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Select item 111091931.

Foxo3 regulates cortical and medullary thymic epithelial cell homeostasis with implications in T cell development

Camila Ribeiro, Pedro Ferreirinha, Jonathan J. M. Landry, Fátima Macedo, Laura G. Sousa, Rute Pinto, Vladimir Benes, Nuno L. Alves

Cell Death Dis. 2024 May; 15(5): 352. Published online 2024 May 21. doi: 10.1038/s41419-024-06728-0

PMCID:: PMC11109193

Abstract Article PDF–3.2M

Select item 110981152.

Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones

Jennifer A. Smith, Benjamin T. K. Yuen, Whitney Purtha, Jared M. Balolong, Jonah D. Phipps, Frances Crawford, Jeffrey A. Bluestone, John W. Kappler, Mark S. Anderson

Proc Natl Acad Sci U S A. 2024 May 14; 121(20): e2320268121. Published online 2024 May 6. doi: 10.1073/pnas.2320268121

PMCID:: PMC11098115

Abstract Article PDF–1.5M

Select item 110918603.

Aire relies on Z-DNA to flag gene targets for thymic T-cell tolerization

Yuan Fang, Kushagra Bansal, Sara Mostafavi, Christophe Benoist, Diane Mathis

Nature. Author manuscript; available in PMC 2024 Oct 1.

Published in final edited form as: Nature. 2024 Apr; 628(8007): 400–407. Published online 2024 Mar 13. doi: 10.1038/s41586-024-07169-7

PMCID:: PMC11091860

Article PDF–5.1M

Select item 110799404.

Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance

Aya Ushio, Mami Matsuda-Lennikov, Felix Kalle-Youngoue, Akihide Shimizu, Abdalla Abdelmaksoud, Michael C. Kelly, Naozumi Ishimaru, Yousuke Takahama

Cell Rep. Author manuscript; available in PMC 2024 May 9.

Published in final edited form as: Cell Rep. 2024 Apr 23; 43(4): 114072. Published online 2024 Apr 5. doi: 10.1016/j.celrep.2024.114072

PMCID:: PMC11079940

Abstract Article PDF–3.1M

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108351376.

Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model

Mianmian Yin, Jennifer A. Smith, Marissa Chou, Jackie Chan, Yingyos Jittayasothorn, Douglas B. Gould, Rachel R. Caspi, Mark S. Anderson, Anthony L. DeFranco

Proc Natl Acad Sci U S A. 2024 Jan 30; 121(5): e2311487121. Published online 2024 Jan 23. doi: 10.1073/pnas.2311487121

PMCID:: PMC10835137

Abstract Article PDF–4.2M

Select item 107958297.

Validation of a murine proteome-wide phage display library for identification of autoantibody specificities

Elze Rackaityte, Irina Proekt, Haleigh S. Miller, Akshaya Ramesh, Jeremy F. Brooks, Andrew F. Kung, Caleigh Mandel-Brehm, David Yu, Colin R. Zamecnik, Rebecca Bair, Sara E. Vazquez, Sara Sunshine, Clare L. Abram, Clifford A. Lowell, Gabrielle Rizzuto, Michael R. Wilson, Julie Zikherman, Mark S. Anderson, Joseph L. DeRisi

JCI Insight. 2023 Dec 8; 8(23): e174976. Published online 2023 Dec 8. doi: 10.1172/jci.insight.174976

PMCID:: PMC10795829

Abstract Article PDF–1.1M

Select item 107323158.

Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells

Matthew D. Taves, Kaitlynn M. Donahue, Jing Bian, Margaret C. Cam, Jonathan D. Ashwell

Sci Immunol. Author manuscript; available in PMC 2023 Dec 20.

Published in final edited form as: Sci Immunol. 2023 Aug 25; 8(86): eabo7975. Published online 2023 Aug 18. doi: 10.1126/sciimmunol.abo7975

PMCID:: PMC10732315

Abstract Article PDF–1.6M

Select item 106511229.

Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development

Justin Malin, Gustavo Ulises Martinez-Ruiz, Yongge Zhao, Susannah C. Shissler, Jennifer E. Cowan, Yi Ding, Abigail Morales-Sanchez, Masaki Ishikawa, Marieke Lavaert, Arundhoti Das, Donna Butcher, Andrew C. Warner, Melissa Kallarakal, Jingqiu Chen, Noemi Kedei, Michael Kelly, Lauren R. Brinster, David Allman, Avinash Bhandoola

Sci Adv. 2023 Nov 17; 9(46): eadg8126. Published online 2023 Nov 15. doi: 10.1126/sciadv.adg8126

PMCID:: PMC10651122

Abstract Article PDF–1.6M

Select item 1061778210.

A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrome type 1

Bergithe Eikeland Oftedal, Amund Holte Berger, Øyvind Bruserud, Yael Goldfarb, Andre Sulen, Lars Breivik, Alexander Hellesen, Shifra Ben-Dor, Rebecca Haffner-Krausz, Per M. Knappskog, Stefan Johansson, Anette S.B. Wolff, Eirik Bratland, Jakub Abramson, Eystein Sverre Husebye

J Clin Invest. 2023 Nov 1; 133(21): e169704. Published online 2023 Nov 1. doi: 10.1172/JCI169704

PMCID:: PMC10617782

Abstract Article PDF–2.5M

Select item 1037268011.

T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity

Sharon A. Sagan, Zahra Moinfar, Carson E. Moseley, Ravi Dandekar, Collin M. Spencer, Alan S. Verkman, Ole Petter Ottersen, Raymond A. Sobel, John Sidney, Alessandro Sette, Mark S. Anderson, Lawrence Steinman, Michael R. Wilson, Joseph J. Sabatino, Jr., Scott S. Zamvil

Proc Natl Acad Sci U S A. 2023 Jul 25; 120(30): e2306572120. Published online 2023 Jul 18. doi: 10.1073/pnas.2306572120

PMCID:: PMC10372680

Abstract Article PDF–1.3M

Select item 1031840712.

Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus

Daniel A. Michelson, Chong Zuo, Michael Verzi, Christophe Benoist, Diane Mathis

J Exp Med. 2023 Oct 2; 220(10): e20230461. Published online 2023 Jul 3. doi: 10.1084/jem.20230461

PMCID:: PMC10318407

Abstract Article PDF–6.6M

Select item 1031544013.

Cutting Edge: Aire Is a Coactivator of the Vitamin D Receptor

Patricio Artusa, Marie-Ève Lebel, Camille Barbier, Babak Memari, Reyhaneh Salehi-Tabar, Sophia Karabatsos, Aiten Ismailova, Heather J. Melichar, John H. White

J Immunol. 2023 Jul 15; 211(2): 175–179. Published online 2023 Jun 2. doi: 10.4049/jimmunol.2300207

PMCID:: PMC10315440

Abstract Article PDF–2.2M

Select item 986032114.

CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance

Daniel A. Michelson, Christophe Benoist, Diane Mathis

Proc Natl Acad Sci U S A. 2022 Nov 29; 119(48): e2215474119. Published online 2022 Nov 21. doi: 10.1073/pnas.2215474119

PMCID:: PMC9860321

Abstract Article PDF–2.9M

Select item 984881015.

Characterisation of APS-1 Experimental Models Is Crucial for Development of Novel Therapies

Sarah Almaghrabi, Thomas Lovewell, Mimoun Azzouz, Rachid Tazi Ahnini

Biomed Res Int. 2023; 2023: 7960443. Published online 2023 Jan 11. doi: 10.1155/2023/7960443

PMCID:: PMC9848810

Abstract Article PDF–2.2M

Select item 956330816.

AIRE in Male Fertility: A New Hypothesis

Jana Petrusová, Jasper Manning, Dominik Filipp

Cells. 2022 Oct; 11(19): 3168. Published online 2022 Oct 9. doi: 10.3390/cells11193168

PMCID:: PMC9563308

Abstract Article PDF–935K

Select item 954993217.

A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration

Yael Efraim, Feeling Yu Ting Chen, Ka Neng Cheong, Eliza A. Gaylord, Nancy A. McNamara, Sarah M. Knox

Cell Rep. Author manuscript; available in PMC 2022 Oct 10.

Published in final edited form as: Cell Rep. 2022 Aug 30; 40(9): 111307. doi: 10.1016/j.celrep.2022.111307

PMCID:: PMC9549932

Abstract Article PDF–2.7M

Select item 946946518.

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

Daniel A. Michelson, Koji Hase, Tsuneyasu Kaisho, Christophe Benoist, Diane Mathis

Cell. Author manuscript; available in PMC 2023 Jul 7.

Published in final edited form as: Cell. 2022 Jul 7; 185(14): 2542–2558.e18. Published online 2022 Jun 16. doi: 10.1016/j.cell.2022.05.018

PMCID:: PMC9469465

Abstract Article PDF–3.2M

Select item 936301919.

Extrathymic Aire-expressing cells support maternal-fetal tolerance

Eva Gillis-Buck, Haleigh Miller, Marina Sirota, Stephan J. Sanders, Vasilis Ntranos, Mark S. Anderson, James M. Gardner, Tippi C. MacKenzie

Sci Immunol. Author manuscript; available in PMC 2022 Aug 9.

Published in final edited form as: Sci Immunol. 2021 Jul 16; 6(61): eabf1968. doi: 10.1126/sciimmunol.abf1968

PMCID:: PMC9363019

Abstract Article PDF–2.1M

Select item 927121820.

Hassall’s corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus

Jianwei Wang, Miho Sekai, Takeshi Matsui, Yosuke Fujii, Mitsuru Matsumoto, Osamu Takeuchi, Nagahiro Minato, Yoko Hamazaki

Int Immunol. 2019 Mar; 31(3): 127–139. Published online 2018 Dec 10. doi: 10.1093/intimm/dxy073

PMCID:: PMC9271218

Abstract Article PDF–3.0M

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