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Select item 110933601.

The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions

Irene Fasciani, Francesco Petragnano, Ziming Wang, Ruairidh Edwards, Narasimha Telugu, Ilaria Pietrantoni, Ulrike Zabel, Henrik Zauber, Marlies Grieben, Maria E. Terzenidou, Jacopo Di Gregorio, Cristina Pellegrini, Silvano Santini, Jr, Anna R. Taddei, Bärbel Pohl, Stefano Aringhieri, Marco Carli, Gabriella Aloisi, Francesco Marampon, Eve Charlesworth, Alexandra Roman, Sebastian Diecke, Vincenzo Flati, Franco Giorgi, Fernanda Amicarelli, Andrew B. Tobin, Marco Scarselli, Kostas Tokatlidis, Mario Rossi, Martin J. Lohse, Paolo Annibale, Roberto Maggio

PLoS Biol. 2024 Apr; 22(4): e3002582. Published online 2024 Apr 29. doi: 10.1371/journal.pbio.3002582

PMCID:: PMC11093360

Abstract Article PDF–4.4M

Select item 86961132.

Deep learning-based classification of breast cancer cells using transmembrane receptor dynamics

Mirae Kim, Soonwoo Hong, Thomas E Yankeelov, Hsin-Chih Yeh, Yen-Liang Liu

Bioinformatics. 2022 Jan 1; 38(1): 243–249. Published online 2021 Aug 15. doi: 10.1093/bioinformatics/btab581

PMCID:: PMC8696113

Abstract Article PDF–583K

Select item 86354173.

Vibrational spectroscopy analysis of ligand efficacy in human M₂ muscarinic acetylcholine receptor (M₂R)

Kota Katayama, Kohei Suzuki, Ryoji Suno, Ryoji Kise, Hirokazu Tsujimoto, So Iwata, Asuka Inoue, Takuya Kobayashi, Hideki Kandori

Commun Biol. 2021; 4: 1321. Published online 2021 Nov 23. doi: 10.1038/s42003-021-02836-1

PMCID:: PMC8635417

Abstract Article PDF–2.0M

Select item 83062994.

M2 Muscarinic Receptor Activation Impairs Mitotic Progression and Bipolar Mitotic Spindle Formation in Human Glioblastoma Cell Lines

Maria Di Bari, Vanessa Tombolillo, Francesco Alessandrini, Claudia Guerriero, Mario Fiore, Italia Anna Asteriti, Emilia Castigli, Miriam Sciaccaluga, Giulia Guarguaglini, Francesca Degrassi, Ada Maria Tata

Cells. 2021 Jul; 10(7): 1727. Published online 2021 Jul 8. doi: 10.3390/cells10071727

PMCID:: PMC8306299

Abstract Article PDF–2.1M

Select item 76708795.

CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients

Silvia Jiménez-Morales, Juan Luis Jiménez-Ruíz, Blanca Estela Del Río-Navarro, Efraín Navarro-Olivos, Guillermo Escamilla-Guerrero, Ram Savan, Michael Dean, Lorena Orozco

Mol Biol Rep. Author manuscript; available in PMC 2020 Nov 17.

Published in final edited form as: Mol Biol Rep. 2014; 41(4): 2109–2117. Published online 2014 Jan 16. doi: 10.1007/s11033-014-3060-6

PMCID:: PMC7670879

Abstract Article PDF–468K

Select item 71623006.

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection

Wai Fook Leong, Vincent T. K. Chow

Cell Microbiol. 2006 Apr; 8(4): 565–580. Published online 2005 Nov 8. doi: 10.1111/j.1462-5822.2005.00644.x

PMCID:: PMC7162300

Abstract Article PDF–345K

Select item 71406747.

Cross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and Survival

Ilaria Cristofaro, Francesco Alessandrini, Zaira Spinello, Claudia Guerriero, Mario Fiore, Elisa Caffarelli, Pietro Laneve, Luciana Dini, Luciano Conti, Ada Maria Tata

Cells. 2020 Mar; 9(3): 657. Published online 2020 Mar 9. doi: 10.3390/cells9030657

PMCID:: PMC7140674

Abstract Article PDF–4.5M

Select item 70330918.

Modeling the allosteric modulation on a G-Protein Coupled Receptor: the case of M2 muscarinic Acetylcholine Receptor in complex with LY211960

L. Maggi, P. Carloni, G. Rossetti

Sci Rep. 2020; 10: 3037. Published online 2020 Feb 20. doi: 10.1038/s41598-020-59289-5

PMCID:: PMC7033091

Abstract Article PDF–2.0M

Select item 61666829.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 589947610.

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling

Dean P. Staus, Laura M. Wingler, Minjung Choi, Biswaranjan Pani, Aashish Manglik, Andrew C. Kruse, Robert J. Lefkowitz

Proc Natl Acad Sci U S A. 2018 Apr 10; 115(15): 3834–3839. Published online 2018 Mar 26. doi: 10.1073/pnas.1722336115

PMCID:: PMC5899476

Abstract Article PDF–823K

Select item 580546611.

Intracellular Permeation of Na⁺ in an Active State G-Protein Coupled Receptor

Owen N. Vickery, Catarina A. Carvalheda, Saheem A. Zaidi, Andrei V. Pisliakov, Vsevolod Katritch, Ulrich Zachariae

Structure. Author manuscript; available in PMC 2019 Jan 2.

Published in final edited form as: Structure. 2018 Jan 2; 26(1): 171–180.e2. Published online 2017 Dec 14. doi: 10.1016/j.str.2017.11.013

PMCID:: PMC5805466

Abstract Article PDF–1.3M

Select item 537173012.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 508701813.

Graded activation and free energy landscapes of a muscarinic G-protein–coupled receptor

Yinglong Miao, J. Andrew McCammon

Proc Natl Acad Sci U S A. 2016 Oct 25; 113(43): 12162–12167. Published online 2016 Oct 10. doi: 10.1073/pnas.1614538113

PMCID:: PMC5087018

Abstract Article PDF–1.9M

Select item 503585914.

Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor

Yinglong Miao, Dahlia Anne Goldfeld, Ee Von Moo, Patrick M. Sexton, Arthur Christopoulos, J. Andrew McCammon, Celine Valant

Proc Natl Acad Sci U S A. 2016 Sep 20; 113(38): E5675–E5684. Published online 2016 Sep 6. doi: 10.1073/pnas.1612353113

PMCID:: PMC5035859

Abstract Article PDF–1.9M

Select item 485126415.

Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants

Andrew Stuart Gibbons, Won Je Jeon, Elizabeth Scarr, Brian Dean

Int J Neuropsychopharmacol. 2016 Apr; 19(4): pyv118. Published online 2015 Oct 16. doi: 10.1093/ijnp/pyv118

PMCID:: PMC4851264

Abstract Article PDF–4.8M

Select item 474573016.

Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC)

Qingnan Zhao, Jinnan Yue, Chun Zhang, Xiajing Gu, Hongzhuan Chen, Lu Xu

Oncotarget. 2015 Oct 6; 6(30): 29335–29346. Published online 2015 Aug 20. doi: 10.18632/oncotarget.5004

PMCID:: PMC4745730

Abstract Article PDF–3.8M

Select item 425484917.

Preliminary Evidence for Associations of CHRM2 with Substance Use and Disinhibition in Adolescence

Christian S. Hendershot, Angela D. Bryan, Sarah W. Feldstein Ewing, Eric D. Claus, Kent E. Hutchison

J Abnorm Child Psychol. Author manuscript; available in PMC 2014 Dec 4.

Published in final edited form as: J Abnorm Child Psychol. 2011 Jul; 39(5): 671–681. doi: 10.1007/s10802-011-9511-9

PMCID:: PMC4254849

Abstract Article PDF–751K

Select item 404112318.

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Verneri Anttila, Bendik S. Winsvold, Padhraig Gormley, Tobias Kurth, Francesco Bettella, George McMahon, Mikko Kallela, Rainer Malik, Boukje de Vries, Gisela Terwindt, Sarah E. Medland, Unda Todt, Wendy L. McArdle, Lydia Quaye, Markku Koiranen, M. Arfan Ikram, Terho Lehtimäki, Anine H. Stam, Lannie Ligthart, Juho Wedenoja, Ian Dunham, Benjamin M. Neale, Priit Palta, Eija Hamalainen, Markus Schürks, Lynda M Rose, Julie E. Buring, Paul M. Ridker, Stacy Steinberg, Hreinn Stefansson, Finnbogi Jakobsson, Debbie A. Lawlor, David M. Evans, Susan M. Ring, Markus Färkkilä, Ville Artto, Mari A Kaunisto, Tobias Freilinger, Jean Schoenen, Rune R. Frants, Nadine Pelzer, Claudia M. Weller, Ronald Zielman, Andrew C. Heath, Pamela A.F. Madden, Grant W. Montgomery, Nicholas G. Martin, Guntram Borck, Hartmut Göbel, Axel Heinze, Katja Heinze-Kuhn, Frances M.K. Williams, Anna-Liisa Hartikainen, Anneli Pouta, Joyce van den Ende, Andre G. Uitterlinden, Albert Hofman, Najaf Amin, Jouke-Jan Hottenga, Jacqueline M. Vink, Kauko Heikkilä, Michael Alexander, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Heinz Erich Wichmann, Arpo Aromaa, Johan G. Eriksson, Bryan Traynor, Daniah Trabzuni, North American Brain Expression Consortium, UK Brain Expression Consortium, Elizabeth Rossin, Kasper Lage, Suzanne B.R. Jacobs, J. Raphael Gibbs, Ewan Birney, Jaakko Kaprio, Brenda W. Penninx, Dorret I. Boomsma, Cornelia van Duijn, Olli Raitakari, Marjo-Riitta Jarvelin, John-Anker Zwart, Lynn Cherkas, David P. Strachan, Christian Kubisch, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Martin Dichgans, Maija Wessman, George Davey Smith, Kari Stefansson, Mark J. Daly, Dale R. Nyholt, Daniel Chasman, Aarno Palotie

Nat Genet. Author manuscript; available in PMC 2014 Jun 2.

Published in final edited form as: Nat Genet. 2013 Aug; 45(8): 912–917. Published online 2013 Jun 23. doi: 10.1038/ng.2676

PMCID:: PMC4041123

Article PDF–571K

Select item 402078919.

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Andrew C. Kruse, Aaron M. Ring, Aashish Manglik, Jianxin Hu, Kelly Hu, Katrin Eitel, Harald Hübner, Els Pardon, Celine Valant, Patrick M. Sexton, Arthur Christopoulos, Christian C. Felder, Peter Gmeiner, Jan Steyaert, William I. Weis, K. Christopher Garcia, Jürgen Wess, Brian K. Kobilka

Nature. Author manuscript; available in PMC 2014 Jun 5.

Published in final edited form as: Nature. 2013 Dec 5; 504(7478): 101–106. Published online 2013 Nov 20. doi: 10.1038/nature12735

PMCID:: PMC4020789

Abstract Article PDF–2.9M

Select item 390064320.

The Correlation between Peripartum Cardiomyopathy and Autoantibodies against Cardiovascular Receptors

Jiamei Liu, Yidan Wang, Mulei Chen, Wenshu Zhao, Xin Wang, Hua Wang, Zhiyong Zhang, Juan Zhang, Lin Xu, Jin Chen, Xinchun Yang, Lin Zhang

PLoS One. 2014; 9(1): e86770. Published online 2014 Jan 23. doi: 10.1371/journal.pone.0086770

PMCID:: PMC3900643

Abstract Article PDF–341K

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