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Select item 108242741.

Impaired hemostatic activity of healthy transfused platelets in inherited and acquired platelet disorders: mechanisms and implications

Robert H. Lee, Raymond Piatt, Ankita Dhenge, María L. Lozano, Verónica Palma-Barqueros, José Rivera, Wolfgang Bergmeier

Sci Transl Med. Author manuscript; available in PMC 2024 Jan 29.

Published in final edited form as: Sci Transl Med. 2019 Dec 11; 11(522): eaay0203. doi: 10.1126/scitranslmed.aay0203

PMCID:: PMC10824274

Abstract Article PDF–1.6M

Select item 108046252.

HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling

Michela Terri, Pilar Sandoval, Giulio Bontempi, Claudia Montaldo, Henar Tomero-Sanz, Valeria de Turris, Flavia Trionfetti, Lucía Pascual-Antón, Irene Clares-Pedrero, Cecilia Battistelli, Sergio Valente, Clemens Zwergel, Antonello Mai, Laura Rosanò, Miguel Ángel del Pozo, Miguel Sánchez-Álvarez, Carlos Cabañas, Marco Tripodi, Manuel López-Cabrera, Raffaele Strippoli

J Exp Clin Cancer Res. 2024; 43: 27. Published online 2024 Jan 23. doi: 10.1186/s13046-023-02930-8

PMCID:: PMC10804625

Abstract Article PDF–7.7M

Select item 107242683.

Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation

Yvonne L. Latour, Kara M. McNamara, Margaret M. Allaman, Daniel P. Barry, Thaddeus M. Smith, Mohammad Asim, Kamery J. Williams, Caroline V. Hawkins, Justin Jacobse, Jeremy A. Goettel, Alberto G. Delgado, M. Blanca Piazuelo, M. Kay Washington, Alain P. Gobert, Keith T. Wilson

Sci Rep. 2023; 13: 22368. Published online 2023 Dec 15. doi: 10.1038/s41598-023-49614-z

PMCID:: PMC10724268

Abstract Article PDF–6.1M

Select item 106161784.

Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice

Xiaoting Hou, Yangshan Chen, Bo Zhou, Wanze Tang, Zhen Ding, Litong Chen, Yun Wu, Hongyu Yang, Changzheng Du, Dazhi Yang, Guixing Ma, Huiling Cao

Cell Death Dis. 2023 Oct; 14(10): 709. Published online 2023 Oct 31. doi: 10.1038/s41419-023-06235-8

PMCID:: PMC10616178

Abstract Article PDF–9.4M

Select item 105924725.

Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow

Yuji Kamioka, Yoshihiro Ueda, Naoyuki Kondo, Keizo Tokuhiro, Yoshiki Ikeda, Wolfgang Bergmeier, Tatsuo Kinashi

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112580. Published online 2023 Jun 1. doi: 10.1016/j.celrep.2023.112580

PMCID:: PMC10592472

Abstract Article PDF–2.2M

Select item 105640876.

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function

Hao Sun, Ho-Sup Lee, Sarah Hyun-Ji Kim, Mikhael Fernandes de Lima, Alexandre R. Gingras, Qinyi Du, Wilma McLaughlin, Jailail Ablack, Miguel A. Lopez-Ramirez, Frederic Lagarrigue, Zhichao Fan, John T. Chang, Derek VanDyke, Jamie B. Spangler, Mark H. Ginsberg

Cell Rep. Author manuscript; available in PMC 2023 Oct 10.

Published in final edited form as: Cell Rep. 2023 Aug 29; 42(8): 112996. Published online 2023 Aug 21. doi: 10.1016/j.celrep.2023.112996

PMCID:: PMC10564087

Abstract Article PDF–2.7M

Select item 103992227.

The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes

Shunsuke Horitani, Yoshihiro Ueda, Yuji Kamioka, Naoyuki Kondo, Yoshiki Ikeda, Makoto Naganuma, Tatsuo Kinashi

Front Immunol. 2023; 14: 1234747. Published online 2023 Jul 20. doi: 10.3389/fimmu.2023.1234747

PMCID:: PMC10399222

Abstract Article PDF–8.9M

Select item 100380398.

Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity

Yvonne L. Latour, Margaret M. Allaman, Daniel P. Barry, Thaddeus M. Smith, Kamery J. Williams, Kara M. McNamara, Justin Jacobse, Jeremy A. Goettel, Alberto G. Delgado, M. Blanca Piazuelo, Shilin Zhao, Alain P. Gobert, Keith T. Wilson

Gut Microbes. 2023; 15(1): 2192623. Published online 2023 Mar 23. doi: 10.1080/19490976.2023.2192623

PMCID:: PMC10038039

Abstract Article PDF–11M

Select item 99321029.

SVEP1 is an endogenous ligand for the orphan receptor PEAR1

Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Alisio, Jorge Di Paola, Nathan O. Stitziel

Nat Commun. 2023; 14: 850. Published online 2023 Feb 15. doi: 10.1038/s41467-023-36486-0

Correction in:: Nat Commun. 2023; 14: 1511.

PMCID:: PMC9932102

Abstract Article PDF–8.9M

Select item 964440910.

Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4⁺ T Cells

Frederic Lagarrigue, Boyang Tan, Qinyi Du, Zhichao Fan, Miguel A. Lopez-Ramirez, Alexandre R. Gingras, Hsin Wang, Weiwei Qi, Hao Sun

J Immunol. Author manuscript; available in PMC 2023 Mar 15.

Published in final edited form as: J Immunol. 2022 Mar 15; 208(6): 1378–1388. Published online 2022 Feb 23. doi: 10.4049/jimmunol.2100843

PMCID:: PMC9644409

Abstract Article PDF–1.9M

Select item 935587811.

Multitier mechanics control stromal adaptations in the swelling lymph node

Frank P. Assen, Jun Abe, Miroslav Hons, Robert Hauschild, Shayan Shamipour, Walter A. Kaufmann, Tommaso Costanzo, Gabriel Krens, Markus Brown, Burkhard Ludewig, Simon Hippenmeyer, Carl-Philipp Heisenberg, Wolfgang Weninger, Edouard Hannezo, Sanjiv A. Luther, Jens V. Stein, Michael Sixt

Nat Immunol. 2022; 23(8): 1246–1255. Published online 2022 Jul 11. doi: 10.1038/s41590-022-01257-4

PMCID:: PMC9355878

Abstract Article PDF–11M

Select item 923958012.

Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract

Marwa Mahmoud, Ian Evans, Laura Wisniewski, Yuen Tam, Claire Walsh, Simon Walker-Samuel, Paul Frankel, Peter Scambler, Ian Zachary

Cardiovasc Res. 2022 May; 118(8): 1993–2005. Published online 2021 Jul 16. doi: 10.1093/cvr/cvab242

PMCID:: PMC9239580

Abstract Article PDF–1.9M

Select item 896388013.

Macrophage network dynamics depend on haptokinesis for optimal local surveillance

Neil Paterson, Tim Lämmermann

eLife. 2022; 11: e75354. Published online 2022 Mar 28. doi: 10.7554/eLife.75354

PMCID:: PMC8963880

Abstract Article PDF–18M

Select item 851897714.

Peptide‐PAINT Enables Investigation of Endogenous Talin with Molecular Scale Resolution in Cells and Tissues

Lisa S. Fischer, Dr. Thomas Schlichthaerle, Dr. Anna Chrostek‐Grashoff, Prof. Dr. Carsten Grashoff

Chembiochem. 2021 Oct 1; 22(19): 2872–2879. Published online 2021 Jul 30. doi: 10.1002/cbic.202100301

PMCID:: PMC8518977

Abstract Article PDF–1.6M

Select item 844196815.

Talin-Dependent Integrin Activation is Required for Endothelial Proliferation and Postnatal Angiogenesis

Fadi E. Pulous, Jamie C. Carnevale, Zaki Al-Yafeai, Brenna H. Pearson, Jamie A.G. Hamilton, Curtis J. Henry, A. Wayne Orr, Brian G. Petrich

Angiogenesis. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Angiogenesis. 2021 Feb; 24(1): 177–190. Published online 2020 Oct 28. doi: 10.1007/s10456-020-09756-4

PMCID:: PMC8441968

Abstract Article PDF–1.0M

Select item 834862716.

Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells

Gink N. Yang, Parinaz Ahangar, Xanthe L. Strudwick, Zlatko Kopecki, Allison J. Cowin

Int J Mol Sci. 2021 Aug; 22(15): 8235. Published online 2021 Jul 30. doi: 10.3390/ijms22158235

PMCID:: PMC8348627

Abstract Article PDF–4.7M

Select item 831323917.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 826087218.

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

Rosemarie E. Gough, Matthew C. Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P. Muench, Jie Yan, Jonathan D. Humphries, Claus Jørgensen, Martin J. Humphries, Benjamin T. Goult

J Biol Chem. 2021 Jul; 297(1): 100837. Published online 2021 Jun 9. doi: 10.1016/j.jbc.2021.100837

PMCID:: PMC8260872

Abstract Article PDF–4.3M

Select item 793877019.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 790237820.

Integrin Affinity Modulation Critically Regulates Atherogenic Endothelial Activation in vitro and in vivo

Zaki Al-Yafeai, Brenna H. Pearson, Jonette M. Peretik, Elizabeth D. Cockerham, Kaylea A. Reeves, Umesh Bhattarai, Dongdong Wang, Brian G. Petrich, A. Wayne Orr

Matrix Biol. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Matrix Biol. 2021 Feb; 96: 87–103. Published online 2020 Nov 4. doi: 10.1016/j.matbio.2020.10.006

PMCID:: PMC7902378

Abstract Article PDF–2.8M

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