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Items: 1 to 20 of 23

1.
Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling
Emma Rose McGlone, Yusman Manchanda, Ben Jones, Phil Pickford, Asuka Inoue, David Carling, Stephen R. Bloom, Tricia Tan, Alejandra Tomas
Mol Metab. 2021 Nov; 53: 101296. Published online 2021 Jul 13. doi: 10.1016/j.molmet.2021.101296
PMCID:
PMC8363841
AbstractArticlePDF–2.8M
2.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
3.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
4.
Development of chimeric and bifunctional antagonists for CLR/RAMP receptors
Chia Lin Chang, Sheau Yu Teddy Hsu
PLoS One. 2019; 14(5): e0216996. Published online 2019 May 31. doi: 10.1371/journal.pone.0216996
PMCID:
PMC6544337
AbstractArticlePDF–2.8M
5.
LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition
Qingsong Hu, Chunlai Li, Shouyu Wang, Yajuan Li, Bo Wen, Yanyan Zhang, Ke Liang, Jun Yao, Youqiong Ye, Heidi Hsiao, Tina K. Nguyen, Peter K. Park, Sergey D. Egranov, David H. Hawke, Jeffrey R. Marks, Leng Han, Mien-Chie Hung, Bing Zhang, Chunru Lin, Liuqing Yang
Cell Res. 2019 Apr; 29(4): 286–304. Published online 2019 Jan 10. doi: 10.1038/s41422-018-0134-3
PMCID:
PMC6461864
AbstractArticlePDF–11M
6.
hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia
Duncan I. Mackie, Fuad Al Mutairi, Reema B. Davis, Daniel O. Kechele, Natalie R. Nielsen, Joshua C. Snyder, Marc G. Caron, Harvey J. Kliman, Jonathan S. Berg, John Simms, David R. Poyner, Kathleen M. Caron
J Exp Med. 2018 Sep 3; 215(9): 2339–2353. doi: 10.1084/jem.20180528
PMCID:
PMC6122977
AbstractArticlePDF–3.3M
7.
Genetic Variants of RAMP2 and CLR are Associated with Stroke
Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Wakiko Takeshita, Komei Iwai, Yoshiyuki Watanabe, Masahiro Nakatochi, Chisato Shimanoe, Keitaro Tanaka, Isao Oze, Hidemi Ito, Hirokazu Uemura, Sakurako Katsuura-Kamano, Rie Ibusuki, Ippei Shimoshikiryo, Naoyuki Takashima, Aya Kadota, Sayo Kawai, Tae Sasakabe, Rieko Okada, Asahi Hishida, Mariko Naito, Kiyonori Kuriki, Kaori Endoh, Norihiro Furusyo, Hiroaki Ikezaki, Sadao Suzuki, Akihiro Hosono, Haruo Mikami, Yohko Nakamura, Michiaki Kubo, Kenji Wakai
J Atheroscler Thromb. 2017 Dec 1; 24(12): 1267–1281. doi: 10.5551/jat.41517
PMCID:
PMC5742372
AbstractArticlePDF–356K
8.
RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling
Jaimini Cegla, Ben J. Jones, James V. Gardiner, David J. Hodson, Thomas Marjot, Emma R. McGlone, Tricia M. Tan, Stephen R. Bloom
Endocrinology. 2017 Aug 1; 158(8): 2680–2693. Published online 2017 Jun 6. doi: 10.1210/en.2016-1755
PMCID:
PMC5551549
AbstractArticle
9.
N-glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity
Sang-Min Lee, Jason M. Booe, Joseph J. Gingell, Virginie Sjoelund, Debbie L. Hay, Augen A. Pioszak
Biochemistry. Author manuscript; available in PMC 2018 Jul 5.
Published in final edited form as: Biochemistry. 2017 Jul 5; 56(26): 3380–3393. Published online 2017 Jun 26. doi: 10.1021/acs.biochem.7b00256
PMCID:
PMC5551398
AbstractArticlePDF–1.7M
10.
Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties
Harriet A. Watkins, Madhuri Chakravarthy, Rekhati S. Abhayawardana, Joseph J. Gingell, Michael Garelja, Meenakshi Pardamwar, James M. W. R. McElhinney, Alex Lathbridge, Arran Constantine, Paul W. R. Harris, Tsz-Ying Yuen, Margaret A. Brimble, James Barwell, David R. Poyner, Michael J. Woolley, Alex C. Conner, Augen A. Pioszak, Christopher A. Reynolds, Debbie L. Hay
J Biol Chem. 2016 May 27; 291(22): 11657–11675. Published online 2016 Mar 24. doi: 10.1074/jbc.M115.688218
PMCID:
PMC4882435
AbstractArticlePDF–6.4M
11.
Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2)
Cathryn Weston, Jing Lu, Naichang Li, Kerry Barkan, Gareth O. Richards, David J. Roberts, Timothy M. Skerry, David Poyner, Meenakshi Pardamwar, Christopher A. Reynolds, Simon J. Dowell, Gary B. Willars, Graham Ladds
J Biol Chem. 2015 Sep 18; 290(38): 23009–23022. Published online 2015 Jul 21. doi: 10.1074/jbc.M114.624601
PMCID:
PMC4645630
AbstractArticlePDF–2.9M
12.
Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor
Jason M. Booe, Christopher S. Walker, James Barwell, Gabriel Kuteyi, John Simms, Muhammad A. Jamaluddin, Margaret L. Warner, Roslyn M. Bill, Paul W. Harris, Margaret A. Brimble, David R. Poyner, Debbie L. Hay, Augen A. Pioszak
Mol Cell. 2015 Jun 18; 58(6): 1040–1052. doi: 10.1016/j.molcel.2015.04.018
PMCID:
PMC4504005
AbstractArticlePDF–6.0M
13.
Expression and Distribution of the Adrenomedullin System in Newborn Human Thymus
Sara De Martin, Giovanna Paliuri, Annasandra Belloni, Genny Orso, Erica Zanarella, Giovanni Stellin, Ornella Milanesi, Giuseppe Basso, Ezia Maria Ruga, Chiara Frasson, Daniela Gabbia, Giada Perdoncin, Pietro Palatini, Sergio Bova
PLoS One. 2014; 9(5): e97592. Published online 2014 May 15. doi: 10.1371/journal.pone.0097592
PMCID:
PMC4022580
AbstractArticlePDF–1.9M
14.
Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology
H A Watkins, C S Walker, K N Ly, R J Bailey, J Barwell, D R Poyner, D L Hay
Br J Pharmacol. 2014 Feb; 171(3): 772–788. Published online 2014 Jan 13. doi: 10.1111/bph.12508
PMCID:
PMC3969088
AbstractArticlePDF–2.2M
15.
Adrenomedullin-RAMP2 System Suppresses ER Stress-Induced Tubule Cell Death and Is Involved in Kidney Protection
Ryuichi Uetake, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Yasuhiro Iesato, Takahiro Yoshizawa, Teruhide Koyama, Lei Yang, Yuichi Toriyama, Akihiro Yamauchi, Kyoko Igarashi, Megumu Tanaka, Takashige Kuwabara, Kiyoshi Mori, Motoko Yanagita, Masashi Mukoyama, Takayuki Shindo
PLoS One. 2014; 9(2): e87667. Published online 2014 Feb 5. doi: 10.1371/journal.pone.0087667
PMCID:
PMC3914859
AbstractArticlePDF–1.4M
16.
Amyloid β (Aβ) Peptide Directly Activates Amylin-3 Receptor Subtype by Triggering Multiple Intracellular Signaling Pathways
Wen Fu, Araya Ruangkittisakul, David MacTavish, Jenny Y. Shi, Klaus Ballanyi, Jack H. Jhamandas
J Biol Chem. 2012 May 25; 287(22): 18820–18830. Published online 2012 Apr 12. doi: 10.1074/jbc.M111.331181
PMCID:
PMC3365692
AbstractArticlePDF–3.6M
17.
Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding
Seisuke Kusano, Mutsuko Kukimoto-Niino, Nobumasa Hino, Noboru Ohsawa, Ken-ichi Okuda, Kensaku Sakamoto, Mikako Shirouzu, Takayuki Shindo, Shigeyuki Yokoyama
Protein Sci. 2012 Feb; 21(2): 199–210. Published online 2011 Nov 18. doi: 10.1002/pro.2003
PMCID:
PMC3324764
AbstractArticlePDF–3.6M
18.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
19.
Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study
Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators
Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452
PMCID:
PMC2945168
AbstractArticlePDF–153K
20.
Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip
Philippa J. Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R. Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li, Juan Pablo Casas, Reecha Sofat, Meena Kumari, Santiago Rodriguez, Toby Johnson, Stephen J. Newhouse, Anna Dominiczak, Nilesh J. Samani, Mark Caulfield, Peter Sever, Alice Stanton, Denis C. Shields, on behalf of the ASCOT investigators, Sandosh Padmanabhan, Olle Melander, Claire Hastie, Christian Delles, on behalf of the NORDIL investigators, Shah Ebrahim, Michael G. Marmot, George Davey Smith, Debbie A. Lawlor, Patricia B. Munroe, for the BRIGHT Consortium, Ian N. Day, Mika Kivimaki, John Whittaker, Steve E. Humphries, Aroon D. Hingorani
Am J Hum Genet. 2009 Nov 13; 85(5): 628–642. doi: 10.1016/j.ajhg.2009.10.014
PMCID:
PMC2775832
AbstractArticlePDF–2.8M

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