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Select item 113818381.

Etomoxir repurposed as a promiscuous fatty acid mimetic chemoproteomic probe

Joseph Choi, Danielle M. Smith, Ye Jin Lee, Danfeng Cai, Mohammad J. Hossain, Tamara J. O’Connor, Pragney Deme, Norman J. Haughey, Susanna Scafidi, Ryan C. Riddle, Michael J. Wolfgang

iScience. 2024 Sep 20; 27(9): 110642. Published online 2024 Aug 2. doi: 10.1016/j.isci.2024.110642

PMCID:: PMC11381838

Abstract Article PDF–5.1M

Select item 113524272.

Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth

Aaron Farley, Yunan Gao, Yan Sun, Sylvia Zohrabian, William T. Pu, Zhiqiang Lin

Cells. 2024 Aug; 13(16): 1342. Published online 2024 Aug 13. doi: 10.3390/cells13161342

PMCID:: PMC11352427

Abstract Article PDF–6.2M

Select item 112940173.

CPT1A‐IL‐10‐mediated macrophage metabolic and phenotypic alterations ameliorate acute lung injury

Muyun Wang, Di Wu, Ximing Liao, Haiyang Hu, Jing Gao, Linlin Meng, Feilong Wang, Wujian Xu, Shaoyong Gao, Jing Hua, Yuanyuan Wang, Qiang Li, Kun Wang, Wei Gao

Clin Transl Med. 2024 Aug; 14(8): e1785. Published online 2024 Aug 1. doi: 10.1002/ctm2.1785

PMCID:: PMC11294017

Abstract Article PDF–9.1M

Select item 111498724.

Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food

Laura Dearden, Isadora C. Furigo, Lucas C. Pantaleão, L W. P. Wong, Denise S. Fernandez-Twinn, Juliana de Almeida-Faria, Katherine A. Kentistou, Maria V. Carreira, Guillaume Bidault, Antonio Vidal-Puig, Ken K. Ong, John R. B. Perry, Jose Donato, Jr, Susan E. Ozanne

PLoS Biol. 2024 Jun; 22(6): e3002641. Published online 2024 Jun 4. doi: 10.1371/journal.pbio.3002641

PMCID:: PMC11149872

Abstract Article PDF–1.7M

Select item 110936125.

Excess glucocorticoids inhibit murine bone turnover via modulating the immunometabolism of the skeletal microenvironment

Xu Li, Tongzhou Liang, Bingyang Dai, Liang Chang, Yuan Zhang, Shiwen Hu, Jiaxin Guo, Shunxiang Xu, Lizhen Zheng, Hao Yao, Hong Lian, Yu Nie, Ye Li, Xuan He, Zhi Yao, Wenxue Tong, Xinluan Wang, Dick Ho Kiu Chow, Jiankun Xu, Ling Qin

J Clin Invest. 2024 May 15; 134(10): e166795. Published online 2024 Mar 21. doi: 10.1172/JCI166795

PMCID:: PMC11093612

Abstract Article PDF–27M

Select item 110639336.

Tubular CPT1A deletion minimally affects aging and chronic kidney injury

Safaa Hammoud, Alla Ivanova, Yosuke Osaki, Steven Funk, Haichun Yang, Olga Viquez, Rachel Delgado, Dongliang Lu, Melanie Phillips Mignemi, Jane Tonello, Selene Colon, Louise Lantier, David H. Wasserman, Benjamin D. Humphreys, Jeffrey Koenitzer, Justin Kern, Mark de Caestecker, Toren Finkel, Agnes Fogo, Nidia Messias, Irfan J. Lodhi, Leslie S. Gewin

JCI Insight. 2024 Mar 22; 9(6): e171961. Published online 2024 Mar 22. doi: 10.1172/jci.insight.171961

Correction in:: JCI Insight. 2024 May 8; 9(9): e181816.

PMCID:: PMC11063933

Abstract Article PDF–18M

Select item 108854117.

ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis

Jian Dong, Muzi Li, Runsheng Peng, Yuchuan Zhang, Zilin Qiao, Na Sun

J Transl Med. 2024; 22: 196. Published online 2024 Feb 23. doi: 10.1186/s12967-024-04942-0

PMCID:: PMC10885411

Abstract Article PDF–3.2M

Select item 108612068.

Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice

Kevin Ibeas, Christian Griñán‐Ferré, Maria del Mar Romero, David Sebastián, Marianela Bastías‐Pérez, Roberto Gómez, M. Carmen Soler‐Vázquez, Sebastián Zagmutt, Mercè Pallás, Margarida Castell, Denise D. Belsham, Paula Mera, Laura Herrero, Dolors Serra

Aging Cell. 2024 Feb; 23(2): e14047. Published online 2023 Nov 22. doi: 10.1111/acel.14047

PMCID:: PMC10861206

Abstract Article PDF–27M

Select item 108077099.

Sexual dimorphism of osteoclast reliance on mitochondrial oxidation of energy substrates in the mouse

Chao Song, Arianna Valeri, Fangfang Song, Xing Ji, Xueyang Liao, Tyler Marmo, Rebecca Seeley, Jared Rutter, Fanxin Long

JCI Insight. 2023 Dec 22; 8(24): e174293. Published online 2023 Dec 22. doi: 10.1172/jci.insight.174293

PMCID:: PMC10807709

Abstract Article PDF–7.7M

Select item 1079643110.

CPT1A as a potential therapeutic target for lipopolysaccharide-induced acute lung injury in mice

Gui-Yun Wang, Xia Xu, Da-Yan Xiong, Lang Deng, Wei Liu, Xiao-Ting Huang

Sci Rep. 2024; 14: 1600. Published online 2024 Jan 18. doi: 10.1038/s41598-024-52042-2

PMCID:: PMC10796431

Abstract Article PDF–2.9M

Select item 1075358811.

Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease

Tao Cheng, Chidera Agwu, Kyuhwan Shim, Baolin Wang, Sanjay Jain, Moe R. Mahjoub

Development. 2023 Dec 15; 150(24): dev201976. Published online 2023 Dec 21. doi: 10.1242/dev.201976

PMCID:: PMC10753588

Abstract Article

Select item 1056856612.

Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice

Mikala M. Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead, Zachary A. Kipp, Evelyn A. Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R. Shelman, Harrison A. Clarke, Tara R. Hawkinson, Terrymar Medina, Ramon C. Sun, Todd A. Lydic, Terry D. Hinds, Jr., J. Mark Brown, Samir Softic, Gregory A. Graf, Robert N. Helsley

Mol Metab. 2023 Dec; 78: 101815. Published online 2023 Oct 4. doi: 10.1016/j.molmet.2023.101815

PMCID:: PMC10568566

Abstract Article PDF–5.3M

Select item 1046999813.

Acidosis attenuates CPT-I-supported bioenergetics as a potential mechanism limiting lipid oxidation

Sara M. Frangos, Geneviève J. DesOrmeaux, Graham P. Holloway

J Biol Chem. 2023 Sep; 299(9): 105079. Published online 2023 Jul 22. doi: 10.1016/j.jbc.2023.105079

PMCID:: PMC10469998

Abstract Article PDF–2.3M

Select item 1007410914.

Goliath induces inflammation in obese mice by linking fatty acid β‐oxidation to glycolysis

Shumeng Hao, Sulin Zhang, Jialin Ye, Lifan Chen, Yan Wang, Siyu Pei, Qingchen Zhu, Jing Xu, Yongzhen Tao, Neng Zhou, Huiyong Yin, Cai‐Wen Duan, Chaoming Mao, Mingyue Zheng, Yichuan Xiao

EMBO Rep. 2023 Apr; 24(4): e56932. Published online 2023 Mar 2. doi: 10.15252/embr.202356932

PMCID:: PMC10074109

Abstract Article PDF–4.7M

Select item 1004014015.

CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst

Sebastián Zagmutt, Paula Mera, Ismael González-García, Kevin Ibeas, María del Mar Romero, Arnaud Obri, Beatriz Martin, Anna Esteve-Codina, M. Carmen Soler-Vázquez, Marianela Bastias-Pérez, Laia Cañes, Elisabeth Augé, Carme Pelegri, Jordi Vilaplana, Xavier Ariza, Jordi García, José Martinez-González, Núria Casals, Miguel López, Richard Palmiter, Elisenda Sanz, Albert Quintana, Laura Herrero, Dolors Serra

Biol Sex Differ. 2023; 14: 14. Published online 2023 Mar 25. doi: 10.1186/s13293-023-00498-8

PMCID:: PMC10040140

Abstract Article PDF–12M

Select item 992544516.

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Stefania Crotta, Matteo Villa, Jack Major, Katja Finsterbusch, Miriam Llorian, Peter Carmeliet, Joerg Buescher, Andreas Wack

Nat Commun. 2023; 14: 721. Published online 2023 Feb 13. doi: 10.1038/s41467-023-36352-z

PMCID:: PMC9925445

Abstract Article PDF–1.7M

Select item 986775317.

Inhibition of carnitine palmitoyl-transferase 1 is a potential target in a mouse model of Parkinson’s disease

Michael Sloth Trabjerg, Dennis Christian Andersen, Pam Huntjens, Kasper Mørk, Nikolaj Warming, Ulla Bismark Kullab, Marie-Louise Nibelius Skjønnemand, Michal Krystian Oklinski, Kirsten Egelund Oklinski, Luise Bolther, Lona J. Kroese, Colin E. J. Pritchard, Ivo J. Huijbers, Angelique Corthals, Mads Toft Søndergaard, Henrik Bech Kjeldal, Cecilie Fjord Morre Pedersen, John Dirk Vestergaard Nieland

NPJ Parkinsons Dis. 2023; 9: 6. Published online 2023 Jan 21. doi: 10.1038/s41531-023-00450-y

PMCID:: PMC9867753

Abstract Article PDF–4.5M

Select item 982946918.

Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism

Song Ah Chae, Jun Seok Son, Jeanene Marie de Avila, Min Du, Mei-Jun Zhu

Am J Physiol Regul Integr Comp Physiol. 2022 Nov 1; 323(5): R728–R738. Published online 2022 Oct 3. doi: 10.1152/ajpregu.00128.2022

PMCID:: PMC9829469

Abstract Article

Select item 952569519.

Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion

Anastasiya Strembitska, Gwenaël Labouèbe, Alexandre Picard, Xavier P. Berney, David Tarussio, Maxime Jan, Bernard Thorens

Nat Commun. 2022; 13: 5761. Published online 2022 Sep 30. doi: 10.1038/s41467-022-33484-6

PMCID:: PMC9525695

Abstract Article PDF–6.3M

Select item 949267920.

miR204 potentially promotes non-alcoholic fatty liver disease by inhibition of cpt1a in mouse hepatocytes

Seonhee Kim, Ikjun Lee, Shuyu Piao, Harsha Nagar, Su-jeong Choi, Young-Rae Kim, Kaikobad Irani, Byeong Hwa Jeon, Cuk-Seong Kim

Commun Biol. 2022; 5: 1002. Published online 2022 Sep 21. doi: 10.1038/s42003-022-03945-1

PMCID:: PMC9492679

Abstract Article PDF–2.0M

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