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Items: 1 to 20 of 23

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice
Yi-Guang Chen, Ashley E. Ciecko, Shamim Khaja, Michael Grzybowski, Aron M. Geurts, Scott M. Lieberman
Sci Rep. 2020; 10: 12019. Published online 2020 Jul 21. doi: 10.1038/s41598-020-68956-6
PMCID:
PMC7374577
AbstractArticlePDF–9.4M
3.
An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling
Yue Yin, David Frank, Weijie Zhou, Neena Kaur, Jarrod B. French, Nick Carpino
J Biol Chem. 2020 Jun 19; 295(25): 8514–8523. Published online 2020 May 5. doi: 10.1074/jbc.RA120.013482
PMCID:
PMC7307200
AbstractArticlePDF–1.5M
4.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
5.
Phagocytes from Mice Lacking the Sts Phosphatases Have an Enhanced Antifungal Response to Candida albicans
David Frank, Shamoon Naseem, Gian Luigi Russo, Cindy Li, Kaustubh Parashar, James B. Konopka, Nick Carpino
mBio. 2018 Jul-Aug; 9(4): e00782-18. Published online 2018 Jul 17. doi: 10.1128/mBio.00782-18
PMCID:
PMC6050958
AbstractArticlePDF–2.1M
6.
Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases
Kaustubh Parashar, Erik Kopping, David Frank, Vinaya Sampath, David G. Thanassi, Nick Carpino
Infect Immun. 2017 Sep; 85(9): e00406-17. Prepublished online 2017 Jun 19. Published online 2017 Aug 18. doi: 10.1128/IAI.00406-17
PMCID:
PMC5563576
AbstractArticlePDF–1.3M
7.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
8.
TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk
Kevin Reppschläger, Jeanne Gosselin, Carol A. Dangelmaier, Dafydd H. Thomas, Nick Carpino, Steven E. McKenzie, Satya P. Kunapuli, Alexander Y. Tsygankov
J Biol Chem. 2016 Oct 21; 291(43): 22427–22441. Published online 2016 Sep 8. doi: 10.1074/jbc.M116.743732
Correction in:
J Biol Chem. 2017 Mar 10; 292(10): 4360.
PMCID:
PMC5077183
AbstractArticlePDF–3.2M
9.
The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness
Jing Zhang, Olesya Vakhrusheva, Srinivasa Rao Bandi, Özlem Demirel, Julhash U. Kazi, Ramona Gomes Fernandes, Katja Jakobi, Astrid Eichler, Lars Rönnstrand, Michael A. Rieger, Nick Carpino, Hubert Serve, Christian H. Brandts
Stem Cell Reports. 2015 Oct 13; 5(4): 633–646. Published online 2015 Sep 10. doi: 10.1016/j.stemcr.2015.08.006
PMCID:
PMC4624938
AbstractArticlePDF–2.6M
10.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
11.
Enhanced Response of T Cells from Murine Gammaherpesvirus 68-Infected Mice Lacking the Suppressor of T Cell Receptor Signaling Molecules Sts-1 and Sts-2
Brandon Cieniewicz, Nicholas Carpino, Laurie T. Krug
PLoS One. 2014; 9(2): e90196. Published online 2014 Feb 28. doi: 10.1371/journal.pone.0090196
PMCID:
PMC3938662
AbstractArticlePDF–1.6M
12.
TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function
Steven H. Back, Naga Suresh Adapala, Mary F. Barbe, Nick C. Carpino, Alexander Y. Tsygankov, Archana Sanjay
Cell Mol Life Sci. 2013 Apr; 70(7): 1269–1284. Published online 2012 Nov 13. doi: 10.1007/s00018-012-1203-2
PMCID:
PMC3752794
AbstractArticlePDF–1.0M
13.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
14.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
15.
Sts-2 Is a Phosphatase That Negatively Regulates Zeta-associated Protein (ZAP)-70 and T Cell Receptor Signaling Pathways
Boris San Luis, Ben Sondgeroth, Nicolas Nassar, Nick Carpino
J Biol Chem. 2011 May 6; 286(18): 15943–15954. Published online 2011 Mar 10. doi: 10.1074/jbc.M110.177634
PMCID:
PMC3091203
AbstractArticlePDF–1.6M
16.
A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets
Dafydd H. Thomas, Todd M. Getz, Tiffanny N. Newman, Carol A. Dangelmaier, Nick Carpino, Satya P. Kunapuli, Alexander Y. Tsygankov, James L. Daniel
Blood. 2010 Oct 7; 116(14): 2570–2578. Prepublished online 2010 Jun 29. doi: 10.1182/blood-2010-02-268136
PMCID:
PMC2953889
AbstractArticle
17.
Structural and Functional Characterization of the 2H-Phosphatase Domain of Sts-2 Reveals an Acid-Dependent Phosphatase Activity
Yunting Chen, Jean Jakoncic, Nick Carpino, Nicolas Nassar
Biochemistry. Author manuscript; available in PMC 2010 Jun 4.
Published in final edited form as: Biochemistry. 2009 Mar 3; 48(8): 1681–1690. doi: 10.1021/bi802219n
PMCID:
PMC2880635
AbstractArticlePDF–2.4M
18.
Structures of the phosphorylated and VO3-bound 2H-phosphatase domain of Sts-2
Yunting Chen, Jean Jakoncic, Kathlyn A. Parker, Nick Carpino, Nicolas Nassar
Biochemistry. Author manuscript; available in PMC 2010 Sep 1.
Published in final edited form as: Biochemistry. 2009 Sep 1; 48(34): 8129. doi: 10.1021/bi9008648
PMCID:
PMC2819845
AbstractArticlePDF–583K
19.
The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways
Nick Carpino, Yunting Chen, Nicolas Nassar, Hye-Won Oh
Mol Immunol. Author manuscript; available in PMC 2010 Oct 1.
Published in final edited form as: Mol Immunol. 2009 Oct; 46(16): 3224–3231. Published online 2009 Sep 5. doi: 10.1016/j.molimm.2009.08.015
PMCID:
PMC2757469
AbstractArticlePDF–684K
20.
A phosphatase activity of Sts-1 contributes to the suppression TCR signaling
Anatoly Mikhailik, Bradley Ford, James Keller, Yunting Chen, Nicolas Nassar, Nick Carpino
Mol Cell. Author manuscript; available in PMC 2009 Jul 13.
Published in final edited form as: Mol Cell. 2007 Aug 3; 27(3): 486–497. doi: 10.1016/j.molcel.2007.06.015
PMCID:
PMC2709417
AbstractArticlePDF–1.0M

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