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Items: 1 to 20 of 86

1.
SUMOylation modulates the stability and function of PI3K-p110β
Ahmed El Motiam, Carlos F. de la Cruz-Herrera, Santiago Vidal, Rocío Seoane, Maite Baz-Martínez, Yanis H. Bouzaher, Emilio Lecona, Mariano Esteban, Manuel S. Rodríguez, Anxo Vidal, Manuel Collado, Carmen Rivas
Cell Mol Life Sci. 2021 Apr; 78(8): 4053–4065. Published online 2021 Apr 8. doi: 10.1007/s00018-021-03826-6
PMCID:
PMC11073289
AbstractArticlePDF–2.7M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
PI3Kβ controls immune evasion in PTEN-deficient breast tumors
Johann S. Bergholz, Qiwei Wang, Qi Wang, Michelle Ramseier, Sanjay Prakadan, Weihua Wang, Rong Fang, Sheheryar Kabraji, Qian Zhou, G. Kenneth Gray, Kayley Abell-Hart, Shaozhen Xie, Xiaocan Guo, Hao Gu, Thanh Von, Tao Jiang, Shuang Tang, Gordon J. Freeman, Hye-Jung Kim, Alex K. Shalek, Thomas M. Roberts, Jean J. Zhao
Nature. Author manuscript; available in PMC 2024 May 1.
Published in final edited form as: Nature. 2023 May; 617(7959): 139–146. Published online 2023 Apr 19. doi: 10.1038/s41586-023-05940-w
PMCID:
PMC10494520
AbstractArticlePDF–7.0M
4.
PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells
Kristina Ames, Imit Kaur, Yang Shi, Meng M. Tong, Taneisha Sinclair, Shayda Hemmati, Shira G. Glushakow-Smith, Ellen Tein, Lindsay Gurska, Ulrich Steidl, Robert Dubin, Jidong Shan, Cristina Montagna, Kith Pradhan, Amit Verma, Kira Gritsman
Sci Adv. 2023 Feb; 9(8): eade8222. Published online 2023 Feb 22. doi: 10.1126/sciadv.ade8222
PMCID:
PMC9946350
AbstractArticlePDF–2.4M
5.
Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway
Guangying Yang, Shan Lu, Jia Jiang, Jun Weng, Xiaomei Zeng
Int J Mol Sci. 2022 Jun; 23(11): 6014. Published online 2022 May 27. doi: 10.3390/ijms23116014
PMCID:
PMC9181541
AbstractArticlePDF–4.4M
6.
Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling
Qian Wang, Chenqi Tao, Abdul Hannan, Sungtae Yoon, Xuanyu Min, John Peregrin, Xiuxia Qu, Hongge Li, Honglian Yu, Jean Zhao, Xin Zhang
Sci Adv. 2021 Jul; 7(27): eabf1068. Published online 2021 Jun 30. doi: 10.1126/sciadv.abf1068
PMCID:
PMC8245041
AbstractArticlePDF–1.8M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas
Shaozhen Xie, Jing Ni, J. Ricardo McFaline-Figueroa, Yanzhi Wang, Roderick T. Bronson, Keith L. Ligon, Patrick Y. Wen, Thomas M. Roberts, Jean J. Zhao
Cell Rep. Author manuscript; available in PMC 2020 Oct 19.
Published in final edited form as: Cell Rep. 2020 Sep 29; 32(13): 108196. doi: 10.1016/j.celrep.2020.108196
PMCID:
PMC7571617
AbstractArticlePDF–907K
9.
A trans-eQTL network regulates osteoclast multinucleation and bone mass
Marie Pereira, Jeong-Hun Ko, John Logan, Hayley Protheroe, Kee-Beom Kim, Amelia Li Min Tan, Peter I Croucher, Kwon-Sik Park, Maxime Rotival, Enrico Petretto, JH Duncan Bassett, Graham R Williams, Jacques Behmoaras
eLife. 2020; 9: e55549. Published online 2020 Jun 19. doi: 10.7554/eLife.55549
PMCID:
PMC7351491
AbstractArticlePDF–5.1M
10.
Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss
Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs
Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931
PMCID:
PMC7227028
AbstractArticlePDF–5.4M
11.
PI3Kβ is selectively required for growth factor-stimulated macropinocytosis
Gilbert Salloum, Charles T. Jakubik, Zahra Erami, Samantha D. Heitz, Anne R. Bresnick, Jonathan M. Backer
J Cell Sci. 2019 Aug 15; 132(16): jcs231639. Published online 2019 Aug 16. doi: 10.1242/jcs.231639
PMCID:
PMC6737911
AbstractArticle
12.
Phosphatidylinositol-3-Kinase–Atypical Protein Kinase C Signaling Is Required for Wnt Attraction and Anterior–Posterior Axon Guidance
Alex M. Wolf, Anna I. Lyuksyutova, Ali G. Fenstermaker, Beth Shafer, Charles G. Lo, Yimin Zou
J Neurosci. 2008 Mar 26; 28(13): 3456–3467. doi: 10.1523/JNEUROSCI.0029-08.2008
PMCID:
PMC6670589
AbstractArticlePDF–700K
13.
Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism
Mengyao Ella Li, Hans P. M. M. Lauritzen, Brian T. O’Neill, Chih-Hao Wang, Weikang Cai, Bruna B. Brandao, Masaji Sakaguchi, Rongya Tao, Michael F. Hirshman, Samir Softic, C. Ronald Kahn
Nat Commun. 2019; 10: 3412. Published online 2019 Jul 30. doi: 10.1038/s41467-019-11265-y
PMCID:
PMC6667496
AbstractArticlePDF–2.8M
14.
Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury
Xueyi Chen, Pavel Zhabyeyev, Abul K Azad, Wang Wang, Rachel A Minerath, Jessica DesAulniers, Chad E Grueter, Allan G Murray, Zamaneh Kassiri, Bart Vanhaesebroeck, Gavin Y Oudit
Cardiovasc Res. 2019 Jul 1; 115(8): 1343–1356. Published online 2018 Nov 28. doi: 10.1093/cvr/cvy298
PMCID:
PMC6587920
AbstractArticlePDF–2.2M
15.
P110β in the ventromedial hypothalamus regulates glucose and energy metabolism
Teppei Fujikawa, Yun-Hee Choi, Dong Joo Yang, Dong Min Shin, Jose Donato, Jr., Daisuke Kohno, Charlotte E. Lee, Carol F. Elias, Syann Lee, Ki Woo Kim
Exp Mol Med. 2019 Apr; 51(4): 52. Published online 2019 Apr 26. doi: 10.1038/s12276-019-0249-8
PMCID:
PMC6486607
AbstractArticlePDF–1.2M
16.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
17.
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease
Vaibhav B. Patel, Pavel Zhabyeyev, Xueyi Chen, Faqi Wang, Manish Paul, Dong Fan, Brent A. McLean, Ratnadeep Basu, Pu Zhang, Saumya Shah, John F. Dawson, W. Glen Pyle, Mousumi Hazra, Zamaneh Kassiri, Saugata Hazra, Bart Vanhaesebroeck, Christopher A. McCulloch, Gavin Y. Oudit
Nat Commun. 2018; 9: 5390. Published online 2018 Dec 19. doi: 10.1038/s41467-018-07812-8
PMCID:
PMC6300608
AbstractArticlePDF–4.9M
18.
Platelet activation and prothrombotic properties in a mouse model of peritoneal sepsis
Fanny Vardon Bounes, Vincent Mémier, Marina Marcaud, Aemilia Jacquemin, Hind Hamzeh-Cognasse, Cédric Garcia, Jennifer Series, Pierre Sié, Vincent Minville, Marie-Pierre Gratacap, Bernard Payrastre
Sci Rep. 2018; 8: 13536. Published online 2018 Sep 10. doi: 10.1038/s41598-018-31910-8
PMCID:
PMC6131186
AbstractArticlePDF–2.1M
19.
PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction
David Garcia-Galiano, Beatriz C. Borges, Jose Donato, Jr., Susan J. Allen, Nicole Bellefontaine, Mengjie Wang, Jean J. Zhao, Kenneth M. Kozloff, Jennifer W. Hill, Carol F. Elias
JCI Insight. 2017 Dec 7; 2(23): e96728. Published online 2017 Dec 7. doi: 10.1172/jci.insight.96728
PMCID:
PMC5752267
AbstractArticlePDF–1.9M
20.
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
Daniel M. Houslay, Karen E. Anderson, Tamara Chessa, Suhasini Kulkarni, Ralph Fritsch, Julian Downward, Jonathan M. Backer, Len R. Stephens, Phillip T. Hawkins
Sci Signal. Author manuscript; available in PMC 2017 Aug 16.
Published in final edited form as: Sci Signal. 2016 Aug 16; 9(441): ra82. Published online 2016 Aug 16. doi: 10.1126/scisignal.aae0453
PMCID:
PMC5417692
AbstractArticlePDF–1.1M

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