PMC Links for GEO Profiles (Select 87497648) - PMC

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105605704.

Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme

Mohamed Ishan, Zhonghou Wang, Peng Zhao, Yao Yao, Steven L. Stice, Lance Wells, Yuji Mishina, Hong-Xiang Liu

Development. 2023 Sep 15; 150(18): dev201838. Published online 2023 Sep 25. doi: 10.1242/dev.201838

PMCID:: PMC10560570

Abstract Article

Select item 105264565.

AAV-Mediated Targeting of the Activin A-ACVR1^R206H Signaling in Fibrodysplasia Ossificans Progressiva

Yeon-Suk Yang, Chujiao Lin, Hong Ma, Jun Xie, Frederick S. Kaplan, Guangping Gao, Jae-Hyuck Shim

Biomolecules. 2023 Sep; 13(9): 1364. Published online 2023 Sep 8. doi: 10.3390/biom13091364

PMCID:: PMC10526456

Abstract Article PDF–3.5M

Select item 97089496.

Overexpression of Wild‐Type ACVR1 in Fibrodysplasia Ossificans Progressiva Mice Rescues Perinatal Lethality and Inhibits Heterotopic Ossification

Masakazu Yamamoto, Sean J Stoessel, Shoko Yamamoto, David J Goldhamer

J Bone Miner Res. 2022 Nov; 37(11): 2077–2093. Published online 2022 Jul 3. doi: 10.1002/jbmr.4617

PMCID:: PMC9708949

Abstract Article PDF–12M

Select item 91975277.

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice

John B. Lees-Shepard, Sean J. Stoessel, Julian T. Chandler, Keith Bouchard, Patricia Bento, Lorraine N. Apuzzo, Parvathi M. Devarakonda, Jeffrey W. Hunter, David J. Goldhamer

J Clin Invest. 2022 Jun 15; 132(12): e153795. Published online 2022 Jun 15. doi: 10.1172/JCI153795

PMCID:: PMC9197527

Abstract Article PDF–3.2M

Select item 83132398.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82277879.

MyD88 Is Not Required for Muscle Injury-Induced Endochondral Heterotopic Ossification in a Mouse Model of Fibrodysplasia Ossificans Progressiva

Huili Lyu, Cody M. Elkins, Jessica L. Pierce, C. Henrique Serezani, Daniel S. Perrien

Biomedicines. 2021 Jun; 9(6): 630. Published online 2021 Jun 1. doi: 10.3390/biomedicines9060630

PMCID:: PMC8227787

Abstract Article PDF–2.9M

Select item 820604310.

Generation of a new mouse line with conditionally activated signaling through the BMP receptor, ACVR1: A tool to characterize pleiotropic roles of BMP functions

Jingwen Yang, Masako Toda Nakamura, Shawn A. Hallett, Hiroki Ueharu, Honghao Zhang, Kristen Kelley, Tomokazu Fukuda, Yoshihiro Komatsu, Yuji Mishina

Genesis. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Genesis. 2021 Jun; 59(5-6): e23419. Published online 2021 Apr 14. doi: 10.1002/dvg.23419

PMCID:: PMC8206043

Abstract Article PDF–6.3M

Select item 811921211.

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva

Eleanor Williams, Jana Bagarova, Georgina Kerr, Dong-Dong Xia, Elsie S. Place, Devaveena Dey, Yue Shen, Geoffrey A. Bocobo, Agustin H. Mohedas, Xiuli Huang, Philip E. Sanderson, Arthur Lee, Wei Zheng, Aris N. Economides, James C. Smith, Paul B. Yu, Alex N. Bullock

JCI Insight. 2021 Apr 22; 6(8): e95042. Published online 2021 Apr 22. doi: 10.1172/jci.insight.95042

PMCID:: PMC8119212

Abstract Article PDF–1.4M

Select item 804842312.

Acvr1 deletion in osteoblasts impaired mandibular bone mass through compromised osteoblast differentiation and enhanced sRANKL‐induced osteoclastogenesis

Yue Hu, Xinqing Hao, Cangwei Liu, Chunxia Ren, Shuangshuang Wang, Guangxing Yan, Yuan Meng, Yuji Mishina, Ce Shi, Hongchen Sun

J Cell Physiol. 2021 Jun; 236(6): 4580–4591. Published online 2020 Nov 29. doi: 10.1002/jcp.30183

PMCID:: PMC8048423

Abstract Article PDF–3.8M

Select item 803597313.

Dysregulated BMP signaling through ACVR1 impairs digit joint development in fibrodysplasia ossificans progressiva (FOP)

O. Will Towler, Sun H. Peck, Frederick S. Kaplan, Eileen M. Shore

Dev Biol. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Dev Biol. 2021 Feb; 470: 136–146. Published online 2020 Nov 17. doi: 10.1016/j.ydbio.2020.11.004

PMCID:: PMC8035973

Abstract Article PDF–1.6M

Select item 797987314.

An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension

Gusty R. T. Ryanto, Koji Ikeda, Kazuya Miyagawa, Ly Tu, Christophe Guignabert, Marc Humbert, Tomoyuki Fujiyama, Masashi Yanagisawa, Ken-ichi Hirata, Noriaki Emoto

Nat Commun. 2021; 12: 1720. Published online 2021 Mar 19. doi: 10.1038/s41467-021-21961-3

PMCID:: PMC7979873

Abstract Article PDF–6.3M

Select item 793646815.

Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation

Jingwen Yang, Megumi Kitami, Haichun Pan, Masako Toda Nakamura, Honghao Zhang, Fei Liu, Lingxin Zhu, Yoshihiro Komatsu, Yuji Mishina

Sci Signal. Author manuscript; available in PMC 2021 Jul 12.

Published in final edited form as: Sci Signal. 2021 Jan 12; 14(665): eaaz9368. Published online 2021 Jan 12. doi: 10.1126/scisignal.aaz9368

PMCID:: PMC7936468

Abstract Article PDF–4.0M

Select item 780512816.

Mast cell inhibition as a therapeutic approach in fibrodysplasia ossificans progressiva (FOP)

Tracy A. Brennan, Carter M. Lindborg, Christian R. Bergbauer, Haitao Wang, Frederick S. Kaplan, Robert J. Pignolo

Bone. Author manuscript; available in PMC 2021 Jan 13.

Published in final edited form as: Bone. 2018 Apr; 109: 259–266. Published online 2017 Aug 26. doi: 10.1016/j.bone.2017.08.023

PMCID:: PMC7805128

Abstract Article PDF–2.4M

Select item 732649217.

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

Senem Aykul, Richard A Corpina, Erich J Goebel, Camille J Cunanan, Alexandra Dimitriou, Hyon Jong Kim, Qian Zhang, Ashique Rafique, Raymond Leidich, Xin Wang, Joyce McClain, Johanna Jimenez, Kalyan C Nannuru, Nyanza J Rothman, John B Lees-Shepard, Erik Martinez-Hackert, Andrew J Murphy, Thomas B Thompson, Aris N Economides, Vincent Idone

eLife. 2020; 9: e54582. Published online 2020 Jun 9. doi: 10.7554/eLife.54582

PMCID:: PMC7326492

Abstract Article PDF–2.2M

Select item 713225618.

Parcellation of the striatal complex into dorsal and ventral districts

Shih-Yun Chen, Kuan-Ming Lu, Hsin-An Ko, Ting-Hao Huang, Janice Hsin-Jou Hao, Yu-Ting Yan, Sunny Li-Yun Chang, Sylvia M. Evans, Fu-Chin Liu

Proc Natl Acad Sci U S A. 2020 Mar 31; 117(13): 7418–7429. Published online 2020 Mar 13. doi: 10.1073/pnas.1921007117

PMCID:: PMC7132256

Abstract Article PDF–4.5M

Select item 710582019.

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

Jerome Fortin, Ruxiao Tian, Ida Zarrabi, Graham Hill, Eleanor Williams, Gonzalo Sanchez-Duffhues, Midory Thorikay, Parameswaran Ramachandran, Robert Siddaway, Jong Fu Wong, Annette Wu, Lorraine N. Apuzzo, Jillian Haight, Annick You-Ten, Bryan E. Snow, Andrew Wakeham, David J. Goldhamer, Daniel Schramek, Alex N. Bullock, Peter ten Dijke, Cynthia Hawkins, Tak W. Mak

Cancer Cell. 2020 Mar 16; 37(3): 308–323.e12. doi: 10.1016/j.ccell.2020.02.002

PMCID:: PMC7105820

Abstract Article

Select item 700536620.

Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3

Chia-Yu Wang, Yang Xu, Lisa Traeger, Deniz Y. Dogan, Xia Xiao, Andrea U. Steinbicker, Jodie L. Babitt

Blood. 2020 Feb 6; 135(6): 453–456. Prepublished online 2019 Dec 4. doi: 10.1182/blood.2019002620

PMCID:: PMC7005366

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