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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 102441712.

TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background

Maria V. Guijarro, Akbar Nawab, Peter Dib, Sandra Burkett, Xiaoping Luo, Michael Feely, Elham Nasri, Robert P. Seifert, Frederic J. Kaye, Maria Zajac-Kaye

Oncogene. 2023; 42(23): 1926–1939. Published online 2023 Apr 27. doi: 10.1038/s41388-023-02694-7

PMCID:: PMC10244171

Abstract Article PDF–4.5M

Select item 83132393.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 80721324.

Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex

Pauline Antonie Ulmke, M. Sadman Sakib, Peter Ditte, Godwin Sokpor, Cemil Kerimoglu, Linh Pham, Yuanbin Xie, Xiaoyi Mao, Joachim Rosenbusch, Ulrike Teichmann, Huu Phuc Nguyen, Andre Fischer, Gregor Eichele, Jochen F. Staiger, Tran Tuoc

Stem Cell Reports. 2021 Apr 13; 16(4): 968–984. Published online 2021 Apr 1. doi: 10.1016/j.stemcr.2021.03.008

PMCID:: PMC8072132

Abstract Article PDF–8.1M

Select item 79620055.

Advanced Spectroscopy and APBS Modeling for Determination of the Role of His190 and Trp103 in Mouse Thymidylate Synthase Interaction with Selected dUMP Analogues

Małgorzata Prokopowicz, Adam Jarmuła, Yannick Casamayou-Boucau, Fiona Gordon, Alan Ryder, Justyna Sobich, Piotr Maj, Joanna Cieśla, Zbigniew Zieliński, Piotr Fita, Wojciech Rode

Int J Mol Sci. 2021 Mar; 22(5): 2661. Published online 2021 Mar 6. doi: 10.3390/ijms22052661

PMCID:: PMC7962005

Abstract Article PDF–9.3M

Select item 77825076.

Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer

Mohammad Aarif Siddiqui, Paradesi Naidu Gollavilli, Vignesh Ramesh, Beatrice Parma, Annemarie Schwab, Maria Eleni Vazakidou, Ramakrishnan Natesan, Ozge Saatci, Ida Rapa, Paolo Bironzo, Harald Schuhwerk, Irfan Ahmed Asangani, Ozgur Sahin, Marco Volante, Paolo Ceppi

Br J Cancer. 2021 Jan 5; 124(1): 281–289. Published online 2020 Oct 7. doi: 10.1038/s41416-020-01095-x

PMCID:: PMC7782507

Abstract Article PDF–1.0M

Select item 74159917.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 69939258.

Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers

Chao Wang, Bin Zhang, Anna C. Ratliff, Justine Arrington, Jingjuan Chen, Yan Xiong, Feng Yue, Yaohui Nie, Keping Hu, Wen Jin, W. Andy Tao, Christine A. Hrycyna, Xiaobo Sun, Shihuan Kuang

FASEB J. 2019 Aug; 33(8): 9672–9684. Published online 2019 Jun 4. doi: 10.1096/fj.201900582R

PMCID:: PMC6993925

Abstract Article

Select item 53812269.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 499138510.

5-Fluorouracil targets thymidylate synthase in the selective suppression of T_H17 cell differentiation

Juan Wang, Liang Peng, Ruihua Zhang, Zihan Zheng, Chun Chen, Ka Lung Cheung, Miao Cui, Guanglin Bian, Feihong Xu, David Chiang, Yuan Hu, Ye Chen, Geming Lu, Jianjun Yang, Hui Zhang, Jianfei Yang, Hongfa Zhu, Shu-hsia Chen, Kebin Liu, Ming-Ming Zhou, Andrew G. Sikora, Liwu Li, Bo Jiang, Huabao Xiong

Oncotarget. 2016 Apr 12; 7(15): 19312–19326. Published online 2016 Mar 24. doi: 10.18632/oncotarget.8344

PMCID:: PMC4991385

Abstract Article PDF–1.7M

Select item 406571311.

Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations

Anna Dowierciał, Piotr Wilk, Wojciech Rypniewski, Wojciech Rode, Adam Jarmuła

Biomed Res Int. 2014; 2014: 945803. Published online 2014 Jun 3. doi: 10.1155/2014/945803

PMCID:: PMC4065713

Abstract Article PDF–6.6M

Select item 401906212.

A Retinoblastoma Allele That Is Mutated at Its Common E2F Interaction Site Inhibits Cell Proliferation in Gene-Targeted Mice

Matthew J. Cecchini, Michael J. Thwaites, Srikanth Talluri, James I. MacDonald, Daniel T. Passos, Jean-Leon Chong, Paul Cantalupo, Paul M. Stafford, M. Teresa Sáenz-Robles, Sarah M. Francis, James M. Pipas, Gustavo Leone, Ian Welch, Frederick A. Dick

Mol Cell Biol. 2014 Jun; 34(11): 2029–2045. doi: 10.1128/MCB.01589-13

PMCID:: PMC4019062

Abstract Article PDF–3.4M

Select item 396495513.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 324351614.

Nuclear Localization of de Novo Thymidylate Biosynthesis Pathway Is Required to Prevent Uracil Accumulation in DNA

Amanda J. MacFarlane, Donald D. Anderson, Per Flodby, Cheryll A. Perry, Robert H. Allen, Sally P. Stabler, Patrick J. Stover

J Biol Chem. 2011 Dec 23; 286(51): 44015–44022. Published online 2011 Nov 4. doi: 10.1074/jbc.M111.307629

PMCID:: PMC3243516

Abstract Article PDF–1.2M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253416.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 268875317.

SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis

Donald D. Anderson, Patrick J. Stover

PLoS One. 2009; 4(6): e5839. Published online 2009 Jun 9. doi: 10.1371/journal.pone.0005839

PMCID:: PMC2688753

Abstract Article PDF–636K

Select item 255627018.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 248143119.

Identification of transcripts with enriched expression in the developing and adult pancreas

Brad G Hoffman, Bogard Zavaglia, Joy Witzsche, Teresa Ruiz de Algara, Mike Beach, Pamela A Hoodless, Steven JM Jones, Marco A Marra, Cheryl D Helgason

Genome Biol. 2008; 9(6): R99. Published online 2008 Jun 14. doi: 10.1186/gb-2008-9-6-r99

PMCID:: PMC2481431

Abstract Article PDF–2.2M

Select item 38695420.

Mouse thymidylate synthase messenger RNA lacks a 3' untranslated region.

C H Jenh, T L Deng, D W Li, J DeWille, L F Johnson

Proc Natl Acad Sci U S A. 1986 Nov; 83(22): 8482–8486. doi: 10.1073/pnas.83.22.8482

PMCID:: PMC386954

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