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Select item 109200741.

Human EXOG Possesses Strong AP Hydrolysis Activity: Implication on Mitochondrial DNA Base Excision Repair

Michal R. Szymanski, Anna Karlowicz, Geoffrey K. Herrmann, Yana Cen, Y. Whitney Yin

J Am Chem Soc. Author manuscript; available in PMC 2024 Mar 8.

Published in final edited form as: J Am Chem Soc. 2022 Dec 28; 144(51): 23543–23550. Published online 2022 Dec 14. doi: 10.1021/jacs.2c10558

PMCID:: PMC10920074

Abstract Article PDF–938K

Select item 93719042.

In vitro reconstitution reveals a key role of human mitochondrial EXOG in RNA primer processing

Anna Karlowicz, Andrzej B Dubiel, Jolanta Czerwinska, Adela Bledea, Piotr Purzycki, Marta Grzelewska, Ryan J McAuley, Roman J Szczesny, Gabriela Brzuska, Ewelina Krol, Bartosz Szczesny, Michal R Szymanski

Nucleic Acids Res. 2022 Aug 12; 50(14): 7991–8007. Published online 2022 Jul 12. doi: 10.1093/nar/gkac581

PMCID:: PMC9371904

Abstract Article PDF–4.7M

Select item 90560263.

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis

Fenglong Jiao, Clinton Yu, Andrew Wheat, Xiaorong Wang, Scott D. Rychnovsky, Lan Huang

Anal Chem. Author manuscript; available in PMC 2022 Apr 30.

Published in final edited form as: Anal Chem. 2022 Mar 15; 94(10): 4236–4242. Published online 2022 Mar 2. doi: 10.1021/acs.analchem.1c04485

PMCID:: PMC9056026

Abstract Article PDF–1.0M

Select item 83641814.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 82827645.

N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

Yuanming Cheng, Wei Xie, Brian F Pickering, Karen L Chu, Angela M Savino, Xuejing Yang, Hanzhi Luo, Diu TT Nguyen, Shanlan Mo, Ersilia Barin, Anthony Velleca, Thomas Rohwetter, Dinshaw J Patel, Samie R Jaffrey, Michael G Kharas

Cancer Cell. Author manuscript; available in PMC 2022 Jul 12.

Published in final edited form as: Cancer Cell. 2021 Jul 12; 39(7): 958–972.e8. Published online 2021 May 27. doi: 10.1016/j.ccell.2021.04.017

PMCID:: PMC8282764

Abstract Article PDF–3.4M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 67964927.

Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression

Shouhua Wang, Yongjie Zhang, Qiang Cai, Mingzhe Ma, Long Yang Jin, Mingzhe Weng, Di Zhou, Zhaohui Tang, Jian Dong Wang, Zhiwei Quan

Mol Cancer. 2019; 18: 145. Published online 2019 Oct 17. doi: 10.1186/s12943-019-1078-z

PMCID:: PMC6796492

Abstract Article PDF–4.1M

Select item 65474218.

A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication

Chyuan-Chuan Wu, Jason L J Lin, Hsin-Fang Yang-Yen, Hanna S Yuan

Nucleic Acids Res. 2019 Jun 4; 47(10): 5405–5419. Published online 2019 Apr 5. doi: 10.1093/nar/gkz241

PMCID:: PMC6547421

Abstract Article PDF–5.4M

Select item 61666829.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 599939610.

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

Tyler B Faust, Yang Li, Curtis W Bacon, Gwendolyn M Jang, Amit Weiss, Bhargavi Jayaraman, Billy W Newton, Nevan J Krogan, Iván D'Orso, Alan D Frankel

eLife. 2018; 7: e31879. Published online 2018 May 30. doi: 10.7554/eLife.31879

PMCID:: PMC5999396

Abstract Article PDF–3.6M

Select item 553161111.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 541859312.

A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease

Michal R. Szymanski, Wangsheng Yu, Aleksandra M. Gmyrek, Mark A. White, Ian J. Molineux, J. Ching Lee, Y. Whitney Yin

Nat Commun. 2017; 8: 14959. Published online 2017 May 3. doi: 10.1038/ncomms14959

PMCID:: PMC5418593

Abstract Article PDF–2.8M

Select item 461721113.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 424595114.

Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function

Bartosz Szczesny, Attila Brunyanszki, Gabor Olah, Sankar Mitra, Csaba Szabo

Nucleic Acids Res. 2014 Dec 1; 42(21): 13161–13173. Published online 2014 Nov 5. doi: 10.1093/nar/gku1089

PMCID:: PMC4245951

Abstract Article PDF–624K

Select item 414102415.

Genetic Determinants of P Wave Duration and PR Segment

Niek Verweij, Irene Mateo Leach, Malou van den Boogaard, Dirk J. van Veldhuisen, Vincent M. Christoffels, LifeLines Cohort Study, Hans L. Hillege, Wiek H. van Gilst, Phil Barnett, Rudolf A. de Boer, Pim van der Harst

Circ Cardiovasc Genet. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Circ Cardiovasc Genet. 2014 Aug; 7(4): 475–481. Published online 2014 May 21. doi: 10.1161/CIRCGENETICS.113.000373

PMCID:: PMC4141024

Abstract Article PDF–410K

Select item 380737416.

Mitochondrial Nucleases ENDOG and EXOG Participate in Mitochondrial DNA Depletion Initiated by Herpes Simplex Virus 1 UL12.5

Brett A. Duguay, James R. Smiley

J Virol. 2013 Nov; 87(21): 11787–11797. doi: 10.1128/JVI.02306-13

PMCID:: PMC3807374

Abstract Article PDF–3.2M

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 317318218.

Apoptosis Induced by Persistent Single-strand Breaks in Mitochondrial Genome: CRITICAL ROLE OF EXOG (5′-EXO/ENDONUCLEASE) IN THEIR REPAIR

Anne W. Tann, Istvan Boldogh, Gregor Meiss, Wei Qian, Bennett Van Houten, Sankar Mitra, Bartosz Szczesny

J Biol Chem. 2011 Sep 16; 286(37): 31975–31983. Published online 2011 Jul 18. doi: 10.1074/jbc.M110.215715

PMCID:: PMC3173182

Abstract Article PDF–1.4M

Select item 294347619.

Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

Sher L. Hendrickson, James A. Lautenberger, Leslie Wei Chinn, Michael Malasky, Efe Sezgin, Lawrence A. Kingsley, James J. Goedert, Gregory D. Kirk, Edward D. Gomperts, Susan P. Buchbinder, Jennifer L. Troyer, Stephen J. O'Brien

PLoS One. 2010; 5(9): e12862. Published online 2010 Sep 21. doi: 10.1371/journal.pone.0012862

PMCID:: PMC2943476

Abstract Article PDF–461K

Select item 227507820.

EXOG, a novel paralog of Endonuclease G in higher eukaryotes

Iwona A. Cymerman, Inn Chung, Benedikt M. Beckmann, Janusz M. Bujnicki, Gregor Meiss

Nucleic Acids Res. 2008 Mar; 36(4): 1369–1379. Published online 2008 Jan 10. doi: 10.1093/nar/gkm1169

PMCID:: PMC2275078

Abstract Article PDF–823K

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