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Items: 1 to 20 of 26

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Absence of indoleamine 2,3-dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice
Tatsuya Ando, Masato Hoshi, Hiroyuki Tezuka, Hiroyasu Ito, Kentaro Nakamoto, Yasuko Yamamoto, Kuniaki Saito
Mol Med Rep. 2023 Feb; 27(2): 24. Published online 2022 Dec 8. doi: 10.3892/mmr.2022.12911
PMCID:
PMC9813552
AbstractArticlePDF–4.3M
3.
The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis Through a Non-Enzymatic Mechanism
Lauren M.F. Merlo, Weidan Peng, James B. DuHadaway, James D. Montgomery, George C. Prendergast, Alexander J. Muller, Laura Mandik-Nayak
J Immunol. Author manuscript; available in PMC 2023 Feb 1.
Published in final edited form as: J Immunol. 2022 Feb 1; 208(3): 571–581. Published online 2021 Dec 29. doi: 10.4049/jimmunol.2100705
PMCID:
PMC8770583
AbstractArticlePDF–2.1M
4.
Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses
Lauren M. F. Merlo, James B. DuHadaway, James D. Montgomery, Wei-Dan Peng, Peter J. Murray, George C. Prendergast, Andrew J. Caton, Alexander J. Muller, Laura Mandik-Nayak
Front Immunol. 2020; 11: 1861. Published online 2020 Aug 18. doi: 10.3389/fimmu.2020.01861
PMCID:
PMC7461966
AbstractArticlePDF–4.2M
5.
Indoleamine 2,3-Dioxygenase 2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation
Kento Fujii, Yasuko Yamamoto, Yoko Mizutani, Kuniaki Saito, Mariko Seishima
Int J Mol Sci. 2020 Aug; 21(15): 5515. Published online 2020 Aug 1. doi: 10.3390/ijms21155515
PMCID:
PMC7432009
AbstractArticlePDF–3.2M
6.
Indoleamine 2,3‐dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma
Wakana Yamasuge, Yasuko Yamamoto, Hidetsugu Fujigaki, Masato Hoshi, Kentaro Nakamoto, Kazuo Kunisawa, Akihiro Mouri, Toshitaka Nabeshima, Kuniaki Saito
Cancer Sci. 2019 Oct; 110(10): 3061–3067. Published online 2019 Sep 25. doi: 10.1111/cas.14179
PMCID:
PMC6778659
AbstractArticlePDF–582K
7.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
8.
Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss
Philip Spinelli, Sarah E Latchney, Jasmine M Reed, Ashley Fields, Brian S Baier, Xiang Lu, Matthew N McCall, Shawn P Murphy, Winifred Mak, Martha Susiarjo
Hum Mol Genet. 2019 Feb 15; 28(4): 662–674. Published online 2018 Nov 7. doi: 10.1093/hmg/ddy383
PMCID:
PMC6360327
AbstractArticlePDF–2.3M
9.
Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling
Yasuko Yamamoto, Wakana Yamasuge, Shinjiro Imai, Kazuo Kunisawa, Masato Hoshi, Hidetsugu Fujigaki, Akihiro Mouri, Toshitaka Nabeshima, Kuniaki Saito
Sci Rep. 2018; 8: 15917. Published online 2018 Oct 29. doi: 10.1038/s41598-018-34166-4
PMCID:
PMC6206095
AbstractArticlePDF–5.0M
10.
Inhibition of acute lethal pulmonary inflammation by the IDO–AhR pathway
Soung-Min Lee, Ha Young Park, Young-Sill Suh, Eun Hye Yoon, Juyang Kim, Won Hee Jang, Won-Sik Lee, Sae-Gwang Park, Il-Whan Choi, Inhak Choi, Sun-Woo Kang, Hwayoung Yun, Takanori Teshima, Byungsuk Kwon, Su-Kil Seo
Proc Natl Acad Sci U S A. 2017 Jul 18; 114(29): E5881–E5890. Published online 2017 Jul 3. doi: 10.1073/pnas.1615280114
PMCID:
PMC5530642
AbstractArticlePDF–2.5M
11.
Therapeutic Antibody Targeting of Indoleamine-2,3-Dioxygenase (IDO2) Inhibits Autoimmune Arthritis
Lauren M.F. Merlo, Samantha Grabler, James B. DuHadaway, Elizabeth Pigott, Kaylend Manley, George C. Prendergast, Lisa D. Laury-Kleintop, Laura Mandik-Nayak
Clin Immunol. Author manuscript; available in PMC 2018 Jun 1.
Published in final edited form as: Clin Immunol. 2017 Jun; 179: 8–16. Published online 2017 Feb 20. doi: 10.1016/j.clim.2017.01.016
PMCID:
PMC5466478
AbstractArticlePDF–1.2M
12.
IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity
Carla Lippens, Fernanda V. Duraes, Juan Dubrot, Dale Brighouse, Mathilde Lacroix, Magali Irla, Jean-Pierre Aubry-Lachainaye, Walter Reith, Judith N. Mandl, Stéphanie Hugues
J Autoimmun. 2016 Dec; 75: 39–49. doi: 10.1016/j.jaut.2016.07.004
PMCID:
PMC5127883
AbstractArticle
13.
Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth
Yanling Liu, Yujuan Zhang, Xiufen Zheng, Xusheng Zhang, Hongmei Wang, Qin Li, Keng Yuan, Nanjing Zhou, Yanrong Yu, Na Song, Jiamin Fu, Weiping Min
Oncotarget. 2016 May 31; 7(22): 32329–32340. Published online 2016 Apr 6. doi: 10.18632/oncotarget.8617
PMCID:
PMC5078016
AbstractArticlePDF–5.1M
14.
IDO2 modulates T cell-dependent autoimmune responses through a B cell-intrinsic mechanism
Lauren M.F. Merlo, James B. DuHadaway, Samantha Grabler, George C. Prendergast, Alexander J. Muller, Laura Mandik-Nayak
J Immunol. Author manuscript; available in PMC 2017 Jun 1.
Published in final edited form as: J Immunol. 2016 Jun 1; 196(11): 4487–4497. Published online 2016 Apr 25. doi: 10.4049/jimmunol.1600141
PMCID:
PMC4875825
AbstractArticlePDF–1.3M
15.
IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation
Richard Metz, Courtney Smith, James B. DuHadaway, Phillip Chandler, Babak Baban, Lauren M. F. Merlo, Elizabeth Pigott, Martin P. Keough, Sonja Rust, Andrew L. Mellor, Laura Mandik-Nayak, Alexander J. Muller, George C. Prendergast
Int Immunol. 2014 Jul; 26(7): 357–367. Published online 2014 Jan 13. doi: 10.1093/intimm/dxt073
Correction in:
Int Immunol. 2019 Mar; 31(3): 181–182.
PMCID:
PMC4432394
AbstractArticlePDF–2.0M
16.
Aryl hydrocarbon receptor control of a disease tolerance defense pathway
Alban Bessede, Marco Gargaro, Maria T Pallotta, Davide Matino, Giuseppe Servillo, Cinzia Brunacci, Silvio Bicciato, Emilia MC Mazza, Antonio Macchiarulo, Carmine Vacca, Rossana Iannitti, Luciana Tissi, Claudia Volpi, Maria L Belladonna, Ciriana Orabona, Roberta Bianchi, Tobias Lanz, Michael Platten, Maria A Della Fazia, Danilo Piobbico, Teresa Zelante, Hiroshi Funakoshi, Toshikazu Nakamura, David Gilot, Michael S Denison, Gilles J Guillemin, James B DuHadaway, George C Prendergast, Richard Metz, Michel Geffard, Louis Boon, Matteo Pirro, Alfonso Iorio, Bernard Veyret, Luigina Romani, Ursula Grohmann, Francesca Fallarino, Paolo Puccetti
Nature. Author manuscript; available in PMC 2015 Feb 10.
Published in final edited form as: Nature. 2014 Jul 10; 511(7508): 184–190. doi: 10.1038/nature13323
PMCID:
PMC4098076
AbstractArticlePDF–1.3M
17.
IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis
Lauren M.F. Merlo, Elizabeth Pigott, James B. DuHadaway, Samantha Grabler, Richard Metz, George C. Prendergast, Laura Mandik-Nayak
J Immunol. Author manuscript; available in PMC 2015 Mar 1.
Published in final edited form as: J Immunol. 2014 Mar 1; 192(5): 2082–2090. Published online 2014 Jan 31. doi: 10.4049/jimmunol.1303012
PMCID:
PMC3947779
AbstractArticlePDF–1.0M
18.
Investigation of the kynurenine pathway in Indoleamine 2, 3 dioxygenase deficient mice with inflammatory arthritis
Lukasz Kolodziej
Transgenic Res. 2013; 22(5): 1049–1054. Published online 2013 Feb 17. doi: 10.1007/s11248-013-9696-5
PMCID:
PMC3781305
AbstractArticlePDF–197K
19.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
20.
Studies on Tissue and Cellular Distribution of Indoleamine 2,3-Dioxygenase 2: The Absence of IDO1 Upregulates IDO2 Expression in the Epididymis
Masakazu Fukunaga, Yasuko Yamamoto, Misaki Kawasoe, Yuko Arioka, Yuki Murakami, Masato Hoshi, Kuniaki Saito
J Histochem Cytochem. 2012 Nov; 60(11): 854–860. doi: 10.1369/0022155412458926
PMCID:
PMC3524572
AbstractArticlePDF–1.1M

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