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Select item 111905581.

Deciphering pathophysiological mechanisms underlying cystathionine beta-synthase-deficient homocystinuria using targeted metabolomics, liver proteomics, sphingolipidomics and analysis of mitochondrial function

Tomas Majtan, Thomas Olsen, Jitka Sokolova, Jakub Krijt, Michaela Křížková, Tomoaki Ida, Tamás Ditrói, Hana Hansikova, Ondrej Vit, Jiri Petrak, Ladislav Kuchař, Warren D. Kruger, Péter Nagy, Takaaki Akaike, Viktor Kožich

Redox Biol. 2024 Jul; 73: 103222. Published online 2024 Jun 4. doi: 10.1016/j.redox.2024.103222

PMCID:: PMC11190558

Abstract Article PDF–6.0M

Select item 109586162.

ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer

Junjia Liu, Xinyi Lu, Siyu Zeng, Rong Fu, Xindong Wang, Lingtao Luo, Ting Huang, Xusheng Deng, Hualei Zheng, Shaoqian Ma, Dan Ning, Lili Zong, Shu-Hai Lin, Yongyou Zhang

Redox Biol. 2024 May; 71: 103118. Published online 2024 Mar 8. doi: 10.1016/j.redox.2024.103118

PMCID:: PMC10958616

Abstract Article PDF–20M

Select item 106765813.

Activating transcription factor (ATF) 6 upregulates cystathionine β synthetase (CBS) expression and hydrogen sulfide (H₂S) synthesis to ameliorate liver metabolic damage

Bingzi Dong, Ying Sun, Bingfei Cheng, Yu Xue, Wei Li, Xiaofang Sun

Eur J Med Res. 2023; 28: 540. Published online 2023 Nov 25. doi: 10.1186/s40001-023-01520-w

PMCID:: PMC10676581

Abstract Article PDF–2.5M

Select item 106638244.

A role for the cystathionine-β-synthase /H₂S axis in astrocyte dysfunction in the aging brain

Anindya Dey, Pijush Kanti Pramanik, Shailendra Kumar Dhar Dwivedi, Fiifi Neizer-Ashun, Tamas Kiss, Abhrajit Ganguly, Heather Rice, Priyabrata Mukherjee, Chao Xu, Mohiuddin Ahmad, Anna Csiszar, Resham Bhattacharya

Redox Biol. 2023 Dec; 68: 102958. Published online 2023 Nov 6. doi: 10.1016/j.redox.2023.102958

PMCID:: PMC10663824

Abstract Article PDF–4.7M

Select item 102840675.

Cystine/Glutamate Xc^– Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis

Karina Orlowska, Russ R. Fling, Rance Nault, Anthony L. Schilmiller, Timothy R. Zacharewski

Chem Res Toxicol. 2023 Jun 19; 36(6): 900–915. Published online 2023 May 15. doi: 10.1021/acs.chemrestox.3c00017

PMCID:: PMC10284067

Abstract Article PDF–5.5M

Select item 101384346.

Selective Hepatic Cbs Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet

Sebastiaan Lambooy, Andries Heida, Christian Joschko, Dalibor Nakladal, Azuwerus van Buiten, Niels Kloosterhuis, Nicolette Huijkman, Albert Gerding, Bart van de Sluis, Robert Henning, Leo Deelman

Int J Mol Sci. 2023 Apr; 24(8): 7019. Published online 2023 Apr 10. doi: 10.3390/ijms24087019

PMCID:: PMC10138434

Abstract Article PDF–2.3M

Select item 98656367.

Warburg Effect as a Novel Mechanism for Homocysteine-Induced Features of Age-Related Macular Degeneration

Yara A. Samra, Yusra Zaidi, Pragya Rajpurohit, Raju Raghavan, Lun Cai, Ismail Kaddour-Djebbar, Amany Tawfik

Int J Mol Sci. 2023 Jan; 24(2): 1071. Published online 2023 Jan 5. doi: 10.3390/ijms24021071

PMCID:: PMC9865636

Abstract Article PDF–7.2M

Select item 94642098.

Cystathionine β-synthase as novel endogenous regulator of lymphangiogenesis via modulating VEGF receptor 2 and 3

Niloofar Hatami, Christian Büttner, Felix Bock, Sara Simfors, Gwen Musial, André Reis, Claus Cursiefen, Thomas Clahsen

Commun Biol. 2022; 5: 950. Published online 2022 Sep 10. doi: 10.1038/s42003-022-03923-7

PMCID:: PMC9464209

Abstract Article PDF–2.3M

Select item 87784869.

A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice

Isao Ishii, Shotaro Kamata, Saki Ito, Aya Shimonaga, Maika Koizumi, Maiko Tsushima, Asumi Miura, Tomoko Nagata, Yuka Tosaka, Haruka Ohtani, Waka Kamichatani, Noriyuki Akahoshi

Int J Mol Sci. 2022 Jan; 23(2): 928. Published online 2022 Jan 15. doi: 10.3390/ijms23020928

PMCID:: PMC8778486

Abstract Article PDF–2.0M

Select item 856465810.

Homocysteine induces podocyte apoptosis by regulating miR‐1929‐5p expression through c‐Myc, DNMT1 and EZH2

Lin Xie, Shengchao Ma, Ning Ding, Yanhua Wang, Guanjun Lu, Lingbo Xu, Qingqing Wang, Kun Liu, Yuzheng Jie, Hui Zhang, Anning Yang, Yujing Gao, Huiping Zhang, Yideng Jiang

Mol Oncol. 2021 Nov; 15(11): 3203–3221. Published online 2021 Jul 19. doi: 10.1002/1878-0261.13032

PMCID:: PMC8564658

Abstract Article PDF–11M

Select item 854859611.

Liver and brain differential expression of one-carbon metabolism genes during ontogenesis

Apolline Imbard, Leslie Schwendimann, Sophie Lebon, Pierre Gressens, Henk J. Blom, Jean-François Benoist

Sci Rep. 2021; 11: 21132. Published online 2021 Oct 26. doi: 10.1038/s41598-021-00311-9

PMCID:: PMC8548596

Abstract Article PDF–1.3M

Select item 843169312.

Implication of N-Methyl-d-Aspartate Receptor in Homocysteine-Induced Age-Related Macular Degeneration

Yara A. Samra, Dina Kira, Pragya Rajpurohit, Riyaz Mohamed, Leah A. Owen, Akbar Shakoor, Ivana K. Kim, Margaret M. DeAngelis, Nader Sheibani, Mohamed Al-Shabrawey, Amany Tawfik

Int J Mol Sci. 2021 Sep; 22(17): 9356. Published online 2021 Aug 28. doi: 10.3390/ijms22179356

PMCID:: PMC8431693

Abstract Article PDF–5.8M

Select item 831507113.

Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice

Jyotirmaya Behera, Anil Kumar, Michael J. Voor, Neetu Tyagi

Theranostics. 2021; 11(16): 7715–7734. Published online 2021 Jun 22. doi: 10.7150/thno.58410

PMCID:: PMC8315071

Abstract Article PDF–3.1M

Select item 821853314.

Analysis of Differential Neonatal Lethality in Cystathionine β-Synthase Deficient Mouse Models using Metabolic Profiling

Sapna Gupta, Liqun Wang, Michael J. Slifker, Kathy Q. Cai, Kenneth N. Maclean, Brandi Wasek, Teodoro Bottiglieri, Warren D. Kruger

FASEB J. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: FASEB J. 2021 Jun; 35(6): e21629. doi: 10.1096/fj.202100302R

PMCID:: PMC8218533

Abstract Article PDF–1.8M

Select item 794762415.

Immunological Feature and Transcriptional Signaling of Ly6C Monocyte Subsets From Transcriptome Analysis in Control and Hyperhomocysteinemic Mice

Pingping Yang, Lu Liu, Lizhe Sun, Pu Fang, Nathaniel Snyder, Jason Saredy, Yong Ji, Wen Shen, Xuebin Qin, Qinghua Wu, Xiaofeng Yang, Hong Wang

Front Immunol. 2021; 12: 632333. Published online 2021 Feb 25. doi: 10.3389/fimmu.2021.632333

PMCID:: PMC7947624

Abstract Article PDF–6.0M

Select item 793877016.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 778567417.

N-methyl-D-aspartate receptor Activation, Novel Mechanism of Homocysteine Induced Blood Retinal Barrier Dysfunction

Amany Tawfik, Riyaz Mohamed, Dina Kira, Suhib Alhusban, Mohamed Al-Shabrawey

J Mol Med (Berl) Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: J Mol Med (Berl). 2021 Jan; 99(1): 119–130. Published online 2020 Nov 6. doi: 10.1007/s00109-020-02000-y

PMCID:: PMC7785674

Abstract Article PDF–1.0M

Select item 764872818.

CRY1-CBS binding regulates circadian clock function and metabolism

Sibel Cal-Kayitmazbatir, Eylem Kulkoyluoglu-Cotul, Jacqueline Growe, Christopher P. Selby, Seth D. Rhoades, Dania Malik, Hasimcan Oner, Hande Asimgil, Lauren J. Francey, Aziz Sancar, Warren D. Kruger, John B. Hogenesch, Aalim Weljie, Ron C. Anafi, Ibrahim Halil Kavakli

FEBS J. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: FEBS J. 2021 Jan; 288(2): 614–639. Published online 2020 Jun 9. doi: 10.1111/febs.15360

PMCID:: PMC7648728

Abstract Article PDF–1.8M

Select item 733639219.

Analysis of the Qatari R336C Cystathionine -Synthase Protein in Mice

Sapna Gupta, Lorena Gallego-Villar, Liqun Wang, Hyung-Ok Lee, Gheyath Nasrallah, Nader Al-Dewik, Johannes Häberle, Beat Thöny, Henk J Blom, Tawfeg Ben-Omran, Warren D. Kruger

J Inherit Metab Dis. Author manuscript; available in PMC 2020 Jul 6.

Published in final edited form as: J Inherit Metab Dis. 2019 Sep; 42(5): 831–838. Published online 2019 Jul 10. doi: 10.1002/jimd.12140

PMCID:: PMC7336392

Abstract Article PDF–715K

Select item 732981420.

Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs^−/− mice and thrombosis-prone CBS^−/− humans

Marta Sikora, Izabela Lewandowska, Łukasz Marczak, Ewa Bretes, Hieronim Jakubowski

Sci Rep. 2020; 10: 10726. Published online 2020 Jul 1. doi: 10.1038/s41598-020-67672-5

PMCID:: PMC7329814

Abstract Article PDF–2.2M

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