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Select item 109266211.

ANGPTL3 is a novel HDL component that regulates HDL function

Longyan Yang, Yan Wang, Yongsong Xu, Kun Li, Ruili Yin, Lijie Zhang, Di Wang, Lingling Wei, Jianan Lang, Yanan Cheng, Lu Wang, Jing Ke, Dong Zhao

J Transl Med. 2024; 22: 263. Published online 2024 Mar 10. doi: 10.1186/s12967-024-05032-x

PMCID:: PMC10926621

Abstract Article PDF–2.1M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 104506173.

The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy

Yanli Ma, Yu Chen, Hong Xu, Ni Du

Front Immunol. 2023; 14: 1228399. Published online 2023 Aug 10. doi: 10.3389/fimmu.2023.1228399

PMCID:: PMC10450617

Abstract Article PDF–4.3M

Select item 102832744.

METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA and potentiates malignant progression of stomach adenocarcinoma

Zhijin Zhang, Jun Fu, Yuhao Zhang, Xianju Qin, Yuexia Wang, Chungen Xing

BMC Gastroenterol. 2023; 23: 217. Published online 2023 Jun 21. doi: 10.1186/s12876-023-02844-x

PMCID:: PMC10283274

Abstract Article PDF–9.4M

Select item 90288605.

The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway

Simone Bini, Valeria Pecce, Alessia Di Costanzo, Luca Polito, Ameneh Ghadiri, Ilenia Minicocci, Federica Tambaro, Stella Covino, Marcello Arca, Laura D’Erasmo

Biomolecules. 2022 Apr; 12(4): 585. Published online 2022 Apr 16. doi: 10.3390/biom12040585

PMCID:: PMC9028860

Abstract Article PDF–1.5M

Select item 89966046.

ANGPTL3 impacts proteinuria and hyperlipidemia in primary nephrotic syndrome

Fu Zhong, Shurao Liu, Yue Li, Guanyu Li, Ming Liu, Jingzhi Wang, Weijing Cui, Yanhong Suo, Xia Gao

Lipids Health Dis. 2022; 21: 38. Published online 2022 Apr 10. doi: 10.1186/s12944-022-01632-y

PMCID:: PMC8996604

Abstract Article PDF–2.0M

Select item 84560557.

Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8

Kelli L. Sylvers-Davie, Ashley Segura-Roman, Alicia M. Salvi, Kylie J. Schache, Brandon S.J. Davies

J Lipid Res. 2021; 62: 100112. Published online 2021 Aug 27. doi: 10.1016/j.jlr.2021.100112

PMCID:: PMC8456055

Abstract Article PDF–2.1M

Select item 84173988.

Antisense oligonucleotide–mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice

Thomas A. Bell, III, Mingxia Liu, Aaron J. Donner, Richard G. Lee, Adam E. Mullick, Rosanne M. Crooke

J Lipid Res. 2021; 62: 100101. Published online 2021 Aug 6. doi: 10.1016/j.jlr.2021.100101

PMCID:: PMC8417398

Abstract Article PDF–764K

Select item 79583519.

Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

Min Qiu, Zachary Glass, Jinjin Chen, Mary Haas, Xin Jin, Xuewei Zhao, Xuehui Rui, Zhongfeng Ye, Yamin Li, Feng Zhang, Qiaobing Xu

Proc Natl Acad Sci U S A. 2021 Mar 9; 118(10): e2020401118. Published online 2021 Mar 1. doi: 10.1073/pnas.2020401118

PMCID:: PMC7958351

Abstract Article PDF–1.6M

Select item 746988710.

Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Rene C. Adam, Ivory J. Mintah, Corey A. Alexa-Braun, Lisa M. Shihanian, Joseph S. Lee, Poulabi Banerjee, Sara C. Hamon, Hye In Kim, Jonathan C. Cohen, Helen H. Hobbs, Cristopher Van Hout, Jesper Gromada, Andrew J. Murphy, George D. Yancopoulos, Mark W. Sleeman, Viktoria Gusarova

J Lipid Res. 2020 Sep; 61(9): 1271–1286. Published online 2020 Jul 9. doi: 10.1194/jlr.RA120000888

PMCID:: PMC7469887

Abstract Article PDF–2.8M

Select item 653375811.

Angiopoietin-like-3 knockout protects against glomerulosclerosis in murine adriamycin-induced nephropathy by attenuating podocyte loss

Rufeng Dai, Haimei Liu, Xinli Han, Junchao Liu, Yihui Zhai, Jia Rao, Qian Shen, Hong Xu

BMC Nephrol. 2019; 20: 185. Published online 2019 May 24. doi: 10.1186/s12882-019-1383-1

PMCID:: PMC6533758

Abstract Article PDF–2.6M

Select item 576953112.

New insights into ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases

Xin Su, Dao-quan Peng

Lipids Health Dis. 2018; 17: 12. Published online 2018 Jan 15. doi: 10.1186/s12944-018-0659-y

PMCID:: PMC5769531

Abstract Article PDF–416K

Select item 575012713.

Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoproteins

Yu-Xin Xu, Valeska Redon, Haojie Yu, William Querbes, James Pirruccello, Abigail Liebow, Amy Deik, Kevin Trindade, Xiao Wang, Kiran Musunuru, Clary B. Clish, Chad Cowan, Kevin Fizgerald, Daniel Rader, Sekar Kathiresan

Atherosclerosis. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Atherosclerosis. 2018 Jan; 268: 196–206. Published online 2017 Sep 21. doi: 10.1016/j.atherosclerosis.2017.08.031

PMCID:: PMC5750127

Abstract Article PDF–2.3M

Select item 545451514.

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance

Jorge F. Haller, Ivory J. Mintah, Lisa M. Shihanian, Panayiotis Stevis, David Buckler, Corey A. Alexa-Braun, Sandra Kleiner, Serena Banfi, Jonathan C. Cohen, Helen H. Hobbs, George D. Yancopoulos, Andrew J. Murphy, Viktoria Gusarova, Jesper Gromada

J Lipid Res. 2017 Jun; 58(6): 1166–1173. Published online 2017 Apr 15. doi: 10.1194/jlr.M075689

PMCID:: PMC5454515

Abstract Article PDF–1.4M

Select item 468519615.

A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase

Zhiyao Fu, Abdul B. Abou-Samra, Ren Zhang

Sci Rep. 2015; 5: 18502. Published online 2015 Dec 21. doi: 10.1038/srep18502

PMCID:: PMC4685196

Abstract Article PDF–1.1M

Select item 457717916.

Hepatic ANGPTL3 regulates adipose tissue energy homeostasis

Yan Wang, Markey C. McNutt, Serena Banfi, Michael G. Levin, William L. Holland, Viktoria Gusarova, Jesper Gromada, Jonathan C. Cohen, Helen H. Hobbs

Proc Natl Acad Sci U S A. 2015 Sep 15; 112(37): 11630–11635. Published online 2015 Aug 24. doi: 10.1073/pnas.1515374112

PMCID:: PMC4577179

Abstract Article PDF–768K

Select item 447933417.

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

Yan Wang, Viktoria Gusarova, Serena Banfi, Jesper Gromada, Jonathan C. Cohen, Helen H. Hobbs

J Lipid Res. 2015 Jul; 56(7): 1296–1307. doi: 10.1194/jlr.M054882

PMCID:: PMC4479334

Abstract Article PDF–1.4M

Select item 431955918.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 414946919.

Angiopoietin-Like Protein 3 Promotes Preservation of Stemness during Ex Vivo Expansion of Murine Hematopoietic Stem Cells

Elnaz Farahbakhshian, Monique M. Verstegen, Trudi P. Visser, Sima Kheradmandkia, Dirk Geerts, Shazia Arshad, Noveen Riaz, Frank Grosveld, Niek P. van Til, Jules P. P. Meijerink

PLoS One. 2014; 9(8): e105642. Published online 2014 Aug 29. doi: 10.1371/journal.pone.0105642

PMCID:: PMC4149469

Abstract Article PDF–708K

Select item 396495520.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

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