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Items: 1 to 20 of 47

1.
USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress
Alexandra Nusawardhana, Lindsey M Pale, Claudia M Nicolae, George-Lucian Moldovan
Nucleic Acids Res. 2024 Mar 21; 52(5): 2340–2354. Published online 2024 Jan 5. doi: 10.1093/nar/gkad1237
PMCID:
PMC10954467
AbstractArticlePDF–2.9M
2.
PRIMPOL ensures robust handoff between on-the-fly and post-replicative DNA lesion bypass
Christopher Mellor, Joelle Nassar, Saša Šviković, Julian E Sale
Nucleic Acids Res. 2024 Jan 11; 52(1): 243–258. Published online 2023 Nov 16. doi: 10.1093/nar/gkad1054
PMCID:
PMC10783524
AbstractArticlePDF–2.9M
3.
3′dNTP Binding Is Modulated during Primer Synthesis and Translesion by Human PrimPol
Cristina Velázquez-Ruiz, Luis Blanco, María Isabel Martínez-Jiménez
Int J Mol Sci. 2024 Jan; 25(1): 51. Published online 2023 Dec 19. doi: 10.3390/ijms25010051
PMCID:
PMC10778844
AbstractArticlePDF–4.0M
4.
The role of catalytic and regulatory domains of human PrimPol in DNA binding and synthesis
Elizaveta O Boldinova, Andrey G Baranovskiy, Diana I Gagarinskaya, Anna A Manukyan, Alena V Makarova, Tahir H Tahirov
Nucleic Acids Res. 2023 Aug 11; 51(14): 7541–7551. Published online 2023 Jun 16. doi: 10.1093/nar/gkad507
PMCID:
PMC10415149
AbstractArticlePDF–1.9M
5.
PRIMPOL competes with RAD51 to resolve G-quadruplex-induced replication stress via its interaction with RPA: PRIMPOL resolves G4-induced replication stress
Tingfang Li, Lu Tang, Haomeng Kou, Feng Wang
Acta Biochim Biophys Sin (Shanghai) 2023 Mar; 55(3): 498–507. Published online 2022 Nov 9. doi: 10.3724/abbs.2022165
PMCID:
PMC10160237
AbstractArticlePDF–2.1M
6.
Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
Stephanie Tirman, Annabel Quinet, Matthew Wood, Alice Meroni, Emily Cybulla, Jessica Jackson, Silvia Pegoraro, Antoine Simoneau, Lee Zou, Alessandro Vindigni
Mol Cell. Author manuscript; available in PMC 2022 Oct 7.
Published in final edited form as: Mol Cell. 2021 Oct 7; 81(19): 4026–4040.e8. doi: 10.1016/j.molcel.2021.09.013
PMCID:
PMC8555837
AbstractArticlePDF–1.4M
7.
Human PrimPol Discrimination against Dideoxynucleotides during Primer Synthesis
Gustavo Carvalho, Alberto Díaz-Talavera, Patricia A. Calvo, Luis Blanco, María I. Martínez-Jiménez
Genes (Basel) 2021 Oct; 12(10): 1487. Published online 2021 Sep 24. doi: 10.3390/genes12101487
PMCID:
PMC8535229
AbstractArticlePDF–1.8M
8.
BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage
Zhihua Kang, Pan Fu, Allen L. Alcivar, Haiqing Fu, Christophe Redon, Tzeh Keong Foo, Yamei Zuo, Caiyong Ye, Ryan Baxley, Advaitha Madireddy, Remi Buisson, Anja-Katrin Bielinsky, Lee Zou, Zhiyuan Shen, Mirit I. Aladjem, Bing Xia
Nat Commun. 2021; 12: 5966. Published online 2021 Oct 13. doi: 10.1038/s41467-021-26227-6
PMCID:
PMC8514439
AbstractArticlePDF–2.6M
9.
Motif WFYY of human PrimPol is crucial to stabilize the incoming 3′-nucleotide during replication fork restart
Patricia A Calvo, María I Martínez-Jiménez, Marcos Díaz, Gorazd Stojkovic, Kazutoshi Kasho, Susana Guerra, Sjoerd Wanrooij, Juan Méndez, Luis Blanco
Nucleic Acids Res. 2021 Aug 20; 49(14): 8199–8213. Published online 2021 Jul 24. doi: 10.1093/nar/gkab634
PMCID:
PMC8373064
AbstractArticlePDF–4.1M
10.
PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks
Daniel González‐Acosta, Elena Blanco‐Romero, Patricia Ubieto‐Capella, Karun Mutreja, Samuel Míguez, Susana Llanos, Fernando García, Javier Muñoz, Luis Blanco, Massimo Lopes, Juan Méndez
EMBO J. 2021 Jul 15; 40(14): e106355. Published online 2021 Jun 15. doi: 10.15252/embj.2020106355
PMCID:
PMC8280817
AbstractArticlePDF–2.6M
11.
Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase
Olga Rechkoblit, Robert E. Johnson, Yogesh K. Gupta, Louise Prakash, Satya Prakash, Aneel K. Aggarwal
Nat Commun. 2021; 12: 4020. Published online 2021 Jun 29. doi: 10.1038/s41467-021-24317-z
PMCID:
PMC8241999
AbstractArticlePDF–2.2M
12.
Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol
E. John Tokarsky, Petra C. Wallenmeyer, Kenneth K. Phi, Zucai Suo
DNA Repair (Amst) Author manuscript; available in PMC 2021 Jun 24.
Published in final edited form as: DNA Repair (Amst). 2017 Jan; 49: 51–59. Published online 2016 Nov 25. doi: 10.1016/j.dnarep.2016.11.003
PMCID:
PMC8225440
AbstractArticlePDF–540K
13.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
14.
The deubiquitinase USP36 Regulates DNA replication stress and confers therapeutic resistance through PrimPol stabilization
Yuanliang Yan, Zhijie Xu, Jinzhou Huang, Guijie Guo, Ming Gao, Wootae Kim, Xiangyu Zeng, Jake A Kloeber, Qian Zhu, Fei Zhao, Kuntian Luo, Zhenkun Lou
Nucleic Acids Res. 2020 Dec 16; 48(22): 12711–12726. Published online 2020 Nov 25. doi: 10.1093/nar/gkaa1090
PMCID:
PMC7736794
AbstractArticlePDF–5.3M
15.
Strand Displacement Activity of PrimPol
Elizaveta O. Boldinova, Ekaterina A. Belousova, Diana I. Gagarinskaya, Ekaterina A. Maltseva, Svetlana N. Khodyreva, Olga I. Lavrik, Alena V. Makarova
Int J Mol Sci. 2020 Dec; 21(23): 9027. Published online 2020 Nov 27. doi: 10.3390/ijms21239027
PMCID:
PMC7729601
AbstractArticlePDF–2.4M
16.
PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
Ann Liza Piberger, Akhil Bowry, Richard D. W. Kelly, Alexandra K. Walker, Daniel González-Acosta, Laura J. Bailey, Aidan J. Doherty, Juan Méndez, Joanna R. Morris, Helen E. Bryant, Eva Petermann
Nat Commun. 2020; 11: 5863. Published online 2020 Nov 17. doi: 10.1038/s41467-020-19570-7
PMCID:
PMC7673990
AbstractArticlePDF–1.8M
17.
Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro
Thomas J Butler, Katrina N Estep, Joshua A Sommers, Robert W Maul, Ann Zenobia Moore, Stefania Bandinelli, Francesco Cucca, Marcus A Tuke, Andrew R Wood, Sanjay Kumar Bharti, Daniel F Bogenhagen, Elena Yakubovskaya, Miguel Garcia-Diaz, Thomas A Guilliam, Alicia K Byrd, Kevin D Raney, Aidan J Doherty, Luigi Ferrucci, David Schlessinger, Jun Ding, Robert M Brosh, Jr
Hum Mol Genet. 2020 May 28; 29(8): 1292–1309. Published online 2020 Mar 19. doi: 10.1093/hmg/ddaa043
PMCID:
PMC7254849
AbstractArticlePDF–1.4M
18.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
19.
PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells
Laura J Bailey, Julie Bianchi, Aidan J Doherty
Nucleic Acids Res. 2019 May 7; 47(8): 4026–4038. Published online 2019 Jan 31. doi: 10.1093/nar/gkz056
PMCID:
PMC6486543
AbstractArticlePDF–1004K
20.
A cancer-associated point mutation disables the steric gate of human PrimPol
Alberto Díaz-Talavera, Patricia A. Calvo, Daniel González-Acosta, Marcos Díaz, Guillermo Sastre-Moreno, Luis Blanco-Franco, Susana Guerra, Maria I. Martínez-Jiménez, Juan Méndez, Luis Blanco
Sci Rep. 2019; 9: 1121. Published online 2019 Feb 4. doi: 10.1038/s41598-018-37439-0
PMCID:
PMC6362072
AbstractArticlePDF–2.2M

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