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Items: 1 to 20 of 103

1.
Deletion of Sigmar1 leads to increased arterial stiffness and altered mitochondrial respiration resulting in vascular dysfunction
Naznin Sultana Remex, Chowdhury S. Abdullah, Richa Aishwarya, Gopi K. Kolluru, James Traylor, Mohammad Alfrad Nobel Bhuiyan, Christopher G. Kevil, A. Wayne Orr, Oren Rom, Christopher B. Pattillo, Md. Shenuarin Bhuiyan
Front Physiol. 2024; 15: 1386296. Published online 2024 Apr 29. doi: 10.3389/fphys.2024.1386296
PMCID:
PMC11089145
AbstractArticlePDF–5.3M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS
Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, Kotaro Oiwa, Mai Horiuchi, Yohei Iguchi, Okiru Komine, Akira Sobue, Masahisa Katsuno, Tomoo Ogi, Koji Yamanaka
Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47): e2315347120. Published online 2023 Nov 15. doi: 10.1073/pnas.2315347120
PMCID:
PMC10666035
AbstractArticlePDF–8.9M
4.
Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury
Ethan Schonfeld, Thomas Michael Johnstone, Ghani Haider, Aaryan Shah, Neelan Joseph Marianayagam, Sandip Biswal, Anand Veeravagu
Sci Rep. 2023; 13: 14762. Published online 2023 Sep 7. doi: 10.1038/s41598-023-42063-8
PMCID:
PMC10484902
AbstractArticlePDF–2.2M
5.
The Sigma-1 Receptor Is a Novel Target for Improving Cold Preservation in Rodent Kidney Transplants
Adam Hosszu, Akos R. Toth, Tamas Lakat, Ganna Stepanova, Zsuzsanna Antal, Laszlo J. Wagner, Attila J. Szabo, Andrea Fekete
Int J Mol Sci. 2023 Jul; 24(14): 11630. Published online 2023 Jul 19. doi: 10.3390/ijms241411630
PMCID:
PMC10380852
AbstractArticlePDF–3.4M
6.
Pharmacological Analysis of GABAA Receptor and Sigma1R Chaperone Interaction: Research Report I―Investigation of the Anxiolytic, Anticonvulsant and Hypnotic Effects of Allosteric GABAA Receptors’ Ligands
Mikhail V. Voronin, Stanislav V. Shangin, Svetlana A. Litvinova, Elena V. Abramova, Rustam D. Kurbanov, Inna V. Rybina, Yulia V. Vakhitova, Sergei B. Seredenin
Int J Mol Sci. 2023 Jun; 24(11): 9580. Published online 2023 May 31. doi: 10.3390/ijms24119580
PMCID:
PMC10253922
AbstractArticlePDF–5.2M
7.
Sigma 1 Receptor activation improves retinal structure and function in the RhoP23H/+ mouse model of autosomal dominant retinitis pigmentosa
Shannon R Barwick, Haiyan Xiao, David Wolff, Jing Wang, Elizabeth Perry, Brendan Marshall, Sylvia B. Smith
Exp Eye Res. Author manuscript; available in PMC 2024 May 1.
Published in final edited form as: Exp Eye Res. 2023 May; 230: 109462. Published online 2023 Mar 31. doi: 10.1016/j.exer.2023.109462
PMCID:
PMC10155485
AbstractArticlePDF–3.9M
8.
Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels
Naznin Sultana Remex, Chowdhury S. Abdullah, Richa Aishwarya, Sadia S. Nitu, James Traylor, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, Christopher G. Kevil, A. Wayne Orr, Md. Shenuarin Bhuiyan
Front Physiol. 2023; 14: 1118770. Published online 2023 Mar 27. doi: 10.3389/fphys.2023.1118770
PMCID:
PMC10083329
AbstractArticlePDF–5.0M
9.
Sigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke
Gufang Zhang, Qi Li, Weijie Tao, Pingping Qin, Jiali Chen, Huicui Yang, Jiaojiao Chen, Hua Liu, Qijun Dai, Xuechu Zhen
Theranostics. 2023; 13(2): 543–559. Published online 2023 Jan 1. doi: 10.7150/thno.77088
PMCID:
PMC9830433
AbstractArticlePDF–8.7M
10.
αN-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers
Javier Garzón-Niño, Elsa Cortés-Montero, María Rodríguez-Muñoz, Pilar Sánchez-Blázquez
Int J Mol Sci. 2023 Jan; 24(1): 582. Published online 2022 Dec 29. doi: 10.3390/ijms24010582
PMCID:
PMC9820303
AbstractArticlePDF–3.7M
11.
Sigma-1 Receptor as a Protective Factor for Diabetes-Associated Cognitive Dysfunction via Regulating Astrocytic Endoplasmic Reticulum-Mitochondrion Contact and Endoplasmic Reticulum Stress
Mengyu Du, Tao Jiang, Shuxuan He, Bo Cheng, Xin Zhang, Liya Li, Lan Yang, Wei Gao, Yansong Li, Qiang Wang
Cells. 2023 Jan; 12(1): 197. Published online 2023 Jan 3. doi: 10.3390/cells12010197
PMCID:
PMC9818229
AbstractArticlePDF–4.4M
12.
Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation
Timur A. Mavlyutov, Jing Li, Xinying Liu, Hongtao Shen, Huan Yang, Christopher R. McCurdy, Bikash Pattnaik, Lian-Wang Guo
Genes (Basel) 2022 Dec; 13(12): 2386. Published online 2022 Dec 16. doi: 10.3390/genes13122386
PMCID:
PMC9778362
AbstractArticlePDF–1.6M
13.
Differential Responses to Sigma-1 or Sigma-2 Receptor Ablation in Adiposity, Fat Oxidation, and Sexual Dimorphism
Jing Li, Elisa Félix-Soriano, Katherine R. Wright, Hongtao Shen, Lisa A. Baer, Kristin I. Stanford, Lian-Wang Guo
Int J Mol Sci. 2022 Sep; 23(18): 10846. Published online 2022 Sep 16. doi: 10.3390/ijms231810846
PMCID:
PMC9506228
AbstractArticlePDF–6.0M
14.
Generation of Sigmar1 conditional knockout mouse using CRISPR-Cas9 gene targeting
Liang Huang, Haiyan Xiao, Xiaoling Xie, Fang Hu, Fulei Tang, Sylvia B. Smith, Lin Gan
Genesis. Author manuscript; available in PMC 2023 Jul 1.
Published in final edited form as: Genesis. 2022 Jul; 60(6-7): e23487. Published online 2022 May 28. doi: 10.1002/dvg.23487
PMCID:
PMC9288523
AbstractArticlePDF–1.2M
15.
Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2
Xiaoan Wei, Zeyu Zheng, Zhenhua Feng, Lin Zheng, Siyue Tao, Bingjie Zheng, Bao Huang, Xuyang Zhang, Junhui Liu, Yilei Chen, Wentian Zong, Zhi Shan, Shunwu Fan, Jian Chen, Fengdong Zhao
EMBO Mol Med. 2022 Jul; 14(7): e15373. Published online 2022 May 25. doi: 10.15252/emmm.202115373
PMCID:
PMC9260208
AbstractArticlePDF–3.5M
16.
Effects of Sigma-1 Receptor Ligands on Peripheral Nerve Regeneration
Patrick Cottilli, Núria Gaja-Capdevila, Xavier Navarro
Cells. 2022 Apr; 11(7): 1083. Published online 2022 Mar 23. doi: 10.3390/cells11071083
PMCID:
PMC8998141
AbstractArticlePDF–4.4M
17.
Sigma 1 Receptor Contributes to Astrocyte-Mediated Retinal Ganglion Cell Protection
Jing Zhao, Graydon B. Gonsalvez, Barbara A. Mysona, Sylvia B. Smith, Kathryn E. Bollinger
Invest Ophthalmol Vis Sci. 2022 Feb; 63(2): 1. Published online 2022 Feb 1. doi: 10.1167/iovs.63.2.1
PMCID:
PMC8819349
AbstractArticlePDF–4.8M
18.
Molecular Characterization of Skeletal Muscle Dysfunction in Sigma 1 Receptor (Sigmar1) Knockout Mice
Richa Aishwarya, Chowdhury S. Abdullah, Naznin S. Remex, Shafiul Alam, Mahboob Morshed, Sadia Nitu, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, A. Wayne Orr, Christopher G. Kevil, Md. Shenuarin Bhuiyan
Am J Pathol. 2022 Jan; 192(1): 160–177. doi: 10.1016/j.ajpath.2021.10.003
PMCID:
PMC8759042
AbstractArticlePDF–9.7M
19.
Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury
Gundega Stelfa, Edijs Vavers, Baiba Svalbe, Rinalds Serzants, Anna Miteniece, Lasma Lauberte, Solveiga Grinberga, Baiba Gukalova, Maija Dambrova, Liga Zvejniece
Int J Mol Sci. 2021 Nov; 22(21): 11611. Published online 2021 Oct 27. doi: 10.3390/ijms222111611
PMCID:
PMC8584110
AbstractArticlePDF–38M
20.
The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models
Luana Naia, Philip Ly, Sandra I. Mota, Carla Lopes, Carina Maranga, Patrícia Coelho, Noga Gershoni-Emek, Maria Ankarcrona, Michal Geva, Michael R. Hayden, A. Cristina Rego
Neurotherapeutics. 2021 Apr; 18(2): 1017–1038. Published online 2021 Apr 1. doi: 10.1007/s13311-021-01022-9
PMCID:
PMC8423985
AbstractArticlePDF–8.4M

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