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Select item 88910181.

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

Teng Ma, Xiao Tian, Baoding Zhang, Mengqi Li, Yu Wang, Chunyan Yang, Jianfeng Wu, Xiaoyan Wei, Qi Qu, Yaxin Yu, Shating Long, Jin-Wei Feng, Chun Li, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Junjie Chen, Yong Yu, Xi Huang, Ying He, Luming Yao, Lei Zhang, Mingxia Zhu, Wen Wang, Zhi-Chao Wang, Mingliang Zhang, Yuqian Bao, Weiping Jia, Shu-Yong Lin, Zhiyun Ye, Hai-Long Piao, Xianming Deng, Chen-Song Zhang, Sheng-Cai Lin

Nature. 2022; 603(7899): 159–165. Published online 2022 Feb 23. doi: 10.1038/s41586-022-04431-8

PMCID:: PMC8891018

Abstract Article PDF–84M

Select item 67252092.

APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic Development

Guojun Ma, Tong Li, Donald L. Price, Philip C. Wong

J Neurosci. 2005 Jan 5; 25(1): 192–198. doi: 10.1523/JNEUROSCI.3814-04.2005

PMCID:: PMC6725209

Abstract Article PDF–351K

Select item 63839543.

Dual role of DMXL2 in olfactory information transmission and the first wave of spermatogenesis

Clara Gobé, Maëva Elzaiat, Nicolas Meunier, Marjolaine André, Eli Sellem, Patrice Congar, Luc Jouneau, Aurélie Allais-Bonnet, Ikrame Naciri, Bruno Passet, Eric Pailhoux, Maëlle Pannetier

PLoS Genet. 2019 Feb; 15(2): e1007909. Published online 2019 Feb 8. doi: 10.1371/journal.pgen.1007909

PMCID:: PMC6383954

Abstract Article PDF–3.2M

Select item 55382974.

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration

Hermien Acx, Lutgarde Serneels, Enrico Radaelli, Serge Muyldermans, Cécile Vincke, Elise Pepermans, Ulrike Müller, Lucía Chávez‐Gutiérrez, Bart De Strooper

EMBO Mol Med. 2017 Aug; 9(8): 1088–1099. Published online 2017 Jun 6. doi: 10.15252/emmm.201707561

PMCID:: PMC5538297

Abstract Article PDF–5.8M

Select item 50130245.

Prostaglandin I₂ upregulates the expression of anterior pharynx‐defective‐1α and anterior pharynx‐defective‐1β in amyloid precursor protein/presenilin 1 transgenic mice

Pu Wang, Pei‐Pei Guan, Jing‐Wen Guo, Long‐Long Cao, Guo‐Biao Xu, Xin Yu, Yue Wang, Zhan‐You Wang

Aging Cell. 2016 Oct; 15(5): 861–871. Published online 2016 May 30. doi: 10.1111/acel.12495

PMCID:: PMC5013024

Abstract Article PDF–2.8M

Select item 49142596.

Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia

Fabrizio Biundo, Keita Ishiwari, Dolores Del Prete, Luciano D'Adamio

Oncotarget. 2016 Mar 15; 7(11): 11923–11944. Published online 2016 Mar 1. doi: 10.18632/oncotarget.7389

PMCID:: PMC4914259

Abstract Article PDF–2.3M

Select item 48202487.

Antagonistic Effects of BACE1 and APH1B-?-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

Soraia Barão, Annette Gärtner, Eduardo Leyva-Díaz, Galina Demyanenko, Sebastian Munck, Tine Vanhoutvin, Lujia Zhou, Melitta Schachner, Guillermina López-Bendito, Patricia F. Maness, Bart De Strooper

Cell Rep. Author manuscript; available in PMC 2016 Apr 4.

Published in final edited form as: Cell Rep. 2015 Sep 1; 12(9): 1367–1376. Published online 2015 Aug 20. doi: 10.1016/j.celrep.2015.07.059

PMCID:: PMC4820248

Abstract Article PDF–801K

Select item 45990098.

A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells

Feihan F. Dai, Alpana Bhattacharjee, Ying Liu, Battsetseg Batchuluun, Ming Zhang, Xinye Serena Wang, Xinyi Huang, Lemieux Luu, Dan Zhu, Herbert Gaisano, Michael B. Wheeler

J Biol Chem. 2015 Oct 9; 290(41): 25045–25061. Published online 2015 Aug 13. doi: 10.1074/jbc.M115.648592

PMCID:: PMC4599009

Abstract Article PDF–2.7M

Select item 43195599.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 407328310.

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

Pietro Fazzari, An Snellinx, Victor Sabanov, Tariq Ahmed, Lutgarde Serneels, Annette Gartner, S Ali M Shariati, Detlef Balschun, Bart De Strooper

eLife. 2014; 3: e02196. Published online 2014 Jun 2. doi: 10.7554/eLife.02196

PMCID:: PMC4073283

Abstract Article PDF–2.5M

Select item 357241011.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 322666412.

Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo

Tong Li, Yue-Ming Li, Kwangwook Ahn, Donald L. Price, Sangram S. Sisodia, Philip C. Wong

PLoS One. 2011; 6(11): e28179. Published online 2011 Nov 29. doi: 10.1371/journal.pone.0028179

PMCID:: PMC3226664

Abstract Article PDF–500K

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253414.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 290441415.

Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin

Po-Min Chiang, Ryan R. Fortna, Donald L. Price, Tong Li, Philip C. Wong

Neurobiol Aging. Author manuscript; available in PMC 2013 Feb 1.

Published in final edited form as: Neurobiol Aging. 2012 Feb; 33(2): 277–285. Published online 2010 Apr 10. doi: 10.1016/j.neurobiolaging.2009.12.028

PMCID:: PMC2904414

Abstract Article PDF–1023K

Select item 274047416.

?-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease

Lutgarde Serneels, Jérôme Van Biervliet, Katleen Craessaerts, Tim Dejaegere, Katrien Horré, Tine Van Houtvin, Hermann Esselmann, Sabine Paul, Martin K. Schäfer, Oksana Berezovska, Bradley T. Hyman, Ben Sprangers, Raf Sciot, Lieve Moons, Mathias Jucker, Zhixiang Yang, Patrick C. May, Eric Karran, Jens Wiltfang, Rudi D’Hooge, Bart De Strooper

Science. Author manuscript; available in PMC 2009 Sep 9.

Published in final edited form as: Science. 2009 May 1; 324(5927): 639–642. Published online 2009 Mar 19. doi: 10.1126/science.1171176

PMCID:: PMC2740474

Abstract Article PDF–3.5M

Select item 247450217.

Deficiency of Aph1B/C-γ-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

T. Dejaegere, L. Serneels, M. K. Schäfer, J. Van Biervliet, K. Horré, C. Depboylu, D. Alvarez-Fischer, A. Herreman, M. Willem, C. Haass, G. U. Höglinger, R. D'Hooge, B. De Strooper

Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28): 9775–9780. Published online 2008 Jul 14. doi: 10.1073/pnas.0800507105

PMCID:: PMC2474502

Abstract Article PDF–1.0M

Select item 54749518.

Differential contribution of the three Aph1 genes to γ-secretase activity in vivo

Lutgarde Serneels, Tim Dejaegere, Katleen Craessaerts, Katrien Horré, Ellen Jorissen, Thomas Tousseyn, Sébastien Hébert, Marcel Coolen, Gerard Martens, An Zwijsen, Wim Annaert, Dieter Hartmann, Bart De Strooper

Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5): 1719–1724. Published online 2005 Jan 21. doi: 10.1073/pnas.0408901102

PMCID:: PMC547495

Abstract Article PDF–685K

Select item 52892819.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 31099220.

RIKEN Integrated Sequence Analysis (RISA) System—384-Format Sequencing Pipeline with 384 Multicapillary Sequencer

Kazuhiro Shibata, Masayoshi Itoh, Katsunori Aizawa, Sumiharu Nagaoka, Nobuya Sasaki, Piero Carninci, Hideaki Konno, Junichi Akiyama, Katsuo Nishi, Tokuji Kitsunai, Hideo Tashiro, Mari Itoh, Noriko Sumi, Yoshiyuki Ishii, Shin Nakamura, Makoto Hazama, Tsutomu Nishine, Akira Harada, Rintaro Yamamoto, Hiroyuki Matsumoto, Sumito Sakaguchi, Takashi Ikegami, Katsuya Kashiwagi, Syuji Fujiwake, Kouji Inoue, Yoshiyuki Togawa, Masaki Izawa, Eiji Ohara, Masanori Watahiki, Yuko Yoneda, Tomokazu Ishikawa, Kaori Ozawa, Takumi Tanaka, Shuji Matsuura, Jun Kawai, Yasushi Okazaki, Masami Muramatsu, Yorinao Inoue, Akira Kira, Yoshihide Hayashizaki

Genome Res. 2000 Nov; 10(11): 1757–1771. doi: 10.1101/gr.152600

PMCID:: PMC310992

Abstract Article PDF–3.4M

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