207 Promotes Colon Cancer Cell Proliferation and Invasion by Regulating miR-3125/TRIM22 Axis

Ronghong Liu, Wenzeng Zhao, Haigang Wang, Jianbing Wang

Biomed Res Int. 2020; 2020: 1216325. Published online 2020 Nov 22. doi: 10.1155/2020/1216325

PMCID:: PMC7704133

Abstract Article PDF–1.9M

Select item 761495720.

TRIM22 genotype is not associated with markers of disease progression in children with HIV-1 infection

Michael T Boswell, Louis-Marie Yindom, Dan Hameiri-Bowen, Grace Mchugh, Ethel Dauya, Tsitsi Bandason, Hilda Mujuru, Joakim Esbjörnsson, Rashida A Ferrand, Sarah Rowland-Jones

AIDS. Author manuscript; available in PMC 2023 Aug 16.

Published in final edited form as: AIDS. 2021 Dec 1; 35(15): 2445–2450. doi: 10.1097/QAD.0000000000003053