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Items: 1 to 20 of 273

1.
PKCδ serves as a potential biomarker and therapeutic target for microglia‐mediated neuroinflammation in Alzheimer's disease
Ying Du, Tiantian Guo, Yunfeng Hao, Chuan Li, Linghui Tang, Xia Li, Xiaoxiao Zhang, Lin Li, Dan Yao, Xia Xu, Huaxing Si, Jinghan Zhang, Nana Zhao, Tong Yu, Yingjun Zhao, Wei Zhang, Huaxi Xu
Alzheimers Dement. 2024 Aug; 20(8): 5511–5527. Published online 2024 Jun 28. doi: 10.1002/alz.14047
PMCID:
PMC11350009
AbstractArticlePDF–7.9M
2.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
3.
Protein kinase C‐δ regulates the stability of hypoxia‐inducible factor‐1α under hypoxia
Ji‐Won Lee, Jeong Ae Park, Se‐Hee Kim, Ji Hae Seo, Kyung‐Joon Lim, Joo‐Won Jeong, Chul‐Ho Jeong, Kwang‐Hoon Chun, Seung‐Ki Lee, Young‐Guen Kwon, Kyu‐Won Kim
Cancer Sci. 2007 Sep; 98(9): 1476–1481. Published online 2007 Jun 30. doi: 10.1111/j.1349-7006.2007.00535.x
PMCID:
PMC11160108
AbstractArticlePDF–527K
4.
Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line
Angel García-Lora, Marisol Martinez, Susana Pedrinaci, Federico Garrido
Cancer Immunol Immunother. 2003 Jan; 52(1): 59–64. Published online 2002 Oct 17. doi: 10.1007/s00262-002-0336-9
PMCID:
PMC11034184
AbstractArticlePDF–327K
5.
Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression
Yujiao Deng, Zhanwu Hou, Yizhen Li, Ming Yi, Ying Wu, Yi Zheng, Fei Yang, Guansheng Zhong, Qian Hao, Zhen Zhai, Meng Wang, Xiaobin Ma, Huafeng Kang, Fanpu Ji, Chenfang Dong, Huadong Liu, Zhijun Dai
Cell Commun Signal. 2024; 22: 115. Published online 2024 Feb 12. doi: 10.1186/s12964-024-01487-z
PMCID:
PMC10860301
AbstractArticlePDF–13M
6.
Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer
Mehdi Chaib, Jeremiah R. Holt, Emilie L. Fisher, Laura M. Sipe, Margaret S. Bohm, Sydney C. Joseph, Boston W. Simmons, Samson Eugin Simon, Johnathan R. Yarbro, Ubaid Tanveer, Jessica L. Halle, James A. Carson, T.J. Hollingsworth, QingQing Wei, Jeffrey C. Rathmell, Paul G. Thomas, D. Neil Hayes, Liza Makowski
Sci Adv. 2023 Dec 22; 9(51): eadd3231. Published online 2023 Dec 22. doi: 10.1126/sciadv.add3231
PMCID:
PMC10745701
AbstractArticlePDF–2.0M
7.
Thrombin-Induced COX-2 Expression and PGE2 Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCδ/Pyk2-Dependent AP-1 Pathway Modulation
Chien-Chung Yang, I-Ta Lee, Yan-Jyun Lin, Wen-Bin Wu, Li-Der Hsiao, Chuen-Mao Yang
Int J Mol Sci. 2023 Oct; 24(20): 15130. Published online 2023 Oct 13. doi: 10.3390/ijms242015130
PMCID:
PMC10606820
AbstractArticlePDF–5.9M
8.
Metabolic reprogramming contributes to radioprotection by protein kinase Cδ
Angela M. Ohm, Trisiani Affandi, Julie A. Reisz, M. Cecilia Caino, Angelo D’Alessandro, Mary E. Reyland
J Biol Chem. 2023 Oct; 299(10): 105186. Published online 2023 Aug 21. doi: 10.1016/j.jbc.2023.105186
PMCID:
PMC10519828
AbstractArticlePDF–1.4M
9.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
10.
Inhibition of protein kinase C delta leads to cellular senescence to induce anti‐tumor effects in colorectal cancer
Yuya Shimoyama, Kohji Yamada, Saishu Yoshida, Akira Kawamura, Yoshito Hannya, Yuta Imaizumi, Tomotaka Kumamoto, Yasuhiro Takeda, Masayuki Shimoda, Ken Eto, Kiyotsugu Yoshida
Cancer Sci. 2023 Jun; 114(6): 2471–2484. Published online 2023 Mar 14. doi: 10.1111/cas.15768
PMCID:
PMC10236638
AbstractArticlePDF–17M
11.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
12.
Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator
Cláudia Bessa, Joana B. Loureiro, Matilde Barros, Vera M. S. Isca, Vilma A. Sardão, Paulo J. Oliveira, Raquel L. Bernardino, Carina Herman-de-Sousa, Maria Adelina Costa, Paulo Correia-de-Sá, Marco G. Alves, Patrícia Rijo, Lucília Saraiva
Int J Mol Sci. 2023 Mar; 24(6): 5710. Published online 2023 Mar 16. doi: 10.3390/ijms24065710
PMCID:
PMC10054007
AbstractArticlePDF–2.8M
13.
Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation
Faik Imeri, Bisera Stepanovska Tanturovska, Roxana Manaila, Hermann Pavenstädt, Josef Pfeilschifter, Andrea Huwiler
Int J Mol Sci. 2023 Feb; 24(4): 3267. Published online 2023 Feb 7. doi: 10.3390/ijms24043267
PMCID:
PMC9965238
AbstractArticlePDF–2.3M
14.
Genetic association of PRKCD and CARD9 polymorphisms with Vogt–Koyanagi–Harada disease in the Chinese Han population
Chunya Zhou, Shiya Cai, Yuhong Xie, Zhen Zeng, Jun Zhang, Guannan Su, Qiuying Wu, Xingsheng Ye, Qingfeng Cao, Peizeng Yang, Jianmin Hu
Hum Genomics. 2023; 17: 9. Published online 2023 Feb 13. doi: 10.1186/s40246-023-00459-7
PMCID:
PMC9926551
AbstractArticlePDF–896K
15.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
16.
The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2
Boyan Li, Rongrong Zhao, Wei Qiu, Ziwen Pan, Shulin Zhao, Yanhua Qi, Jiawei Qiu, Shouji Zhang, Qindong Guo, Yang Fan, Hao Xu, Ming Li, Gang Li, Hao Xue
Theranostics. 2022; 12(14): 6363–6379. Published online 2022 Aug 29. doi: 10.7150/thno.74600
PMCID:
PMC9475453
AbstractArticlePDF–4.4M
17.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
18.
Extracellular PKCδ signals to epidermal growth factor receptor for tumor proliferation in liver cancer cells
Kohji Yamada, Ryusuke Kizawa, Ayano Yoshida, Rei Koizumi, Saya Motohashi, Yuya Shimoyama, Yoshito Hannya, Saishu Yoshida, Tsunekazu Oikawa, Masayuki Shimoda, Kiyotsugu Yoshida
Cancer Sci. 2022 Jul; 113(7): 2378–2385. Published online 2022 May 12. doi: 10.1111/cas.15386
PMCID:
PMC9277411
AbstractArticlePDF–2.4M
19.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
20.
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang
J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009
PMCID:
PMC9058836
AbstractArticlePDF–2.9M

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