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Items: 1 to 20 of 25

1.
Achaete-scute complex-like 2 regulated inflammatory mechanism through Toll-like receptor 4 activating in stomach adenocarcinoma
Enqi Zheng, Zhun Cai, Wangyong Li, Chuandou Ni, Qian Fang
World J Surg Oncol. 2022; 20: 266. Published online 2022 Aug 25. doi: 10.1186/s12957-022-02722-y
PMCID:
PMC9404661
AbstractArticlePDF–7.6M
2.
TET2–BCLAF1 transcription repression complex epigenetically regulates the expression of colorectal cancer gene Ascl2 via methylation of its promoter
Yangyang Shang, Tao Jiang, Lijian Ran, Wenjing Hu, Yun Wu, Jun Ye, Zhihong Peng, Lei Chen, Rongquan Wang
J Biol Chem. 2022 Jul; 298(7): 102095. Published online 2022 Jun 3. doi: 10.1016/j.jbc.2022.102095
PMCID:
PMC9251787
AbstractArticlePDF–5.8M
3.
ASCL2 Affects the Efficacy of Immunotherapy in Colon Adenocarcinoma Based on Single-Cell RNA Sequencing Analysis
Lei Wu, Shengnan Sun, Fei Qu, Xiuxiu Liu, Meili Sun, Ying Pan, Yan Zheng, Guohai Su
Front Immunol. 2022; 13: 829640. Published online 2022 Jun 3. doi: 10.3389/fimmu.2022.829640
PMCID:
PMC9237783
AbstractArticlePDF–16M
4.
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale
Science. Author manuscript; available in PMC 2021 Mar 30.
Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239
PMCID:
PMC8009048
AbstractArticlePDF–2.6M
5.
ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development
Kaela M. Varberg, Khursheed Iqbal, Masanaga Muto, Mikaela E. Simon, Regan L. Scott, Keisuke Kozai, Ruhul H. Choudhury, John D. Aplin, Rebecca Biswell, Margaret Gibson, Hiroaki Okae, Takahiro Arima, Jay L. Vivian, Elin Grundberg, Michael J. Soares
Proc Natl Acad Sci U S A. 2021 Mar 9; 118(10): e2016517118. Published online 2021 Mar 1. doi: 10.1073/pnas.2016517118
PMCID:
PMC7958375
AbstractArticlePDF–2.5M
6.
Potential Mechanism of Immune Evasion Associated with the Master Regulator ASCL2 in Microsatellite Stability in Colorectal Cancer
Qian Yang, Guowei Huang, Liyan Li, Enmin Li, Liyan Xu
J Immunol Res. 2021; 2021: 5964752. Published online 2021 Feb 10. doi: 10.1155/2021/5964752
PMCID:
PMC7892217
AbstractArticlePDF–2.3M
7.
Aberrant upregulation of ASCL2 by promoter demethylation promotes the growth and resistance to 5‐fluorouracil of gastric cancer cells
Oh‐Hyung Kwon, Jong‐Lyul Park, Su‐Jin Baek, Seung‐Moo Noh, Kyu‐Sang Song, Seon‐Young Kim, Yong Sung Kim
Cancer Sci. 2013 Mar; 104(3): 391–397. Published online 2013 Feb 14. doi: 10.1111/cas.12076
PMCID:
PMC7657231
AbstractArticlePDF–884K
8.
ASCL2 expression contributes to gastric tumor migration and invasion by downregulating miR223 and inducing EMT
Qingsong Zuo, Jie Wang, Chao Chen, Yong Zhang, Dian-Xu Feng, Ronghua Zhao, Teng Chen
Mol Med Rep. 2018 Oct; 18(4): 3751–3759. Published online 2018 Aug 8. doi: 10.3892/mmr.2018.9363
PMCID:
PMC6131580
AbstractArticlePDF–1.6M
9.
R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells
Jun Ye, Shanxi Liu, Yangyang Shang, Haoyuan Chen, Rongquan Wang
Cell Cycle. 2018; 17(8): 1014–1025. Published online 2018 Jun 25. doi: 10.1080/15384101.2018.1469874
PMCID:
PMC6103697
AbstractArticlePDF–2.2M
10.
Intrinsic DNA binding properties demonstrated for lineage-specifying basic helix-loop-helix transcription factors
Bradford H. Casey, Rahul K. Kollipara, Karine Pozo, Jane E. Johnson
Genome Res. 2018 Apr; 28(4): 484–496. doi: 10.1101/gr.224360.117
PMCID:
PMC5880239
AbstractArticlePDF–11M
11.
Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair
Huiming Lu, Raghavendra A. Shamanna, Jessica K. de Freitas, Mustafa Okur, Prabhat Khadka, Tomasz Kulikowicz, Priscella P. Holland, Jane Tian, Deborah L. Croteau, Anthony J. Davis, Vilhelm A. Bohr
Nat Commun. 2017; 8: 2039. Published online 2017 Dec 11. doi: 10.1038/s41467-017-02146-3
PMCID:
PMC5725494
AbstractArticlePDF–4.0M
12.
SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer
Kerstin Rönsch, Sabine Jägle, Katja Rose, Maximilian Seidl, Francis Baumgartner, Vivien Freihen, Afsheen Yousaf, Eric Metzger, Silke Lassmann, Roland Schüle, Robert Zeiser, Tom Michoel, Andreas Hecht
Mol Oncol. 2015 Feb; 9(2): 335–354. Published online 2014 Sep 16. doi: 10.1016/j.molonc.2014.08.016
PMCID:
PMC5528665
AbstractArticlePDF–5.0M
13.
Achaete scute-like 2 suppresses CDX2 expression and inhibits intestinal neoplastic epithelial cell differentiation
Yangyang Shang, Qiong Pan, Lei Chen, Jun Ye, Xiaoli Zhong, Xiaohuan Li, Linkuan Meng, Jin Guo, Yin Tian, Yonghong He, Wensheng Chen, Zhihong Peng, Rongquan Wang
Oncotarget. 2015 Oct 13; 6(31): 30993–31006. Published online 2015 Aug 17. doi: 10.18632/oncotarget.5206
PMCID:
PMC4741583
AbstractArticlePDF–4.1M
14.
MicroRNA-200 (miR-200) Cluster Regulation by Achaete Scute-like 2 (Ascl2): IMPACT ON THE EPITHELIAL-MESENCHYMAL TRANSITION IN COLON CANCER CELLS
Yin Tian, Qiong Pan, Yangyang Shang, Rong Zhu, Jun Ye, Yun Liu, Xiaoli Zhong, Shanshan Li, Yonghong He, Lei Chen, Jingjing Zhao, Wensheng Chen, Zhihong Peng, Rongquan Wang
J Biol Chem. 2014 Dec 26; 289(52): 36101–36115. Published online 2014 Nov 4. doi: 10.1074/jbc.M114.598383
PMCID:
PMC4276874
AbstractArticlePDF–4.3M
15.
Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes
Maggie C. Y. Ng, Daniel Shriner, Brian H. Chen, Jiang Li, Wei-Min Chen, Xiuqing Guo, Jiankang Liu, Suzette J. Bielinski, Lisa R. Yanek, Michael A. Nalls, Mary E. Comeau, Laura J. Rasmussen-Torvik, Richard A. Jensen, Daniel S. Evans, Yan V. Sun, Ping An, Sanjay R. Patel, Yingchang Lu, Jirong Long, Loren L. Armstrong, Lynne Wagenknecht, Lingyao Yang, Beverly M. Snively, Nicholette D. Palmer, Poorva Mudgal, Carl D. Langefeld, Keith L. Keene, Barry I. Freedman, Josyf C. Mychaleckyj, Uma Nayak, Leslie J. Raffel, Mark O. Goodarzi, Y-D Ida Chen, Herman A. Taylor, Jr., Adolfo Correa, Mario Sims, David Couper, James S. Pankow, Eric Boerwinkle, Adebowale Adeyemo, Ayo Doumatey, Guanjie Chen, Rasika A. Mathias, Dhananjay Vaidya, Andrew B. Singleton, Alan B. Zonderman, Robert P. Igo, Jr., John R. Sedor, the FIND Consortium, Edmond K. Kabagambe, David S. Siscovick, Barbara McKnight, Kenneth Rice, Yongmei Liu, Wen-Chi Hsueh, Wei Zhao, Lawrence F. Bielak, Aldi Kraja, Michael A. Province, Erwin P. Bottinger, Omri Gottesman, Qiuyin Cai, Wei Zheng, William J. Blot, William L. Lowe, Jennifer A. Pacheco, Dana C. Crawford, the eMERGE Consortium, the DIAGRAM Consortium, Elin Grundberg, the MuTHER Consortium, Stephen S. Rich, M. Geoffrey Hayes, Xiao-Ou Shu, Ruth J. F. Loos, Ingrid B. Borecki, Patricia A. Peyser, Steven R. Cummings, Bruce M. Psaty, Myriam Fornage, Sudha K. Iyengar, Michele K. Evans, Diane M. Becker, W. H. Linda Kao, James G. Wilson, Jerome I. Rotter, Michèle M. Sale, Simin Liu, Charles N. Rotimi, Donald W. Bowden, for the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium
PLoS Genet. 2014 Aug; 10(8): e1004517. Published online 2014 Aug 7. doi: 10.1371/journal.pgen.1004517
PMCID:
PMC4125087
AbstractArticlePDF–1.0M
16.
Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development
Xindong Liu, Xin Chen, Bo Zhong, Aibo Wang, Xiaohu Wang, Fuliang Chu, Roza I. Nurieva, Xiaowei Yan, Ping Chen, Laurens G. van der Flier, Hiroko Nakatsukasa, Sattva S Neelapu, Wanjun Chen, Hans Clevers, Qiang Tian, Hai Qi, Lai Wei, Chen Dong
Nature. Author manuscript; available in PMC 2014 Sep 27.
Published in final edited form as: Nature. 2014 Mar 27; 507(7493): 513–518. Published online 2014 Jan 19. doi: 10.1038/nature12910
PMCID:
PMC4012617
AbstractArticlePDF–4.1M
17.
A Possible Mechanism behind Autoimmune Disorders Discovered By Genome-Wide Linkage and Association Analysis in Celiac Disease
Malin Östensson, Caroline Montén, Jonas Bacelis, Audur H. Gudjonsdottir, Svetlana Adamovic, Johan Ek, Henry Ascher, Elisabet Pollak, Henrik Arnell, Lars Browaldh, Daniel Agardh, Jan Wahlström, Staffan Nilsson, Åsa Torinsson-Naluai
PLoS One. 2013; 8(8): e70174. Published online 2013 Aug 2. doi: 10.1371/journal.pone.0070174
PMCID:
PMC3732286
AbstractArticlePDF–1.7M
18.
The Human ASCL2 Gene Escaping Genomic Imprinting and Its Expression Pattern
Toshinobu Miyamoto, Shiga Hasuike, Yoshihiro Jinno, Hidenobu Soejima, Kankatsu Yun, Kiyonori Miura, Mutsuo Ishikawa, Norio Niikawa
J Assist Reprod Genet. 2002 May; 19(5): 240–244. doi: 10.1023/A:1015362903486
PMCID:
PMC3468234
SummaryPDF–580K
19.
Ascl2 Knockdown Results in Tumor Growth Arrest by miRNA-302b-Related Inhibition of Colon Cancer Progenitor Cells
Rong Zhu, Yongtao Yang, Yin Tian, Jianying Bai, Xin Zhang, Xiaohuan Li, Zhihong Peng, Yonghong He, Lei Chen, Qiong Pan, Dianchun Fang, Wensheng Chen, Chen Qian, Xiuwu Bian, Rongquan Wang
PLoS One. 2012; 7(2): e32170. Published online 2012 Feb 23. doi: 10.1371/journal.pone.0032170
PMCID:
PMC3285660
AbstractArticlePDF–1.9M
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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