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Select item 112039251.

The PD-1/PD-L1 Gateway: Peripheral Immune Regulation in the Pathogenesis of Endometriosis

Małgorzata Sobstyl, Paulina Mertowska, Sebastian Mertowski, Monika Zaborek-Łyczba, Dominik Dudziński, Grzegorz Polak, Ewelina Grywalska

Int J Mol Sci. 2024 Jun; 25(12): 6775. Published online 2024 Jun 20. doi: 10.3390/ijms25126775

PMCID:: PMC11203925

Abstract Article PDF–11M

Select item 111769572.

PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation

Daniela Chmiest, Silvia Podavini, Kalliopi Ioannidou, David Vallois, Chantal Décaillet, Montserrat Gonzalez, Manfredo Quadroni, Kevin Blackney, Rebekka Schairer, Laurence de Leval, Margot Thome

Blood Adv. 2024 Jun 11; 8(11): 2908–2923. Published online 2024 Mar 26. doi: 10.1182/bloodadvances.2023011901

PMCID:: PMC11176957

Abstract Article PDF–6.3M

Select item 111230553.

Association of Polymorphisms in PD-1 and LAG-3 Genes with Acute Myeloid Leukemia

Lamjed Mansour, Mashael Alqahtani, Ali Aljuaimlani, Jameel Al-Tamimi, Nouf Al-Harbi, Suliman Alomar

Medicina (Kaunas) 2024 May; 60(5): 721. Published online 2024 Apr 26. doi: 10.3390/medicina60050721

PMCID:: PMC11123055

Abstract Article PDF–2.7M

Select item 110813484.

Association of tuberculosis risk with genetic polymorphisms of the immune checkpoint genes PDCD1, CTLA-4, and TIM3

Chi-Wei Liu, Lawrence Shih-Hsin Wu, Chou-Jui Lin, Hsing-Chu Wu, Kuei-Chi Liu, Shih-Wei Lee

PLoS One. 2024; 19(5): e0303431. Published online 2024 May 9. doi: 10.1371/journal.pone.0303431

PMCID:: PMC11081348

Abstract Article PDF–862K

Select item 110321095.

Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency

Matthew B. Johnson, Masato Ogishi, Clara Domingo-Vila, Elisa De Franco, Matthew N. Wakeling, Zineb Imane, Brittany Resnick, Evangelia Williams, Rui Pedro Galão, Richard Caswell, James Russ-Silsby, Yoann Seeleuthner, Darawan Rinchai, Iris Fagniez, Basilin Benson, Matthew J. Dufort, Cate Speake, Megan E. Smithmyer, Michelle Hudson, Rebecca Dobbs, EXE-T1D consortium, Zoe Quandt, Andrew T. Hattersley, Peng Zhang, Stephanie Boisson-Dupuis, Mark S. Anderson, Jean-Laurent Casanova, Timothy I. Tree, Richard A. Oram

J Exp Med. 2024 Jun 3; 221(6): e20231704. Published online 2024 Apr 18. doi: 10.1084/jem.20231704

PMCID:: PMC11032109

Abstract Article PDF–7.7M

Select item 110287056.

Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma

Tatiana Salles de Souza Malaspina, Thaís Helena Gasparoto, Maria Renata Sales Nogueira Costa, Edgard Franco de Melo, Jr, Maura Rosane Valério Ikoma, José Humberto Damante, Karen Angélica Cavassani, Gustavo Pompermaier Garlet, João Santana da Silva, Ana Paula Campanelli

Cancer Immunol Immunother. 2011 Jul; 60(7): 965–974. Published online 2011 Mar 27. doi: 10.1007/s00262-011-1007-5

PMCID:: PMC11028705

Abstract Article PDF–635K

Select item 110281967.

Melanoma-associated antigen-A and programmed death-ligand 1 expression are associated with advanced urothelial carcinoma

Izak Faiena, Stephanie H. Astrow, David A. Elashoff, Rajul Jain, Adrian Bot, Karim Chamie, Arie S. Belldegrun, Allan J. Pantuck, Alexandra Drakaki

Cancer Immunol Immunother. 2019 May; 68(5): 743–751. Published online 2019 Feb 21. doi: 10.1007/s00262-019-02316-w

PMCID:: PMC11028196

Abstract Article PDF–781K

Select item 110280458.

Cytosolic high-mobility group box protein 1 (HMGB1) and/or PD-1+ TILs in the tumor microenvironment may be contributing prognostic biomarkers for patients with locally advanced rectal cancer who have undergone neoadjuvant chemoradiotherapy

Chih-Yang Huang, Shu-Fen Chiang, Tao-Wei Ke, Tsung-Wei Chen, Yu-Ching Lan, Ying-Shu You, An-Cheng Shiau, William Tzu-Liang Chen, K. S. Clifford Chao

Cancer Immunol Immunother. 2018 Apr; 67(4): 551–562. Published online 2017 Dec 21. doi: 10.1007/s00262-017-2109-5

PMCID:: PMC11028045

Abstract Article PDF–2.7M

Select item 110276599.

A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas

Martin F. Orth, Veit Leonhard Buecklein, Eric Kampmann, Marion Subklewe, Elfriede Noessner, Florencia Cidre-Aranaz, Laura Romero-Pérez, Fabienne Sophie Wehweck, Lars Lindner, Rolf Issels, Thomas Kirchner, Annelore Altendorf-Hofmann, Thomas G. P. Grünewald, Thomas Knösel

Cancer Immunol Immunother. 2020 Jul; 69(7): 1353–1362. Published online 2020 Mar 28. doi: 10.1007/s00262-020-02552-5

PMCID:: PMC11027659

Abstract Article PDF–1.1M

Select item 1100081310.

GHITM regulates malignant phenotype and sensitivity to PD‐1 blockade of renal cancer cells via Notch signalling

Shiyu Huang, Jiachen Liu, Juncheng Hu, Yanguang Hou, Min Hu, Banghua Zhang, Hongbo Luo, Shujie Fu, Yujie Chen, Xiuheng Liu, Zhiyuan Chen, Lei Wang

J Cell Mol Med. 2024 Apr; 28(8): e18290. Published online 2024 Apr 8. doi: 10.1111/jcmm.18290

PMCID:: PMC11000813

Abstract Article PDF–41M

Select item 1099230311.

COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade

Kyle Hansen, Sandeep Kumar, Kathryn Logronio, Sarah Whelan, Samir Qurashi, Hsin-Yuan Cheng, Andrew Drake, Margaret Tang, Patrick Wall, David Bernados, Ling Leung, Eran Ophir, Zoya Alteber, Gady Cojocaru, Moran Galperin, Masha Frenkel, Mark White, John Hunter, Spencer C. Liang, Maya F. Kotturi

Cancer Immunol Immunother. 2021 Dec; 70(12): 3525–3540. Published online 2021 Apr 26. doi: 10.1007/s00262-021-02921-8

PMCID:: PMC10992303

Abstract Article PDF–2.4M

Select item 1099222912.

Development and validation of a PD-L1/PD-1/CD8 axis-based classifier to predict cancer survival of upper tract urothelial carcinoma after radical nephroureterectomy

Junyu Chen, Wenlong Zhong, Meng Yang, Weibin Hou, Xiaofei Wang, Kun Xia, Hao Yu, Meihua Yang, Bingkun Zhou, Bo Wang, Jian Huang, Tianxin Lin

Cancer Immunol Immunother. 2021 Sep; 70(9): 2657–2668. Published online 2021 Feb 19. doi: 10.1007/s00262-020-02827-x

PMCID:: PMC10992229

Abstract Article PDF–4.0M

Select item 1099207613.

Preexisting autoimmune disease and immune-related adverse events associated with anti-PD-1 cancer immunotherapy: a national case series from the Canadian Research Group of Rheumatology in Immuno-Oncology

Sabrina Hoa, Linda Laaouad, Janet Roberts, Daniel Ennis, Carrie Ye, Karam Al Jumaily, Janet Pope, Tatiana Nevskaya, Alexandra Saltman, Megan Himmel, Robert Rottapel, Christina Ly, Ines Colmegna, Aurore Fifi-Mah, Nancy Maltez, Annaliese Tisseverasinghe, Marie Hudson, Shahin Jamal

Cancer Immunol Immunother. 2021 Aug; 70(8): 2197–2207. Published online 2021 Jan 20. doi: 10.1007/s00262-021-02851-5

PMCID:: PMC10992076

Abstract Article PDF–711K

Select item 1098918914.

PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens

Martina Damo, Noah I. Hornick, Aarthi Venkat, Ivana William, Kathryn Clulo, Srividhya Venkatesan, Jiaming He, Eric Fagerberg, Jennifer L. Loza, Darwin Kwok, Aya Tal, Jessica Buck, Can Cui, Jaiveer Singh, William E. Damsky, Jonathan S. Leventhal, Smita Krishnaswamy, Nikhil S. Joshi

Nature. Author manuscript; available in PMC 2024 Apr 3.

Published in final edited form as: Nature. 2023 Jul; 619(7968): 151–159. Published online 2023 Jun 21. doi: 10.1038/s41586-023-06217-y

PMCID:: PMC10989189

Abstract Article PDF–7.4M

Select item 1098140815.

The clinical association of programmed death-1/PD-L1 axis, myeloid derived suppressor cells subsets and regulatory T cells in peripheral blood of stable COPD patients

Mingqiang Zhang, Yinghua Wan, Jie Han, Jun Li, Haihong Gong, Xiangdong Mu

PeerJ. 2024; 12: e16988. Published online 2024 Mar 27. doi: 10.7717/peerj.16988

PMCID:: PMC10981408

Abstract Article PDF–5.1M

Select item 1096868816.

HOXC9 characterizes a suppressive tumor immune microenvironment and integration with multiple immune biomarkers predicts response to PD-1 blockade plus chemotherapy in lung adenocarcinoma

Liang Liu, Zhenshan Zhang, Chenxue Jiang, Yaoyao Zhu, Ruiqin Han, Leilei Wu, Yaping Xu

Aging (Albany NY) 2024 Mar 15; 16(5): 4841–4861. Published online 2024 Mar 5. doi: 10.18632/aging.205637

PMCID:: PMC10968688

Abstract Article PDF–3.4M

Select item 1090481117.

IFN-γ decreases PD-1 in T lymphocytes from convalescent COVID-19 patients via the AKT/GSK3β signaling pathway

Meijuan Song, Xiangqun Liu, Weiyu Shen, Zhengxia Wang, Jingjing Wu, Jingxian Jiang, Yanan Liu, Tingting Xu, Tao Bian, Mingshun Zhang, Wei Sun, Mao Huang, Ningfei Ji

Sci Rep. 2024; 14: 5038. Published online 2024 Feb 29. doi: 10.1038/s41598-024-55191-6

PMCID:: PMC10904811

Abstract Article PDF–5.7M

Select item 1090359918.

Higher PD-1/Tim-3 expression on IFN-γ+ T cells is associated with poor prognosis in patients with acute myeloid leukemia

Shuxin Huang, Yujie Zhao, Wenpu Lai, Jiaxiong Tan, Xue Zheng, Xianfeng Zha, Yangqiu Li, Shaohua Chen

Cancer Biol Ther. 2023; 24(1): 2278229. Published online 2023 Nov 14. doi: 10.1080/15384047.2023.2278229

PMCID:: PMC10903599

Abstract Article PDF–4.9M

Select item 1087877519.

The prognostic significance of programmed cell death protein 1 and its ligand on lymphoma cells and tumor-immune cells in diffuse large B-cell lymphoma, not otherwise specified

Teja Cas Slak, Simona Miceska, Gorana Gasljevic, Lucka Boltezar, Veronika Kloboves-Prevodnik

Radiol Oncol. 2024 Mar; 58(1): 99–109. Published online 2024 Feb 21. doi: 10.2478/raon-2024-0010

PMCID:: PMC10878775

Abstract Article PDF–1.0M

Select item 1083133820.

PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-κB Signaling in Patients with Pancreatic Cancer

Lestat R. Ali, Patrick J. Lenehan, Victoire Cardot-Ruffino, Andressa Dias Costa, Matthew H.G. Katz, Todd W. Bauer, Jonathan A. Nowak, Brian M. Wolpin, Thomas A. Abrams, Anuj Patel, Thomas E. Clancy, Jiping Wang, Joseph D. Mancias, Matthew J. Reilley, Chee-Chee H. Stucky, Tanios S. Bekaii-Saab, Rawad Elias, Nipun Merchant, Craig L. Slingluff, Jr, Osama E. Rahma, Stephanie K. Dougan

Clin Cancer Res. 2024 Feb 1; 30(3): 542–553. Published online 2023 Sep 21. doi: 10.1158/1078-0432.CCR-23-1444

PMCID:: PMC10831338

Abstract Article PDF–5.8M

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