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Items: 1 to 20 of 168

1.
c-KIT inhibitors reduce pathology and improve behavior in the Tg(SwDI) model of Alzheimer’s disease
Max Stevenson, Michaeline L Hebron, Xiaoguang Liu, Kaluvu Balaraman, Christian Wolf, Charbel Moussa
Life Sci Alliance. 2024 Oct; 7(10): e202402625. Published online 2024 Jul 15. doi: 10.26508/lsa.202402625
PMCID:
PMC11249953
AbstractArticlePDF–2.7M
2.
Individualized high-resolution analysis to categorize diverse learning and memory deficits in tau rTg4510 mice exposed to low-intensity blast
Amitai Zuckerman, Heather R. Siedhoff, Ashley Balderrama, Runting Li, Grace Y. Sun, David X. Cifu, Ibolja Cernak, Jiankun Cui, Zezong Gu
Front Cell Neurosci. 2024; 18: 1397046. Published online 2024 Jun 13. doi: 10.3389/fncel.2024.1397046
PMCID:
PMC11212475
AbstractArticlePDF–3.0M
3.
Overexpression of pathogenic tau in astrocytes causes a reduction in AQP4 and GLT1, an immunosuppressed phenotype and unique transcriptional responses to repetitive mild TBI without appreciable changes in tauopathy
Camila Ortiz, Andrew Pearson, Robyn McCartan, Shawn Roche, Nolan Carothers, Mackenzie Browning, Sylvia Perez, Bin He, Stephen D. Ginsberg, Michael Mullan, Elliott J. Mufson, Fiona Crawford, Joseph Ojo
J Neuroinflammation. 2024; 21: 130. Published online 2024 May 15. doi: 10.1186/s12974-024-03117-4
PMCID:
PMC11096096
AbstractArticlePDF–8.0M
4.
The Chronic Effects of a Single Low-Intensity Blast Exposure on Phosphoproteome Networks and Cognitive Function Influenced by Mutant Tau Overexpression
Marcus Jackson, Shanyan Chen, Thao Thi Nguyen, Heather R. Siedhoff, Ashley Balderrama, Amitai Zuckerman, Runting Li, C. Michael Greenlief, Gregory Cole, Sally A. Frautschy, Jiankun Cui, Zezong Gu
Int J Mol Sci. 2024 Mar; 25(6): 3338. Published online 2024 Mar 15. doi: 10.3390/ijms25063338
PMCID:
PMC10970429
AbstractArticlePDF–5.0M
5.
Updates on mouse models of Alzheimer’s disease
Michael Z. Zhong, Thomas Peng, Mariana Lemos Duarte, Minghui Wang, Dongming Cai
Mol Neurodegener. 2024; 19: 23. Published online 2024 Mar 11. doi: 10.1186/s13024-024-00712-0
PMCID:
PMC10926682
AbstractArticlePDF–3.2M
6.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
7.
P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes
Paula Beltran-Lobo, Martina M. Hughes, Claire Troakes, Cara L. Croft, Huzefa Rupawala, Daniel Jutzi, Marc-David Ruepp, Maria Jimenez-Sanchez, Michael S. Perkinton, Michael Kassiou, Todd E. Golde, Diane P. Hanger, Alexei Verkhratsky, Beatriz G. Perez-Nievas, Wendy Noble
Brain Behav Immun. 2023 Nov; 114: 414–429. doi: 10.1016/j.bbi.2023.09.011
PMCID:
PMC10896738
AbstractArticle
8.
TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria
Nolan M. Dvorak, Nadia D. Domingo, Cynthia M. Tapia, Paul A. Wadsworth, Mate Marosi, Yosef Avchalumov, Chanida Fongsaran, Leandra Koff, Jessica Di Re, Catherine M. Sampson, Timothy J. Baumgartner, Pingyuan Wang, Paula P. Villarreal, Olivia D. Solomon, Sonja J. Stutz, Aditi, Jacob Porter, Komi Gbedande, Brendan Prideaux, Thomas A. Green, Erin H. Seeley, Parimal Samir, Kelley T. Dineley, Gracie Vargas, Jia Zhou, Irma Cisneros, Robin Stephens, Fernanda Laezza
J Neuroinflammation. 2023; 20: 306. Published online 2023 Dec 19. doi: 10.1186/s12974-023-02992-7
PMCID:
PMC10729485
AbstractArticlePDF–4.1M
9.
Deleterious and protective effects of epothilone-D alone and in the context of amyloid β- and tau-induced alterations
Ángel Abdiel Robles-Gómez, Benito Ordaz, Jonathan-Julio Lorea-Hernández, Fernando Peña-Ortega
Front Mol Neurosci. 2023; 16: 1198299. Published online 2023 Oct 12. doi: 10.3389/fnmol.2023.1198299
PMCID:
PMC10603193
AbstractArticlePDF–11M
10.
Progressive tauopathy disrupts breathing stability and chemoreflexes during presumptive sleep in mice
Alexandria B. Marciante, Carter Lurk, Luz Mata, Jada Lewis, Leah R. Reznikov, Gordon S. Mitchell
Front Physiol. 2023; 14: 1272980. Published online 2023 Sep 21. doi: 10.3389/fphys.2023.1272980
PMCID:
PMC10551153
AbstractArticlePDF–3.7M
11.
Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease
Seo-Hyun Kim, Young-Sin Cho, Youbin Kim, Jisu Park, Seung-Min Yoo, Jimin Gwak, Youngwon Kim, Youngdae Gwon, Tae-in Kam, Yong-Keun Jung
Autophagy. 2023; 19(8): 2318–2337. Published online 2023 Feb 26. doi: 10.1080/15548627.2023.2181614
PMCID:
PMC10351450
AbstractArticlePDF–6.5M
12.
Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer’s disease
Lan-Ting Zhou, Dan Liu, Hui-Cong Kang, Lu Lu, He-Zhou Huang, Wen-Qing Ai, Yang Zhou, Man-Fei Deng, Hao Li, Zhi-Qiang Liu, Wei-Feng Zhang, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Jun Jia, Avijite Kumer Sarkar, Saldin Sharaydeh, Jie Wang, Heng-Ye Man, Marcel Schilling, Lars Bertram, Youming Lu, Ziyuan Guo, Ling-Qiang Zhu
Sci Adv. 2023 Apr; 9(16): eabq7105. Published online 2023 Apr 21. doi: 10.1126/sciadv.abq7105
PMCID:
PMC10121173
AbstractArticlePDF–2.9M
13.
Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice
Steven S. Hou, Joyce Yang, Jeong Heon Lee, Yeseo Kwon, Maria Calvo-Rodriguez, Kai Bao, Sung Ahn, Satoshi Kashiwagi, Anand T. N. Kumar, Brian J. Bacskai, Hak Soo Choi
Nat Biomed Eng. Author manuscript; available in PMC 2023 Mar 27.
Published in final edited form as: Nat Biomed Eng. 2023 Mar; 7(3): 270–280. Published online 2023 Feb 6. doi: 10.1038/s41551-023-01003-7
PMCID:
PMC10040441
AbstractArticlePDF–3.7M
14.
Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation
Elizabeth Ochoa, Paulino Ramirez, Elias Gonzalez, Jasmine De Mange, William J. Ray, Kevin F. Bieniek, Bess Frost
Sci Adv. 2023 Jan; 9(1): eabq5423. Published online 2023 Jan 6. doi: 10.1126/sciadv.abq5423
PMCID:
PMC9821943
AbstractArticlePDF–1.8M
15.
Altered low-frequency brain rhythms precede changes in gamma power during tauopathy
Fabio R. Rodrigues, Amalia Papanikolaou, Joanna Holeniewska, Keith G. Phillips, Aman B. Saleem, Samuel G. Solomon
iScience. 2022 Oct 21; 25(10): 105232. Published online 2022 Sep 28. doi: 10.1016/j.isci.2022.105232
PMCID:
PMC9579020
AbstractArticlePDF–2.8M
16.
Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology
Koyo Tsujikawa, Kohei Hamanaka, Yuichi Riku, Yuki Hattori, Norikazu Hara, Yohei Iguchi, Shinsuke Ishigaki, Atsushi Hashizume, Satoko Miyatake, Satomi Mitsuhashi, Yu Miyazaki, Mayumi Kataoka, Li Jiayi, Keizo Yasui, Satoshi Kuru, Haruki Koike, Kenta Kobayashi, Naruhiko Sahara, Norio Ozaki, Mari Yoshida, Akiyoshi Kakita, Yuko Saito, Yasushi Iwasaki, Akinori Miyashita, Takeshi Iwatsubo, Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI), Takeshi Ikeuchi, Japanese Longitudinal Biomarker Study in PSP and CBD (JALPAC) Consortium, Takaki Miyata, Gen Sobue, Naomichi Matsumoto, Kentaro Sahashi, Masahisa Katsuno
Sci Adv. 2022 May; 8(21): eabm5029. Published online 2022 May 25. doi: 10.1126/sciadv.abm5029
PMCID:
PMC9132466
AbstractArticlePDF–1.8M
17.
Evidence against a contribution of the CCAAT-enhancer binding protein homologous protein (CHOP) in mediating neurotoxicity in rTg4510 mice
Marangelie Criado-Marrero, Danielle M. Blazier, Lauren A. Gould, Niat T. Gebru, Santiago Rodriguez Ospina, Debra S. Armendariz, April L. Darling, David Beaulieu-Abdelahad, Laura J. Blair
Sci Rep. 2022; 12: 7372. Published online 2022 May 5. doi: 10.1038/s41598-022-11025-x
PMCID:
PMC9072347
AbstractArticlePDF–6.3M
18.
Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice
Paula de Oliveira, Claire Cella, Nicolas Locker, Kiran K. G. Ravindran, Agampodi Mendis, Keith Wafford, Gary Gilmour, Derk-Jan Dijk, Raphaelle Winsky-Sommerer
J Neurosci. 2022 Apr 20; 42(16): 3494–3509. doi: 10.1523/JNEUROSCI.2162-21.2022
PMCID:
PMC9034788
AbstractArticlePDF–4.9M
19.
PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain
Ari W. Schaler, Avery M. Runyan, Catherine L. Clelland, Eric J. Sydney, Stephanie L. Fowler, Helen Y. Figueroa, Seiji Shioda, Ismael Santa-Maria, Karen E. Duff, Natura Myeku
Sci Transl Med. Author manuscript; available in PMC 2022 Apr 7.
Published in final edited form as: Sci Transl Med. 2021 May 26; 13(595): eaba7394. doi: 10.1126/scitranslmed.aba7394
PMCID:
PMC8988215
AbstractArticlePDF–3.1M
20.
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy
Kevin R. Nash, Daniel C. Lee, Jerry B. Hunt, Jr., Josh M. Morganti, Maj-Linda Selenica, Peter Moran, Patrick Reid, Milene Brownlow, Clement Guang-Yu Yang, Miloni Savalia, Carmelina Gemma, Paula C. Bickford, Marcia N. Gordon, David Morgan
Neurobiol Aging. Author manuscript; available in PMC 2022 Mar 31.
Published in final edited form as: Neurobiol Aging. 2013 Jun; 34(6): 1540–1548. Published online 2013 Jan 16. doi: 10.1016/j.neurobiolaging.2012.12.011
PMCID:
PMC8970215
AbstractArticlePDF–922K

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