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Select item 85510571.

Dietary Neu5Ac Intervention Protects Against Atherosclerosis Associated with Human-Like Neu5Gc loss

Kunio Kawanishi, Joanna K Coker, Kaare V. Grunddal, Chirag Dhar, Jason Hsiao, Karsten Zengler, Nissi Varki, Ajit Varki, Philip L.S.M. Gordts

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2021 Nov; 41(11): 2730–2739. Published online 2021 Sep 30. doi: 10.1161/ATVBAHA.120.315280

PMCID:: PMC8551057

Abstract Article PDF–1.7M

Select item 83511282.

Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmah^−/−mdx Mice

Paul T. Martin, Kunio Kawanishi, Anna Ashbrook, Bethannie Golden, Annie Samraj, Kelly E. Crowe, Deborah A. Zygmunt, Jonathan Okerblom, Hai Yu, Agatha Maki, Sandra Diaz, Xi Chen, Paul M.L. Janssen, Ajit Varki

Am J Pathol. 2021 Aug; 191(8): 1474–1486. doi: 10.1016/j.ajpath.2021.04.015

PMCID:: PMC8351128

Abstract Article PDF–2.1M

Select item 78456483.

Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae

Sudeshna Saha, Alison Coady, Aniruddha Sasmal, Kunio Kawanishi, Biswa Choudhury, Hai Yu, Ricardo U. Sorensen, Jaime Inostroza, Ian C. Schoenhofen, Xi Chen, Anja Münster-Kühnel, Chihiro Sato, Ken Kitajima, Sanjay Ram, Victor Nizet, Ajit Varki

mBio. 2021 Jan-Feb; 12(1): e03226-20. Published online 2021 Jan 19. doi: 10.1128/mBio.03226-20

PMCID:: PMC7845648

Abstract Article PDF–3.4M

Select item 73218004.

Therapeutic CMP-nonulosonates against multidrug-resistant Neisseria gonorrhoeae

Sunita Gulati, Ian C. Schoenhofen, Theresa Lindhout-Djukic, Melissa J. Schur, Corinna Landig, Sudeshna Saha, Lingquan Deng, Lisa A. Lewis, Bo Zheng, Ajit Varki, Sanjay Ram

J Immunol. Author manuscript; available in PMC 2021 Jun 15.

Published in final edited form as: J Immunol. 2020 Jun 15; 204(12): 3283–3295. Published online 2020 May 20. doi: 10.4049/jimmunol.1901398

PMCID:: PMC7321800

Abstract Article PDF–962K

Select item 72927765.

Salmonella Typhoid Toxin PltB Subunit and Its Nontyphoidal Salmonella Orthologue Confer Differential Host Adaptation and Virulence

Sohyoung Lee, Yi-An Yang, Shawn K. Milano, Tri Nguyen, Changhwan Ahn, Ji Hyun Sim, Andrew J. Thompson, Eric C. Hillpot, Gyeongshik Yoo, James C. Paulson, Jeongmin Song

Cell Host Microbe. Author manuscript; available in PMC 2021 Jun 10.

Published in final edited form as: Cell Host Microbe. 2020 Jun 10; 27(6): 937–949.e6. Published online 2020 May 11. doi: 10.1016/j.chom.2020.04.005

PMCID:: PMC7292776

Abstract Article PDF–2.9M

Select item 69949356.

A comparison of the bone and growth phenotype of mdx, mdx:Cmah^−/− and mdx:Utrn^+/− murine models with the C57BL/10 wild-type mouse

Claire L. Wood, Karla J. Suchacki, Rob van ’t Hof, Will P. Cawthorn, Scott Dillon, Volker Straub, Sze Choong Wong, Syed F. Ahmed, Colin Farquharson

Dis Model Mech. 2020 Feb 1; 13(2): dmm040659. Published online 2020 Jan 10. doi: 10.1242/dmm.040659

PMCID:: PMC6994935

Abstract Article

Select item 66900337.

Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms

Kunio Kawanishi, Chirag Dhar, Raymond Do, Nissi Varki, Philip L. S. M. Gordts, Ajit Varki

Proc Natl Acad Sci U S A. 2019 Aug 6; 116(32): 16036–16045. Published online 2019 Jul 22. doi: 10.1073/pnas.1902902116

PMCID:: PMC6690033

Abstract Article PDF–3.0M

Select item 63377038.

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment

Corinne A Betts, Graham McClorey, Richard Healicon, Suzan M Hammond, Raquel Manzano, Sofia Muses, Vicky Ball, Caroline Godfrey, Thomas M Merritt, Tirsa van Westering, Liz O’Donovan, Kim E Wells, Michael J Gait, Dominic J Wells, Damian Tyler, Matthew J Wood

Hum Mol Genet. 2019 Feb 1; 28(3): 396–406. Published online 2018 Oct 2. doi: 10.1093/hmg/ddy346

PMCID:: PMC6337703

Abstract Article PDF–3.6M

Select item 63222839.

Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection

Raghubendra Singh Dagur, Amanda Branch-Woods, Saumi Mathews, Poonam S. Joshi, Rolen M. Quadros, Donald W. Harms, Yan Cheng, Shana M. Miles, Samuel J. Pirruccello, Channabasavaiah B. Gurumurthy, Santhi Gorantla, Larisa Y. Poluektova

BMC Immunol. 2019; 20: 2. Published online 2019 Jan 7. doi: 10.1186/s12865-018-0279-3

PMCID:: PMC6322283

Abstract Article PDF–5.0M

Select item 615852810.

Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution

Jonathan Okerblom, William Fletes, Hemal H. Patel, Simon Schenk, Ajit Varki, Ellen C. Breen

Proc Biol Sci. 2018 Sep 12; 285(1886): 20181656. Published online 2018 Sep 12. doi: 10.1098/rspb.2018.1656

PMCID:: PMC6158528

Abstract Article PDF–914K

Select item 600547911.

Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy

Alison M. Blain, Elizabeth Greally, Graham McClorey, Raquel Manzano, Corinne A. Betts, Caroline Godfrey, Liz O’Donovan, Thibault Coursindel, Mike J. Gait, Matthew J. Wood, Guy A. MacGowan, Volker W. Straub

PLoS One. 2018; 13(6): e0198897. Published online 2018 Jun 18. doi: 10.1371/journal.pone.0198897

PMCID:: PMC6005479

Abstract Article PDF–17M

Select item 570526012.

Evolution of host adaptation in the Salmonella typhoid toxin

Xiang Gao, Lingquan Deng, Gabrielle Stack, Hai Yu, Xi Chen, Yuko Naito-Matsui, Ajit Varki, Jorge E. Galán

Nat Microbiol. Author manuscript; available in PMC 2018 Apr 9.

Published in final edited form as: Nat Microbiol. 2017 Dec; 2(12): 1592–1599. Published online 2017 Oct 9. doi: 10.1038/s41564-017-0033-2

Correction in:: Nat Microbiol. 2017 Nov 1

PMCID:: PMC5705260

Abstract Article PDF–1.0M

Select item 556651113.

Extrinsic sialylation is dynamically regulated by systemic triggers in vivo

Charles T. Manhardt, Patrick R. Punch, Christopher W. L. Dougher, Joseph T. Y. Lau

J Biol Chem. 2017 Aug 18; 292(33): 13514–13520. Published online 2017 Jul 17. doi: 10.1074/jbc.C117.795138

PMCID:: PMC5566511

Abstract Article PDF–755K

Select item 534061514.

Loss of CMAH During Human Evolution Primed the Monocyte-Macrophage Lineage Towards a More Inflammatory and Phagocytic State

Jonathan J. Okerblom, Flavio Schwarz, Josh Olson, William Fletes, Syed Raza Ali, Paul T. Martin, Christopher K. Glass, Victor Nizet, Ajit Varki

J Immunol. Author manuscript; available in PMC 2018 Mar 15.

Published in final edited form as: J Immunol. 2017 Mar 15; 198(6): 2366–2373. Published online 2017 Feb 1. doi: 10.4049/jimmunol.1601471

PMCID:: PMC5340615

Abstract Article PDF–856K

Select item 531415615.

Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain

Yuko Naito-Matsui, Leela R. L. Davies, Hiromu Takematsu, Hsun-Hua Chou, Pam Tangvoranuntakul, Aaron F. Carlin, Andrea Verhagen, Charles J. Heyser, Seung-Wan Yoo, Biswa Choudhury, James C. Paton, Adrienne W. Paton, Nissi M. Varki, Ronald L. Schnaar, Ajit Varki

J Biol Chem. 2017 Feb 17; 292(7): 2557–2570. Published online 2017 Jan 3. doi: 10.1074/jbc.M116.768531

PMCID:: PMC5314156

Abstract Article PDF–2.8M

Select item 500007016.

A Mouse Model for Dietary Xenosialitis: ANTIBODIES TO XENOGLYCAN CAN REDUCE FERTILITY

Fang Ma, Liwen Deng, Patrick Secrest, Linda Shi, June Zhao, Pascal Gagneux

J Biol Chem. 2016 Aug 26; 291(35): 18222–18231. Published online 2016 Jul 5. doi: 10.1074/jbc.M116.739169

PMCID:: PMC5000070

Abstract Article PDF–2.3M

Select item 494680317.

Sialylation Facilitates the Maturation of Mammalian Sperm and Affects Its Survival in Female Uterus

Xue Ma, Qian Pan, Ying Feng, Biswa P. Choudhury, Qianhong Ma, Pascal Gagneux, Fang Ma

Biol Reprod. 2016 Jun; 94(6): 123. Published online 2016 Apr 13. doi: 10.1095/biolreprod.115.137810

PMCID:: PMC4946803

Abstract Article PDF–1.4M

Select item 462900218.

CMP-Neu5Ac Hydroxylase Null Mice as a Model for Studying Metabolic Disorders Caused by the Evolutionary Loss of Neu5Gc in Humans

Deug-Nam Kwon, Yun-Jung Choi, Ssang-Goo Cho, Chankyu Park, Han Geuk Seo, Hyuk Song, Jin-Hoi Kim

Biomed Res Int. 2015; 2015: 830315. Published online 2015 Oct 19. doi: 10.1155/2015/830315

PMCID:: PMC4629002

Abstract Article PDF–3.5M

Select item 458610319.

Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss

Deug-Nam Kwon, Woo-Jin Park, Yun-Jung Choi, Sangiliyandi Gurunathan, Jin-Hoi Kim

Aging (Albany NY) 2015 Aug; 7(8): 579–592. Published online 2015 Aug 29. doi: 10.18632/aging.100800

PMCID:: PMC4586103

Abstract Article PDF–2.2M

Select item 429922420.

A red meat-derived glycan promotes inflammation and cancer progression

Annie N. Samraj, Oliver M. T. Pearce, Heinz Läubli, Alyssa N. Crittenden, Anne K. Bergfeld, Kalyan Banda, Christopher J. Gregg, Andrea E. Bingman, Patrick Secrest, Sandra L. Diaz, Nissi M. Varki, Ajit Varki

Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2): 542–547. Published online 2014 Dec 29. doi: 10.1073/pnas.1417508112