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Items: 1 to 20 of 107

1.
Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice
Kazuyoshi Furukawa, Kahori Okamoto-Matsuda, Kouji H. Harada, Mutsuko Minata, Toshiaki Hitomi, Hatasu Kobayashi, Akio Koizumi
Environ Health Prev Med. 2024; 29: 21. Published online 2024 Mar 22. doi: 10.1265/ehpm.23-00284
PMCID:
PMC10965415
AbstractArticlePDF–1.2M
2.
Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers
Arimi Fujita, Saki Noguchi, Rika Hamada, Satoko Inoue, Tsutomu Shimada, Satomi Katakura, Tetsuo Maruyama, Yoshimichi Sai, Tomohiro Nishimura, Masatoshi Tomi
Pharm Res. 2022; 39(7): 1645–1658. Published online 2022 Jan 26. doi: 10.1007/s11095-022-03165-6
PMCID:
PMC9246986
AbstractArticlePDF–582K
3.
P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss
Caiyun Ge, Dan Xu, Pengxia Yu, Man Fang, Juanjuan Guo, Dan Xu, Yuan Qiao, Sijia Chen, Yuanzhen Zhang, Hui Wang
BMC Med. 2021; 19: 311. Published online 2021 Dec 8. doi: 10.1186/s12916-021-02173-4
Correction in:
BMC Med. 2022; 20: 126.
PMCID:
PMC8653610
AbstractArticlePDF–6.9M
4.
Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis
Charles N. Zawatsky, Joshua K. Park, Jasmina Abdalla, George Kunos, Malliga R. Iyer, Resat Cinar
Front Endocrinol (Lausanne) 2021; 12: 744857. Published online 2021 Sep 28. doi: 10.3389/fendo.2021.744857
PMCID:
PMC8505776
AbstractArticlePDF–3.0M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-κB (Nuclear Factor-κB)-Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice
Lin Zhang, Irina Graf, Yaoyun Kuang, Xuan Zheng, Matteo Haupt, Arshad Majid, Ertugrul Kilic, Dirk M. Hermann, Marios-Nikos Psychogios, Martin S. Weber, Jasmin Ochs, Mathias Bähr, Thorsten R. Doeppner
Arterioscler Thromb Vasc Biol. 2021 Mar; 41(3): 1127–1145. Published online 2020 Dec 17. doi: 10.1161/ATVBAHA.120.315031
PMCID:
PMC7901534
AbstractArticlePDF–3.7M
7.
Integrin β1 Establishes Liver Microstructure and Modulates Transforming Growth Factor β during Liver Development and Regeneration
Ryota Masuzaki, Kevin C. Ray, Joseph Roland, Roy Zent, Youngmin A. Lee, Seth J. Karp
Am J Pathol. 2021 Feb; 191(2): 309–319. doi: 10.1016/j.ajpath.2020.10.011
PMCID:
PMC7888191
AbstractArticlePDF–3.1M
8.
ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost
Mark C. de Gooijer, E. Marleen Kemper, Levi C.M. Buil, Ceren H. Çitirikkaya, Tessa Buckle, Jos H. Beijnen, Olaf van Tellingen
Cell Rep Med. 2021 Jan 19; 2(1): 100184. Published online 2021 Jan 19. doi: 10.1016/j.xcrm.2020.100184
PMCID:
PMC7817868
AbstractArticlePDF–2.7M
9.
Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1-Mutated Mouse Mammary Tumors
Janneke E. Jaspers, Ariena Kersbergen, Ute Boon, Wendy Sol, Liesbeth van Deemter, Serge A. Zander, Rinske Drost, Ellen Wientjens, Jiuping Ji, Amal Aly, James H. Doroshow, Aaron Cranston, Niall M.B. Martin, Alan Lau, Mark J. O’Connor, Shridar Ganesan, Piet Borst, Jos Jonkers, Sven Rottenberg
Cancer Discov. Author manuscript; available in PMC 2020 Sep 25.
Published in final edited form as: Cancer Discov. 2013 Jan; 3(1): 68–81. Published online 2012 Oct 25. doi: 10.1158/2159-8290.CD-12-0049
PMCID:
PMC7518105
AbstractArticlePDF–1.6M
10.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
11.
Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives
Ling Zou, Peter Spanogiannopoulos, Lindsey M. Pieper, Huan-Chieh Chien, Wenlong Cai, Natalia Khuri, Joshua Pottel, Bianca Vora, Zhanglin Ni, Eleftheria Tsakalozou, Wenjun Zhang, Brian K. Shoichet, Kathleen M. Giacomini, Peter J. Turnbaugh
Proc Natl Acad Sci U S A. 2020 Jul 7; 117(27): 16009–16018. Published online 2020 Jun 22. doi: 10.1073/pnas.1920483117
PMCID:
PMC7355017
AbstractArticlePDF–1.1M
12.
OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation
Yaogeng Wang, Rolf W. Sparidans, Wenlong Li, Maria C. Lebre, Jos H. Beijnen, Alfred H. Schinkel
Br J Pharmacol. 2020 Jul; 177(13): 3060–3074. Published online 2020 Apr 12. doi: 10.1111/bph.15034
PMCID:
PMC7279963
AbstractArticlePDF–3.3M
13.
Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes
Mei Lan Chen, Amy Sun, Wei Cao, Amber Eliason, Kayla M. Mendez, Adam J. Getzler, Shanel Tsuda, Huitian Diao, Clever Mukori, Nelson E. Bruno, Sang Yong Kim, Matthew E. Pipkin, Sergei B. Koralov, Mark S. Sundrud
J Exp Med. 2020 May 4; 217(5): e20191388. Published online 2020 Apr 16. doi: 10.1084/jem.20191388
PMCID:
PMC7201929
AbstractArticlePDF–4.6M
14.
Brain Region-Specific Regulation of Histone Acetylation and Efflux Transporters in Mice
Dahea You, Hye Min Shin, Fatimah Mosaad, Jason R. Richardson, Lauren M. Aleksunes
J Biochem Mol Toxicol. Author manuscript; available in PMC 2020 Jun 5.
Published in final edited form as: J Biochem Mol Toxicol. 2019 Jun; 33(6): e22318. Published online 2019 Mar 21. doi: 10.1002/jbt.22318
PMCID:
PMC6754812
AbstractArticlePDF–782K
15.
Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling
Alper Okyar, Swati A. Kumar, Elisabeth Filipski, Enza Piccolo, Narin Ozturk, Helena Xandri-Monje, Zeliha Pala, Kristin Abraham, Ana Rita Gato de Jesus Gomes, Mehmet N. Orman, Xiao-Mei Li, Robert Dallmann, Francis Lévi, Annabelle Ballesta
Sci Rep. 2019; 9: 10505. Published online 2019 Jul 19. doi: 10.1038/s41598-019-46977-0
PMCID:
PMC6642159
AbstractArticlePDF–3.6M
16.
Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes
Amie Perry, Rachel M. Lynch, Ivan Rusyn, David W. Threadgill
G3 (Bethesda) 2019 May; 9(5): 1729–1737. Published online 2019 Mar 21. doi: 10.1534/g3.119.400161
PMCID:
PMC6505147
AbstractArticlePDF–1.4M
17.
L1210 Cells Overexpressing ABCB1 Drug Transporters Are Resistant to Inhibitors of the N- and O-glycosylation of Proteins
Lucia Pavlikova, Mario Seres, Milan Hano, Viera Bohacova, Ivana Sevcikova, Tomas Kyca, Albert Breier, Zdena Sulova
Molecules. 2017 Jul; 22(7): 1104. Published online 2017 Jul 3. doi: 10.3390/molecules22071104
PMCID:
PMC6152248
AbstractArticlePDF–1.2M
18.
Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine
Liping Ma, Shijie Wei, Bei Yang, Wei Ma, Xiuli Wu, Hongyan Ji, Hong Sui, Jing Chen
Pharm Biol. 2017; 55(1): 374–380. Published online 2016 Dec 8. doi: 10.1080/13880209.2016.1241810
PMCID:
PMC6130654
AbstractArticlePDF–874K
19.
Evolutionarily conserved roles for blood-brain barrier xenobiotic transporters in endogenous steroid partitioning and behavior
Samantha J. Hindle, Roeben N. Munji, Elena Dolghih, Garrett Gaskins, Souvinh Orng, Hiroshi Ishimoto, Allison Soung, Michael DeSalvo, Toshihiro Kitamoto, Michael J. Keiser, Matthew P. Jacobson, Richard Daneman, Roland J. Bainton
Cell Rep. Author manuscript; available in PMC 2018 Jan 19.
Published in final edited form as: Cell Rep. 2017 Oct 31; 21(5): 1304–1316. doi: 10.1016/j.celrep.2017.10.026
PMCID:
PMC5774027
AbstractArticlePDF–1.0M
20.
The xenobiotic transporter Mdr1 enforces T cell homeostasis in the presence of intestinal bile acids
Wei Cao, Hisako Kayama, Mei Lan Chen, Amber Delmas, Amy Sun, Sang Yong Kim, Erumbi S. Rangarajan, Kelly McKevitt, Amanda P. Beck, Cody B. Jackson, Gogce Crynen, Angelos Oikonomopoulos, Precious N. Lacey, Gustavo J. Martinez, Tina Izard, Robin G. Lorenz, Alex Rodriguez-Palacios, Fabio Cominelli, Maria T. Abreu, Daniel W. Hommes, Sergei B. Koralov, Kiyoshi Takeda, Mark S. Sundrud
Immunity. Author manuscript; available in PMC 2018 Dec 19.
Published in final edited form as: Immunity. 2017 Dec 19; 47(6): 1182–1196.e10. doi: 10.1016/j.immuni.2017.11.012
Correction in:
Immunity. 2020 Mar 17; 52(3): 571.
PMCID:
PMC5741099
AbstractArticlePDF–1.6M

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