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Select item 109485821.

GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression

Xiaoting Xi, Yanni Yang, Qianbo Chen, Jia Ma, Xuewei Wang, Yachun Deng, Xi Wang, Yan Li

Mol Biol Rep. 2024; 51(1): 428. Published online 2024 Mar 18. doi: 10.1007/s11033-024-09388-7

PMCID:: PMC10948582

Abstract Article PDF–8.1M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516153.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 92316234.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 88892565.

N-acetylglucosaminyltransferase-V requires a specific noncatalytic luminal domain for its activity toward glycoprotein substrates

Reina F. Osuka, Tetsuya Hirata, Masamichi Nagae, Miyako Nakano, Hiroyuki Shibata, Ryo Okamoto, Yasuhiko Kizuka

J Biol Chem. 2022 Mar; 298(3): 101666. Published online 2022 Jan 30. doi: 10.1016/j.jbc.2022.101666

PMCID:: PMC8889256

Abstract Article PDF–2.4M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80672927.

Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing

Emilie Marhuenda, Christine Fabre, Cunjie Zhang, Martà Martin-Fernandez, Thomas Iskratsch, Ali Saleh, Luc Bauchet, Julien Cambedouzou, Jean-Philippe Hugnot, Hugues Duffau, James W. Dennis, David Cornu, Norbert Bakalara

J Exp Clin Cancer Res. 2021; 40: 139. Published online 2021 Apr 24. doi: 10.1186/s13046-021-01925-7

PMCID:: PMC8067292

Abstract Article PDF–3.0M

Select item 80589908.

The polymorphisms of FGFR2 and MGAT5 affect the susceptibility to COPD in the Chinese people

Xiaobo Li, Guangyu Zhou, Xiaobo Tian, Fei Chen, Guoyao Li, Yipeng Ding

BMC Pulm Med. 2021; 21: 129. Published online 2021 Apr 20. doi: 10.1186/s12890-021-01498-3

PMCID:: PMC8058990

Abstract Article PDF–975K

Select item 76571689.

Clinical and prognostic implications of β1, 6‐N‐acetylglucosaminyltransferase V in patients with gastric cancer

Xuefei Wang, Hongyong He, Heng Zhang, Weidong Chen, Yuan Ji, Zhaoqing Tang, Yong Fang, Cong Wang, Fenglin Liu, Zhenbin Shen, Jing Qin, Yu Zhu, Haiou Liu, Jiejie Xu, Jianxin Gu, Xinyu Qin, Yihong Sun

Cancer Sci. 2013 Feb; 104(2): 185–193. Published online 2012 Dec 6. doi: 10.1111/cas.12049

PMCID:: PMC7657168

Abstract Article PDF–1.6M

Select item 744841610.

N-glycosylation and receptor tyrosine kinase signaling affect claudin-3 levels in colorectal cancer cells

Amelia G. Pérez, Jéssica Andrade-Da-Costa, Waldemir F. De Souza, Michelle De Souza Ferreira, Mariana Boroni, Ivanir M. De Oliveira, Carlos A. Freire-Neto, Priscila V. Fernandes, Cristóvão A. De Lanna, Paulo Thiago Souza-Santos, José A. Morgado-Díaz, Julio Cesar M. De-Freitas-Junior

Oncol Rep. 2020 Oct; 44(4): 1649–1661. Published online 2020 Aug 11. doi: 10.3892/or.2020.7727

PMCID:: PMC7448416

Abstract Article PDF–1.4M

Select item 726365311.

Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulation of T Cells Glycosylation and Plasma IgG Glycome Composition in Ulcerative Colitis

Márcia S. Pereira, Cecília Durães, Telmo A. Catarino, José L. Costa, Isabelle Cleynen, Mislav Novokmet, Jasminka Krištić, Jerko Štambuk, Nádia Conceição-Neto, José C. Machado, Ricardo Marcos-Pinto, Fernando Magro, Séverine Vermeire, Gordan Lauc, Paula Lago, Salomé S. Pinho

Clin Transl Gastroenterol. 2020 Apr; 11(4): e00166. Published online 2020 Apr 22. doi: 10.14309/ctg.0000000000000166

PMCID:: PMC7263653

Abstract Article PDF–625K

Select item 610755012.

Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V

Masamichi Nagae, Yasuhiko Kizuka, Emiko Mihara, Yu Kitago, Shinya Hanashima, Yukishige Ito, Junichi Takagi, Naoyuki Taniguchi, Yoshiki Yamaguchi

Nat Commun. 2018; 9: 3380. Published online 2018 Aug 23. doi: 10.1038/s41467-018-05931-w

PMCID:: PMC6107550

Abstract Article PDF–2.1M

Select item 582692613.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 567858114.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 553161115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 471201816.

Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased β1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding

Claudia S. Priglinger, Jara Obermann, Christoph M. Szober, Juliane Merl-Pham, Uli Ohmayer, Jennifer Behler, Fabian Gruhn, Thomas C. Kreutzer, Christian Wertheimer, Arie Geerlof, Siegfried G. Priglinger, Stefanie M. Hauck

PLoS One. 2016; 11(1): e0146887. Published online 2016 Jan 13. doi: 10.1371/journal.pone.0146887

PMCID:: PMC4712018

Abstract Article PDF–5.6M

Select item 463707417.

Hexosamine-Induced TGF-β Signaling and Osteogenic Differentiation of Dental Pulp Stem Cells Are Dependent on N-Acetylglucosaminyltransferase V

Yi-Jane Chen, Chung-Chen Yao, Chien-Hsun Huang, Hao-Hueng Chang, Tai-Horng Young

Biomed Res Int. 2015; 2015: 924397. Published online 2015 Oct 25. doi: 10.1155/2015/924397

PMCID:: PMC4637074

Abstract Article PDF–3.3M

Select item 461721118.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 452862319.

Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants

Carey F. Li, Raymond W. Zhou, Haik Mkhikian, Barbara L. Newton, Zhaoxia Yu, Michael Demetriou

J Neuroimmunol. Author manuscript; available in PMC 2015 Aug 7.

Published in final edited form as: J Neuroimmunol. 2013 Mar 15; 256(0): 71–76. Published online 2013 Jan 22. doi: 10.1016/j.jneuroim.2012.12.008

PMCID:: PMC4528623

Abstract Article PDF–741K

Select item 450546220.

UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats)

Dorota Maszczak-Seneczko, Paulina Sosicka, Beata Kaczmarek, Michał Majkowski, Marcin Luzarowski, Teresa Olczak, Mariusz Olczak

J Biol Chem. 2015 Jun 19; 290(25): 15475–15486. Published online 2015 May 5. doi: 10.1074/jbc.M115.636670

PMCID:: PMC4505462

Abstract Article PDF–2.4M

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