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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 94819332.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 94423483.

Ahnak depletion accelerates liver regeneration by modulating the TGF-β/Smad signaling pathway

Insook Yang, Yeri Son, Jae Hoon Shin, Il Yong Kim, Je Kyung Seong

BMB Rep. 2022 Aug 31; 55(8): 401–406. Published online 2022 Aug 31. doi: 10.5483/BMBRep.2022.55.8.071

PMCID:: PMC9442348

Abstract Article PDF–1.8M

Select item 83503324.

Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells

Jung Min Suh, Yelin Son, Jung-Yeon Yoo, Yookyung Goh, Nabil G. Seidah, Sanghyuk Lee, Yun Soo Bae

Neoplasia. 2021 Sep; 23(9): 993–1001. Published online 2021 Aug 3. doi: 10.1016/j.neo.2021.07.007

PMCID:: PMC8350332

Abstract Article PDF–1.8M

Select item 80807125.

Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction

Yo Na Kim, Jae Hoon Shin, Dong Soo Kyeong, Soo Young Cho, Mi-Young Kim, Hee Jung Lim, Maria Raquel Rojas Jimenez, Il Yong Kim, Mi-Ock Lee, Yun Soo Bae, Je Kyung Seong

Exp Mol Med. 2021 Mar; 53(3): 468–482. Published online 2021 Mar 30. doi: 10.1038/s12276-021-00573-3

PMCID:: PMC8080712

Abstract Article PDF–3.0M

Select item 72978126.

Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening

Jiuann-Huey I. Lin, Timothy N. Feinstein, Anupma Jha, Jacob T. McCleary, Juan Xu, Angelo B. Arrigo, Grace Rong, Lindsey M. Maclay, Taylor Ridge, XinXiu Xu, Cecilia W. Lo

Commun Biol. 2020; 3: 312. Published online 2020 Jun 16. doi: 10.1038/s42003-020-1035-9

PMCID:: PMC7297812

Abstract Article PDF–9.8M

Select item 69939257.

Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers

Chao Wang, Bin Zhang, Anna C. Ratliff, Justine Arrington, Jingjuan Chen, Yan Xiong, Feng Yue, Yaohui Nie, Keping Hu, Wen Jin, W. Andy Tao, Christine A. Hrycyna, Xiaobo Sun, Shihuan Kuang

FASEB J. 2019 Aug; 33(8): 9672–9684. Published online 2019 Jun 4. doi: 10.1096/fj.201900582R

PMCID:: PMC6993925

Abstract Article

Select item 66922568.

Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior

Junghee Jin, Dionnet L. Bhatti, Ko-Woon Lee, Lucian Medrihan, Jia Cheng, Jing Wei, Ping Zhong, Zhen Yan, Cassandra Kooiker, Claire Song, Jung-Hyuck Ahn, Gerald J. Obermair, Amy Lee, Jodi Gresack, Paul Greengard, Yong Kim

Mol Psychiatry. 2020; 25(5): 1035–1049. Published online 2019 Feb 13. doi: 10.1038/s41380-019-0371-y

PMCID:: PMC6692256

Abstract Article PDF–3.0M

Select item 66555519.

WDFY4 is required for cross-presentation in response to viral and tumor antigens

Derek J. Theisen, Jesse T. Davidson, IV, Carlos G. Briseño, Marco Gargaro, Elvin J. Lauron, Qiuling Wang, Pritesh Desai, Vivek Durai, Prachi Bagadia, Joshua R. Brickner, Wandy L. Beatty, Herbert W. Virgin, William E. Gillanders, Nima Mosammaparast, Michael S. Diamond, L. David Sibley, Wayne Yokoyama, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy

Science. Author manuscript; available in PMC 2019 Jul 24.

Published in final edited form as: Science. 2018 Nov 9; 362(6415): 694–699. doi: 10.1126/science.aat5030

PMCID:: PMC6655551

Abstract Article PDF–1020K

Select item 629804010.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 615819411.

Ahnak promotes tumor metastasis through transforming growth factor-β-mediated epithelial-mesenchymal transition

Mira Sohn, Sunmee Shin, Jung-Yeon Yoo, Yookyung Goh, In Hye Lee, Yun Soo Bae

Sci Rep. 2018; 8: 14379. Published online 2018 Sep 26. doi: 10.1038/s41598-018-32796-2

PMCID:: PMC6158194

Abstract Article PDF–1.7M

Select item 611328112.

Essential role of Ahnak in adipocyte differentiation leading to the transcriptional regulation of Bmpr1α expression

Jong Kyu Woo, Jae Hoon Shin, Seo Hyun Lee, Hun-Min Park, Soo Young Cho, You Me Sung, Il Yong Kim, Je Kyung Seong

Cell Death Dis. 2018 Sep; 9(9): 864. Published online 2018 Aug 28. doi: 10.1038/s41419-018-0873-6

PMCID:: PMC6113281

Abstract Article PDF–3.6M

Select item 586277113.

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

David K. Breslow, Sascha Hoogendoorn, Adam R. Kopp, David W. Morgens, Brandon K. Vu, Margaret C. Kennedy, Kyuho Han, Amy Li, Gaelen T. Hess, Michael C. Bassik, James K. Chen, Maxence V. Nachury

Nat Genet. Author manuscript; available in PMC 2018 Aug 19.

Published in final edited form as: Nat Genet. 2018 Mar; 50(3): 460–471. Published online 2018 Feb 19. doi: 10.1038/s41588-018-0054-7

PMCID:: PMC5862771

Abstract Article PDF–2.5M

Select item 566564314.

CHIP as a membrane-shuttling proteostasis sensor

Yannick Kopp, Wei-Han Lang, Tobias B Schuster, Adrián Martínez-Limón, Harald F Hofbauer, Robert Ernst, Giulia Calloni, R Martin Vabulas

eLife. 2017; 6: e29388. Published online 2017 Nov 1. doi: 10.7554/eLife.29388

PMCID:: PMC5665643

Abstract Article PDF–2.2M

Select item 550974015.

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling

Brent Wilkinson, Jing Li, Marcelo P. Coba

Sci Rep. 2017; 7: 5272. Published online 2017 Jul 13. doi: 10.1038/s41598-017-05588-3

PMCID:: PMC5509740

Abstract Article PDF–4.6M

Select item 538122616.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 529582117.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 479681218.

AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to β-adrenergic signalling

Jae Hoon Shin, Seo Hyun Lee, Yo Na Kim, Il Yong Kim, Youn Ju Kim, Dong Soo Kyeong, Hee Jung Lim, Soo Young Cho, Junhee Choi, Young Jin Wi, Jae-Hoon Choi, Yeo Sung Yoon, Yun Soo Bae, Je Kyung Seong

Sci Rep. 2016; 6: 23426. Published online 2016 Mar 18. doi: 10.1038/srep23426

PMCID:: PMC4796812

Abstract Article PDF–1.5M

Select item 470539519.

Regulation of c-Myc Expression by Ahnak Promotes Induced Pluripotent Stem Cell Generation

Hee Jung Lim, Jusong Kim, Chang-Hwan Park, Sang A. Lee, Man Ryul Lee, Kye-Seong Kim, Jaesang Kim, Yun Soo Bae

J Biol Chem. 2016 Jan 8; 291(2): 752–761. Published online 2015 Nov 23. doi: 10.1074/jbc.M115.659276

PMCID:: PMC4705395

Abstract Article PDF–2.6M

Select item 460577620.

Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak^-/- Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure

Jae Hoon Shin, Il Yong Kim, Yo Na Kim, Sun Mee Shin, Kyung Jin Roh, Seo Hyun Lee, Mira Sohn, Soo Young Cho, Sang Hyuk Lee, Chang-Yong Ko, Han-Sung Kim, Cheol Soo Choi, Yun Soo Bae, Je Kyung Seong

PLoS One. 2015; 10(10): e0139720. Published online 2015 Oct 14. doi: 10.1371/journal.pone.0139720

Correction in:: PLoS One. 2015; 10(12): e0144478.

PMCID:: PMC4605776

Abstract Article PDF–3.9M

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