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Select item 108053851.

A deregulated HOX gene axis confers an epigenetic vulnerability in KRAS-mutant lung cancers

Stephanie L. Guerra, Ophélia Maertens, Ryan Kuzmickas, Thomas De Raedt, Richard O. Adeyemi, Caroline J. Guild, Shawna Guillemette, Amanda J. Redig, Emily S. Chambers, Man Xu, Hong Tiv, Sandro Santagata, Pasi A. Jänne, Steve Elledge, Karen Cichowski

Cancer Cell. Author manuscript; available in PMC 2024 Jan 23.

Published in final edited form as: Cancer Cell. 2020 May 11; 37(5): 705–719.e6. Published online 2020 Apr 2. doi: 10.1016/j.ccell.2020.03.004

PMCID:: PMC10805385

Abstract Article PDF–2.6M

Select item 107814532.

Pan-cancer analysis of homeodomain-containing gene C10 and its carcinogenesis in lung adenocarcinoma

Xiangyuan Tan, Zhanzhan Li, Huayan Xie, Jiarong Chen, Jian Xiao, Yaofeng Zhi, Haixin Mo, Yanming Huang, Aibin Liu

Aging (Albany NY) 2023 Dec 31; 15(24): 15243–15266. Published online 2023 Dec 27. doi: 10.18632/aging.205348

PMCID:: PMC10781453

Abstract Article PDF–5.8M

Select item 107346663.

m⁶A-modified HOXC10 promotes HNSCC progression via co-activation of ADAM17/EGFR and Wnt/β-catenin signaling

Yujuan Zhou, Qiang Huang, Chunping Wu, Ye Xu, Yang Guo, Xiaohui Yuan, Chengzhi Xu, Liang Zhou

Int J Oncol. 2024 Feb; 64(2): 10. Published online 2023 Dec 6. doi: 10.3892/ijo.2023.5598

PMCID:: PMC10734666

Abstract Article PDF–13M

Select item 88059244.

Homeodomain-containing gene 10 contributed to breast cancer malignant behaviors by activating Interleukin-6/Janus kinase 2/Signal transducer and activator of transcription 3 pathway

Jun Shen, Meng Wang, Fan Li, Huanhuan Yan, Jun Zhou

Bioengineered. 2022; 13(1): 1335–1345. Published online 2022 Jan 5. doi: 10.1080/21655979.2021.2016088

PMCID:: PMC8805924

Abstract Article PDF–4.1M

Select item 84563445.

Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells

Ying Xie, Ran Chen, Liujia Yan, Zhangjun Jia, Guangshu Liang, Qin Wang

Mol Med Rep. 2021 Nov; 24(5): 797. Published online 2021 Sep 14. doi: 10.3892/mmr.2021.12437

PMCID:: PMC8456344

Abstract Article PDF–13M

Select item 83638386.

The lncRNA HMS recruits RNA-binding protein HuR to stabilize the 3′-UTR of HOXC10 mRNA

Priyanka Priyanka, Madhur Sharma, Sanjeev Das, Sandeep Saxena

J Biol Chem. 2021 Aug; 297(2): 100997. Published online 2021 Jul 22. doi: 10.1016/j.jbc.2021.100997

PMCID:: PMC8363838

Abstract Article PDF–3.8M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80090488.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 75438869.

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

Abhik K. Banerjee, Mario R. Blanco, Emily A. Bruce, Drew D. Honson, Linlin M. Chen, Amy Chow, Prashant Bhat, Noah Ollikainen, Sofia A. Quinodoz, Colin Loney, Jasmine Thai, Zachary D. Miller, Aaron E. Lin, Madaline M. Schmidt, Douglas G. Stewart, Daniel Goldfarb, Giuditta De Lorenzo, Suzannah J. Rihn, Rebecca M. Voorhees, Jason W. Botten, Devdoot Majumdar, Mitchell Guttman

Cell. 2020 Nov 25; 183(5): 1325–1339.e21. doi: 10.1016/j.cell.2020.10.004

PMCID:: PMC7543886

Abstract Article

Select item 716998310.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 706908411.

Interleukin 1β-mediated HOXC10 Overexpression Promotes Hepatocellular Carcinoma Metastasis by Upregulating PDPK1 and VASP

Yunzhi Dang, Jie Chen, Weibo Feng, Chenyang Qiao, Weili Han, Yongzhan Nie, Kaichun Wu, Daiming Fan, Limin Xia

Theranostics. 2020; 10(8): 3833–3848. Published online 2020 Feb 19. doi: 10.7150/thno.41712

PMCID:: PMC7069084

Abstract Article PDF–3.8M

Select item 654907812.

HOXC10 overexpression promotes cell proliferation and migration in gastric cancer

Jina Kim, Dong-Hyuck Bae, Jong Hwan Kim, Kyu-Sang Song, Yong Sung Kim, Seon-Young Kim

Oncol Rep. 2019 Jul; 42(1): 202–212. Published online 2019 May 17. doi: 10.3892/or.2019.7164

PMCID:: PMC6549078

Abstract Article PDF–1.3M

Select item 642009713.

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination in sister chromatids

Kyosuke Nakamura, Giulia Saredi, Jordan R. Becker, Benjamin M. Foster, Nhuong V. Nguyen, Tracey Beyer, Laura C. Cesa, Peter A. Faull, Saulius Lukauskas, Thomas Frimurer, J. Ross Chapman, Till Bartke, Anja Groth

Nat Cell Biol. Author manuscript; available in PMC 2019 Aug 25.

Published in final edited form as: Nat Cell Biol. 2019 Mar; 21(3): 311–318. Published online 2019 Feb 25. doi: 10.1038/s41556-019-0282-9

PMCID:: PMC6420097

Article PDF–1.7M

Select item 621706114.

Overexpression of HOXC10 promotes angiogenesis in human glioma via interaction with PRMT5 and upregulation of VEGFA expression

Zhanyao Tan, Kun Chen, Wenjiao Wu, Yanqing Zhou, Jinrong Zhu, Geyan Wu, Lixue Cao, Xin Zhang, Hongyu Guan, Yi Yang, Wei Zhang, Jun Li

Theranostics. 2018; 8(18): 5143–5158. Published online 2018 Oct 6. doi: 10.7150/thno.27310

PMCID:: PMC6217061

Abstract Article PDF–3.2M

Select item 567858115.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 533655717.

HOXC10 suppresses browning of white adipose tissues

Yvonne Ng, Shi-Xiong Tan, Sook Yoong Chia, Hwee Yim Angeline Tan, Sin Yee Gun, Lei Sun, Wanjin Hong, Weiping Han

Exp Mol Med. 2017 Feb; 49(2): e292. Published online 2017 Feb 10. doi: 10.1038/emm.2016.144

PMCID:: PMC5336557

Abstract Article PDF–2.7M

Select item 470210318.

The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety

Sang Jun Han, Khurshida Begum, Charles E. Foulds, Ross A. Hamilton, Suzanna Bailey, Anna Malovannaya, Doug Chan, Jun Qin, Bert W. O’Malley

Mol Pharmacol. 2016 Jan; 89(1): 14–26. Published online 2016 Jan. doi: 10.1124/mol.115.100925

PMCID:: PMC4702103

Abstract Article PDF–1.6M

Select item 447536119.

Anterior migration of lateral plate mesodermal cells during embryogenesis of the pufferfishTakifugu niphobles: insight into the rostral positioning of pelvic fins

Mikiko Tanaka, Reiko Yu, Daisuke Kurokawa

J Anat. 2015 Jul; 227(1): 81–88. Published online 2015 May 28. doi: 10.1111/joa.12324

PMCID:: PMC4475361

Abstract Article PDF–1.8M

Select item 427786220.

Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer

Thushangi N. Pathiraja, Shweta Nayak, Yuanxin Xi, Shiming Jiang, Jason P. Garee, Dean P. Edwards, Adrian V. Lee, Jian Chen, Martin J. Shea, Richard J. Santen, Frank Gannon, Sara Kangaspeska, Jaroslav Jelinek, Jean-Pierre J. Issa, Jennifer K. Richer, Anthony Elias, Marie McIlroy, Leonie Young, Nancy E. Davidson, Rachel Schiff, Wei Li, Steffi Oesterreich

Sci Transl Med. Author manuscript; available in PMC 2014 Dec 28.

Published in final edited form as: Sci Transl Med. 2014 Mar 26; 6(229): 229ra41. doi: 10.1126/scitranslmed.3008326

PMCID:: PMC4277862

Abstract Article PDF–3.4M

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