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Select item 109887501.

Oncogenic K‐Ras^G12V cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts

Mai Ito, Nobuhiro Tanuma, Yui Kotani, Kokoro Murai, Ayumi Kondo, Mami Sumiyoshi, Hiroshi Shima, Satoshi Matsuda, Toshio Watanabe

FEBS Open Bio. 2024 Apr; 14(4): 545–554. Published online 2024 Feb 6. doi: 10.1002/2211-5463.13775

PMCID:: PMC10988750

Abstract Article PDF–1.1M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 92885363.

Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1

Yonggang Zou, Qi Zheng, Bin Jiang, Yuning Liu, Yanhua Xu, Liang Ma, Zonghao Hu, Ming Wu, Hai Song

Cell Death Dis. 2022 Jul; 13(7): 618. Published online 2022 Jul 16. doi: 10.1038/s41419-022-05076-1

PMCID:: PMC9288536

Abstract Article PDF–5.1M

Select item 91281714.

PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia‐like features

Katsuya Fukui, Miyuki Nomura, Kazuhiro Kishimoto, Nobuhiro Tanuma, Koreyuki Kurosawa, Kosuke Kanazawa, Hiroyuki Kato, Tomoki Sato, Shinji Miura, Koh Miura, Ikuro Sato, Hiroyuki Tsuji, Yoji Yamashita, Keiichi Tamai, Toshio Watanabe, Jun Yasuda, Takuji Tanaka, Kennichi Satoh, Toru Furukawa, Keiichi Jingu, Hiroshi Shima

Cancer Sci. 2022 May; 113(5): 1613–1624. Published online 2022 Mar 22. doi: 10.1111/cas.15315

PMCID:: PMC9128171

Abstract Article PDF–2.6M

Select item 84765145.

Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis

Wen-Long Lei, Yuan-Yuan Li, Tie-Gang Meng, Yan Ning, Si-Min Sun, Chun-Hui Zhang, Yaoting Gui, Zhen-Bo Wang, Wei-Ping Qian, Qing-Yuan Sun

Cell Death Dis. 2021 Oct; 12(10): 883. Published online 2021 Sep 27. doi: 10.1038/s41419-021-04172-y

PMCID:: PMC8476514

Abstract Article PDF–9.4M

Select item 82671376.

Ppp6c deficiency accelerates K‐ras^G12D‐induced tongue carcinogenesis

Kazuhiro Kishimoto, Kosuke Kanazawa, Miyuki Nomura, Takuji Tanaka, Taeko Shigemoto‐Kuroda, Katsuya Fukui, Koh Miura, Koreyuki Kurosawa, Masaaki Kawai, Hiroyuki Kato, Keiko Terasaki, Yoshimi Sakamoto, Yoji Yamashita, Ikuro Sato, Nobuhiro Tanuma, Keiichi Tamai, Issay Kitabayashi, Kazuto Matsuura, Toshio Watanabe, Jun Yasuda, Hiroyuki Tsuji, Hiroshi Shima

Cancer Med. 2021 Jul; 10(13): 4451–4464. Published online 2021 Jun 18. doi: 10.1002/cam4.3962

PMCID:: PMC8267137

Abstract Article PDF–2.9M

Select item 81777677.

Ppp6c haploinsufficiency accelerates UV‐induced BRAF(V600E)‐initiated melanomagenesis

Kosuke Kanazawa, Kazuhiro Kishimoto, Miyuki Nomura, Koreyuki Kurosawa, Hiroyuki Kato, Yui Inoue, Koh Miura, Katsuya Fukui, Yoji Yamashita, Ikuro Sato, Hiroyuki Tsuji, Toshio Watanabe, Takuji Tanaka, Jun Yasuda, Nobuhiro Tanuma, Hiroshi Shima

Cancer Sci. 2021 Jun; 112(6): 2233–2244. Published online 2021 Apr 10. doi: 10.1111/cas.14895

PMCID:: PMC8177767

Abstract Article PDF–1.2M

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 73815199.

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

Mi Li, Hong-Bing Shu

Protein Cell. 2020 Aug; 11(8): 584–599. Published online 2020 May 30. doi: 10.1007/s13238-020-00729-3

PMCID:: PMC7381519

Abstract Article PDF–1.9M

Select item 624418310.

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch

Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262

PMCID:: PMC6244183

Abstract Article PDF–753K

Select item 602981511.

Loss of protein phosphatase 6 in mouse keratinocytes enhances K‐ras^G12D‐driven tumor promotion

Koreyuki Kurosawa, Yui Inoue, Yoichiro Kakugawa, Yoji Yamashita, Kosuke Kanazawa, Kazuhiro Kishimoto, Miyuki Nomura, Yuki Momoi, Ikuro Sato, Natsuko Chiba, Mai Suzuki, Honami Ogoh, Hidekazu Yamada, Koh Miura, Toshio Watanabe, Nobuhiro Tanuma, Masahiro Tachi, Hiroshi Shima

Cancer Sci. 2018 Jul; 109(7): 2178–2187. Published online 2018 Jun 25. doi: 10.1111/cas.13638

PMCID:: PMC6029815

Abstract Article PDF–3.8M

Select item 564508212.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 534152013.

The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4^WDTC¹ E3 ligase

Beezly S Groh, Feng Yan, Matthew D Smith, Yanbao Yu, Xian Chen, Yue Xiong

EMBO Rep. 2016 May; 17(5): 638–647. Published online 2016 Apr 9. doi: 10.15252/embr.201540500

PMCID:: PMC5341520

Abstract Article PDF–1.1M

Select item 529582114.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 517912815.

Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity

Meng-Wen Hu, Tie-Gang Meng, Zong-Zhe Jiang, Ming-Zhe Dong, Heide Schatten, Xingzhi Xu, Zhen-Bo Wang, Qing-Yuan Sun

PLoS Genet. 2016 Dec; 12(12): e1006513. Published online 2016 Dec 8. doi: 10.1371/journal.pgen.1006513

PMCID:: PMC5179128

Abstract Article PDF–3.4M

Select item 468613616.

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells

Bin Xia Yang, Chadi A. EL Farran, Hong Chao Guo, Tao Yu, Hai Tong Fang, Hao Fei Wang, Sharon Schlesinger, Yu Fen Samantha Seah, Germaine Yen Lin Goh, Suat Peng Neo, Yinghui Li, Matthew C. Lorincz, Vinay Tergaonkar, Tit-Meng Lim, Lingyi Chen, Jayantha Gunaratne, James J. Collins, Stephen P. Goff, George Q. Daley, Hu Li, Frederic A. Bard, Yuin-Han Loh

Cell. Author manuscript; available in PMC 2015 Dec 21.

Published in final edited form as: Cell. 2015 Sep 24; 163(1): 230–245. Published online 2015 Sep 10. doi: 10.1016/j.cell.2015.08.037

PMCID:: PMC4686136

Abstract Article PDF–1.2M

Select item 450651117.

NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis

Sha Yan, Zhenyao Xu, Fangzhou Lou, Lingyun Zhang, Fang Ke, Jing Bai, Zhaoyuan Liu, Jinlin Liu, Hong Wang, Huiyuan Zhu, Yang Sun, Wei Cai, Yuanyuan Gao, Bing Su, Qun Li, Xiao Yang, Jianxiu Yu, Yuping Lai, Xue-Zhong Yu, Yan Zheng, Nan Shen, Y. Eugene Chin, Honglin Wang

Nat Commun. 2015; 6: 7652. Published online 2015 Jul 3. doi: 10.1038/ncomms8652

PMCID:: PMC4506511

Abstract Article PDF–1.9M

Select item 340690218.

A PP6-Type Phosphatase Holoenzyme Directly Regulates PIN Phosphorylation and Auxin Efflux in Arabidopsis

Mingqiu Dai, Chen Zhang, Urszula Kania, Fang Chen, Qin Xue, Tyra Mccray, Gang Li, Genji Qin, Michelle Wakeley, William Terzaghi, Jianmin Wan, Yunde Zhao, Jian Xu, Jiří Friml, Xing Wang Deng, Haiyang Wang

Plant Cell. 2012 Jun; 24(6): 2497–2514. Published online 2012 Jun 19. doi: 10.1105/tpc.112.098905

PMCID:: PMC3406902

Abstract Article PDF–2.0M

Select item 325273619.

Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma

Y Shen, Y Wang, K Sheng, X Fei, Q Guo, J Larner, X Kong, Y Qiu, J Mi

Cell Death Dis. 2011 Dec; 2(12): e241. Published online 2011 Dec 8. doi: 10.1038/cddis.2011.126

PMCID:: PMC3252736

Abstract Article PDF–725K

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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