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Items: 1 to 20 of 26

1.
The Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons
Tenzin Ngodup, Tomohiko Irie, Seán P Elkins, Laurence O Trussell
eLife. 2024; 12: RP89520. Published online 2024 Jan 10. doi: 10.7554/eLife.89520
PMCID:
PMC10945507
AbstractArticlePDF–3.2M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Contributions of the Sodium Leak Channel NALCN to Pacemaking of Medial Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons
Dana E. Cobb-Lewis, Lorenzo Sansalone, Zayd M. Khaliq
J Neurosci. 2023 Oct 11; 43(41): 6841–6853. doi: 10.1523/JNEUROSCI.0930-22.2023
PMCID:
PMC10573758
AbstractArticlePDF–3.7M
4.
Effects of NALCN-Encoded Na+ Leak Currents on the Repetitive Firing Properties of SCN Neurons Depend on K+-Driven Rhythmic Changes in Input Resistance
Nien-Du Yang, Rebecca L. Mellor, Tracey O. Hermanstyne, Jeanne M. Nerbonne
J Neurosci. 2023 Jul 12; 43(28): 5132–5141. doi: 10.1523/JNEUROSCI.0182-23.2023
PMCID:
PMC10342223
AbstractArticlePDF–1.2M
5.
The NALCN channel regulates metastasis and nonmalignant cell dissemination
Eric P. Rahrmann, David Shorthouse, Amir Jassim, Linda P. Hu, Mariaestela Ortiz, Betania Mahler-Araujo, Peter Vogel, Marta Paez-Ribes, Atefeh Fatemi, Gregory J. Hannon, Radhika Iyer, Jay A. Blundon, Filipe C. Lourenço, Jonathan Kay, Rosalynn M. Nazarian, Benjamin A. Hall, Stanislav S. Zakharenko, Douglas J. Winton, Liqin Zhu, Richard J. Gilbertson
Nat Genet. 2022; 54(12): 1827–1838. Published online 2022 Sep 29. doi: 10.1038/s41588-022-01182-0
PMCID:
PMC9729110
AbstractArticlePDF–21M
6.
TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons
Ki Bum Um, Suyun Hahn, So Woon Kim, Yoon Je Lee, Lutz Birnbaumer, Hyun Jin Kim, Myoung Kyu Park
eLife. 2021; 10: e70920. Published online 2021 Aug 19. doi: 10.7554/eLife.70920
PMCID:
PMC8456572
AbstractArticlePDF–6.2M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
A Leptin-Mediated Neural Mechanism Linking Breathing to Metabolism
Jeehaeh Do, Zheng Chang, Gabriella Sekerková, Donald R. McCrimmon, Marco Martina
Cell Rep. Author manuscript; available in PMC 2020 Nov 28.
Published in final edited form as: Cell Rep. 2020 Nov 10; 33(6): 108358. doi: 10.1016/j.celrep.2020.108358
PMCID:
PMC7698346
AbstractArticlePDF–3.3M
9.
Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex
Jinhong Wie, Apoorva Bharthur, Morgan Wolfgang, Vinodh Narayanan, Keri Ramsey, C4RCD Research Group, Kimberly Aranda, Qi Zhang, Yandong Zhou, Dejian Ren
Nat Commun. 2020; 11: 3351. Published online 2020 Jul 3. doi: 10.1038/s41467-020-17105-8
PMCID:
PMC7335163
AbstractArticlePDF–2.3M
10.
Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells
Seul-Yi Lee, Tuan Anh Vuong, Xianlan Wen, Hyeon-Ju Jeong, Hyun-Kyung So, Ilmin Kwon, Jong-Sun Kang, Hana Cho
Exp Mol Med. 2019 Oct; 51(10): 119. Published online 2019 Oct 10. doi: 10.1038/s12276-019-0325-0
PMCID:
PMC6802672
AbstractArticlePDF–1.8M
11.
Gi/o protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN
Fabian Philippart, Zayd M Khaliq
eLife. 2018; 7: e40984. Published online 2018 Dec 17. doi: 10.7554/eLife.40984
PMCID:
PMC6305199
AbstractArticlePDF–7.5M
12.
Forward genetic analysis of sleep in randomly mutagenized mice
Hiromasa Funato, Chika Miyoshi, Tomoyuki Fujiyama, Takeshi Kanda, Makito Sato, Zhiqiang Wang, Jing Ma, Shin Nakane, Jun Tomita, Aya Ikkyu, Miyo Kakizaki, Noriko Hotta, Satomi Kanno, Haruna Komiya, Fuyuki Asano, Takato Honda, Staci J. Kim, Kanako Harano, Hiroki Muramoto, Toshiya Yonezawa, Seiya Mizuno, Shinichi Miyazaki, Linzi Connor, Vivek Kumar, Ikuo Miura, Tomohiro Suzuki, Atsushi Watanabe, Manabu Abe, Fumihiro Sugiyama, Satoru Takahashi, Kenji Sakimura, Yu Hayashi, Qinghua Liu, Kazuhiko Kume, Shigeharu Wakana, Joseph S Takahashi, Masashi Yanagisawa
Nature. Author manuscript; available in PMC 2018 Aug 4.
Published in final edited form as: Nature. 2016 Nov 17; 539(7629): 378–383. Published online 2016 Nov 2. doi: 10.1038/nature20142
PMCID:
PMC6076225
AbstractArticlePDF–4.4M
13.
Respiratory network stability and modulatory response to substance P require Nalcn
Szu-Ying Yeh, Wei-Hsiang Huang, Wei Wang, Christopher S. Ward, Eugene S. Chao, Zhenyu Wu, Bin Tang, Jianrong Tang, Jenny J. Sun, Meike Esther van der Heijden, Paul A. Gray, Mingshan Xue, Russell S. Ray, Dejian Ren, Huda Y. Zoghbi
Neuron. Author manuscript; available in PMC 2018 Apr 19.
Published in final edited form as: Neuron. 2017 Apr 19; 94(2): 294–303.e4. Published online 2017 Apr 6. doi: 10.1016/j.neuron.2017.03.024
PMCID:
PMC5702257
AbstractArticlePDF–1.3M
14.
Nalcn Is a “Leak” Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing
Yingtang Shi, Chikara Abe, Benjamin B. Holloway, Shaofang Shu, Natasha N. Kumar, Janelle L. Weaver, Josh Sen, Edward Perez-Reyes, Ruth L. Stornetta, Patrice G. Guyenet, Douglas A. Bayliss
J Neurosci. 2016 Aug 3; 36(31): 8174–8187. doi: 10.1523/JNEUROSCI.1096-16.2016
PMCID:
PMC4971364
AbstractArticlePDF–3.1M
15.
The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons
Andrew Lutas, Carolina Lahmann, Magali Soumillon, Gary Yellen
eLife. 2016; 5: e15271. Published online 2016 May 13. doi: 10.7554/eLife.15271
PMCID:
PMC4902561
AbstractArticlePDF–1007K
16.
A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability
Matthieu Flourakis, Elzbieta Kula-Eversole, Alan L. Hutchison, Tae Hee Han, Kimberly Aranda, Devon L. Moose, Kevin P. White, Aaron R. Dinner, Bridget C. Lear, Dejian Ren, Casey O. Diekman, Indira M. Raman, Ravi Allada
Cell. Author manuscript; available in PMC 2016 Aug 13.
Published in final edited form as: Cell. 2015 Aug 13; 162(4): 836–848. doi: 10.1016/j.cell.2015.07.036
PMCID:
PMC4537776
AbstractArticlePDF–2.5M
17.
Involvement of Na+-leak Channel in Substance P-induced Depolarization of Pacemaking Activity in Interstitial Cells of Cajal
Byung Joo Kim, In Youb Chang, Seok Choi, Jae Yeoul Jun, Ju-Hong Jeon, Wen-Xie Xu, Young Kyu Kwon, Dejian Ren, Insuk So
Cell Physiol Biochem. 2012 Apr; 29(3-4): 501–510. doi: 10.1159/000338504
PMCID:
PMC3711580
AbstractArticlePDF–1.0M
18.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
19.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
20.
Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation
Anne P. Sinke, Christina Caputo, Shirng-Wern Tsaih, Rong Yuan, Dejian Ren, Peter M. T. Deen, Ron Korstanje
Physiol Genomics. 2011 Mar; 43(5): 265–270. Published online 2010 Dec 21. doi: 10.1152/physiolgenomics.00188.2010
PMCID:
PMC3068516
AbstractArticle

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