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Select item 94860521.

Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication

Ruo-Wen Xiao, Fang Wang, Tong-Min Wang, Jiang-Bo Zhang, Zi-Yi Wu, Chang-Mi Deng, Ying Liao, Ting Zhou, Da-Wei Yang, Si-Qi Dong, Wen-Qiong Xue, Yong-Qiao He, Xiao-Hui Zheng, Xi-Zhao Li, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Yu-Ying Liu, Yun-Fei Xia, Song Gao, Jian-Bing Mu, Lin Feng, Wei-Hua Jia

eBioMedicine. 2022 Oct; 84: 104267. Published online 2022 Sep 15. doi: 10.1016/j.ebiom.2022.104267

PMCID:: PMC9486052

Abstract Article PDF–3.4M

Select item 84638532.

DNA polymerases η and κ bypass N²-guanine-O⁶-alkylguanine DNA alkyltransferase cross-linked DNA-peptides

Pratibha P. Ghodke, F. Peter Guengerich

J Biol Chem. 2021 Oct; 297(4): 101124. Published online 2021 Aug 28. doi: 10.1016/j.jbc.2021.101124

PMCID:: PMC8463853

Abstract Article PDF–1.9M

Select item 82017713.

Multiple deprotonation paths of the nucleophile 3′-OH in the DNA synthesis reaction

Mark T. Gregory, Yang Gao, Qiang Cui, Wei Yang

Proc Natl Acad Sci U S A. 2021 Jun 8; 118(23): e2103990118. Published online 2021 Jun 4. doi: 10.1073/pnas.2103990118

PMCID:: PMC8201771

Abstract Article PDF–1.5M

Select item 77461414.

Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η

Hummin Jung, Rayala Naveen Kumar, Seongmin Lee

Biochem J. Author manuscript; available in PMC 2020 Dec 17.

Published in final edited form as: Biochem J. 2020 Dec 11; 477(23): 4543–4558. doi: 10.1042/BCJ20200767

PMCID:: PMC7746141

Abstract Article PDF–2.2M

Select item 71359945.

The roles of polymerases ν and θ in replicative bypass of O⁶- and N²-alkyl-2′-deoxyguanosine lesions in human cells

Hua Du, Pengcheng Wang, Jun Wu, Xiaomei He, Yinsheng Wang

J Biol Chem. 2020 Apr 3; 295(14): 4556–4562. Published online 2020 Feb 25. doi: 10.1074/jbc.RA120.012830

PMCID:: PMC7135994

Abstract Article PDF–1.0M

Select item 66578086.

Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase η

Hala Ouzon-Shubeita, Meghan Baker, Myong-Chul Koag, Seongmin Lee

Biochem J. Author manuscript; available in PMC 2019 Jul 25.

Published in final edited form as: Biochem J. 2019 Feb 28; 476(4): 747–758. Published online 2019 Feb 28. doi: 10.1042/BCJ20180848

PMCID:: PMC6657808

Abstract Article PDF–1.1M

Select item 64636947.

Human DNA polymerase η has reverse transcriptase activity in cellular environments

Yan Su, Pratibha P. Ghodke, Martin Egli, Lin Li, Yinsheng Wang, F. Peter Guengerich

J Biol Chem. 2019 Apr 12; 294(15): 6073–6081. Published online 2019 Mar 6. doi: 10.1074/jbc.RA119.007925

PMCID:: PMC6463694

Abstract Article PDF–1.1M

Select item 64264558.

Mapping the genetic landscape of human cells

Max A. Horlbeck, Albert Xu, Min Wang, Neal K. Bennett, Chong Y. Park, Derek Bogdanoff, Britt Adamson, Eric D. Chow, Martin Kampmann, Tim R. Peterson, Ken Nakamura, Michael A. Fischbach, Jonathan S. Weissman, Luke A. Gilbert

Cell. Author manuscript; available in PMC 2019 Aug 9.

Published in final edited form as: Cell. 2018 Aug 9; 174(4): 953–967.e22. Published online 2018 Jul 19. doi: 10.1016/j.cell.2018.06.010

PMCID:: PMC6426455

Abstract Article PDF–3.6M

Select item 63197599.

Crystallographic evidence for two‐metal‐ion catalysis in human pol η

Jimin Wang, Zachary B. Smithline

Protein Sci. 2019 Feb; 28(2): 439–447. Published online 2018 Dec 11. doi: 10.1002/pro.3541

PMCID:: PMC6319759

Abstract Article PDF–3.7M

Select item 607772210.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 582744511.

Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct

Jung-Hoon Yoon, Richard P. Hodge, Linda C. Hackfeld, Jeseong Park, Jayati Roy Choudhury, Satya Prakash, Louise Prakash

J Biol Chem. 2018 Feb 23; 293(8): 2949–2958. Published online 2018 Jan 12. doi: 10.1074/jbc.RA117.000962

PMCID:: PMC5827445

Abstract Article PDF–722K

Select item 510495012.

Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O⁶-Methyl-2′-deoxyguanosine by Human DNA Polymerase η

Amitraj Patra, Qianqian Zhang, F. Peter Guengerich, Martin Egli

J Biol Chem. 2016 Nov 11; 291(46): 24304–24313. Published online 2016 Sep 30. doi: 10.1074/jbc.M116.755462

PMCID:: PMC5104950

Abstract Article PDF–3.2M

Select item 493317213.

Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N⁶-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η

Amritraj Patra, Yan Su, Qianqian Zhang, Kevin M. Johnson, F. Peter Guengerich, Martin Egli

J Biol Chem. 2016 Jul 1; 291(27): 14134–14145. Published online 2016 May 16. doi: 10.1074/jbc.M116.732487

PMCID:: PMC4933172

Abstract Article PDF–3.9M

Select item 486144214.

The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1

Elizabeth M. Boehm, Kyle T. Powers, Christine M. Kondratick, Maria Spies, Jon C. D. Houtman, M. Todd Washington

J Biol Chem. 2016 Apr 15; 291(16): 8735–8744. Published online 2016 Feb 22. doi: 10.1074/jbc.M115.697938

PMCID:: PMC4861442

Abstract Article PDF–2.0M

Select item 475915615.

Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η

Yan Su, Martin Egli, F. Peter Guengerich

J Biol Chem. 2016 Feb 19; 291(8): 3747–3756. Published online 2016 Jan 6. doi: 10.1074/jbc.M115.706226

PMCID:: PMC4759156

Abstract Article PDF–3.0M

Select item 459181416.

Conserved Overlapping Gene Arrangement, Restricted Expression, and Biochemical Activities of DNA Polymerase ν (POLN)

Kei-ichi Takata, Junya Tomida, Shelley Reh, Lisa M. Swanhart, Minoru Takata, Neil A. Hukriede, Richard D. Wood

J Biol Chem. 2015 Oct 2; 290(40): 24278–24293. Published online 2015 Aug 12. doi: 10.1074/jbc.M115.677419

PMCID:: PMC4591814

Abstract Article PDF–3.2M

Select item 448122817.

Human DNA Polymerase ν Catalyzes Correct and Incorrect DNA Synthesis with High Catalytic Efficiency

A. S. Prakasha Gowda, George-Lucian Moldovan, Thomas E. Spratt

J Biol Chem. 2015 Jun 26; 290(26): 16292–16303. Published online 2015 May 11. doi: 10.1074/jbc.M115.653287

PMCID:: PMC4481228

Abstract Article PDF–1007K

Select item 351677418.

Enhancement of Human DNA Polymerase η Activity and Fidelity Is Dependent Upon a Bipartite Interaction with the Werner Syndrome Protein

Leena Maddukuri, Amit Ketkar, Sarah Eddy, Maroof K. Zafar, Wezley C. Griffin, Robert L. Eoff

J Biol Chem. 2012 Dec 7; 287(50): 42312–42323. Published online 2012 Oct 8. doi: 10.1074/jbc.M112.410332

PMCID:: PMC3516774

Abstract Article PDF–1.8M

Select item 342167419.

Epstein-Barr Virus BPLF1 Deubiquitinates PCNA and Attenuates Polymerase η Recruitment to DNA Damage Sites

Christopher B. Whitehurst, Cyrus Vaziri, Julia Shackelford, Joseph S. Pagano

J Virol. 2012 Aug; 86(15): 8097–8106. doi: 10.1128/JVI.00588-12

PMCID:: PMC3421674

Abstract Article PDF–1.4M

Select item 335692120.

A Comprehensive Genetic Association Study of Alzheimer Disease in African Americans

Dr. Mark W. Logue, Messr. Matthew Schu, Messr. Badri N. Vardarajan, Ms Jacki Buros, Dr. Robert C. Green, Dr. Rodney C. P. Go, Dr. Patrick Griffith, Dr. Thomas O. Obisesan, Dr. Rhonna Shatz, Dr. Amy Borenstein, Dr. L. Adrienne Cupples, Dr. Kathryn L. Lunetta, Dr. M. Daniele Fallin, Dr. Clinton T. Baldwin, Dr. Lindsay A. Farrer

Arch Neurol. Author manuscript; available in PMC 2012 May 21.

Published in final edited form as: Arch Neurol. 2011 Dec; 68(12): 1569–1579. doi: 10.1001/archneurol.2011.646

PMCID:: PMC3356921

Abstract Article PDF–1.4M

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