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Select item 110989381.

Csk restrains BCR-mediated ROS production and contributes to germinal center selection and affinity maturation

Takeshi Inoue, Yuma Matsumoto, Chie Kawai, Mao Ito, Shigeyuki Nada, Masato Okada, Tomohiro Kurosaki

J Exp Med. 2024 Jul 1; 221(7): e20231996. Published online 2024 May 16. doi: 10.1084/jem.20231996

PMCID:: PMC11098938

Abstract Article PDF–4.7M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 95286863.

Targeted Disruption of Leucine-Rich Repeat Kinase 1 But Not Leucine-Rich Repeat Kinase 2 in Mice Causes Severe Osteopetrosis

Weirong Xing, Jeff Liu, Shaohong Cheng, Peter Vogel, Subburaman Mohan, Robert Brommage

J Bone Miner Res. Author manuscript; available in PMC 2022 Oct 3.

Published in final edited form as: J Bone Miner Res. 2013 Sep; 28(9): 1962–1974. doi: 10.1002/jbmr.1935

PMCID:: PMC9528686

Abstract Article PDF–2.7M

Select item 90329764.

A dominant function of LynB kinase in preventing autoimmunity

Ben F. Brian, IV, Monica L. Sauer, Joseph T. Greene, S. Erandika Senevirathne, Anders J. Lindstedt, Olivia L. Funk, Brian L. Ruis, Luis A. Ramirez, Jennifer L. Auger, Whitney L. Swanson, Myra G. Nunez, Branden S. Moriarity, Clifford A. Lowell, Bryce A. Binstadt, Tanya S. Freedman

Sci Adv. 2022 Apr; 8(16): eabj5227. Published online 2022 Apr 22. doi: 10.1126/sciadv.abj5227

PMCID:: PMC9032976

Abstract Article PDF–2.8M

Select item 90145595.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 89899186.

SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding

Ben F. Brian, IV, Frances V. Sjaastad, Tanya S. Freedman

Sci Rep. 2022; 12: 5875. Published online 2022 Apr 7. doi: 10.1038/s41598-022-09589-9

PMCID:: PMC8989918

Abstract Article PDF–2.5M

Select item 80874447.

eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

Takeshi Ninchoji, Dominic T Love, Ross O Smith, Marie Hedlund, Dietmar Vestweber, William C Sessa, Lena Claesson-Welsh

eLife. 2021; 10: e64944. Published online 2021 Apr 28. doi: 10.7554/eLife.64944

PMCID:: PMC8087444

Abstract Article PDF–5.6M

Select item 78229418.

Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death

Juan Carlos Yam-Puc, Lingling Zhang, Raul A Maqueda-Alfaro, Laura Garcia-Ibanez, Yang Zhang, Jessica Davies, Yotis A Senis, Michael Snaith, Kai-Michael Toellner

iScience. 2021 Feb 19; 24(2): 102038. Published online 2021 Jan 7. doi: 10.1016/j.isci.2021.102038

PMCID:: PMC7822941

Abstract Article PDF–5.2M

Select item 74159919.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 729195510.

Interplay between the tyrosine kinases Chk and Csk and phosphatase PTPRJ is critical for regulating platelets in mice

Zoltan Nagy, Jun Mori, Vanesa-Sindi Ivanova, Alexandra Mazharian, Yotis A. Senis

Blood. 2020 Apr 30; 135(18): 1574–1587. Prepublished online 2020 Feb 3. doi: 10.1182/blood.2019002848

PMCID:: PMC7291955

Abstract Article

Select item 666584011.

Src Family Kinases Are Required for Limb Trajectory Selection by Spinal Motor Axons

Tzu-Jen Kao, Elena Palmesino, Artur Kania

J Neurosci. 2009 Apr 29; 29(17): 5690–5700. doi: 10.1523/JNEUROSCI.0265-09.2009

PMCID:: PMC6665840

Abstract Article PDF–21M

Select item 648445712.

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions

Zoltan Nagy, Timo Vögtle, Mitchell J. Geer, Jun Mori, Silke Heising, Giada Di Nunzio, Ralph Gareus, Alexander Tarakhovsky, Arthur Weiss, Benjamin G. Neel, Guillaume E. Desanti, Alexandra Mazharian, Yotis A. Senis

Blood. 2019 Jan 24; 133(4): 331–343. Prepublished online 2018 Nov 14. doi: 10.1182/blood-2018-09-877787

PMCID:: PMC6484457

Abstract Article

Select item 633346013.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

Select item 608536314.

c-Src regulates cargo transit via the Golgi in pancreatic acinar cells

Sergiy Kostenko, Chan C. Heu, Jordan R. Yaron, Garima Singh, Cristiane de Oliveira, William J. Muller, Vijay P. Singh

Sci Rep. 2018; 8: 11903. Published online 2018 Aug 9. doi: 10.1038/s41598-018-30370-4

PMCID:: PMC6085363

Abstract Article PDF–4.2M

Select item 597443415.

RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development

Dhananjaya D, Kuan-Yang Hung, Woan-Yuh Tarn

Mol Cell Biol. 2018 Jun 15; 38(12): e00007-18. Prepublished online 2018 Mar 26. Published online 2018 May 29. doi: 10.1128/MCB.00007-18

PMCID:: PMC5974434

Abstract Article PDF–4.4M

Select item 588834116.

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148

Jun Mori, Zoltan Nagy, Giada Di Nunzio, Christopher W. Smith, Mitchell J. Geer, Rashid Al Ghaithi, Johanna P. van Geffen, Silke Heising, Luke Boothman, Bibian M. E. Tullemans, Joao N. Correia, Louise Tee, Marijke J. E. Kuijpers, Paul Harrison, Johan W. M. Heemskerk, Gavin E. Jarvis, Alexander Tarakhovsky, Arthur Weiss, Alexandra Mazharian, Yotis A. Senis

Blood. 2018 Mar 8; 131(10): 1122–1144. Prepublished online 2018 Jan 4. doi: 10.1182/blood-2017-02-768077