PMC Links for GEO Profiles (Select 89818289) - PMC

Arimi Fujita, Saki Noguchi, Rika Hamada, Satoko Inoue, Tsutomu Shimada, Satomi Katakura, Tetsuo Maruyama, Yoshimichi Sai, Tomohiro Nishimura, Masatoshi Tomi

Pharm Res. 2022; 39(7): 1645–1658. Published online 2022 Jan 26. doi: 10.1007/s11095-022-03165-6

PMCID:: PMC9246986

Abstract Article PDF–582K

Select item 85904704.

Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function

Zhengrong Yang, Qingxian Zhou, Leo Mok, Anukriti Singh, Douglas J. Swartz, Ina L. Urbatsch, Christie G. Brouillette

Biochim Biophys Acta Biomembr. Author manuscript; available in PMC 2021 Nov 13.

Published in final edited form as: Biochim Biophys Acta Biomembr. 2017 Jan; 1859(1): 48–60. Published online 2016 Oct 23. doi: 10.1016/j.bbamem.2016.10.009

PMCID:: PMC8590470

Abstract Article PDF–1.2M

Select item 85057765.

Peripheral Hybrid CB₁R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis

Charles N. Zawatsky, Joshua K. Park, Jasmina Abdalla, George Kunos, Malliga R. Iyer, Resat Cinar

Front Endocrinol (Lausanne) 2021; 12: 744857. Published online 2021 Sep 28. doi: 10.3389/fendo.2021.744857

PMCID:: PMC8505776

Abstract Article PDF–3.0M

Select item 81109636.

Cage and maternal effects on the bacterial communities of the murine gut

Gurdeep Singh, Andrew Brass, Sheena M. Cruickshank, Christopher G. Knight

Sci Rep. 2021; 11: 9841. Published online 2021 May 10. doi: 10.1038/s41598-021-89185-5

PMCID:: PMC8110963

Abstract Article PDF–2.7M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 75212778.

Malaria in pregnancy regulates P‐glycoprotein (P‐gp/Abcb1a) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac

Lilian M. Martinelli, Klaus N. Fontes, Mila W. Reginatto, Cherley B. V. Andrade, Victoria R. S. Monteiro, Hanailly R. Gomes, Joao L. Silva‐Filho, Ana A. S. Pinheiro, Annamaria R. Vago, Fernanda R. C. L. Almeida, Flavia F. Bloise, Stephen G. Matthews, Tania M. Ortiga‐Carvalho, Enrrico Bloise

J Cell Mol Med. 2020 Sep; 24(18): 10636–10647. Published online 2020 Aug 11. doi: 10.1111/jcmm.15682

PMCID:: PMC7521277

Abstract Article PDF–1.5M

Select item 75181059.

Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1-Mutated Mouse Mammary Tumors

Janneke E. Jaspers, Ariena Kersbergen, Ute Boon, Wendy Sol, Liesbeth van Deemter, Serge A. Zander, Rinske Drost, Ellen Wientjens, Jiuping Ji, Amal Aly, James H. Doroshow, Aaron Cranston, Niall M.B. Martin, Alan Lau, Mark J. O’Connor, Shridar Ganesan, Piet Borst, Jos Jonkers, Sven Rottenberg

Cancer Discov. Author manuscript; available in PMC 2020 Sep 25.

Published in final edited form as: Cancer Discov. 2013 Jan; 3(1): 68–81. Published online 2012 Oct 25. doi: 10.1158/2159-8290.CD-12-0049

PMCID:: PMC7518105

Abstract Article PDF–1.6M

Select item 735501710.

Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives

Ling Zou, Peter Spanogiannopoulos, Lindsey M. Pieper, Huan-Chieh Chien, Wenlong Cai, Natalia Khuri, Joshua Pottel, Bianca Vora, Zhanglin Ni, Eleftheria Tsakalozou, Wenjun Zhang, Brian K. Shoichet, Kathleen M. Giacomini, Peter J. Turnbaugh

Proc Natl Acad Sci U S A. 2020 Jul 7; 117(27): 16009–16018. Published online 2020 Jun 22. doi: 10.1073/pnas.1920483117

PMCID:: PMC7355017

Abstract Article PDF–1.1M

Select item 727996311.

OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation

Yaogeng Wang, Rolf W. Sparidans, Wenlong Li, Maria C. Lebre, Jos H. Beijnen, Alfred H. Schinkel

Br J Pharmacol. 2020 Jul; 177(13): 3060–3074. Published online 2020 Apr 12. doi: 10.1111/bph.15034

PMCID:: PMC7279963

Abstract Article PDF–3.3M

Select item 720192912.

Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes

Mei Lan Chen, Amy Sun, Wei Cao, Amber Eliason, Kayla M. Mendez, Adam J. Getzler, Shanel Tsuda, Huitian Diao, Clever Mukori, Nelson E. Bruno, Sang Yong Kim, Matthew E. Pipkin, Sergei B. Koralov, Mark S. Sundrud

J Exp Med. 2020 May 4; 217(5): e20191388. Published online 2020 Apr 16. doi: 10.1084/jem.20191388

PMCID:: PMC7201929

Abstract Article PDF–4.6M

Select item 692854613.

Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET

Viktoria Zoufal, Thomas Wanek, Markus Krohn, Severin Mairinger, Thomas Filip, Michael Sauberer, Johann Stanek, Thomas Pekar, Martin Bauer, Jens Pahnke, Oliver Langer

J Cereb Blood Flow Metab. 2020 Jan; 40(1): 150–162. Published online 2018 Oct 24. doi: 10.1177/0271678X18806640

PMCID:: PMC6928546

Abstract Article PDF–806K

Select item 664215914.

Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling

Alper Okyar, Swati A. Kumar, Elisabeth Filipski, Enza Piccolo, Narin Ozturk, Helena Xandri-Monje, Zeliha Pala, Kristin Abraham, Ana Rita Gato de Jesus Gomes, Mehmet N. Orman, Xiao-Mei Li, Robert Dallmann, Francis Lévi, Annabelle Ballesta

Sci Rep. 2019; 9: 10505. Published online 2019 Jul 19. doi: 10.1038/s41598-019-46977-0

PMCID:: PMC6642159

Abstract Article PDF–3.6M

Select item 661013315.

Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary

Haley Clark, Laura O. Knapik, Zijing Zhang, Xiaotian Wu, Mandar T. Naik, Nathalie Oulhen, Gary M. Wessel, Lynae M. Brayboy

Sci Rep. 2019; 9: 9616. Published online 2019 Jul 3. doi: 10.1038/s41598-019-46025-x

PMCID:: PMC6610133

Abstract Article PDF–4.1M

Select item 650514716.

Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes

Amie Perry, Rachel M. Lynch, Ivan Rusyn, David W. Threadgill

G3 (Bethesda) 2019 May; 9(5): 1729–1737. Published online 2019 Mar 21. doi: 10.1534/g3.119.400161

PMCID:: PMC6505147

Abstract Article PDF–1.4M

Select item 648900617.

WYE-354 restores Adriamycin sensitivity in multidrug-resistant acute myeloid leukemia cell lines

Sara M. Ibrahim, Sherin Bakhashab, Asad M. Ilyas, Peter N. Pushparaj, Sajjad Karim, Jalaluddin A. Khan, Adel M. Abuzenadah, Adeel G. Chaudhary, Muhammed H. Al-Qahtani, Farid Ahmed

Oncol Rep. 2019 Jun; 41(6): 3179–3188. Published online 2019 Apr 2. doi: 10.3892/or.2019.7093

PMCID:: PMC6489006

Abstract Article PDF–1.1M

Select item 631789318.

A conformationally-gated model of methadone and loperamide transport by P-glycoprotein

Morgan E. Gibbs, Laura A. Wilt, Kaitlyn V. Ledwitch, Arthur G. Roberts

J Pharm Sci. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: J Pharm Sci. 2018 Jul; 107(7): 1937–1947. Published online 2018 Feb 28. doi: 10.1016/j.xphs.2018.02.019

PMCID:: PMC6317893

Abstract Article PDF–2.7M

Select item 613065419.

Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine

Liping Ma, Shijie Wei, Bei Yang, Wei Ma, Xiuli Wu, Hongyan Ji, Hong Sui, Jing Chen

Pharm Biol. 2017; 55(1): 374–380. Published online 2016 Dec 8. doi: 10.1080/13880209.2016.1241810

PMCID:: PMC6130654

Abstract Article PDF–874K

Select item 611859320.

Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis

Rose L. Szabady, Christopher Louissaint, Anneke Lubben, Bailu Xie, Shaun Reeksting, Christine Tuohy, Zachary Demma, Sage E. Foley, Christina S. Faherty, Alejandro Llanos-Chea, Andrew J. Olive, Randall J. Mrsny, Beth A. McCormick

J Clin Invest. 2018 Aug 31; 128(9): 4044–4056. Published online 2018 Aug 13. doi: 10.1172/JCI96817

PMCID:: PMC6118593

Abstract Article PDF–4.3M

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