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Select item 112909731.

GPR126 is a specifier of blood-brain barrier formation in the mouse central nervous system

Nikolaos Kakogiannos, Anna Agata Scalise, Emanuele Martini, Claudio Maderna, Andrea Francesco Benvenuto, Michele D’Antonio, Laura Carmignani, Serena Magni, Giorgia Serena Gullotta, Maria Grazia Lampugnani, Fabio Iannelli, Galina V. Beznoussenko, Alexander A. Mironov, Camilla Cerutti, Katie Bentley, Andrew Philippides, Federica Zanardi, Marco Bacigaluppi, Sara Sigismund, Claudia Bassani, Cinthia Farina, Gianvito Martino, Marco De Giovanni, Elisabetta Dejana, Matteo Iannacone, Donato Inverso, Monica Giannotta

J Clin Invest. 2024 Aug 1; 134(15): e165368. Published online 2024 Jun 6. doi: 10.1172/JCI165368

PMCID:: PMC11290973

Abstract Article PDF–16M

Select item 108643632.

Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy

Yan Guo, Pan Xiang, Xiaojiao Sun, Wei Liu, Jiafeng Zhou, Bin Yin, Lin Hou, Boqin Qiang, Huiliang Li, Pengcheng Shu, Xiaozhong Peng

Signal Transduct Target Ther. 2024; 9: 32. Published online 2024 Feb 14. doi: 10.1038/s41392-024-01742-2

PMCID:: PMC10864363

Abstract Article PDF–9.9M

Select item 104171763.

Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney

Salvador Cazorla-Vázquez, Peter Kösters, Simone Bertz, Frederick Pfister, Christoph Daniel, Mark Dedden, Sebastian Zundler, Tilman Jobst-Schwan, Kerstin Amann, Felix B. Engel

Cells. 2023 Aug; 12(15): 1988. Published online 2023 Aug 2. doi: 10.3390/cells12151988

PMCID:: PMC10417176

Abstract Article PDF–3.4M

Select item 85893104.

Adhesion G protein–coupled receptor Gpr126/Adgrg6 is essential for placental development

Rebeca Torregrosa-Carrión, Rebeca Piñeiro-Sabarís, Marcos Siguero-Álvarez, Joaquím Grego-Bessa, Luis Luna-Zurita, Vitor Samuel Fernandes, Donal MacGrogan, Didier Y. R. Stainier, José Luis de la Pompa

Sci Adv. 2021 Nov; 7(46): eabj5445. Published online 2021 Nov 12. doi: 10.1126/sciadv.abj5445

PMCID:: PMC8589310

Abstract Article PDF–19M

Select item 83285155.

An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment

Zhaoyang Liu, Amro A Hussien, Yunjia Wang, Terry Heckmann, Roberto Gonzalez, Courtney M Karner, Jess G Snedeker, Ryan S Gray

eLife. 2021; 10: e67781. Published online 2021 Jul 28. doi: 10.7554/eLife.67781

PMCID:: PMC8328515

Abstract Article PDF–8.1M

Select item 71481756.

Gpr126/Adgrg6 contributes to the terminal Schwann cell response at the NMJ following peripheral nerve injury

Albina Jablonka-Shariff, Chuieng-Yi Lu, Katherine Campbell, Kelly R. Monk, Alison K. Snyder-Warwick

Glia. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Glia. 2020 Jun; 68(6): 1182–1200. Published online 2019 Dec 24. doi: 10.1002/glia.23769

PMCID:: PMC7148175

Abstract Article PDF–3.4M

Select item 70836047.

Regulation of body length and bone mass by Gpr126/Adgrg6

Peng Sun, Liang He, Kunhang Jia, Zhiying Yue, Shichang Li, Yunyun Jin, Zhenxi Li, Stefan Siwko, Feng Xue, Jiacan Su, Mingyao Liu, Jian Luo

Sci Adv. 2020 Mar; 6(12): eaaz0368. Published online 2020 Mar 20. doi: 10.1126/sciadv.aaz0368

PMCID:: PMC7083604

Abstract Article PDF–1.3M

Select item 68342878.

Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice

Zhaoyang Liu, Garrett W. D. Easson, Jingjing Zhao, Nadja Makki, Nadav Ahituv, Matthew J. Hilton, Simon Y. Tang, Ryan S. Gray

PLoS Genet. 2019 Oct; 15(10): e1008096. Published online 2019 Oct 25. doi: 10.1371/journal.pgen.1008096

PMCID:: PMC6834287

Abstract Article PDF–5.6M

Select item 66292409.

Tie2 regulates endocardial sprouting and myocardial trabeculation

Xianghu Qu, Cristina Harmelink, H. Scott Baldwin

JCI Insight. 2019 Jul 11; 4(13): e96002. Published online 2019 Jul 11. doi: 10.1172/jci.insight.96002

PMCID:: PMC6629240

Abstract Article PDF–60M

Select item 661907910.

Sox10 Cooperates with the Mediator Subunit 12 during Terminal Differentiation of Myelinating Glia

Michael R. Vogl, Simone Reiprich, Melanie Küspert, Thomas Kosian, Heinrich Schrewe, Klaus-Armin Nave, Michael Wegner

J Neurosci. 2013 Apr 10; 33(15): 6679–6690. doi: 10.1523/JNEUROSCI.5178-12.2013

PMCID:: PMC6619079

Abstract Article PDF–2.3M

Select item 549970611.

The prion protein is an agonistic ligand of the G protein-coupled receptor Gpr126/Adgrg6

Alexander Küffer, Asvin KK Lakkaraju, Amit Mogha, Sarah C. Petersen, Kristina Airich, Cédric Doucerain, Rajlakshmi Marpakwar, Pamela Bakirci, Assunta Senatore, Arnaud Monnard, Carmen Schiavi, Mario Nuvolone, Bianka Grosshans, Simone Hornemann, Frederic Bassilana, Kelly R. Monk, Adriano Aguzzi

Nature. Author manuscript; available in PMC 2017 Jul 6.

Published in final edited form as: Nature. 2016 Aug 25; 536(7617): 464–468. Published online 2016 Aug 8. doi: 10.1038/nature19312

PMCID:: PMC5499706

Abstract Article PDF–2.7M

Select item 514822612.

Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair

Amit Mogha, Breanne L. Harty, Dan Carlin, Jessica Joseph, Nicholas E. Sanchez, Ueli Suter, Xianhua Piao, Valeria Cavalli, Kelly R. Monk

J Neurosci. 2016 Dec 7; 36(49): 12351–12367. doi: 10.1523/JNEUROSCI.3854-15.2016

PMCID:: PMC5148226

Abstract Article PDF–8.5M

Select item 481649313.

Sequential Notch activation regulates ventricular chamber development

Gaetano D'Amato, Guillermo Luxán, Gonzalo del Monte-Nieto, Beatriz Martínez-Poveda, Carlos Torroja, Wencke Walter, Matthew S. Bochter, Rui Benedito, Susan Cole, Fernando Martinez, Anna-Katerina Hadjantonakis, Akiyoshi Uemura, Luis J. Jiménez-Borreguero, José Luis de la Pompa

Nat Cell Biol. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Nat Cell Biol. 2016 Jan; 18(1): 7–20. Published online 2015 Dec 7. doi: 10.1038/ncb3280

PMCID:: PMC4816493

Abstract Article PDF–4.5M

Select item 449239914.

Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice

Courtney M. Karner, Fanxin Long, Lilianna Solnica-Krezel, Kelly R. Monk, Ryan S. Gray

Hum Mol Genet. 2015 Aug 1; 24(15): 4365–4373. Published online 2015 May 7. doi: 10.1093/hmg/ddv170

PMCID:: PMC4492399

Abstract Article PDF–1.2M

Select item 439468715.

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors

Jörg Hamann, Gabriela Aust, Demet Araç, Felix B. Engel, Caroline Formstone, Robert Fredriksson, Randy A. Hall, Breanne L. Harty, Christiane Kirchhoff, Barbara Knapp, Arunkumar Krishnan, Ines Liebscher, Hsi-Hsien Lin, David C. Martinelli, Kelly R. Monk, Miriam C. Peeters, Xianhua Piao, Simone Prömel, Torsten Schöneberg, Thue W. Schwartz, Kathleen Singer, Martin Stacey, Yuri A. Ushkaryov, Mario Vallon, Uwe Wolfrum, Mathew W. Wright, Lei Xu, Tobias Langenhan, Helgi B. Schiöth

Pharmacol Rev. 2015 Apr; 67(2): 338–367. Published online 2015 Apr. doi: 10.1124/pr.114.009647

PMCID:: PMC4394687

Abstract Article PDF–3.0M

Select item 433526516.

The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with Laminin-211

Sarah C. Petersen, Rong Luo, Ines Liebscher, Stefanie Giera, Sung-jin Jeong, Amit Mogha, Monica Ghidinelli, M. Laura Feltri, Torsten Schöneberg, Xianhua Piao, Kelly R. Monk

Neuron. Author manuscript; available in PMC 2016 Feb 18.

Published in final edited form as: Neuron. 2015 Feb 18; 85(4): 755–769. doi: 10.1016/j.neuron.2014.12.057

PMCID:: PMC4335265

Abstract Article PDF–3.7M

Select item 426388617.

GPR126 Protein Regulates Developmental and Pathological Angiogenesis through Modulation of VEGFR2 Receptor Signaling

Hengxiang Cui, Yeqi Wang, Huizhe Huang, Wenjie Yu, Min Bai, Long Zhang, Brad A. Bryan, Yuan Wang, Jian Luo, Dali Li, Yanlin Ma, Mingyao Liu

J Biol Chem. 2014 Dec 12; 289(50): 34871–34885. Published online 2014 Sep 12. doi: 10.1074/jbc.M114.571000

PMCID:: PMC4263886

Abstract Article PDF–3.4M

Select item 382845418.

Gpr126 Functions in Schwann Cells to Control Differentiation and Myelination via G-Protein Activation

Amit Mogha, Andrew E. Benesh, Chinmoy Patra, Felix B. Engel, Torsten Schöneberg, Ines Liebscher, Kelly R. Monk

J Neurosci. 2013 Nov 13; 33(46): 17976–17985. doi: 10.1523/JNEUROSCI.1809-13.2013

PMCID:: PMC3828454

Abstract Article PDF–3.1M

Select item 380100019.

Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent

Chinmoy Patra, Machteld J. van Amerongen, Subhajit Ghosh, Filomena Ricciardi, Amna Sajjad, Tatyana Novoyatleva, Amit Mogha, Kelly R. Monk, Christian Mühlfeld, Felix B. Engel

Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42): 16898–16903. Published online 2013 Sep 30. doi: 10.1073/pnas.1304837110

Correction in:: Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3): 1222.

PMCID:: PMC3801000

Abstract Article PDF–1.6M

Select item 357241020.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

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