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Items: 1 to 20 of 232

1.
The Immunostimulatory RNA RN7SL1 Enables CAR-T Cells to Enhance Autonomous and Endogenous Immune Function
Lexus R. Johnson, Daniel Y. Lee, Jacqueline S. Eacret, Darwin Ye, Carl H. June, Andy J. Minn
Cell. Author manuscript; available in PMC 2024 Aug 21.
Published in final edited form as: Cell. 2021 Sep 16; 184(19): 4981–4995.e14. Published online 2021 Aug 30. doi: 10.1016/j.cell.2021.08.004
PMCID:
PMC11338632
AbstractArticlePDF–3.5M
2.
Batf3+ DCs and the 4–1BB/4–1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy
Andrea Ziblat, Brendan L. Horton, Emily F. Higgs, Ken Hatogai, Anna Martinez, Jason W. Shapiro, Danny E.C. Kim, YuanYuan Zha, Randy F. Sweis, Thomas F. Gajewski
Cell Rep. Author manuscript; available in PMC 2024 Jul 8.
Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114141. Published online 2024 Apr 23. doi: 10.1016/j.celrep.2024.114141
PMCID:
PMC11229087
AbstractArticlePDF–3.0M
3.
Necroptosis stimulates interferon-mediated protective anti-tumor immunity
A. Justin Rucker, Christa S. Park, Qi Jing Li, E. Ashley Moseman, Francis Ka-Ming Chan
Cell Death Dis. 2024 Jun; 15(6): 403. Published online 2024 Jun 10. doi: 10.1038/s41419-024-06801-8
PMCID:
PMC11164861
AbstractArticlePDF–4.1M
4.
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Jonathan Serody, Benjamin Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li
Nat Cancer. 2024; 5(4): 601–624. Published online 2024 Feb 27. doi: 10.1038/s43018-024-00736-x
PMCID:
PMC11056319
AbstractArticlePDF–33M
5.
Batf3-dependent orchestration of the robust Th1 responses and fungal control during cryptococcal infection, the role of cDC1
Jintao Xu, Rylan Hissong, Rachel Bareis, Arianna Creech, Kristie D. Goughenour, Christine M. Freeman, Michal A. Olszewski
mBio. 2024 Mar; 15(3): e02853-23. Published online 2024 Feb 13. doi: 10.1128/mbio.02853-23
PMCID:
PMC10936214
AbstractArticlePDF–4.0M
6.
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer
Maria Zagorulya, Leon Yim, Duncan M. Morgan, Austin Edwards, Elen Torres-Mejia, Noor Momin, Chloe V. McCreery, Izabella L. Zamora, Brendan L. Horton, James G. Fox, K. Dane Wittrup, J. Christopher Love, Stefani Spranger
Immunity. Author manuscript; available in PMC 2024 Feb 21.
Published in final edited form as: Immunity. 2023 Feb 14; 56(2): 386–405.e10. Published online 2023 Feb 2. doi: 10.1016/j.immuni.2023.01.010
PMCID:
PMC10880816
AbstractArticlePDF–3.2M
7.
Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity
Ellen Duong, Tim B. Fessenden, Emi Lutz, Teresa Dinter, Leon Yim, Sarah Blatt, Arjun Bhutkar, Karl Dane Wittrup, Stefani Spranger
Immunity. Author manuscript; available in PMC 2024 Jan 30.
Published in final edited form as: Immunity. 2022 Feb 8; 55(2): 308–323.e9. Published online 2021 Nov 19. doi: 10.1016/j.immuni.2021.10.020
PMCID:
PMC10827482
AbstractArticlePDF–2.4M
8.
FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and NK cell homeostasis
Paul Régnier, Mathias Vetillard, Adèle Bansard, Eméranne Pierre, Xinyue Li, Nicolas Cagnard, Emmanuel L. Gautier, Pierre Guermonprez, Bénédicte Manoury, Katrina Podsypanina, Guillaume Darrasse-Jèze
Cell Rep Med. 2023 Dec 19; 4(12): 101256. Published online 2023 Dec 19. doi: 10.1016/j.xcrm.2023.101256
PMCID:
PMC10772324
AbstractArticlePDF–6.1M
9.
KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance
Anastasia-Maria Zavitsanou, Ray Pillai, Yuan Hao, Warren L. Wu, Eric Bartnicki, Triantafyllia Karakousi, Sahith Rajalingam, Alberto Herrera, Angeliki Karatza, Ali Rashidfarrokhi, Sabrina Solis, Metamia Ciampricotti, Anna H. Yeaton, Ellie Ivanova, Corrin A. Wohlhieter, Terkild B. Buus, Makiko Hayashi, Burcu Karadal-Ferrena, Harvey I. Pass, John T. Poirier, Charles M. Rudin, Kwok-Kin Wong, Andre L. Moreira, Kamal M. Khanna, Aristotelis Tsirigos, Thales Papagiannakopoulos, Sergei B. Koralov
Cell Rep. Author manuscript; available in PMC 2023 Dec 29.
Published in final edited form as: Cell Rep. 2023 Nov 28; 42(11): 113295. Published online 2023 Oct 26. doi: 10.1016/j.celrep.2023.113295
PMCID:
PMC10755970
AbstractArticlePDF–2.3M
10.
Essential role for Batf3-dependent dendritic cells in regulating CD8 T-cell response during SARS-CoV-2 infection
Liat Bar-On, Hani Dekel, Moshe Aftalion, Theodor Chitlaru, Noam Erez
PLoS One. 2023; 18(12): e0294176. Published online 2023 Dec 27. doi: 10.1371/journal.pone.0294176
PMCID:
PMC10752548
AbstractArticlePDF–1.4M
11.
Lung cDC1 and cDC2 dendritic cells priming naive CD8+ T cells in situ prior to migration to draining lymph nodes
Youhui Si, Yihan Wang, Qiaomu Tian, Qiang Wang, Jared M. Pollard, Pramod K. Srivastava, Aaron P. Esser-Kahn, Joel H. Collier, Anne I. Sperling, Anita S. Chong
Cell Rep. Author manuscript; available in PMC 2023 Nov 26.
Published in final edited form as: Cell Rep. 2023 Oct 31; 42(10): 113299. doi: 10.1016/j.celrep.2023.113299
PMCID:
PMC10676754
AbstractArticlePDF–2.3M
12.
Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8+ T cells
Diego Calzada-Fraile, Salvador Iborra, Marta Ramírez-Huesca, Inmaculada Jorge, Enrico Dotta, Elena Hernández-García, Noa Martín-Cófreces, Estanislao Nistal-Villán, Esteban Veiga, Jesús Vázquez, Giulia Pasqual, Francisco Sánchez-Madrid
Nat Commun. 2023; 14: 6772. Published online 2023 Oct 25. doi: 10.1038/s41467-023-42480-3
PMCID:
PMC10600134
AbstractArticlePDF–2.0M
13.
IL-15 synergizes with CD40 agonist antibodies to induce durable immunity against bladder cancer
Jeffrey L. Wong, Patrick Smith, Juan Angulo-Lozano, Daniel Ranti, Bernard H. Bochner, John P. Sfakianos, Amir Horowitz, Jeffrey V. Ravetch, David A. Knorr
Proc Natl Acad Sci U S A. 2023 Aug 29; 120(35): e2306782120. Published online 2023 Aug 22. doi: 10.1073/pnas.2306782120
PMCID:
PMC10467355
AbstractArticlePDF–4.4M
14.
Membrane-localized neoantigens predict the efficacy of cancer immunotherapy
Zoe Goldberger, Sylvie Hauert, Kevin Chang, Trevin Kurtanich, Aaron T. Alpar, Grégoire Repond, Yue Wang, Suzana Gomes, Raga Krishnakumar, Prabha Siddarth, Melody A. Swartz, Jeffrey A. Hubbell, Priscilla S. Briquez
Cell Rep Med. 2023 Aug 15; 4(8): 101145. Published online 2023 Aug 7. doi: 10.1016/j.xcrm.2023.101145
PMCID:
PMC10439248
AbstractArticlePDF–5.8M
15.
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity
Chuansheng Guo, Zhiyuan You, Hao Shi, Yu Sun, Xingrong Du, Gustavo Palacios, Cliff Guy, Sujing Yuan, Nicole M. Chapman, Seon Ah Lim, Xiang Sun, Jordy Saravia, Sherri Rankin, Yogesh Dhungana, Hongbo Chi
Nature. 2023; 620(7972): 200–208. Published online 2023 Jul 5. doi: 10.1038/s41586-023-06299-8
PMCID:
PMC10396969
AbstractArticlePDF–17M
16.
Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
Leyuan Ma, Alexander Hostetler, Duncan M. Morgan, Laura Maiorino, Ina Sulkaj, Charles A. Whittaker, Alexandra Neeser, Ivan Susin Pires, Parisa Yousefpour, Justin Gregory, Kashif Qureshi, Jonathan Dye, Wuhbet Abraham, Heikyung Suh, Na Li, J. Christopher Love, Darrell J. Irvine
Cell. Author manuscript; available in PMC 2023 Jul 27.
Published in final edited form as: Cell. 2023 Jul 20; 186(15): 3148–3165.e20. Published online 2023 Jul 5. doi: 10.1016/j.cell.2023.06.002
PMCID:
PMC10372881
AbstractArticlePDF–3.0M
17.
Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs
Aaron Silva–Sanchez, Selene Meza–Perez, Mingyong Liu, Sara L Stone, Leopoldo Flores–Romo, Eric Ubil, Frances E. Lund, Alexander F. Rosenberg, Troy D. Randall
Sci Immunol. Author manuscript; available in PMC 2023 Dec 23.
Published in final edited form as: Sci Immunol. 2023 Jun 23; 8(84): eadc9081. Published online 2023 Jun 16. doi: 10.1126/sciimmunol.adc9081
PMCID:
PMC10351240
AbstractArticlePDF–1.7M
18.
Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma
Ilgen Mender, Silvia Siteni, Summer Barron, Ann Marie Flusche, Naoto Kubota, Chunhua Yu, Crystal Cornelius, Enzo Tedone, Mazvita Maziveyi, Anthony Grichuk, Niranjan Venkateswaran, Maralice Conacci-Sorrell, Yujin Hoshida, Rui Kang, Daolin Tang, Sergei Gryaznov, Jerry W. Shay
Mol Cancer Ther. 2023 Jun 1; 22(6): 737–750. Published online 2023 Apr 18. doi: 10.1158/1535-7163.MCT-23-0039
PMCID:
PMC10233358
AbstractArticlePDF–7.6M
19.
A neutrophil response linked to tumor control in immunotherapy
Jeremy Gungabeesoon, Nicolas A. Gort-Freitas, Máté Kiss, Evangelia Bolli, Marius Messemaker, Marie Siwicki, Mehdi Hicham, Ruben Bill, Peter Koch, Chiara Cianciaruso, Florent Duval, Christina Pfirschke, Michael Mazzola, Solange Peters, Krisztian Homicsko, Christopher Garris, Ralph Weissleder, Allon M. Klein, Mikael J. Pittet
Cell. Author manuscript; available in PMC 2024 Mar 30.
Published in final edited form as: Cell. 2023 Mar 30; 186(7): 1448–1464.e20. doi: 10.1016/j.cell.2023.02.032
PMCID:
PMC10132778
AbstractArticlePDF–2.7M
20.
Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation
Sachin H. Bhagchandani, Farrukh Vohidov, Lauren E. Milling, Evelyn Yuzhou Tong, Christopher M. Brown, Michelle L. Ramseier, Bin Liu, Timothy B. Fessenden, Hung V.-T. Nguyen, Gavin R. Kiel, Lori Won, Robert S. Langer, Stefani Spranger, Alex K. Shalek, Darrell J. Irvine, Jeremiah A. Johnson
Sci Adv. 2023 Apr; 9(16): eadg2239. Published online 2023 Apr 19. doi: 10.1126/sciadv.adg2239
PMCID:
PMC10115420
AbstractArticlePDF–1.9M

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