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Select item 110609611.

Tanycytes release glucose using the glucose-6-phosphatase system during hypoglycemia to control hypothalamic energy balance

María José Barahona, Luciano Ferrada, Matías Vera, Francisco Nualart

Mol Metab. 2024 Jun; 84: 101940. Published online 2024 Apr 17. doi: 10.1016/j.molmet.2024.101940

PMCID:: PMC11060961

Abstract Article PDF–5.5M

Select item 107554982.

Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion

Chun-Guang Guo, Rui Sun, Xiao Wang, Ye Yuan, Yan Xu, Shihan Li, Xueting Sun, Jue Wang, Xinli Hu, Tiannan Guo, Xiao-Wei Chen, Rui-Ping Xiao, Xiuqin Zhang

Mol Metab. 2024 Jan; 79: 101847. Published online 2023 Nov 30. doi: 10.1016/j.molmet.2023.101847

PMCID:: PMC10755498

Abstract Article PDF–3.6M

Select item 106219213.

Precision pharmacological reversal of strain-specific diet-induced metabolic syndrome in mice informed by epigenetic and transcriptional regulation

Phillip Wulfridge, Adam Davidovich, Anna C. Salvador, Gabrielle C. Manno, Rakel Tryggvadottir, Adrian Idrizi, M. Nazmul Huda, Brian J. Bennett, L. Garry Adams, Kasper D. Hansen, David W. Threadgill, Andrew P. Feinberg

PLoS Genet. 2023 Oct; 19(10): e1010997. Published online 2023 Oct 23. doi: 10.1371/journal.pgen.1010997

PMCID:: PMC10621921

Abstract Article PDF–2.9M

Select item 106165064.

G6PC1 and G6PC2 Influence Glucose-6-Phosphate Flux but not 11β-Hydroxysteroid Dehydrogenase Type 1 Activity

Emily M. Hawes, Kayla A. Boortz, James K. Oeser, Margaret L. O’Rourke, Richard M. O’Brien

J Mol Endocrinol. Author manuscript; available in PMC 2024 Nov 1.

Published in final edited form as: J Mol Endocrinol. 2023 Nov 1; 71(4): e230070. Published online 2023 Oct 18. doi: 10.1530/JME-23-0070

PMCID:: PMC10616506

Abstract Article PDF–1005K

Select item 105979925.

Maternal thyroid hormone receptor β activation in mice sparks brown fat thermogenesis in the offspring

Rebecca Oelkrug, Lisbeth Harder, Mehdi Pedaran, Anne Hoffmann, Beke Kolms, Julica Inderhees, Sogol Gachkar, Julia Resch, Kornelia Johann, Olaf Jöhren, Kerstin Krause, Jens Mittag

Nat Commun. 2023; 14: 6742. Published online 2023 Oct 24. doi: 10.1038/s41467-023-42425-w

PMCID:: PMC10597992

Abstract Article PDF–1.8M

Select item 100239576.

A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production

Amandine Gautier-Stein, Julien Chilloux, Maud Soty, Bernard Thorens, Christophe Place, Carine Zitoun, Adeline Duchampt, Lorine Da Costa, Fabienne Rajas, Christophe Lamaze, Gilles Mithieux

Mol Metab. 2023 Apr; 70: 101700. Published online 2023 Mar 2. doi: 10.1016/j.molmet.2023.101700

PMCID:: PMC10023957

Abstract Article PDF–2.7M

Select item 96874557.

Maternal Calorie Restriction Induces a Transcriptional Cytoprotective Response in Embryonic Liver Partially Dependent on Nrf2

George I. Habeos, Fotini Filippopoulou, Evagelia E. Habeos, Electra Kalaitzopoulou, Marianna Skipitari, Polyxeni Papadea, George Lagoumintzis, Athanasios Niarchos, Christos D. Georgiou, Dionysios V. Chartoumpekis

Antioxidants (Basel) 2022 Nov; 11(11): 2274. Published online 2022 Nov 17. doi: 10.3390/antiox11112274

PMCID:: PMC9687455

Abstract Article PDF–2.0M

Select item 93823898.

Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism

Patrycja A Jazwiec, Violet S Patterson, Tatiane A Ribeiro, Erica Yeo, Katherine M Kennedy, Paulo C F Mathias, Jim J Petrik, Deborah M Sloboda

Biol Reprod. 2022 Aug; 107(2): 574–589. Published online 2022 Apr 4. doi: 10.1093/biolre/ioac066

PMCID:: PMC9382389

Abstract Article PDF–1.7M

Select item 87919999.

Intestinal gluconeogenesis shapes gut microbiota, fecal and urine metabolome in mice with gastric bypass surgery

Justine Vily-Petit, Aude Barataud, Carine Zitoun, Amandine Gautier-Stein, Matteo Serino, Gilles Mithieux

Sci Rep. 2022; 12: 1415. Published online 2022 Jan 26. doi: 10.1038/s41598-022-04902-y

PMCID:: PMC8791999

Abstract Article PDF–5.0M

Select item 874519710.

Exosomal MicroRNAs as Potential Biomarkers of Hepatic Injury and Kidney Disease in Glycogen Storage Disease Type Ia Patients

Roberta Resaz, Davide Cangelosi, Daniela Segalerba, Martina Morini, Paolo Uva, Maria Carla Bosco, Giuseppe Banderali, Ana Estrella, Corbinian Wanner, David A. Weinstein, Annalisa Sechi, Sabrina Paci, Daniela Melis, Maja Di Rocco, Young Mok Lee, Alessandra Eva

Int J Mol Sci. 2022 Jan; 23(1): 328. Published online 2021 Dec 28. doi: 10.3390/ijms23010328

PMCID:: PMC8745197

Abstract Article PDF–1.2M

Select item 824352411.

Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia

Anouk M. La Rose, Venetia Bazioti, Joanne A. Hoogerland, Arthur F. Svendsen, Anouk G. Groenen, Martijn van Faassen, Martijn G.S. Rutten, Niels J. Kloosterhuis, Bertien Dethmers-Ausema, J. Hendrik Nijland, Gilles Mithieux, Fabienne Rajas, Folkert Kuipers, Michaël V. Lukens, Oliver Soehnlein, Maaike H. Oosterveer, Marit Westerterp

Mol Metab. 2021 Nov; 53: 101265. Published online 2021 Jun 4. doi: 10.1016/j.molmet.2021.101265

PMCID:: PMC8243524

Abstract Article PDF–1.6M

Select item 814945512.

mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease

Jingsong Cao, Minjung Choi, Eleonora Guadagnin, Maud Soty, Marine Silva, Vincent Verzieux, Edward Weisser, Arianna Markel, Jenny Zhuo, Shi Liang, Ling Yin, Andrea Frassetto, Anne-Renee Graham, Kristine Burke, Tatiana Ketova, Cosmin Mihai, Zach Zalinger, Becca Levy, Gilles Besin, Meredith Wolfrom, Barbara Tran, Christopher Tunkey, Erik Owen, Joe Sarkis, Athanasios Dousis, Vladimir Presnyak, Christopher Pepin, Wei Zheng, Lei Ci, Marjie Hard, Edward Miracco, Lisa Rice, Vi Nguyen, Mike Zimmer, Uma Rajarajacholan, Patrick F. Finn, Gilles Mithieux, Fabienne Rajas, Paolo G. V. Martini, Paloma H. Giangrande

Nat Commun. 2021; 12: 3090. Published online 2021 May 25. doi: 10.1038/s41467-021-23318-2

PMCID:: PMC8149455

Abstract Article PDF–3.9M

Select item 805844013.

Correction of metabolic abnormalities in a mouse model of glycogen storage disease type Ia by CRISPR/Cas9-based gene editing

Irina Arnaoutova, Lisa Zhang, Hung-Dar Chen, Brian C. Mansfield, Janice Y. Chou

Mol Ther. 2021 Apr 7; 29(4): 1602–1610. Published online 2020 Dec 23. doi: 10.1016/j.ymthe.2020.12.027

PMCID:: PMC8058440

Abstract Article PDF–2.3M

Select item 769171914.

The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice

Fabienne Rajas, Renaud Dentin, Alexane Cannella Miliano, Marine Silva, Margaux Raffin, Françoise Levavasseur, Amandine Gautier-Stein, Catherine Postic, Gilles Mithieux

Mol Metab. 2021 Jan; 43: 101108. Published online 2020 Oct 31. doi: 10.1016/j.molmet.2020.101108

PMCID:: PMC7691719

Abstract Article PDF–2.1M

Select item 752045715.

Circulating exosomal microRNAs as potential biomarkers of hepatic injury and inflammation in a murine model of glycogen storage disease type 1a

Roberta Resaz, Davide Cangelosi, Martina Morini, Daniela Segalerba, Luca Mastracci, Federica Grillo, Maria Carla Bosco, Cristina Bottino, Irma Colombo, Alessandra Eva

Dis Model Mech. 2020 Sep 1; 13(9): dmm043364. Published online 2020 Sep 18. doi: 10.1242/dmm.043364

PMCID:: PMC7520457

Abstract Article

Select item 730927616.

Gene therapy using a novel G6PC-S298C variant enhances the long-term efficacy for treating glycogen storage disease type Ia

Lisa Zhang, Cheol Lee, Irina Arnaoutova, Javier Anduaga, Matthew F. Starost, Brian C. Mansfield, Janice Y. Chou

Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Jun 30.

Published in final edited form as: Biochem Biophys Res Commun. 2020 Jun 30; 527(3): 824–830. Published online 2020 May 16. doi: 10.1016/j.bbrc.2020.04.124

PMCID:: PMC7309276

Abstract Article PDF–1.4M

Select item 710468017.

The signaling pathways implicated in impairment of hepatic autophagy in glycogen storage disease type Ia

Sudeep Gautam, Lisa Zhang, Irina Arnaoutova, Cheol Lee, Brian C Mansfield, Janice Y Chou

Hum Mol Genet. 2020 Mar 27; 29(5): 834–844. Published online 2020 Jan 21. doi: 10.1093/hmg/ddaa007

PMCID:: PMC7104680

Abstract Article PDF–1.6M

Select item 700171918.

Glycogen storage disease type 1a is associated with disturbed vitamin A metabolism and elevated serum retinol levels

Ali Saeed, Joanne A Hoogerland, Hanna Wessel, Janette Heegsma, Terry G J Derks, Eveline van der Veer, Gilles Mithieux, Fabienne Rajas, Maaike H Oosterveer, Klaas Nico Faber

Hum Mol Genet. 2020 Jan 15; 29(2): 264–273. Published online 2019 Dec 9. doi: 10.1093/hmg/ddz283

PMCID:: PMC7001719

Abstract Article PDF–1.2M

Select item 695430319.

Activation of tumor-promoting pathways implicated in hepatocellular adenoma/carcinoma, a long-term complication of glycogen storage disease type Ia

Jun-Ho Cho, Young Mok Lee, Seong-Ho Bae, Janice Y. Chou

Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Jan 29.

Published in final edited form as: Biochem Biophys Res Commun. 2020 Jan 29; 522(1): 1–7. Published online 2019 Nov 15. doi: 10.1016/j.bbrc.2019.11.061

PMCID:: PMC6954303

Abstract Article PDF–1.7M

Select item 665797720.

Circular RNA profile in liver tissue of EpCAM knockout mice

Yanhong Yang, Shaomin Liu, Zili Lei, Guibin Chen, Li Huang, Fei Yang, Yuting Lei, Yanyan Liu, Lanxiang Yang, Wanwan Liu, Liangxue Lai, Jiao Guo

Int J Mol Med. 2019 Sep; 44(3): 1063–1077. Published online 2019 Jul 8. doi: 10.3892/ijmm.2019.4270

PMCID:: PMC6657977

Abstract Article PDF–2.4M

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