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Select item 106913441.

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity

Henrik Schmidt, Timsse Raj, Thomas J. O'Neill, Andreas Muschaweckh, Florian Giesert, Arlinda Negraschus, Kai P. Hoefig, Gesine Behrens, Lena Esser, Christina Baumann, Regina Feederle, Carlos Plaza-Sirvent, Arie Geerlof, Andreas Gewies, Sophie E. Isay, Jürgen Ruland, Ingo Schmitz, Wolfgang Wurst, Thomas Korn, Daniel Krappmann, Vigo Heissmeyer

Proc Natl Acad Sci U S A. 2023 Nov 28; 120(48): e2309205120. Published online 2023 Nov 21. doi: 10.1073/pnas.2309205120

PMCID:: PMC10691344

Abstract Article PDF–2.0M

Select item 89963442.

Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses

Gesine Behrens, Stephanie L. Edelmann, Timsse Raj, Nina Kronbeck, Thomas Monecke, Elena Davydova, Elaine H. Wong, Lisa Kifinger, Florian Giesert, Martin E. Kirmaier, Christine Hohn, Laura S. de Jonge, Mariano Gonzalez Pisfil, Mingui Fu, Sebastian Theurich, Stefan Feske, Naoto Kawakami, Wolfgang Wurst, Dierk Niessing, Vigo Heissmeyer

Nat Immunol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Nat Immunol. 2021 Dec; 22(12): 1563–1576. Published online 2021 Nov 22. doi: 10.1038/s41590-021-01064-3

PMCID:: PMC8996344

Abstract Article PDF–4.8M

Select item 84107613.

Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation

Kai P. Hoefig, Alexander Reim, Christian Gallus, Elaine H. Wong, Gesine Behrens, Christine Conrad, Meng Xu, Lisa Kifinger, Taku Ito-Kureha, Kyra A. Y. Defourny, Arie Geerlof, Josef Mautner, Stefanie M. Hauck, Dirk Baumjohann, Regina Feederle, Matthias Mann, Michael Wierer, Elke Glasmacher, Vigo Heissmeyer

Nat Commun. 2021; 12: 5208. Published online 2021 Sep 1. doi: 10.1038/s41467-021-25345-5

PMCID:: PMC8410761

Abstract Article PDF–16M

Select item 81109294.

Programmed Death-Ligand 1 Expression Potentiates the Immune Modulatory Function Of Myeloid-Derived Suppressor Cells in Systemic Lupus Erythematosus

Min-Jung Park, Jin-Ah Baek, Jeong Won Choi, Se Gwang Jang, Da-Som Kim, Sung-Hwan Park, Mi-La Cho, Seung-Ki Kwok

Front Immunol. 2021; 12: 606024. Published online 2021 Apr 27. doi: 10.3389/fimmu.2021.606024

PMCID:: PMC8110929

Abstract Article PDF–7.8M

Select item 80195155.

Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice

Dina Montufar-Solis, Alexander Williams, Nadarajah Vigneswaran, John R. Klein

Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Apr 4.

Published in final edited form as: Biochem Biophys Res Commun. 2017 Jan 29; 483(1): 590–595. Published online 2016 Dec 21. doi: 10.1016/j.bbrc.2016.12.099

PMCID:: PMC8019515

Abstract Article PDF–1.4M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 70267717.

Roquin-1 Regulates Macrophage Immune Response and Participates in Hepatic Ischemia–Reperfusion Injury

Lei Zheng, Wei Ling, Deming Zhu, Zhi Li, Lianbao Kong

J Immunol. 2020 Mar 1; 204(5): 1322–1333. Published online 2020 Jan 29. doi: 10.4049/jimmunol.1900053

PMCID:: PMC7026771

Abstract Article PDF–2.5M

Select item 68037058.

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

S. J. Tavernier, V. Athanasopoulos, P. Verloo, G. Behrens, J. Staal, D. J. Bogaert, L. Naesens, M. De Bruyne, S. Van Gassen, E. Parthoens, J. Ellyard, J. Cappello, L. X. Morris, H. Van Gorp, G. Van Isterdael, Y. Saeys, M. Lamkanfi, P. Schelstraete, J. Dehoorne, V. Bordon, R. Van Coster, B. N. Lambrecht, B. Menten, R. Beyaert, C. G. Vinuesa, V. Heissmeyer, M. Dullaers, F. Haerynck

Nat Commun. 2019; 10: 4779. Published online 2019 Oct 21. doi: 10.1038/s41467-019-12704-6

Correction in:: Nat Commun. 2019; 10: 5337.

PMCID:: PMC6803705

Abstract Article PDF–2.4M

Select item 66057579.

Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3

Matthias von Gamm, Annalisa Schaub, Alisha N. Jones, Christine Wolf, Gesine Behrens, Johannes Lichti, Katharina Essig, Anna Macht, Joachim Pircher, Andreas Ehrlich, Kathrin Davari, Dhruv Chauhan, Benjamin Busch, Wolfgang Wurst, Regina Feederle, Annette Feuchtinger, Matthias H. Tschöp, Caroline C. Friedel, Stefanie M. Hauck, Michael Sattler, Arie Geerlof, Veit Hornung, Vigo Heissmeyer, Christian Schulz, Mathias Heikenwalder, Elke Glasmacher

J Exp Med. 2019 Jul 1; 216(7): 1700–1723. Published online 2019 May 24. doi: 10.1084/jem.20181762

PMCID:: PMC6605757

Abstract Article PDF–6.1M

Select item 647832610.

Structural and diffusion weighted MRI demonstrates responses to ibrutinib in a mouse model of follicular helper (Tfh) T-cell lymphoma

Rebecca L. Allchin, Michael E. Kelly, Sami Mamand, Anthony G. Doran, Thomas Keane, Matthew J. Ahearne, Simon D. Wagner

PLoS One. 2019; 14(4): e0215765. Published online 2019 Apr 23. doi: 10.1371/journal.pone.0215765

PMCID:: PMC6478326

Abstract Article PDF–1.1M

Select item 643565311.

Inhibition of IL-17 ameliorates systemic lupus erythematosus in Roquin^san/san mice through regulating the balance of TFH cells, GC B cells, Treg and Breg

Seon-yeong Lee, Seung Hoon Lee, Hyeon-Beom Seo, Jun-Geol Ryu, KyungAh Jung, Jeong Won Choi, JooYeon Jhun, Jin-Sil Park, Ji Ye Kwon, Seung-Ki Kwok, Jeehee Youn, Sung-Hwan Park, Mi-La Cho

Sci Rep. 2019; 9: 5227. Published online 2019 Mar 26. doi: 10.1038/s41598-019-41534-1

PMCID:: PMC6435653

Abstract Article PDF–6.1M

Select item 629449312.

Identification of new high affinity targets for Roquin based on structural conservation

Johannes Braun, Sandra Fischer, Zhenjiang Z Xu, Hongying Sun, Dalia H Ghoneim, Anna T Gimbel, Uwe Plessmann, Henning Urlaub, David H Mathews, Julia E Weigand

Nucleic Acids Res. 2018 Dec 14; 46(22): 12109–12125. Published online 2018 Oct 8. doi: 10.1093/nar/gky908

PMCID:: PMC6294493

Abstract Article PDF–3.6M

Select item 614589213.

Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

Katharina Essig, Nina Kronbeck, Joao C. Guimaraes, Claudia Lohs, Andreas Schlundt, Anne Hoffmann, Gesine Behrens, Sven Brenner, Joanna Kowalska, Cristina Lopez-Rodriguez, Jacek Jemielity, Helmut Holtmann, Kristin Reiche, Jörg Hackermüller, Michael Sattler, Mihaela Zavolan, Vigo Heissmeyer

Nat Commun. 2018; 9: 3810. Published online 2018 Sep 19. doi: 10.1038/s41467-018-06184-3

PMCID:: PMC6145892

Abstract Article PDF–3.3M

Select item 603467914.

Role for IL-10 in the transcriptional regulation of Roquin-1

Jeremy S. Schaefer, Dina Montufar-Solis, John R. Klein

Gene. Author manuscript; available in PMC 2018 Jul 6.

Published in final edited form as: Gene. 2014 Oct 1; 549(1): 134–140. Published online 2014 Jul 23. doi: 10.1016/j.gene.2014.07.056

PMCID:: PMC6034679

Abstract Article PDF–721K

Select item 599279115.

Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells

Jin-Sil Park, Sung-Min Kim, Sun-Hee Hwang, Si-Young Choi, Ji Ye Kwon, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park

Int J Immunopathol Pharmacol. 2018 Mar-Dec; 32: 2058738418778724. Published online 2018 Jun 6. doi: 10.1177/2058738418778724

PMCID:: PMC5992791

Abstract Article PDF–826K

Select item 577525716.

Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA

Nina Rehage, Elena Davydova, Christine Conrad, Gesine Behrens, Andreas Maiser, Jenny E. Stehklein, Sven Brenner, Juliane Klein, Aicha Jeridi, Anne Hoffmann, Eunhae Lee, Umberto Dianzani, Rob Willemsen, Regina Feederle, Kristin Reiche, Jörg Hackermüller, Heinrich Leonhardt, Sonia Sharma, Dierk Niessing, Vigo Heissmeyer

Nat Commun. 2018; 9: 299. Published online 2018 Jan 19. doi: 10.1038/s41467-017-02582-1

PMCID:: PMC5775257

Abstract Article PDF–2.9M

Select item 560372717.

Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40

Robert Janowski, Gitta A. Heinz, Andreas Schlundt, Nina Wommelsdorf, Sven Brenner, Andreas R. Gruber, Michael Blank, Thorsten Buch, Raymund Buhmann, Mihaela Zavolan, Dierk Niessing, Vigo Heissmeyer, Michael Sattler

Nat Commun. 2016; 7: 11032. Published online 2016 Mar 24. doi: 10.1038/ncomms11032

PMCID:: PMC5603727

Abstract Article PDF–3.7M

Select item 557052618.

Modulation of Roquin function in myeloid cells reduces Mycobacterium tuberculosis induced inflammation

Gayathri Nagalingam, Carola G. Vinuesa, Warwick J Britton, Bernadette M. Saunders

J Immunol. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: J Immunol. 2017 Sep 1; 199(5): 1796–1804. Published online 2017 Jul 26. doi: 10.4049/jimmunol.1602069

PMCID:: PMC5570526

Abstract Article PDF–2.7M

Select item 477764919.

Roquin – a multifunctional regulator of immune homeostasis

J. S. Schaefer, J. R. Klein

Genes Immun. Author manuscript; available in PMC 2016 Jun 17.

Published in final edited form as: Genes Immun. 2016 Mar; 17(2): 79–84. Published online 2015 Dec 17. doi: 10.1038/gene.2015.58

PMCID:: PMC4777649

Abstract Article PDF–343K

Select item 471684120.

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

Roybel R Ramiscal, Ian A Parish, Robert S Lee-Young, Jeffrey J Babon, Julianna Blagih, Alvin Pratama, Jaime Martin, Naomi Hawley, Jean Y Cappello, Pablo F Nieto, Julia I Ellyard, Nadia J Kershaw, Rebecca A Sweet, Christopher C Goodnow, Russell G Jones, Mark A Febbraio, Carola G Vinuesa, Vicki Athanasopoulos

eLife. 2015; 4: e08698. Published online 2015 Oct 23. doi: 10.7554/eLife.08698

PMCID:: PMC4716841

Abstract Article PDF–3.5M

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