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Select item 105924471.

Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung

Kelly Kersten, Ran You, Sophia Liang, Kevin M. Tharp, Joshua Pollack, Valerie M. Weaver, Matthew F. Krummel, Mark B. Headley

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112582. Published online 2023 May 31. doi: 10.1016/j.celrep.2023.112582

PMCID:: PMC10592447

Abstract Article PDF–1.1M

Select item 104849952.

mTORC2 regulates auditory hair cell structure and function

Maurizio Cortada, Soledad Levano, Michael N. Hall, Daniel Bodmer

iScience. 2023 Sep 15; 26(9): 107687. Published online 2023 Aug 19. doi: 10.1016/j.isci.2023.107687

PMCID:: PMC10484995

Abstract Article PDF–4.9M

Select item 103123923.

Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells

Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis

Cell Rep. Author manuscript; available in PMC 2023 Jun 30.

Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112529. Published online 2023 May 17. doi: 10.1016/j.celrep.2023.112529

PMCID:: PMC10312392

Abstract Article PDF–3.8M

Select item 100219894.

Maternal hyperglycemia inhibits pulmonary vasculogenesis during mouse fetal lung development by promoting GβL Ubiquitination-dependent mammalian target of Rapamycin assembly

Qingqing Luo, Xinqun Chai, Xiaoyan Xin, Weixiang Ouyang, Feitao Deng

Diabetol Metab Syndr. 2023; 15: 49. Published online 2023 Mar 17. doi: 10.1186/s13098-022-00974-y

PMCID:: PMC10021989

Abstract Article PDF–1.5M

Select item 98885145.

mTORC2 Loss in Oligodendrocyte Progenitor Cells Results in Regional Hypomyelination in the Central Nervous System

Kristin D. Dahl, Adam R. Almeida, Hannah A. Hathaway, Jennifer Bourne, Tanya L. Brown, Lisbet T. Finseth, Teresa L. Wood, Wendy B. Macklin

J Neurosci. 2023 Jan 25; 43(4): 540–558. doi: 10.1523/JNEUROSCI.0010-22.2022

PMCID:: PMC9888514

Abstract Article PDF–9.9M

Select item 97156966.

Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis

Guy Werlen, Mei-Ling Li, Luca Tottone, Victoria da Silva-Diz, Xiaoyang Su, Daniel Herranz, Estela Jacinto

Nat Commun. 2022; 13: 7404. Published online 2022 Dec 1. doi: 10.1038/s41467-022-35014-w

PMCID:: PMC9715696

Abstract Article PDF–4.3M

Select item 95017207.

Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

Teayoun Kim, Shelly Nason, Jessica Antipenko, Brian Finan, Anath Shalev, Richard DiMarchi, Kirk M. Habegger

Diabetes. 2022 Oct; 71(10): 2123–2135. Published online 2022 Jul 25. doi: 10.2337/db21-1018

PMCID:: PMC9501720

Abstract Article PDF–83M

Select item 93634838.

Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex

Vasiliki Karalis, Franklin Caval-Holme, Helen S. Bateup

Nat Commun. 2022; 13: 4665. Published online 2022 Aug 9. doi: 10.1038/s41467-022-31961-6

PMCID:: PMC9363483

Abstract Article PDF–9.8M

Select item 93378259.

mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation

Calvin Wong, Omer Barkai, Feng Wang, Carolina Thörn Perez, Shaya Lev, Weihua Cai, Shannon Tansley, Noosha Yousefpour, Mehdi Hooshmandi, Kevin C. Lister, Mariam Latif, A. Claudio Cuello, Masha Prager-Khoutorsky, Jeffrey S. Mogil, Philippe Séguéla, Yves De Koninck, Alfredo Ribeiro-da-Silva, Alexander M. Binshtok, Arkady Khoutorsky

J Clin Invest. 2022 Aug 1; 132(15): e152635. Published online 2022 Aug 1. doi: 10.1172/JCI152635

PMCID:: PMC9337825

Abstract Article PDF–6.7M

Select item 932876610.

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

Polina Kosillo, Kamran M Ahmed, Erin E Aisenberg, Vasiliki Karalis, Bradley M Roberts, Stephanie J Cragg, Helen S Bateup

eLife. 2022; 11: e75398. Published online 2022 Jul 26. doi: 10.7554/eLife.75398

PMCID:: PMC9328766

Abstract Article PDF–15M

Select item 913740511.

Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum

Ines Serra, Ana Stravs, Catarina Osório, Maria Roa Oyaga, Martijn Schonewille, Christian Tudorache, Aleksandra Badura

Front Mol Neurosci. 2022; 15: 831687. Published online 2022 May 13. doi: 10.3389/fnmol.2022.831687

PMCID:: PMC9137405

Abstract Article PDF–4.0M

Select item 897141012.

IL-1β-activated mTORC2 promotes accumulation of IFN-γ⁺ γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis

Qihui Liu, Quanli Yang, Zengfeng Wu, Yanfang Chen, Miaomiao Xu, Hua Zhang, Jiliang Zhao, Zonghua Liu, Zerong Guan, Jing Luo, Zhi-yong Li, Guodong Sun, Qiong Wen, Yan Xu, Zhenhua Li, Kebing Chen, Xiaosong Ben, Wanchun He, Xueshi Li, Zhinan Yin, Jianlei Hao, Ligong Lu

Cell Death Dis. 2022 Apr; 13(4): 289. Published online 2022 Apr 1. doi: 10.1038/s41419-022-04739-3

PMCID:: PMC8971410

Abstract Article PDF–7.0M

Select item 893371013.

Intracellular metabolic adaptation of intraepithelial CD4⁺CD8αα⁺ T lymphocytes

Yosuke Harada, Tomohisa Sujino, Kentaro Miyamoto, Ena Nomura, Yusuke Yoshimatsu, Shun Tanemoto, Satoko Umeda, Keiko Ono, Yohei Mikami, Nobuhiro Nakamoto, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Tuneo Ikenoue, Atsushi Hirao, Yoshiaki Kubota, Takanori Kanai

iScience. 2022 Apr 15; 25(4): 104021. Published online 2022 Mar 4. doi: 10.1016/j.isci.2022.104021

PMCID:: PMC8933710

Abstract Article PDF–3.3M

Select item 891738314.

Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss

Xiaolong Fu, Peipei Li, Linqing Zhang, Yuning Song, Yachun An, Aizhen Zhang, Wenwen Liu, Chao Ye, Yuan Zhang, Rongyu Yue, Xiaoyang Sun, Renjie Chai, Haibo Wang, Jiangang Gao

Proc Natl Acad Sci U S A. 2022 Mar 8; 119(10): e2107357119. Published online 2022 Mar 1. doi: 10.1073/pnas.2107357119

Correction in:: Proc Natl Acad Sci U S A. 2022 May 17; 119(20): e2204956119.

PMCID:: PMC8917383

Abstract Article PDF–2.5M

Select item 881401915.

miR-582 negatively regulates pre-B cell proliferation and survival through targeting Hif1α and Rictor

Xinxin Li, Yufei Zhang, Minhua Zheng, Xiuli Cao, Min Guo, Xiangyu Gao, Hua Han

Cell Death Dis. 2022 Feb; 13(2): 107. Published online 2022 Feb 3. doi: 10.1038/s41419-022-04560-y

PMCID:: PMC8814019

Abstract Article PDF–5.2M

Select item 880334816.

Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice

Neha Bhat, Anand Narayanan, Mohsen Fathzadeh, Mario Kahn, Dongyan Zhang, Leigh Goedeke, Arpita Neogi, Rebecca L. Cardone, Richard G. Kibbey, Carlos Fernandez-Hernando, Henry N. Ginsberg, Dhanpat Jain, Gerald I. Shulman, Arya Mani

J Clin Invest. 2022 Feb 1; 132(3): e153724. Published online 2022 Feb 1. doi: 10.1172/JCI153724

PMCID:: PMC8803348

Abstract Article PDF–18M

Select item 880065317.

Rictor对小鼠胚胎干细胞来源心肌细胞线粒体钙信号的调控

Ying SHAO, Jiadan WANG, Danyan ZHU

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019 Feb 25; 48(1): 65–74. Chinese. doi: 10.3785/j.issn.1008-9292.2019.02.11

PMCID:: PMC8800653

Abstract Article PDF–8.1M

Select item 877660318.

Cholesterol-lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity

Yanping Wang, Sungyong You, Shengchen Su, Austin Yeon, Eric M. Lo, Sungjin Kim, James L. Mohler, Michael R. Freeman, Hyung L. Kim

Clin Cancer Res. Author manuscript; available in PMC 2022 Jul 15.

Published in final edited form as: Clin Cancer Res. 2022 Jan 15; 28(2): 414–424. Published online 2021 Nov 2. doi: 10.1158/1078-0432.CCR-21-1535

PMCID:: PMC8776603

Abstract Article PDF–1.7M

Select item 875825019.

A glycolytic shift in Schwann cells supports injured axons

Elisabetta Babetto, Keit Men Wong, Bogdan Beirowski

Nat Neurosci. Author manuscript; available in PMC 2022 Jan 13.

Published in final edited form as: Nat Neurosci. 2020 Oct; 23(10): 1215–1228. Published online 2020 Aug 17. doi: 10.1038/s41593-020-0689-4

PMCID:: PMC8758250

Abstract Article PDF–4.2M

Select item 866514720.

Efferocytosis Induces Macrophage Proliferation to Help Resolve Tissue Injury

Brennan D. Gerlach, Patrick B. Ampomah, Arif Yurdagul, Jr, Chuang Liu, Max C. Lauring, Xiaobo Wang, Canan Kasikara, Na Kong, Jinjun Shi, Wei Tao, Ira Tabas

Cell Metab. Author manuscript; available in PMC 2022 Dec 7.

Published in final edited form as: Cell Metab. 2021 Dec 7; 33(12): 2445–2463.e8. Published online 2021 Nov 15. doi: 10.1016/j.cmet.2021.10.015

PMCID:: PMC8665147

Abstract Article PDF–1.6M

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