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Select item 111724251.

Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells

Jung-Eun Lee, Ju-Hyun Lee, Jung-Min Koh, Dong-Soon Im

Int J Mol Sci. 2024 Jun; 25(11): 5866. Published online 2024 May 28. doi: 10.3390/ijms25115866

PMCID:: PMC11172425

Abstract Article PDF–3.8M

Select item 109150952.

Oral Clostridium butyricum on mice endometritis through uterine microbiome and metabolic alternations

Mao Hagihara, Tadashi Ariyoshi, Shuhei Eguchi, Kentaro Oka, Motomichi Takahashi, Hideo Kato, Yuichi Shibata, Takumi Umemura, Takeshi Mori, Narimi Miyazaki, Jun Hirai, Nobuhiro Asai, Nobuaki Mori, Hiroshige Mikamo

Front Microbiol. 2024; 15: 1351899. Published online 2024 Feb 21. doi: 10.3389/fmicb.2024.1351899

PMCID:: PMC10915095

Abstract Article PDF–2.7M

Select item 108367233.

Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome

Wei Wang, Jinyou Li, Siyuan Cui, Jiayu Li, Xianlong Ye, Zhe Wang, Tingting Zhang, Xuan Jiang, Yulin Kong, Xin Chen, Yong Q. Chen, Shenglong Zhu

Sci Adv. 2024 Feb 2; 10(5): eadj7813. Published online 2024 Feb 2. doi: 10.1126/sciadv.adj7813

PMCID:: PMC10836723

Abstract Article PDF–7.2M

Select item 107295324.

Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness- and anxiety-like behaviors

Shingo Nakajima, Geneviève Demers, Arturo Israel Machuca-Parra, Zahra Dashtehei Pour, Diane Bairamian, Khalil Bouyakdan, Alexandre Fisette, Anita Kabahizi, Josephine Robb, Demetra Rodaros, Cyril Laurent, Guillaume Ferreira, Nathalie Arbour, Thierry Alquier, Stephanie Fulton

J Neuroinflammation. 2023; 20: 302. Published online 2023 Dec 19. doi: 10.1186/s12974-023-02978-5

PMCID:: PMC10729532

Abstract Article PDF–6.5M

Select item 107071075.

Generating Bone Marrow Chimeric Mouse Using GPR120 Deficient Mouse for the Study of DHA Inhibitory Effect on Osteoclast Formation and Bone Resorption

Jinghan Ma, Hideki Kitaura, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Ria Kinjo, Kayoko Kanou, Jiayi Ren, Mariko Miura, Kohei Narita, Itaru Mizoguchi

Int J Mol Sci. 2023 Dec; 24(23): 17000. Published online 2023 Nov 30. doi: 10.3390/ijms242317000

PMCID:: PMC10707107

Abstract Article PDF–2.7M

Select item 106540946.

Akkermansia muciniphila supplementation improves glucose tolerance in intestinal Ffar4 knockout mice during the daily light to dark transition

Zhe Wang, Siyuan Cui, TingTing Zhang, Wei Wang, JiaYu Li, Y. Q. Chen, Sheng long Zhu

mSystems. 2023 Sep-Oct; 8(5): e00573-23. Published online 2023 Oct 3. doi: 10.1128/msystems.00573-23

PMCID:: PMC10654094

Abstract Article PDF–2.7M

Select item 102093407.

FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome

Naixin Zhang, Brian Harsch, Michael J. Zhang, Dylan J. Gyberg, Jackie A. Stevens, Brandon M. Wagner, Jenna Mendelson, Michael T. Patterson, Devin A. Orchard, Chastity L. Healy, Jesse W. Williams, DeWayne Townsend, Gregory C. Shearer, Katherine A. Murphy, Timothy D. O'Connell

J Lipid Res. 2023 Jun; 64(6): 100374. Published online 2023 Apr 17. doi: 10.1016/j.jlr.2023.100374

PMCID:: PMC10209340

Abstract Article PDF–1.5M

Select item 101389358.

Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA)

Stefanie N. Sveiven, Kyle Anesko, Joshua Morgan, Meera G. Nair, Tara M. Nordgren

Int J Mol Sci. 2023 Apr; 24(8): 7072. Published online 2023 Apr 11. doi: 10.3390/ijms24087072

PMCID:: PMC10138935

Abstract Article PDF–2.8M

Select item 100269049.

GPR120 promotes neutrophil control of intestinal bacterial infection

Zheng Zhou, Wenjing Yang, Tianming Yu, Yu Yu, Xiaojing Zhao, Yanbo Yu, Chuncai Gu, Anthony J Bilotta, Suxia Yao, Qihong Zhao, George Golovko, Mingsong Li, Yingzi Cong

Gut Microbes. 2023; 15(1): 2190311. Published online 2023 Mar 16. doi: 10.1080/19490976.2023.2190311

Correction in:: Gut Microbes. 2024; 16(1): 2329383.

PMCID:: PMC10026904

Abstract Article PDF–1.5M

Select item 991970610.

Endogenous n-3 PUFAs Improve Non-Alcoholic Fatty Liver Disease through FFAR4-Mediated Gut–Liver Crosstalk

Xuan Jiang, Qin Yang, Hongyan Qu, Yongquan Chen, Shenglong Zhu

Nutrients. 2023 Feb; 15(3): 586. Published online 2023 Jan 22. doi: 10.3390/nu15030586

PMCID:: PMC9919706

Abstract Article PDF–3.6M

Select item 988998811.

Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and orthodontic tooth movement through GPR120

Jinghan Ma, Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Kayoko Kanou, Akiko Kishikawa, Atsuhiko Ichimura, Itaru Mizoguchi

Front Immunol. 2022; 13: 929690. Published online 2023 Jan 18. doi: 10.3389/fimmu.2022.929690

PMCID:: PMC9889988

Abstract Article PDF–14M

Select item 971254412.

FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury

Letian Yang, Bo Wang, Fan Guo, Rongshuang Huang, Yan Liang, Lingzhi Li, Sibei Tao, Ting Yin, Ping Fu, Liang Ma

Signal Transduct Target Ther. 2022; 7: 384. Published online 2022 Nov 30. doi: 10.1038/s41392-022-01254-x

PMCID:: PMC9712544

Abstract Article PDF–9.7M

Select item 954492813.

The role of free fatty acid receptor pathways in a selective regulation of TRPA1 and TRPV1 by resolvins in primary sensory neurons

Hyun‐jeong Pyo, Xue An, Hana Cho

J Cell Physiol. 2022 Sep; 237(9): 3651–3660. Published online 2022 Jul 8. doi: 10.1002/jcp.30826

PMCID:: PMC9544928

Abstract Article PDF–1.3M

Select item 930882314.

Effects of dietary omega-3 fatty acids on orthotopic prostate cancer progression, tumor associated macrophages, angiogenesis and T-cell activation—dependence on GPR120

Pei Liang, Susanne M. Henning, Tristan Grogan, David Elashoff, Huihui Ye, Pinchas Cohen, William J. Aronson

Prostate Cancer Prostatic Dis. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: Prostate Cancer Prostatic Dis. 2022 Sep; 25(3): 539–546. Published online 2022 Jan 24. doi: 10.1038/s41391-021-00440-2

PMCID:: PMC9308823

Abstract Article PDF–564K

Select item 912024315.

Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway

Shenglong Zhu, Jingwei Zhang, Xuan Jiang, Wei Wang, Yong Q. Chen

eBioMedicine. 2022 Jun; 80: 104060. Published online 2022 May 16. doi: 10.1016/j.ebiom.2022.104060

PMCID:: PMC9120243

Abstract Article PDF–4.9M

Select item 893006916.

Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload

Katherine A Murphy, Brian A Harsch, Chastity L Healy, Sonal S Joshi, Shue Huang, Rachel E Walker, Brandon M Wagner, Katherine M Ernste, Wei Huang, Robert C Block, Casey D Wright, Nathan Tintle, Brian C Jensen, Quinn S Wells, Gregory C Shearer, Timothy D O’Connell

Cardiovasc Res. 2022 Mar; 118(4): 1061–1073. Published online 2021 Mar 22. doi: 10.1093/cvr/cvab111

PMCID:: PMC8930069

Abstract Article PDF–1.1M

Select item 874881917.

GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity

Federica Rubbino, Valentina Garlatti, Valeria Garzarelli, Luca Massimino, Salvatore Spanò, Paolo Iadarola, Maddalena Cagnone, Martin Giera, Marieke Heijink, Simone Guglielmetti, Vincenzo Arena, Alberto Malesci, Luigi Laghi, Silvio Danese, Stefania Vetrano

Sci Rep. 2022; 12: 381. Published online 2022 Jan 10. doi: 10.1038/s41598-021-03787-7

PMCID:: PMC8748819

Abstract Article PDF–6.1M

Select item 871118818.

A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD₂-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus

Kensuke Iwasa, Shinji Yamamoto, Kota Yamashina, Nan Yagishita-kyo, Kei Maruyama, Takeo Awaji, Yoshinori Takei, Akira Hirasawa, Keisuke Yoshikawa

J Neuroinflammation. 2021; 18: 304. Published online 2021 Dec 27. doi: 10.1186/s12974-021-02361-2

PMCID:: PMC8711188

Abstract Article PDF–2.9M

Select item 867829419.

GPR120 inhibits colitis through regulation of CD4⁺T cell IL-10 production

Wenjing Yang, Han Liu, Leiqi Xu, Tianming Yu, Xiaojing Zhao, Suxia Yao, Qihong Zhao, Sean Barnes, Steven M. Cohn, Sara M. Dann, Hongjie Zhang, Xiuli Zuo, Yanqing Li, Yingzi Cong

Gastroenterology. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Gastroenterology. 2022 Jan; 162(1): 150–165. Published online 2021 Sep 16. doi: 10.1053/j.gastro.2021.09.018

PMCID:: PMC8678294

Abstract Article PDF–3.2M

Select item 862765020.

Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice

Yohei Tomita, Bertan Cakir, Chi-Hsiu Liu, Zhongjie Fu, Shuo Huang, Steve S. Cho, William R. Britton, Ye Sun, Mark Puder, Ann Hellström, Saswata Talukdar, Lois E. H. Smith

Angiogenesis. Author manuscript; available in PMC 2021 Nov 28.

Published in final edited form as: Angiogenesis. 2020 Aug; 23(3): 385–394. Published online 2020 Mar 5. doi: 10.1007/s10456-020-09717-x