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Select item 109193291.

DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis

Zhengping Shao, Ryan A. Flynn, Jennifer L. Crowe, Yimeng Zhu, Jialiang Liang, Wenxia Jiang, Fardin Aryan, Patrick Aoude, Carolyn R. Bertozzi, Verna M. Estes, Brian J. Lee, Govind Bhagat, Shan Zha, Eliezer Calo

Nature. Author manuscript; available in PMC 2024 Mar 7.

Published in final edited form as: Nature. 2020 Mar; 579(7798): 291–296. Published online 2020 Feb 26. doi: 10.1038/s41586-020-2041-2

PMCID:: PMC10919329

Abstract Article PDF–5.4M

Select item 108167152.

Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome

Abhimanu Pandey, Cheng Shen, Shouya Feng, Daniel Enosi Tuipulotu, Chinh Ngo, Cheng Liu, Melan Kurera, Anukriti Mathur, Shweta Venkataraman, Jing Zhang, Dipti Talaulikar, Renhua Song, Justin J.-L. Wong, Narci Teoh, Nadeem O. Kaakoush, Si Ming Man

Sci Adv. 2024 Jan 26; 10(4): eadh3409. Published online 2024 Jan 26. doi: 10.1126/sciadv.adh3409

PMCID:: PMC10816715

Abstract Article PDF–4.5M

Select item 104974183.

DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres

Logan R. Myler, Beatrice Toia, Cara K. Vaughan, Kaori Takai, Andreea M. Matei, Peng Wu, Tanya T. Paull, Titia de Lange, Francisca Lottersberger

Nat Struct Mol Biol. 2023; 30(9): 1346–1356. Published online 2023 Aug 31. doi: 10.1038/s41594-023-01072-x

PMCID:: PMC10497418

Abstract Article PDF–17M

Select item 94819334.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 92017675.

SETD4-mediated KU70 methylation suppresses apoptosis

Yuan Wang, Bochao Liu, Huimei Lu, Jingmei Liu, Peter J. Romanienko, Gaetano T. Montelione, Zhiyuan Shen

Cell Rep. Author manuscript; available in PMC 2022 Jun 16.

Published in final edited form as: Cell Rep. 2022 May 10; 39(6): 110794. doi: 10.1016/j.celrep.2022.110794

PMCID:: PMC9201767

Abstract Article PDF–1.2M

Select item 87442576.

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins

Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo

BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y

PMCID:: PMC8744257

Abstract Article PDF–6.0M

Select item 84640627.

Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma

Janapriya Saha, Jinsung Bae, Shih-Ya Wang, Huiming Lu, Lori J Chappell, Purva Gopal, Anthony J Davis

Nucleic Acids Res. 2021 Sep 27; 49(17): 9836–9850. Published online 2021 Aug 24. doi: 10.1093/nar/gkab743

PMCID:: PMC8464062

Abstract Article PDF–6.2M

Select item 79488558.

Diminished or inversed dose-rate effect on clonogenic ability in Ku-deficient rodent cells

Hisayo Tsuchiya, Mikio Shimada, Kaima Tsukada, Qingmei Meng, Junya Kobayashi, Yoshihisa Matsumoto

J Radiat Res. 2021 Mar; 62(2): 198–205. Published online 2020 Dec 29. doi: 10.1093/jrr/rraa128

PMCID:: PMC7948855

Abstract Article PDF–757K

Select item 79387709.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 755569110.

C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties

Takabumi Inagawa, Thomas Wennink, Joyce H. G. Lebbink, Guido Keijzers, Bogdan I. Florea, Nicole S. Verkaik, Dik C. van Gent

Int J Mol Sci. 2020 Sep; 21(18): 6725. Published online 2020 Sep 14. doi: 10.3390/ijms21186725

PMCID:: PMC7555691

Abstract Article PDF–1.4M

Select item 740735911.

PARP6 suppresses the proliferation and metastasis of hepatocellular carcinoma by degrading XRCC6 to regulate the Wnt/β-catenin pathway

Bo Tang, Yi Zhang, Wei Wang, Guangying Qi, Fumio Shimamoto

Am J Cancer Res. 2020; 10(7): 2100–2113. Published online 2020 Jul 1.

PMCID:: PMC7407359

Abstract Article PDF–1.7M

Select item 699424712.

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells

Samudyata, Paulo P. Amaral, Pär G. Engström, Samuel C. Robson, Michael L. Nielsen, Tony Kouzarides, Gonçalo Castelo-Branco

Exp Cell Res. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Exp Cell Res. 2019 Aug 1; 381(1): 129–138. Published online 2019 May 9. doi: 10.1016/j.yexcr.2019.05.006

PMCID:: PMC6994247

Abstract Article PDF–1.6M

Select item 633346013.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

Select item 608388314.

MRI is a DNA Damage Response Adaptor during Classical Non-Homologous End Joining

Putzer J. Hung, Britney Johnson, Bo-Ruei Chen, Andrea K. Byrum, Andrea L. Bredemeyer, William T. Yewdell, Tanya E. Johnson, Brian J. Lee, Shruthi Deivasigamani, Issa Hindi, Parmeshwar Amatya, Michael L. Gross, Tanya T. Paull, David J. Pisapia, Jayanta Chaudhuri, John J. H. Petrini, Nima Mosammaparast, Gaya K. Amarasinghe, Shan Zha, Jessica K. Tyler, Barry P. Sleckman

Mol Cell. Author manuscript; available in PMC 2019 Jul 19.

Published in final edited form as: Mol Cell. 2018 Jul 19; 71(2): 332–342.e8. Published online 2018 Jul 12. doi: 10.1016/j.molcel.2018.06.018

PMCID:: PMC6083883

Abstract Article PDF–1.2M

Select item 604774315.

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

Juan I. Garaycoechea, Gerry P. Crossan, Frederic Langevin, Lee Mulderrig, Sandra Louzada, Fentang Yang, Guillaume Guilbaud, Naomi Park, Sophie Roerink, Serena Nik-Zainal, Michael R Stratton, Ketan J Patel

Nature. Author manuscript; available in PMC 2018 Jul 16.

Published in final edited form as: Nature. 2018 Jan 11; 553(7687): 171–177. Published online 2018 Jan 3. doi: 10.1038/nature25154

PMCID:: PMC6047743

Abstract Article PDF–7.3M

Select item 596137316.

ATF7 mediates TNF-α–induced telomere shortening

Toshio Maekawa, Binbin Liu, Daisuke Nakai, Keisuke Yoshida, Ken-ichi Nakamura, Mami Yasukawa, Manabu Koike, Kaiyo Takubo, Bruno Chatton, Fuyuki Ishikawa, Kenkichi Masutomi, Shunsuke Ishii

Nucleic Acids Res. 2018 May 18; 46(9): 4487–4504. Published online 2018 Feb 27. doi: 10.1093/nar/gky155

PMCID:: PMC5961373

Abstract Article PDF–4.5M

Select item 590944417.

Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors

Guang Yang, Chao Liu, Shih-Hsun Chen, Muzaffer A Kassab, J Damon Hoff, Nils G Walter, Xiaochun Yu

Nucleic Acids Res. 2018 Apr 20; 46(7): 3446–3457. Published online 2018 Feb 13. doi: 10.1093/nar/gky088

PMCID:: PMC5909444

Abstract Article PDF–5.1M

Select item 576131918.

A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining

N Puebla-Osorio, J Kim, S Ojeda, H Zhang, O Tavana, S Li, Y Wang, Q Ma, KS Schluns, C Zhu

Oncogene. Author manuscript; available in PMC 2018 Jan 10.

Published in final edited form as: Oncogene. 2014 May 22; 33(21): 2748–2757. Published online 2013 Jun 10. doi: 10.1038/onc.2013.234

PMCID:: PMC5761319

Abstract Article PDF–1.3M

Select item 564508219.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 558457120.

Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70

Mengtan Xing, Magnar Bjørås, Jeremy A. Daniel, Frederick W. Alt, Valentyn Oksenych

DNA Repair (Amst) Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: DNA Repair (Amst). 2017 Sep; 57: 133–138. Published online 2017 Jul 26. doi: 10.1016/j.dnarep.2017.07.008

PMCID:: PMC5584571

Abstract Article PDF–793K

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