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Select item 111764331.

C1q is elevated during chronic Staphylococcus epidermidis central nervous system catheter infection

Matthew Beaver, Lara Bergdolt, Anna Dunaevsky, Tammy Kielian, Gwenn L. Skar

Front Immunol. 2024; 15: 1342467. Published online 2024 May 31. doi: 10.3389/fimmu.2024.1342467

PMCID:: PMC11176433

Abstract Article PDF–1.8M

Select item 110884622.

DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses

Elham Asghari Adib, Jennifer L. Shadrach, Lauren Reilly-Jankowiak, Manish K. Dwivedi, Abigail E. Rogers, Shameena Shahzad, Ryan Passino, Roman J. Giger, Brian A. Pierchala, Catherine A. Collins

Cell Rep. Author manuscript; available in PMC 2024 May 11.

Published in final edited form as: Cell Rep. 2024 Feb 27; 43(2): 113801. Published online 2024 Feb 14. doi: 10.1016/j.celrep.2024.113801

PMCID:: PMC11088462

Abstract Article PDF–3.9M

Select item 110146693.

Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice

Arijita Jash, Thomas Pridmore, James B. Collins, Ariel M. Hay, Krystalyn E. Hudson, Chance John Luckey, James C. Zimring

J Clin Invest. 2024 Apr 15; 134(8): e167665. Published online 2024 Apr 15. doi: 10.1172/JCI167665

PMCID:: PMC11014669

Abstract Article PDF–2.3M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109074475.

Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice

Ying Chen, John Man-Tak Chu, Gordon Tin-Chun Wong, Raymond Chuen-Chung Chang

J Neuroimmune Pharmacol. 2024; 19(1): 8. Published online 2024 Mar 1. doi: 10.1007/s11481-024-10107-z

PMCID:: PMC10907447

Abstract Article PDF–5.1M

Select item 108973376.

Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus

Aura R. Garrison, Vanessa Moresco, Xiankun Zeng, Curtis R. Cline, Michael D. Ward, Keersten M. Ricks, Scott P. Olschner, Lisa H. Cazares, Elif Karaaslan, Collin J. Fitzpatrick, Éric Bergeron, Scott D. Pegan, Joseph W. Golden

Nat Commun. 2024; 15: 1722. Published online 2024 Feb 26. doi: 10.1038/s41467-024-46110-4

PMCID:: PMC10897337

Abstract Article PDF–7.8M

Select item 108911547.

Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress

Silvia Cardarelli, Martina Biglietto, Tiziana Orsini, Valentina Fustaino, Lucia Monaco, Ana Gabriela de Oliveira do Rêgo, Francesca Liccardo, Silvia Masciarelli, Francesco Fazi, Fabio Naro, Luciana De Angelis, Manuela Pellegrini

Cell Death Dis. 2024 Feb; 15(2): 169. Published online 2024 Feb 23. doi: 10.1038/s41419-024-06549-1

PMCID:: PMC10891154

Abstract Article PDF–2.6M

Select item 108778408.

Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3

Wenzhi Hao, Qingyu Ma, Lu Wang, Naijun Yuan, Hua Gan, Liangliang He, Xiaojuan Li, Junqing Huang, Jiaxu Chen

Microbiome. 2024; 12: 34. Published online 2024 Feb 20. doi: 10.1186/s40168-024-01756-6

PMCID:: PMC10877840

Abstract Article PDF–8.5M

Select item 107809479.

Discovery and validation of genes driving drug‐intake and related behavioral traits in mice

Tyler A. Roy, Jason A. Bubier, Price E. Dickson, Troy D. Wilcox, Juliet Ndukum, James W. Clark, Stacey J. Sukoff Rizzo, John C. Crabbe, James M. Denegre, Karen L. Svenson, Robert E. Braun, Vivek Kumar, Stephen A. Murray, Jacqueline K. White, Vivek M. Philip, Elissa J. Chesler

Genes Brain Behav. 2024 Feb; 23(1): e12875. Published online 2024 Jan 2. doi: 10.1111/gbb.12875

PMCID:: PMC10780947

Abstract Article PDF–2.6M

Select item 1068271810.

Mice deficient in complement C3 are protected against recognition memory deficits and astrogliosis induced by status epilepticus

Nicole D. Schartz, Alisha Aroor, Yibo Li, Nicole Pinzón-Hoyos, Amy L. Brewster

Front Mol Neurosci. 2023; 16: 1265944. Published online 2023 Nov 14. doi: 10.3389/fnmol.2023.1265944

PMCID:: PMC10682718

Abstract Article PDF–7.3M

Select item 1052978611.

Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis

Máté G. Kiss, Nikolina Papac-Miličević, Florentina Porsch, Dimitrios Tsiantoulas, Tim Hendrikx, Minoru Takaoka, Huy Q. Dinh, Marie-Sophie Narzt, Laura Göderle, Mária Ozsvár-Kozma, Michael Schuster, Nikolaus Fortelny, Anastasiya Hladik, Sylvia Knapp, Florian Gruber, Matthew C. Pickering, Christoph Bock, Filip K. Swirski, Klaus Ley, Alma Zernecke, Clément Cochain, Claudia Kemper, Ziad Mallat, Christoph J. Binder

Immunity. Author manuscript; available in PMC 2024 Aug 8.

Published in final edited form as: Immunity. 2023 Aug 8; 56(8): 1809–1824.e10. Published online 2023 Jul 26. doi: 10.1016/j.immuni.2023.06.026

PMCID:: PMC10529786

Abstract Article PDF–3.4M

Select item 1052487912.

The complement-targeted inhibitor mini-FH protects against experimental periodontitis via both C3–dependent and C3–independent mechanisms

Xiaofei Li, Hui Wang, Christoph Q. Schmidt, Viviana P. Ferreira, Despina Yancopoulou, Dimitrios C. Mastellos, John D. Lambris, George Hajishengallis

J Immunol. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: J Immunol. 2023 Aug 1; 211(3): 453–461. doi: 10.4049/jimmunol.2300242

PMCID:: PMC10524879

Abstract Article PDF–1.8M

Select item 1049989313.

Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain

Ria Thomas, Kyle J. Connolly, Oeystein R. Brekk, Anthony J. Hinrich, Michelle L. Hastings, Ole Isacson, Penelope J. Hallett

Sci Rep. 2023; 13: 15164. Published online 2023 Sep 13. doi: 10.1038/s41598-023-41240-z

PMCID:: PMC10499893

Abstract Article PDF–2.2M

Select item 1041552714.

Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway

Ran Zhou, Shih-Heng Chen, Zhan Zhao, Dezhen Tu, Sheng Song, Yubao Wang, Qingshan Wang, Jing Feng, Jau-Shyong Hong

Mol Neurobiol. 2023; 60(9): 5167–5183. Published online 2023 Jun 3. doi: 10.1007/s12035-023-03393-w

PMCID:: PMC10415527

Abstract Article PDF–1.6M

Select item 1036325315.

Complement-dependent loss of inhibitory synapses on pyramidal neurons following Toxoplasma gondii infection

Gabriela L. Carrillo, Jianmin Su, Mikel L. Cawley, Derek Wei, Simran K. Gill, Ira J. Blader, Michael A. Fox

J Neurochem. Author manuscript; available in PMC 2025 Oct 1.

Published in final edited form as: J Neurochem. 2024 Oct; 168(10): 3365–3385. Published online 2023 Feb 17. doi: 10.1111/jnc.15770

PMCID:: PMC10363253

Currently embargoed: Free in PMC on Oct 1, 2025; PubMed

Select item 1030762416.

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

Andrew S. Mendiola, Zhaoqi Yan, Karuna Dixit, Jeffrey R. Johnson, Mehdi Bouhaddou, Anke Meyer-Franke, Min-Gyoung Shin, Yu Yong, Ayushi Agrawal, Eilidh MacDonald, Gayathri Muthukumar, Clairice Pearce, Nikhita Arun, Belinda Cabriga, Rosa Meza-Acevedo, Maria del Pilar S. Alzamora, Scott S. Zamvil, Alexander R. Pico, Jae Kyu Ryu, Nevan J. Krogan, Katerina Akassoglou

Nat Immunol. 2023; 24(7): 1173–1187. Published online 2023 Jun 8. doi: 10.1038/s41590-023-01522-0

PMCID:: PMC10307624

Abstract Article PDF–18M

Select item 1029010217.

NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation

Isidoro Cobo, Sumit Paliwal, Cristina Bodas, Irene Felipe, Júlia Melià-Alomà, Ariadna Torres, Jaime Martínez-Villarreal, Marina Malumbres, Fernando García, Irene Millán, Natalia del Pozo, Joo-Cheol Park, Ray J. MacDonald, Javier Muñoz, Raúl Méndez, Francisco X. Real

Nat Commun. 2023; 14: 3761. Published online 2023 Jun 23. doi: 10.1038/s41467-023-39291-x

PMCID:: PMC10290102

Abstract Article PDF–3.4M

Select item 1024416318.

Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner

Mariusz Z. Ratajczak, Mateusz Adamiak, Ahmed Abdelbaset-Ismail, Kamila Bujko, Arjun Thapa, Vira Chumak, Stephanie Franczak, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magdalena Kucia

Leukemia. 2023; 37(6): 1401–1405. Published online 2023 Apr 13. doi: 10.1038/s41375-023-01894-0

PMCID:: PMC10244163

Article PDF–1.3M

Select item 1020600719.

Complement C4-deficient mice have a high mortality rate during PTZ-induced epileptic seizures, which correlates with cognitive problems and the deficiency in the expression of Egr1 and other immediate early genes

Tatyana Veremeyko, Rongcai Jiang, Mingliang He, Eugene D. Ponomarev

Front Cell Neurosci. 2023; 17: 1170031. Published online 2023 May 10. doi: 10.3389/fncel.2023.1170031

PMCID:: PMC10206007

Abstract Article PDF–5.6M

Select item 1018534020.

Macrophages regulate gastrointestinal motility through complement component 1q

Mihir Pendse, Haley De Selle, Nguyen Vo, Gabriella Quinn, Chaitanya Dende, Yun Li, Cristine N Salinas, Tarun Srinivasan, Daniel C Propheter, Alexander A Crofts, Eugene Koo, Brian Hassell, Kelly A Ruhn, Prithvi Raj, Yuuki Obata, Lora V Hooper

eLife. 2023; 12: e78558. Published online 2023 Apr 26. doi: 10.7554/eLife.78558

PMCID:: PMC10185340

Abstract Article PDF–6.5M

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