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Select item 112657951.

Aberrant hippocampal Ca²⁺ microwaves following synapsin-dependent adeno-associated viral expression of Ca²⁺ indicators

Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A O'Neil, Fabian J Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck, Michael Wenzel, Tony Kelly

eLife. 2024; 13: RP93804. Published online 2024 Jul 23. doi: 10.7554/eLife.93804

PMCID:: PMC11265795

Abstract Article PDF–2.3M

Select item 111451242.

SIRT1 mediates the excitability of spinal CaMKIIα‐positive neurons and participates in neuropathic pain by controlling Nav1.3

Yuanzeng Wang, Yidan Zhang, Nan Ma, Wen Zhao, Xiuhua Ren, Yanyan Sun, Weidong Zang, Jing Cao

CNS Neurosci Ther. 2024 Jun; 30(6): e14764. Published online 2024 Jun 3. doi: 10.1111/cns.14764

PMCID:: PMC11145124

Abstract Article PDF–24M

Select item 109579243.

Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of Na_V1.2 and Na_V1.6

Luis Manuel Arratia, Juan David Bermudes-Contreras, Jorge Armando Juarez-Monroy, Erik Alan Romero-Macías, Julio Cesar Luna-Rojas, Marisol López-Hidalgo, Ana Victoria Vega, Absalom Zamorano-Carrillo

Sci Rep. 2024; 14: 6761. Published online 2024 Mar 21. doi: 10.1038/s41598-024-57117-8

PMCID:: PMC10957924

Abstract Article PDF–4.0M

Select item 107941514.

Na_v1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis

Wenyu Fu, Dmytro Vasylyev, Yufei Bi, Mingshuang Zhang, Guodong Sun, Asya Khleborodova, Guiwu Huang, Libo Zhao, Renpeng Zhou, Yonggang Li, Shujun Liu, Xianyi Cai, Wenjun He, Min Cui, Xiangli Zhao, Aubryanna Hettinghouse, Julia Good, Ellen Kim, Eric Strauss, Philipp Leucht, Ran Schwarzkopf, Edward X. Guo, Jonathan Samuels, Wenhuo Hu, Mukundan Attur, Stephen G. Waxman, Chuan-ju Liu

Nature. 2024; 625(7995): 557–565. Published online 2024 Jan 3. doi: 10.1038/s41586-023-06888-7

PMCID:: PMC10794151

Abstract Article PDF–85M

Select item 107693505.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz

Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700

PMCID:: PMC10769350

Abstract Article PDF–11M

Select item 107577376.

Evaluating the interplay between estrous cyclicity and flurothyl-induced seizure susceptibility in Scn2a ^K1422E mice

Dennis M. Echevarria-Cooper, Jennifer A. Kearney

MicroPubl Biol. 2023; 2023: 10.17912/micropub.biology.000850. Published online 2023 Dec 16. doi: 10.17912/micropub.biology.000850

PMCID:: PMC10757737

Abstract Article PDF–670K

Select item 107556407.

Dynamic Foraging Behavior Performance Is Not Affected by Scn2a Haploinsufficiency

Selin Schamiloglu, Hao Wu, Mingkang Zhou, Alex C. Kwan, Kevin J. Bender

eNeuro. 2023 Dec; 10(12): ENEURO.0367-23.2023. Published online 2023 Dec 8. doi: 10.1523/ENEURO.0367-23.2023

PMCID:: PMC10755640

Abstract Article PDF–644K

Select item 104107618.

Identification and targeting of a unique Na_V1.7 domain driving chronic pain

Kimberly Gomez, Harrison J. Stratton, Paz Duran, Santiago Loya, Cheng Tang, Aida Calderon-Rivera, Liberty François-Moutal, May Khanna, Cynthia L. Madura, Shizhen Luo, Bryan McKiver, Edward Choi, Dongzhi Ran, Lisa Boinon, Samantha Perez-Miller, M. Imad Damaj, Aubin Moutal, Rajesh Khanna

Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2217800120. Published online 2023 Jul 27. doi: 10.1073/pnas.2217800120

PMCID:: PMC10410761

Abstract Article PDF–18M

Select item 103078529.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 1027213910.

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice

Hyoseon Oh, Suho Lee, Yusang Oh, Seongbin Kim, Young Seo Kim, Yeji Yang, Woochul Choi, Ye-Eun Yoo, Heejin Cho, Seungjoon Lee, Esther Yang, Wuhyun Koh, Woojin Won, Ryunhee Kim, C. Justin Lee, Hyun Kim, Hyojin Kang, Jin Young Kim, Taeyun Ku, Se-Bum Paik, Eunjoon Kim

Nat Commun. 2023; 14: 3547. Published online 2023 Jun 15. doi: 10.1038/s41467-023-39203-z

PMCID:: PMC10272139

Abstract Article PDF–4.3M

Select item 1019144111.

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities

Chao Liu, Lingang Sun, Yijun Tan, Qi Wang, Tao Luo, Chenlu Li, Nan Yao, Yuting Xie, Xiao Yi, Yi Zhu, Tiannan Guo, Junfeng Ji

Sci Adv. 2023 May; 9(20): eade3888. Published online 2023 May 17. doi: 10.1126/sciadv.ade3888

PMCID:: PMC10191441

Abstract Article PDF–2.4M

Select item 1017135912.

Na_v 1.7 gain-of-function mutation I228M triggers age-dependent nociceptive insensitivity and C-LTMR dysregulation

Nivanthika K. Wimalasena, Daniel G. Taub, Jaehoon Shim, Sara Hakim, Riki Kawaguchi, Lubin Chen, Mahmoud El-Rifai, Daniel H. Geschwind, Sulayman D. Dib-Hajj, Stephen G. Waxman, Clifford J. Woolf

Exp Neurol. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Exp Neurol. 2023 Jun; 364: 114393. Published online 2023 Mar 30. doi: 10.1016/j.expneurol.2023.114393

PMCID:: PMC10171359

Abstract Article PDF–1.9M

Select item 1014792313.

Pain-causing stinging nettle toxins target TMEM233 to modulate Na_V1.7 function

Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter

Nat Commun. 2023; 14: 2442. Published online 2023 Apr 28. doi: 10.1038/s41467-023-37963-2

PMCID:: PMC10147923

Abstract Article PDF–3.8M

Select item 958654714.

Na_v1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice

Steven J Middleton, Irene Perini, Andreas C Themistocleous, Greg A Weir, Kirsty McCann, Allison M Barry, Andrew Marshall, Michael Lee, Leah M Mayo, Manon Bohic, Georgios Baskozos, India Morrison, Line S Löken, Sarah McIntyre, Saad S Nagi, Roland Staud, Isac Sehlstedt, Richard D Johnson, Johan Wessberg, John N Wood, Christopher G Woods, Aziz Moqrich, Håkan Olausson, David L Bennett

Brain. 2022 Oct; 145(10): 3637–3653. Published online 2021 Dec 27. doi: 10.1093/brain/awab482

PMCID:: PMC9586547

Abstract Article PDF–1.9M

Select item 953684215.

Selective optogenetic activation of Na_V1.7–expressing afferents in Na_V1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli

Toyoaki Maruta, Kotaro Hidaka, Satoshi Kouroki, Tomohiro Koshida, Mio Kurogi, Yohko Kage, Seiya Mizuno, Tetsuro Shirasaka, Toshihiko Yanagita, Satoru Takahashi, Ryu Takeya, Isao Tsuneyoshi

PLoS One. 2022; 17(10): e0275751. Published online 2022 Oct 6. doi: 10.1371/journal.pone.0275751

PMCID:: PMC9536842

Abstract Article PDF–1.4M

Select item 943373016.

Cellular and behavioral effects of altered Na_V1.2 sodium channel ion permeability in Scn2a^K1422E mice

Dennis M Echevarria-Cooper, Nicole A Hawkins, Sunita N Misra, Alexandra M Huffman, Tyler Thaxton, Christopher H Thompson, Roy Ben-Shalom, Andrew D Nelson, Anna M Lipkin, Alfred L George Jr, Kevin J Bender, Jennifer A Kearney

Hum Mol Genet. 2022 Sep 1; 31(17): 2964–2988. Published online 2022 Apr 13. doi: 10.1093/hmg/ddac087

PMCID:: PMC9433730

Abstract Article PDF–2.9M

Select item 901861717.

Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms

Zhixiong Ma, Muriel Eaton, Yushuang Liu, Jingliang Zhang, Xiaoling Chen, Xinyu Tu, Yiqiang Shi, Zhefu Que, Kyle Wettschurack, Zaiyang Zhang, Riyi Shi, Yueyi Chen, Adam Kimbrough, Nadia A. Lanman, Leah Schust, Zhuo Huang, Yang Yang

Neurobiol Dis. Author manuscript; available in PMC 2023 Jun 15.

Published in final edited form as: Neurobiol Dis. 2022 Jun 15; 168: 105690. Published online 2022 Mar 14. doi: 10.1016/j.nbd.2022.105690

PMCID:: PMC9018617

Abstract Article PDF–2.0M

Select item 871964918.

Paradoxical hyperexcitability from Na_V1.2 sodium channel loss in neocortical pyramidal cells

Perry W.E. Spratt, Ryan P.D. Alexander, Roy Ben-Shalom, Atehsa Sahagun, Henry Kyoung, Caroline M. Keeshen, Stephan J. Sanders, Kevin J. Bender

Cell Rep. Author manuscript; available in PMC 2021 Dec 31.

Published in final edited form as: Cell Rep. 2021 Aug 3; 36(5): 109483. doi: 10.1016/j.celrep.2021.109483

PMCID:: PMC8719649

Abstract Article PDF–2.5M

Select item 863159919.

Antisense oligonucleotide therapy reduces seizures and extends life span in an SCN2A gain-of-function epilepsy model

Melody Li, Nikola Jancovski, Paymaan Jafar-Nejad, Lisseth E. Burbano, Ben Rollo, Kay Richards, Lisa Drew, Alicia Sedo, Jacqueline Heighway, Svenja Pachernegg, Armand Soriano, Linghan Jia, Todd Blackburn, Blaine Roberts, Alex Nemiroff, Kelley Dalby, Snezana Maljevic, Christopher A. Reid, Frank Rigo, Steven Petrou

J Clin Invest. 2021 Dec 1; 131(23): e152079. Published online 2021 Dec 1. doi: 10.1172/JCI152079

PMCID:: PMC8631599

Abstract Article PDF–4.9M

Select item 849743920.

Dissecting the precise nature of itch-evoked scratching

Nivanthika K. Wimalasena, George Milner, Ricardo Silva, Cliff Vuong, Zihe Zhang, Diana M. Bautista, Clifford J. Woolf

Neuron. Author manuscript; available in PMC 2021 Oct 8.

Published in final edited form as: Neuron. 2021 Oct 6; 109(19): 3075–3087.e2. Published online 2021 Aug 18. doi: 10.1016/j.neuron.2021.07.020

PMCID:: PMC8497439

Abstract Article PDF–1.4M

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