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Select item 113030711.

ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation

Na Cui, Chengyu Liu, Xiang Tang, Liangliang Song, Zixuan Xiao, Chen Wang, Yancai Wu, Yihao Zhou, Chentai Peng, Yuxia Liu, Ling Zheng, Xinran Liu, Kun Huang, Hong Chen

Theranostics. 2024; 14(11): 4536–4553. Published online 2024 Jul 22. doi: 10.7150/thno.95796

PMCID:: PMC11303071

Abstract Article PDF–15M

Select item 110747912.

ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection

Clara Bredow, Fabien Thery, Eva Katrin Wirth, Sarah Ochs, Meike Kespohl, Gunnar Kleinau, Nicolas Kelm, Niclas Gimber, Jan Schmoranzer, Martin Voss, Karin Klingel, Joachim Spranger, Kostja Renko, Markus Ralser, Michael Mülleder, Arnd Heuser, Klaus-Peter Knobeloch, Patrick Scheerer, Jennifer Kirwan, Ulrike Brüning, Nikolaus Berndt, Francis Impens, Antje Beling

Cardiovasc Res. 2024 Apr; 120(6): 644–657. Published online 2024 Feb 3. doi: 10.1093/cvr/cvae026

PMCID:: PMC11074791

Abstract Article PDF–1.5M

Select item 110039913.

Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage

Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Shinichi Shirai, Yuka Hama, Hajime Komano, Yuko Saito, Ichiro Yabe, Hideyuki Okano, Hidenao Sasaki, Hikari Tanaka, Hitoshi Okazawa

Commun Biol. 2024; 7: 413. Published online 2024 Apr 9. doi: 10.1038/s42003-024-06066-z

PMCID:: PMC11003991

Abstract Article PDF–5.9M

Select item 108226694.

Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18

Sayuri Miyauchi, Kei-ichiro Arimoto, Mengdan Liu, Yue Zhang, Dong-Er Zhang

Cell Rep. Author manuscript; available in PMC 2024 Jan 28.

Published in final edited form as: Cell Rep. 2023 Dec 26; 42(12): 113560. Published online 2023 Dec 13. doi: 10.1016/j.celrep.2023.113560

PMCID:: PMC10822669

Abstract Article PDF–2.5M

Select item 102698065.

ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular Virions

Martina Bécares, Manuel Albert, Céline Tárrega, Rocío Coloma, Michela Falqui, Emma K. Luhmann, Lilliana Radoshevich, Susana Guerra

Microbiol Spectr. 2023 May-Jun; 11(3): e04508-22. Published online 2023 Apr 10. doi: 10.1128/spectrum.04508-22

PMCID:: PMC10269806

Abstract Article PDF–2.2M

Select item 102041616.

ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma

Tongyuan Qu, Wenshuai Zhang, Chenhui Yan, Danyang Ren, Yalei Wang, Yuhong Guo, Qianru Guo, Jinpeng Wang, Liren Liu, Lei Han, Lingmei Li, Qiujuan Huang, Lu Cao, Zhaoxiang Ye, Bin Zhang, Qiang Zhao, Wenfeng Cao

J Transl Med. 2023; 21: 341. Published online 2023 May 22. doi: 10.1186/s12967-023-04135-1

PMCID:: PMC10204161

Abstract Article PDF–16M

Select item 101767487.

ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1

Yaru Chen, Jiawei Zhou, Shang Wu, Lei Wang, Gaogui Chen, Dake Chen, Xianwen Peng, Yi-Liang Miao, Shuqi Mei, Fenge Li

Cell Biosci. 2023; 13: 84. Published online 2023 May 11. doi: 10.1186/s13578-023-01024-4

PMCID:: PMC10176748

Abstract Article PDF–3.3M

Select item 101459418.

Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure

Veera Ganesh Yerra, Sri Nagarjun Batchu, Harmandeep Kaur, MD Golam Kabir, Youan Liu, Suzanne L. Advani, Duc Tin Tran, Shadi Sadeghian, Phelopater Sedrak, Filio Billia, Uros Kuzmanov, Anthony O. Gramolini, Deema O. Qasrawi, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kim A. Connelly, Andrew Advani

J Clin Invest. 2023 May 1; 133(9): e161453. Published online 2023 May 1. doi: 10.1172/JCI161453

PMCID:: PMC10145941

Abstract Article PDF–12M

Select item 101330969.

ISGylation of NF-κBp65 by SCF^FBXL19 E3 ligase diminishes endothelial inflammation

Lian Li, Jiaxing Miao, Nargis Shaheen, Sarah J. Taleb, Jian Hu, Qinmao Ye, Jinshan He, Jiasheng Yan, Rama K. Mallampalli, Jing Zhao, Yutong Zhao

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 May; 43(5): 674–683. Published online 2023 Mar 30. doi: 10.1161/ATVBAHA.122.318894

PMCID:: PMC10133096

Abstract Article PDF–1.9M

Select item 1011050110.

Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling

Dhwani N. Rupani, Fredrik I. Thege, Vidhi Chandra, Hajar Rajaei, Robert W. Cowan, Sonja M. Wörmann, Olivereen Le Roux, Prerna Malaney, Sara L. Manning, Jack Hashem, Jennifer Bailey-Lundberg, Andrew D. Rhim, Florencia McAllister

Development. 2023 Jan 15; 150(2): dev201097. Published online 2023 Jan 16. doi: 10.1242/dev.201097

PMCID:: PMC10110501

Abstract Article

Select item 964884011.

Free ISG15 inhibits Pseudorabies virus infection by positively regulating type I IFN signaling

Huimin Liu, Chen Li, Wenfeng He, Jing Chen, Guoqing Yang, Lu Chen, Hongtao Chang

PLoS Pathog. 2022 Oct; 18(10): e1010921. Published online 2022 Oct 31. doi: 10.1371/journal.ppat.1010921

PMCID:: PMC9648840

Abstract Article PDF–3.5M

Select item 950284512.

Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity

Chen Li, Wen-Feng He, Long-Xi Li, Jing Chen, Guo-Qing Yang, Hong-Tao Chang, Hui-Min Liu

Viruses. 2022 Sep; 14(9): 1862. Published online 2022 Aug 24. doi: 10.3390/v14091862

PMCID:: PMC9502845

Abstract Article PDF–2.7M

Select item 868669013.

Genome Instability Independent of Type I Interferon Signaling Drives Neuropathology Caused by Impaired Ribonucleotide Excision Repair

Aditi, Susanna M. Downing, Patrick A. Schreiner, Young Don Kwak, Yang Li, Timothy I. Shaw, Helen R. Russell, Peter J. McKinnon

Neuron. Author manuscript; available in PMC 2022 Dec 15.

Published in final edited form as: Neuron. 2021 Dec 15; 109(24): 3962–3979.e6. Published online 2021 Oct 15. doi: 10.1016/j.neuron.2021.09.040

PMCID:: PMC8686690

Abstract Article PDF–4.1M

Select item 856021114.

Endocardial/endothelial angiocrines regulate cardiomyocyte development and maturation and induce features of ventricular non-compaction

Siyeon Rhee, David T Paik, Johnson Y Yang, Danielle Nagelberg, Ian Williams, Lei Tian, Robert Roth, Mark Chandy, Jiyeon Ban, Nadjet Belbachir, Seokho Kim, Hao Zhang, Ragini Phansalkar, Ka Man Wong, Devin A King, Caroline Valdez, Virginia D Winn, Ashby J Morrison, Joseph C Wu, Kristy Red-Horse

Eur Heart J. 2021 Nov 1; 42(41): 4264–4276. Published online 2021 Jul 19. doi: 10.1093/eurheartj/ehab298

PMCID:: PMC8560211

Abstract Article PDF–1.8M

Select item 801190415.

IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis

Shuai Yan, Manju Kumari, Haopeng Xiao, Christopher Jacobs, Shihab Kochumon, Mark Jedrychowski, Edward Chouchani, Rasheed Ahmad, Evan D. Rosen

J Clin Invest. 2021 Apr 1; 131(7): e144888. Published online 2021 Apr 1. doi: 10.1172/JCI144888

PMCID:: PMC8011904

Abstract Article PDF–4.6M

Select item 793877016.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 756758817.

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

Wioletta Rut, Zongyang Lv, Mikolaj Zmudzinski, Stephanie Patchett, Digant Nayak, Scott J. Snipas, Farid El Oualid, Tony T. Huang, Miklos Bekes, Marcin Drag, Shaun K. Olsen

Sci Adv. 2020 Oct; 6(42): eabd4596. Published online 2020 Oct 16. doi: 10.1126/sciadv.abd4596

PMCID:: PMC7567588

Abstract Article PDF–5.6M

Select item 746102018.

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine GC Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi‐Tunnicliffe, Peter E Czabotar, Jeffrey P Mitchell, Rebecca Feltham, Bernhard C Lechtenberg, Kym N Lowes, Grant Dewson, Marc Pellegrini, Guillaume Lessene, David Komander

EMBO J. 2020 Sep 15; 39(18): e106275. Published online 2020 Aug 26. doi: 10.15252/embj.2020106275

PMCID:: PMC7461020

Abstract Article PDF–2.8M

Select item 740572119.

ISG15 Acts as a Mediator of Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6J Mouse Corneas

Nan Gao, Rao Me, Chenyang Dai, Fu-shin X. Yu

Invest Ophthalmol Vis Sci. 2020 May; 61(5): 26. Published online 2020 May 16. doi: 10.1167/iovs.61.5.26

PMCID:: PMC7405721

Abstract Article PDF–11M

Select item 737022620.

Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15

EunBin Kong, Hag Dong Kim, Joon Kim

Cell Death Differ. 2020 Aug; 27(8): 2517–2530. Published online 2020 Mar 3. doi: 10.1038/s41418-020-0519-y

PMCID:: PMC7370226

Abstract Article PDF–2.6M

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