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Select item 112109041.

Foot-and-mouth disease virus VP1 degrades YTHDF2 through autophagy to regulate IRF3 activity for viral replication

Huisheng Liu, Qiao Xue, Fan Yang, Weijun Cao, Pengfei Liu, Xiangtao Liu, Zixiang Zhu, Haixue Zheng

Autophagy. 2024; 20(7): 1597–1615. Published online 2024 Mar 22. doi: 10.1080/15548627.2024.2330105

PMCID:: PMC11210904

Abstract Article PDF–4.1M

Select item 111433262.

AgRP neuron cis-regulatory analysis across hunger states reveals that IRF3 mediates leptin’s acute effects

Frankie D. Heyward, Nan Liu, Christopher Jacobs, Natalia L. S. Machado, Rachael Ivison, Aykut Uner, Harini Srinivasan, Suraj J. Patel, Anton Gulko, Tyler Sermersheim, Linus Tsai, Evan D. Rosen

Nat Commun. 2024; 15: 4646. Published online 2024 May 31. doi: 10.1038/s41467-024-48885-y

PMCID:: PMC11143326

Abstract Article PDF–5.3M

Select item 111399943.

Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels

Shuai Yan, Anna Santoro, Micah J. Niphakis, Antonio M. Pinto, Christopher L. Jacobs, Rasheed Ahmad, Radu M. Suciu, Bryan R. Fonslow, Rachel A. Herbst-Graham, Nhi Ngo, Cassandra L. Henry, Dylan M. Herbst, Alan Saghatelian, Barbara B. Kahn, Evan D. Rosen

Nat Commun. 2024; 15: 4605. Published online 2024 May 30. doi: 10.1038/s41467-024-48220-5

PMCID:: PMC11139994

Abstract Article PDF–2.9M

Select item 111398934.

Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression

Jong Ho Park, Mahsa Mortaja, Heehwa G. Son, Xutu Zhao, Lauren M. Sloat, Marjan Azin, Jun Wang, Michael R. Collier, Krishna S. Tummala, Anna Mandinova, Nabeel Bardeesy, Yevgeniy R. Semenov, Mari Mino-Kenudson, Shadmehr Demehri

Nat Commun. 2024; 15: 4099. Published online 2024 May 30. doi: 10.1038/s41467-024-48441-8

PMCID:: PMC11139893

Abstract Article PDF–2.6M

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108208806.

Therapeutic Effects of IL-1RA against Acute Bacterial Infections, including Antibiotic-Resistant Strains

Ines Ambite, Thi Hien Tran, Daniel S. C. Butler, Michele Cavalera, Murphy Lam Yim Wan, Shahram Ahmadi, Catharina Svanborg

Pathogens. 2024 Jan; 13(1): 42. Published online 2023 Dec 31. doi: 10.3390/pathogens13010042

PMCID:: PMC10820880

Abstract Article PDF–4.1M

Select item 108172277.

ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus

Biao Chen, Guijie Guo, Guoqing Wang, Qianwen Zhu, Lulu Wang, Wenhao Shi, Song Wang, Yuhai Chen, Xiaojuan Chi, Faxin Wen, Mohamed Maarouf, Shile Huang, Zhou Yang, Ji-Long Chen

PLoS Pathog. 2024 Jan; 20(1): e1011958. Published online 2024 Jan 16. doi: 10.1371/journal.ppat.1011958

PMCID:: PMC10817227

Abstract Article PDF–4.0M

Select item 105472078.

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo

Marie Bourdon, Caroline Manet, Laurine Conquet, Corentin Ramaugé Parra, Etienne Kornobis, Eliette Bonnefoy, Xavier Montagutelli

PLoS Pathog. 2023 Sep; 19(9): e1011446. Published online 2023 Sep 21. doi: 10.1371/journal.ppat.1011446

PMCID:: PMC10547207

Abstract Article PDF–2.4M

Select item 105150229.

Astrocytes evoke a robust IRF7-independent type I interferon response upon neurotropic viral infection

Loreen Weichert, Henning Peter Düsedau, David Fritzsch, Sarah Schreier, Annika Scharf, Martina Grashoff, Kristin Cebulski, Kristin Michaelsen-Preusse, Christian Erck, Stefan Lienenklaus, Ildiko Rita Dunay, Andrea Kröger

J Neuroinflammation. 2023; 20: 213. Published online 2023 Sep 22. doi: 10.1186/s12974-023-02892-w

PMCID:: PMC10515022

Abstract Article PDF–7.2M

Select item 1025232810.

IRF3 Activation in Mast Cells Promotes FcεRI-Mediated Allergic Inflammation

Young-Ae Choi, Hima Dhakal, Soyoung Lee, Namkyung Kim, Byungheon Lee, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim

Cells. 2023 Jun; 12(11): 1493. Published online 2023 May 28. doi: 10.3390/cells12111493

PMCID:: PMC10252328

Abstract Article PDF–2.9M

Select item 1006465711.

Identification and characterization of small molecule IRF3-dependent immune activators for pharmaceutical development

Marie H. Foss, Susan L. Stevens, Haihong Jin, Elyse M. Allen, Dylan Nelson, Victor DeFilippis, Aaron Nilsen, Mary P. Stenzel-Poore

ACS Chem Biol. Author manuscript; available in PMC 2023 May 20.

Published in final edited form as: ACS Chem Biol. 2022 May 20; 17(5): 1073–1081. Published online 2022 Apr 26. doi: 10.1021/acschembio.1c00912

PMCID:: PMC10064657

Abstract Article PDF–1.2M

Select item 972290812.

Pim1 promotes IFN-β production by interacting with IRF3

Ryeojin Ko, Jeongin Seo, Hana Park, Nawon Lee, Soo Young Lee

Exp Mol Med. 2022 Nov; 54(11): 2092–2103. Published online 2022 Nov 29. doi: 10.1038/s12276-022-00893-y

PMCID:: PMC9722908

Abstract Article PDF–3.5M

Select item 947867613.

IRF3 inhibits nuclear translocation of NF-κB to prevent viral inflammation

Sonam Popli, Sukanya Chakravarty, Shumin Fan, Anna Glanz, Siddhesh Aras, Laura E. Nagy, Ganes C. Sen, Ritu Chakravarti, Saurabh Chattopadhyay

Proc Natl Acad Sci U S A. 2022 Sep 13; 119(37): e2121385119. Published online 2022 Sep 6. doi: 10.1073/pnas.2121385119

PMCID:: PMC9478676

Abstract Article PDF–2.1M

Select item 947464314.

The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging

Seungjin Ryu, Sviatoslav Sidorov, Eric Ravussin, Maxim Artyomov, Akiko Iwasaki, Andrew Wang, Vishwa Deep Dixit

Immunity. Author manuscript; available in PMC 2023 Sep 13.

Published in final edited form as: Immunity. 2022 Aug 10 : S1074-7613(22)00340-5. Published online 2022 Aug 10. doi: 10.1016/j.immuni.2022.07.007

PMCID:: PMC9474643

Abstract Article PDF–3.6M

Select item 940299215.

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

Nina Kessler, Susanne F. Viehmann, Calvin Krollmann, Karola Mai, Katharina M. Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M.C. Böhner, Dennis Huugen, Carina C. de Oliveira Mann, Simon Otten, Stefanie A.I. Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E. Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A. Lyons, Peter Boor, Angela Rösen-Wolff, Lino L. Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi

J Exp Med. 2022 Oct 3; 219(10): e20220759. Published online 2022 Aug 23. doi: 10.1084/jem.20220759

Correction in:: J Exp Med. 2022 Dec 5; 219(12): e2022075911022022c.

PMCID:: PMC9402992

Abstract Article PDF–6.5M

Select item 916205616.

Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b

Suraj J. Patel, Nan Liu, Sam Piaker, Anton Gulko, Maynara L. Andrade, Frankie D. Heyward, Tyler Sermersheim, Nufar Edinger, Harini Srinivasan, Margo P. Emont, Gregory P. Westcott, Jay Luther, Raymond T. Chung, Shuai Yan, Manju Kumari, Reeby Thomas, Yann Deleye, André Tchernof, Phillip J. White, Guido A. Baselli, Marica Meroni, Dario F. De Jesus, Rasheed Ahmad, Rohit N. Kulkarni, Luca Valenti, Linus Tsai, Evan D. Rosen

Sci Transl Med. Author manuscript; available in PMC 2022 Jun 2.

Published in final edited form as: Sci Transl Med. 2022 Mar 23; 14(637): eabh3831. Published online 2022 Mar 23. doi: 10.1126/scitranslmed.abh3831

PMCID:: PMC9162056

Abstract Article PDF–3.1M

Select item 892620217.

Differences in neuroinvasion and protective innate immune pathways between encephalitic California Serogroup orthobunyaviruses

Alyssa B. Evans, Clayton W. Winkler, Karin E. Peterson

PLoS Pathog. 2022 Mar; 18(3): e1010384. Published online 2022 Mar 4. doi: 10.1371/journal.ppat.1010384

PMCID:: PMC8926202

Abstract Article PDF–4.0M

Select item 889504818.

PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS‐STING‐Mediated Interferon Response

Xinwei Geng, Chao Zhang, Miao Li, Jiaqi Wang, Fang Ji, Hanrong Feng, Meichun Xing, Fei Li, Lingling Zhang, Wen Li, Zhihua Chen, Ian D. Hickson, Huahao Shen, Songmin Ying

Adv Sci (Weinh) 2022 Mar; 9(7): 2103837. Published online 2022 Jan 17. doi: 10.1002/advs.202103837

PMCID:: PMC8895048

Abstract Article PDF–3.9M

Select item 888356819.

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma

Kanagaraju Ponnusamy, Maria Myrsini Tzioni, Murshida Begum, Mark E. Robinson, Valentina S. Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, Irene Roberts, Pritesh Trivedi, Holger W. Auner, Kikkeri Naresh, Aristeidis Chaidos, Anastasios Karadimitris

Haematologica. 2022 Mar 1; 107(3): 721–732. Published online 2021 Feb 18. doi: 10.3324/haematol.2020.274480

PMCID:: PMC8883568

Abstract Article PDF–1.9M

Select item 885366220.

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

Jacob A Van Winkle, Stefan T Peterson, Elizabeth A Kennedy, Michael J Wheadon, Harshad Ingle, Chandni Desai, Rachel Rodgers, David A Constant, Austin P Wright, Lena Li, Maxim N Artyomov, Sanghyun Lee, Megan T Baldridge, Timothy J Nice

eLife. 2022; 11: e74072. Published online 2022 Feb 9. doi: 10.7554/eLife.74072

PMCID:: PMC8853662

Abstract Article PDF–21M

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