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Select item 114915401.

Morphological, electrophysiological, and molecular alterations in foetal noncompacted cardiomyopathy induced by disruption of ROCK signalling

David Sedmera, Veronika Olejnickova, Barbora Sankova, Hana Kolesova, Martin Bartos, Alena Kvasilova, Lauren C. Phillips, Simon D. Bamforth, Helen M. Phillips

Front Cell Dev Biol. 2024; 12: 1471751. Published online 2024 Oct 7. doi: 10.3389/fcell.2024.1471751

PMCID:: PMC11491540

Abstract Article PDF–10M

Select item 111644932.

miR-101a-3p/ROCK2 axis regulates neuronal injury in Parkinson’s disease models

Xiang Tao, Wenfei Zhang, Chen Chen, Yang Tao, Yun Tao, Zhibiao Chen, Ge Zhang

Aging (Albany NY) 2024 May 30; 16(10): 8732–8746. Published online 2024 May 21. doi: 10.18632/aging.205836

PMCID:: PMC11164493

Abstract Article PDF–2.5M

Select item 111481223.

Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice

Takahiro Akamine, Takeshi Terabayashi, Takako Sasaki, Riku Hayashi, Ichitaro Abe, Fumihiro Hirayama, Shin‐ichi Nureki, Masahito Ikawa, Haruhiko Miyata, Akinori Tokunaga, Takashi Kobayashi, Katsuhiro Hanada, Dean Thumkeo, Shuh Narumiya, Toshimasa Ishizaki

FEBS Open Bio. 2024 Jun; 14(6): 906–921. Published online 2024 Apr 11. doi: 10.1002/2211-5463.13802

PMCID:: PMC11148122

Abstract Article PDF–12M

Select item 109875594.

Deletion of podocyte Rho-associated, coiled-coil-containing protein kinase 2 protects mice from focal segmental glomerulosclerosis

Keiichiro Matoba, Yosuke Nagai, Kensuke Sekiguchi, Shinji Ohashi, Etsuko Mitsuyoshi, Masayuki Shimoda, Toshiaki Tachibana, Daiji Kawanami, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura

Commun Biol. 2024; 7: 402. Published online 2024 Apr 2. doi: 10.1038/s42003-024-06127-3

PMCID:: PMC10987559

Abstract Article PDF–3.3M

Select item 107819525.

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Cornelius Miething, Uta S. Martens, Khalid Shoumariyeh, Rosa P. Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R. Blazar, Burkhard Becher, Melanie Boerries, Robert Zeiser

Nat Commun. 2024; 15: 446. Published online 2024 Jan 10. doi: 10.1038/s41467-024-44703-7

PMCID:: PMC10781952

Abstract Article PDF–4.3M

Select item 107535886.

Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease

Tao Cheng, Chidera Agwu, Kyuhwan Shim, Baolin Wang, Sanjay Jain, Moe R. Mahjoub

Development. 2023 Dec 15; 150(24): dev201976. Published online 2023 Dec 21. doi: 10.1242/dev.201976

PMCID:: PMC10753588

Abstract Article

Select item 105760617.

A 3D biomimetic model of lymphatics reveals cell–cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex

Esak Lee, Siu-Lung Chan, Yang Lee, William J. Polacheck, Sukyoung Kwak, Aiyun Wen, Duc-Huy T. Nguyen, Matthew L. Kutys, Stella Alimperti, Anna M. Kolarzyk, Tae Joon Kwak, Jeroen Eyckmans, Diane R. Bielenberg, Hong Chen, Christopher S. Chen

Proc Natl Acad Sci U S A. 2023 Oct 10; 120(41): e2308941120. Published online 2023 Oct 2. doi: 10.1073/pnas.2308941120

PMCID:: PMC10576061

Abstract Article PDF–3.1M

Select item 103078528.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 94686039.

α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes

Chien-Chun Tseng, Ru-Hsuan Zheng, Ting-Wei Lin, Chih-Chiang Chou, Yu-Chia Shih, Shao-Wei Liang, Hsiao-Hui Lee

Life Sci Alliance. 2022 Nov; 5(11): e202201557. Published online 2022 Sep 12. doi: 10.26508/lsa.202201557

PMCID:: PMC9468603

Abstract Article PDF–3.0M

Select item 899385710.

ROCK2-induced metabolic rewiring in diabetic podocytopathy

Keiichiro Matoba, Yusuke Takeda, Yosuke Nagai, Kensuke Sekiguchi, Rikako Ukichi, Hiroshi Takahashi, Daisuke Aizawa, Masahiro Ikegami, Toshiaki Tachibana, Daiji Kawanami, Yasushi Kanazawa, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura

Commun Biol. 2022; 5: 341. Published online 2022 Apr 8. doi: 10.1038/s42003-022-03300-4

PMCID:: PMC8993857

Abstract Article PDF–2.9M

Select item 897796711.

RhoA/ROCK2 signalling is enhanced by PDGF‐AA in fibro‐adipogenic progenitor cells: implications for Duchenne muscular dystrophy

Esther Fernández‐Simón, Xavier Suárez‐Calvet, Ana Carrasco‐Rozas, Patricia Piñol‐Jurado, Susana López‐Fernández, Gemma Pons, Joan Josep Bech Serra, Carolina de la Torre, Noemí de Luna, Eduard Gallardo, Jordi Díaz‐Manera

J Cachexia Sarcopenia Muscle. 2022 Apr; 13(2): 1373–1384. Published online 2022 Feb 7. doi: 10.1002/jcsm.12923

PMCID:: PMC8977967

Abstract Article PDF–18M

Select item 860078212.

Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons

Audrey J. Weber, Ashley B. Adamson, Kelsey M. Greathouse, Julia P. Andrade, Cameron D. Freeman, Jung Vin Seo, Rosaria J. Rae, Courtney K. Walker, Jeremy H. Herskowitz

Mol Brain. 2021; 14: 169. Published online 2021 Nov 18. doi: 10.1186/s13041-021-00878-4

PMCID:: PMC8600782

Abstract Article PDF–7.0M

Select item 852783613.

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V. Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T. Heneka

Cell. 2021 Sep 30; 184(20): 5089–5106.e21. doi: 10.1016/j.cell.2021.09.007

PMCID:: PMC8527836

Abstract Article

Select item 825684114.

Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice

Vitor R. Muñoz, Rafael C. Gaspar, Matheus B. Severino, Ana P. A. Macêdo, Fernando M. Simabuco, Eduardo R. Ropelle, Dennys E. Cintra, Adelino S. R. da Silva, Young-Bum Kim, José Rodrigo Pauli

Front Immunol. 2021; 12: 702025. Published online 2021 Jun 21. doi: 10.3389/fimmu.2021.702025

PMCID:: PMC8256841

Abstract Article PDF–6.5M

Select item 799800515.

miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease

Kai Zheng, Fan Hu, Yang Zhou, Juan Zhang, Jie Zheng, Chuan Lai, Wan Xiong, Ke Cui, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Guo Chen, Heng-Ye Man, Dan Liu, Youming Lu, Ling-Qiang Zhu

Nat Commun. 2021; 12: 1903. Published online 2021 Mar 26. doi: 10.1038/s41467-021-22196-y

PMCID:: PMC7998005

Abstract Article PDF–6.9M

Select item 798601616.

0.5-Gy X-ray irradiation induces reorganization of cytoskeleton and differentiation of osteoblasts

Qun Huang, Hao Chai, Shendong Wang, Yongming Sun, Wei Xu

Mol Med Rep. 2021 May; 23(5): 379. Published online 2021 Mar 17. doi: 10.3892/mmr.2021.12018

PMCID:: PMC7986016

Abstract Article PDF–2.6M

Select item 793877017.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003