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Select item 112271001.

Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice

Daniel A.C. Fisher, Angelo B.A. Laranjeira, Tim Kong, Steven C. Snyder, Kevin Shim, Mary C. Fulbright, Stephen T. Oh

Exp Hematol. Author manuscript; available in PMC 2024 Jul 6.

Published in final edited form as: Exp Hematol. 2023 Dec; 128: 48–66. Published online 2023 Aug 21. doi: 10.1016/j.exphem.2023.08.005

PMCID:: PMC11227100

Abstract Article PDF–3.9M

Select item 111282112.

Activation of the IKK2/NF-κB pathway in VSMCs inhibits calcified vascular stiffness in CKD

Shinobu Miyazaki-Anzai, Masashi Masuda, Audrey L. Keenan, Yuji Shiozaki, Jose G. Miranda, Makoto Miyazaki

JCI Insight. 2024 Apr 8; 9(7): e174977. Published online 2024 Mar 12. doi: 10.1172/jci.insight.174977

PMCID:: PMC11128211

Abstract Article PDF–7.5M

Select item 110576803.

Sustained activation of NF-κB through constitutively active IKKβ leads to senescence bypass in murine dermal fibroblasts

Masayuki Harada, Kanae Su-Harada, Takeshi Kimura, Koh Ono, Noboru Ashida

Cell Cycle. 2024; 23(3): 308–327. Published online 2024 Mar 10. doi: 10.1080/15384101.2024.2325802

PMCID:: PMC11057680

Abstract Article PDF–1.9M

Select item 109637994.

IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model

Chelisa Cardinez, Yuwei Hao, Kristy Kwong, Ainsley R. Davies, Morgan B. Downes, Nadia A. Roberts, Jason D. Price, Raquel A. Hernandez, Jessica Lovell, Rochna Chand, Zhi-Ping Feng, Anselm Enders, Carola G. Vinuesa, Bahar Miraghazadeh, Matthew C. Cook

Nat Commun. 2024; 15: 2345. Published online 2024 Mar 25. doi: 10.1038/s41467-024-45870-3

PMCID:: PMC10963799

Abstract Article PDF–6.0M

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108214076.

IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Maria Avloniti, Maria Evangelidou, Maria Gomini, Theodore Loupis, Mary Emmanouil, Adamantia Mitropoulou, Theodore Tselios, Hans Lassmann, Agnès Gruart, José M. Delgado-García, Lesley Probert, Vasiliki Kyrargyri

J Neuroinflammation. 2024; 21: 34. Published online 2024 Jan 27. doi: 10.1186/s12974-024-03023-9

PMCID:: PMC10821407

Abstract Article PDF–7.0M

Select item 107834337.

IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation

Yohei Iguchi, Yuhei Takahashi, Jiayi Li, Kunihiko Araki, Yoshinobu Amakusa, Yu Kawakami, Kenta Kobayashi, Satoshi Yokoi, Masahisa Katsuno

J Cell Biol. 2024 Feb 5; 223(2): e202302048. Published online 2024 Jan 10. doi: 10.1083/jcb.202302048

PMCID:: PMC10783433

Abstract Article PDF–6.5M

Select item 104169848.

Differential Modulation of miR-122 Transcription by TGFβ1/BMP6: Implications for Nonresolving Inflammation and Hepatocarcinogenesis

Martha Paluschinski, Claus Kordes, Mihael Vucur, Veronika Buettner, Christoph Roderburg, Haifeng C. Xu, Prashant V. Shinte, Philipp A. Lang, Tom Luedde, Mirco Castoldi

Cells. 2023 Aug; 12(15): 1955. Published online 2023 Jul 27. doi: 10.3390/cells12151955

PMCID:: PMC10416984

Abstract Article PDF–4.8M

Select item 102403929.

Toll-like receptors 2, 4, and 9 modulate promoting effect of COPD-like airway inflammation on K-ras-driven lung cancer through activation of the MyD88/NF-ĸB pathway in the airway epithelium

Walter V. Velasco, Nasim Khosravi, Susana Castro-Pando, Nelly Torres-Garza, Maria T. Grimaldo, Avantika Krishna, Michael J. Clowers, Misha Umer, Sabah Tariq Amir, Diana Del Bosque, Soudabeh Daliri, Maria Miguelina De La Garza, Marco Ramos-Castaneda, Scott E. Evans, Seyed Javad Moghaddam

Front Immunol. 2023; 14: 1118721. Published online 2023 May 22. doi: 10.3389/fimmu.2023.1118721

PMCID:: PMC10240392

Abstract Article PDF–3.5M

Select item 1016535510.

Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses

Zhuqi Huang, Sirui Shen, Xue Han, Weixin Li, Wu Luo, Liming Lin, Mingjiang Xu, Yi Wang, Weijian Huang, Gaojun Wu, Guang Liang

EMBO Mol Med. 2023 May; 15(5): e17198. Published online 2023 Mar 10. doi: 10.15252/emmm.202217198

PMCID:: PMC10165355

Abstract Article PDF–3.6M

Select item 1007958411.

Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise

Kenta Kuramoto, Huijia Liang, Jung-Hwa Hong, Congcong He

Cell Metab. Author manuscript; available in PMC 2024 Apr 4.

Published in final edited form as: Cell Metab. 2023 Apr 4; 35(4): 620–632.e5. Published online 2023 Feb 21. doi: 10.1016/j.cmet.2023.01.011

PMCID:: PMC10079584

Abstract Article PDF–2.5M

Select item 1004709612.

Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ

Magda Spella, Giannoula Ntaliarda, Georgios Skiadas, Anne-Sophie Lamort, Malamati Vreka, Antonia Marazioti, Ioannis Lilis, Eleni Bouloukou, Georgia A. Giotopoulou, Mario A. A. Pepe, Stefanie A. I. Weiss, Agnese Petrera, Stefanie M. Hauck, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Kristina A. M. Arendt, Ioanna Giopanou, David Brunn, Rajkumar Savai, Dieter E. Jenne, Maarten de Château, Fiona E. Yull, Timothy S. Blackwell, Georgios T. Stathopoulos

Cancers (Basel) 2023 Mar; 15(6): 1866. Published online 2023 Mar 20. doi: 10.3390/cancers15061866

PMCID:: PMC10047096

Abstract Article PDF–6.8M

Select item 1000869013.

Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer

Chenxi Zhong, Guosheng Xiong, Haitang Yang, Xiaohua Du, Jiankui Du, Feng Yao, Wentao Fang, Yuezhen Deng

Int J Biol Sci. 2023; 19(4): 1110–1122. Published online 2023 Feb 5. doi: 10.7150/ijbs.82015

PMCID:: PMC10008690

Abstract Article PDF–6.9M

Select item 982752314.

Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation

Kang I. Ko, Brett P. DerGarabedian, Zhaoxu Chen, Rahul Debnath, Annette Ko, Brittany N. Link, Jonathan M. Korostoff, Dana T. Graves

J Exp Med. 2023 Mar 6; 220(3): e20221350. Published online 2022 Dec 30. doi: 10.1084/jem.20221350

PMCID:: PMC9827523

Abstract Article PDF–8.6M

Select item 953567815.

Astrocyte inflammatory signaling mediates α-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis

Collin M. Bantle, Savannah M. Rocha, C. Tenley French, Aaron T. Phillips, Kevin Tran, Kenneth E. Olson, Todd A. Bass, Tawfik Aboellail, Richard J. Smeyne, Ronald B. Tjalkens

Exp Neurol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Exp Neurol. 2021 Dec; 346: 113845. Published online 2021 Aug 26. doi: 10.1016/j.expneurol.2021.113845

PMCID:: PMC9535678

Abstract Article PDF–2.1M

Select item 950254416.

Inflammation in VTA Caused by HFD Induces Activation of Dopaminergic Neurons Accompanied by Binge-like Eating

Runan Sun, Mariko Sugiyama, Sixian Wang, Mitsuhiro Kuno, Tomoyuki Sasaki, Tomonori Hirose, Takashi Miyata, Tomoko Kobayashi, Taku Tsunekawa, Takeshi Onoue, Yoshinori Yasuda, Hiroshi Takagi, Daisuke Hagiwara, Shintaro Iwama, Hidetaka Suga, Hiroshi Arima

Nutrients. 2022 Sep; 14(18): 3835. Published online 2022 Sep 16. doi: 10.3390/nu14183835

PMCID:: PMC9502544

Abstract Article PDF–2.8M

Select item 945640117.

Tubular IKKβ Deletion Alleviates Acute Ischemic Kidney Injury and Facilitates Tissue Regeneration

Eileen Dahlke, Toni Engmann, Yaman Anan, Robert Häsler, Giovanni Solinas, Franziska Theilig

Int J Mol Sci. 2022 Sep; 23(17): 10199. Published online 2022 Sep 5. doi: 10.3390/ijms231710199

PMCID:: PMC9456401

Abstract Article PDF–3.0M

Select item 913963718.

p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation

Vangelis Kondylis, Farina Schneider, Fabian Schorn, Nikos Oikonomou, Beate Katharina Straub, Sabine Werner, Philip Rosenstiel, Manolis Pasparakis

Cancers (Basel) 2022 May; 14(10): 2436. Published online 2022 May 15. doi: 10.3390/cancers14102436

PMCID:: PMC9139637

Abstract Article PDF–8.6M

Select item 901455919.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 896548220.

An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages

Sandro Satta, Zhaojie Meng, Rebecca Hernandez, Susana Cavallero, Tong Zhou, Tzung K. Hsiai, Changcheng Zhou

Theranostics. 2022; 12(6): 2639–2657. Published online 2022 Mar 6. doi: 10.7150/thno.66831

PMCID:: PMC8965482

Abstract Article PDF–4.3M

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