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Select item 115650401.

Single-cell RNA transcriptomics in mice reveals embryonic origin of fibrosis due to maternal obesity

Md Nazmul Hossain, Yao Gao, Xinrui Li, Liang Zhao, Xiangdong Liu, Jeanene Marie de Avila, Mei-Jun Zhu, Min Du

eBioMedicine. 2024 Nov; 109: 105421. Published online 2024 Oct 30. doi: 10.1016/j.ebiom.2024.105421

PMCID:: PMC11565040

Abstract Article PDF–4.9M

Select item 115549552.

Pathogenic variants in the paired-related homeobox 1 gene (PRRX1) cause craniosynostosis with incomplete penetrance

Rebecca S. Tooze, Kerry A. Miller, Sigrid M.A. Swagemakers, Eduardo Calpena, Simon J. McGowan, Odile Boute, Corinne Collet, David Johnson, Fanny Laffargue, Nicole de Leeuw, Jenny V. Morton, Peter Noons, Charlotte W. Ockeloen, Julie M. Phipps, Tiong Yang Tan, Andrew T. Timberlake, Clemence Vanlerberghe, Steven A. Wall, Astrid Weber, Louise C. Wilson, Elaine H. Zackai, Irene M.J. Mathijssen, Stephen R.F. Twigg, Andrew O.M. Wilkie

Genet Med. 2023 Sep; 25(9): 100883. doi: 10.1016/j.gim.2023.100883

PMCID:: PMC11554955

Abstract Article

Select item 114113393.

In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells

Ioannis Oikonomakos, Melina Tedesco, Fariba Jian Motamedi, Mirko Peitzsch, Serge Nef, Stefan R. Bornstein, Andreas Schedl, Charlotte Steenblock, Yasmine Neirijnck

Stem Cell Reports. 2024 Sep 10; 19(9): 1289–1303. Published online 2024 Aug 22. doi: 10.1016/j.stemcr.2024.07.010

PMCID:: PMC11411339

Abstract Article PDF–5.7M

Select item 110567054.

Transcription factor PBX4 regulates limb development and haematopoiesis in mice

Yan Ning, Shuguang Duo, Xiwen Lin, Hongbo Zhang, Jifeng Fei, Bao Zhang, Yanyun Zeng, Dan Xie, Jian Chen, Xiaowei Liu, Chunsheng Han

Cell Prolif. 2024 May; 57(5): e13580. Published online 2024 Jan 17. doi: 10.1111/cpr.13580

PMCID:: PMC11056705

Abstract Article PDF–4.5M

Select item 109017395.

A single-cell time-lapse of mouse prenatal development from gastrula to birth

Chengxiang Qiu, Beth K. Martin, Ian C. Welsh, Riza M. Daza, Truc-Mai Le, Xingfan Huang, Eva K. Nichols, Megan L. Taylor, Olivia Fulton, Diana R. O’Day, Anne Roshella Gomes, Saskia Ilcisin, Sanjay Srivatsan, Xinxian Deng, Christine M. Disteche, William Stafford Noble, Nobuhiko Hamazaki, Cecilia B. Moens, David Kimelman, Junyue Cao, Alexander F. Schier, Malte Spielmann, Stephen A. Murray, Cole Trapnell, Jay Shendure

Nature. 2024; 626(8001): 1084–1093. Published online 2024 Feb 14. doi: 10.1038/s41586-024-07069-w

PMCID:: PMC10901739

Abstract Article PDF–63M

Select item 107034196.

Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves

Rachel Queen, Moira Crosier, Lorraine Eley, Janet Kerwin, Jasmin E. Turner, Jianshi Yu, Ahlam Alqahtani, Tamilvendhan Dhanaseelan, Lynne Overman, Hannah Soetjoadi, Richard Baldock, Jonathan Coxhead, Veronika Boczonadi, Alex Laude, Simon J. Cockell, Maureen A. Kane, Steven Lisgo, Deborah J. Henderson

PLoS Genet. 2023 Nov; 19(11): e1010777. Published online 2023 Nov 27. doi: 10.1371/journal.pgen.1010777

PMCID:: PMC10703419

Abstract Article PDF–9.6M

Select item 103259897.

A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2

Marta Losa, Iros Barozzi, Marco Osterwalder, Viviana Hermosilla-Aguayo, Angela Morabito, Brandon H. Chacón, Peyman Zarrineh, Ausra Girdziusaite, Jean Denis Benazet, Jianjian Zhu, Susan Mackem, Terence D. Capellini, Diane Dickel, Nicoletta Bobola, Aimée Zuniga, Axel Visel, Rolf Zeller, Licia Selleri

Nat Commun. 2023; 14: 3993. Published online 2023 Jul 6. doi: 10.1038/s41467-023-39443-z

PMCID:: PMC10325989

Abstract Article PDF–9.8M

Select item 102756398.

Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis

Emmeline Marchal-Duval, Méline Homps-Legrand, Antoine Froidure, Madeleine Jaillet, Mada Ghanem, Deneuville Lou, Aurélien Justet, Arnaud Maurac, Aurelie Vadel, Emilie Fortas, Aurelie Cazes, Audrey Joannes, Laura Giersh, Herve Mal, Pierre Mordant, Tristan Piolot, Marin Truchin, Carine M Mounier, Ksenija Schirduan, Martina Korfei, Andreas Gunther, Bernard Mari, Frank Jaschinski, Bruno Crestani, Arnaud A Mailleux

eLife. 2023; 12: e79840. Published online 2023 Jun 1. doi: 10.7554/eLife.79840

PMCID:: PMC10275639

Abstract Article PDF–18M

Select item 95542199.

Meis2 controls skeletal formation in the hyoid region

Jaroslav Fabik, Viktorie Psutkova, Ondrej Machon

Front Cell Dev Biol. 2022; 10: 951063. Published online 2022 Sep 28. doi: 10.3389/fcell.2022.951063

PMCID:: PMC9554219

Abstract Article PDF–10M

Select item 930434110.

Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud

Naoko Koyano-Nakagawa, Wuming Gong, Satyabrata Das, Joshua W. M. Theisen, Tran B. Swanholm, Daniel Van Ly, Nikita Dsouza, Bhairab N. Singh, Hiroko Kawakami, Samantha Young, Katherine Q. Chen, Yasuhiko Kawakami, Daniel J. Garry

Nat Commun. 2022; 13: 4221. Published online 2022 Jul 21. doi: 10.1038/s41467-022-31848-6

PMCID:: PMC9304341

Abstract Article PDF–5.7M

Select item 925674811.

Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification

Charles Petitpré, Louis Faure, Phoebe Uhl, Paula Fontanet, Iva Filova, Gabriela Pavlinkova, Igor Adameyko, Saida Hadjab, Francois Lallemend

Nat Commun. 2022; 13: 3878. Published online 2022 Jul 5. doi: 10.1038/s41467-022-31580-1

PMCID:: PMC9256748

Abstract Article PDF–3.9M

Select item 912001412.

PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression

Keun-Woo Lee, So-Young Yeo, Jeong-Ryeol Gong, Ok-Jae Koo, Insuk Sohn, Woo Yong Lee, Hee Cheol Kim, Seong Hyeon Yun, Yong Beom Cho, Mi-Ae Choi, Sugyun An, Juhee Kim, Chang Ohk Sung, Kwang-Hyun Cho, Seok-Hyung Kim

Nat Commun. 2022; 13: 2793. Published online 2022 May 19. doi: 10.1038/s41467-022-30484-4

PMCID:: PMC9120014

Abstract Article PDF–11M

Select item 910810913.

Age-Progressive and Gender-Dependent Bone Phenotype in Mice Lacking Both Ebf1 and Ebf2 in Prrx1-Expressing Mesenchymal Cells

Vappu Nieminen-Pihala, Petri Rummukainen, Fan Wang, Kati Tarkkonen, Kaisa K. Ivaska, Riku Kiviranta

Calcif Tissue Int. 2022; 110(6): 746–758. Published online 2022 Feb 8. doi: 10.1007/s00223-022-00951-7

PMCID:: PMC9108109

Abstract Article PDF–8.6M

Select item 874093514.

Limb development genes underlie variation in human fingerprint patterns

Jinxi Li, James D. Glover, Haiguo Zhang, Meifang Peng, Jingze Tan, Chandana Basu Mallick, Dan Hou, Yajun Yang, Sijie Wu, Yu Liu, Qianqian Peng, Shijie C. Zheng, Edie I. Crosse, Alexander Medvinsky, Richard A. Anderson, Helen Brown, Ziyu Yuan, Shen Zhou, Yanqing Xu, John P. Kemp, Yvonne Y.W. Ho, Danuta Z. Loesch, Lizhong Wang, Yingxiang Li, Senwei Tang, Xiaoli Wu, Robin G. Walters, Kuang Lin, Ruogu Meng, Jun Lv, Jonathan M. Chernus, Katherine Neiswanger, Eleanor Feingold, David M. Evans, Sarah E. Medland, Nicholas G. Martin, Seth M. Weinberg, Mary L. Marazita, Gang Chen, Zhengming Chen, Yong Zhou, Michael Cheeseman, Lan Wang, Li Jin, Denis J. Headon, Sijia Wang

Cell. 2022 Jan 6; 185(1): 95–112.e18. doi: 10.1016/j.cell.2021.12.008

PMCID:: PMC8740935

Abstract Article

Select item 835533715.

The developing mouse coronal suture at single-cell resolution

D’Juan T. Farmer, Hana Mlcochova, Yan Zhou, Nils Koelling, Guanlin Wang, Neil Ashley, Helena Bugacov, Hung-Jhen Chen, Riana Parvez, Kuo-Chang Tseng, Amy E. Merrill, Robert E. Maxson, Jr., Andrew O. M. Wilkie, J. Gage Crump, Stephen R. F. Twigg

Nat Commun. 2021; 12: 4797. Published online 2021 Aug 10. doi: 10.1038/s41467-021-24917-9

PMCID:: PMC8355337

Abstract Article PDF–9.6M

Select item 831323916.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 817777817.

PRRX1 deficiency induces mesenchymal‐epithelial transition through PITX2/miR‐200–dependent SLUG/CTNNB1 regulation in hepatocellular carcinoma

Weibo Chen, Junyi Wu, Weiwei Shi, Guang Zhang, Xuemin Chen, Anlai Ji, Zhongxia Wang, Junhua Wu, Chunping Jiang

Cancer Sci. 2021 Jun; 112(6): 2158–2172. Published online 2021 Apr 8. doi: 10.1111/cas.14853

PMCID:: PMC8177778

Abstract Article PDF–2.5M

Select item 796892518.

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

Xiaochen Fan, V Pragathi Masamsetti, Jane QJ Sun, Kasper Engholm-Keller, Pierre Osteil, Joshua Studdert, Mark E Graham, Nicolas Fossat, Patrick PL Tam

eLife. 2021; 10: e62873. Published online 2021 Feb 8. doi: 10.7554/eLife.62873

PMCID:: PMC7968925

Abstract Article PDF–4.0M

Select item 782307619.

Genetic association and characterization of FSTL5 in isolated clubfoot

Anas M Khanshour, Yared H Kidane, Julia Kozlitina, Reuel Cornelia, Alexandra Rafipay, Vanessa De Mello, Mitchell Weston, Nandina Paria, Aysha Khalid, Jacqueline T Hecht, Matthew B Dobbs, B Stephens Richards, Neil Vargesson, F Kent Hamra, Megan Wilson, Carol Wise, Christina A Gurnett, Jonathan J Rios

Hum Mol Genet. 2020 Nov 15; 29(22): 3717–3728. Published online 2020 Oct 26. doi: 10.1093/hmg/ddaa236

PMCID:: PMC7823076

Abstract Article PDF–1.0M

Select item 774251220.

Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis

Tripp Leavitt, Michael S. Hu, Mimi R. Borrelli, Michael Januszyk, Julia T. Garcia, Ryan C. Ransom, Shamik Mascharak, Heather E. desJardins-Park, Ulrike M. Litzenburger, Graham G. Walmsley, Clement D. Marshall, Alessandra L. Moore, Bryan Duoto, Sandeep Adem, Deshka S. Foster, Ankit Salhotra, Abra H. Shen, Michelle Griffin, Ethan Z. Shen, Leandra A. Barnes, Elizabeth R. Zielins, Zeshaan N. Maan, Yuning Wei, Charles K.F. Chan, Derrick C. Wan, Hermann P. Lorenz, Howard Y. Chang, Geoffrey C. Gurtner, Michael T. Longaker

Cell Rep. Author manuscript; available in PMC 2020 Dec 16.

Published in final edited form as: Cell Rep. 2020 Nov 10; 33(6): 108356. doi: 10.1016/j.celrep.2020.108356

PMCID:: PMC7742512

Abstract Article PDF–2.0M

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