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Select item 105164171.

Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer

Jingxiong Xu, Wei Xu, Jiyeon Choi, Yonathan Brhane, David C. Christiani, Jui Kothari, James McKay, John K. Field, Michael P. A. Davies, Geoffrey Liu, Christopher I. Amos, Rayjean J. Hung, Laurent Briollais

PLoS Genet. 2023 Sep; 19(9): e1010902. Published online 2023 Sep 22. doi: 10.1371/journal.pgen.1010902

PMCID:: PMC10516417

Abstract Article PDF–735K

Select item 101679272.

Reduced Cathepsin L expression and secretion into the extracellular milieu contribute to lung fibrosis in systemic sclerosis

Joe E Mouawad, Shailza Sharma, Ludivine Renaud, Joseph M Pilewski, Satish N Nadig, Carol Feghali-Bostwick

Rheumatology (Oxford) 2023 Mar; 62(3): 1306–1316. Published online 2022 Jul 28. doi: 10.1093/rheumatology/keac411

PMCID:: PMC10167927

Abstract Article PDF–799K

Select item 99860913.

Methyltransferase‐like 3 promotes cervical cancer metastasis by enhancing cathepsin L mRNA stability in an N6‐methyladenosine‐dependent manner

Pingping Liu, Mingxiu Ju, Xiaojing Zheng, Yinan Jiang, Xingjuan Yu, Baoyue Pan, Rongzhen Luo, Weihua Jia, Min Zheng

Cancer Sci. 2023 Mar; 114(3): 837–854. Published online 2023 Jan 2. doi: 10.1111/cas.15658

PMCID:: PMC9986091

Abstract Article PDF–9.6M

Select item 95538884.

A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer

Kaisa Cui, Surui Yao, Bingxin Liu, Shengbai Sun, Liang Gong, Qilin Li, Bojian Fei, Zhaohui Huang

Br J Cancer. 2022 Nov 1; 127(8): 1450–1460. Published online 2022 Aug 8. doi: 10.1038/s41416-022-01936-x

PMCID:: PMC9553888

Abstract Article PDF–3.7M

Select item 93485765.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 92316236.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 89904737.

COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2

Lianmei Zhang, Chunli Wei, Dabing Li, Jiayue He, Shuguang Liu, Haoyue Deng, Jingliang Cheng, Jiaman Du, Xiaoyan Liu, Hanchun Chen, Suan Sun, Hong Yu, Junjiang Fu

Int J Biol Sci. 2022; 18(6): 2362–2371. Published online 2022 Mar 6. doi: 10.7150/ijbs.70172

PMCID:: PMC8990473

Abstract Article PDF–2.2M

Select item 87483948.

XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells

Saman Khan, William Cvammen, Nadeen Anabtawi, Jun-Hyuk Choi, Michael G. Kemp

DNA Repair (Amst) Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: DNA Repair (Amst). 2022 Jan; 109: 103260. Published online 2021 Dec 2. doi: 10.1016/j.dnarep.2021.103260

PMCID:: PMC8748394

Abstract Article PDF–598K

Select item 86074109.

Expressions and significances of CTSL, the target of COVID‐19 on GBM

Qiang Dong, Qiao Li, Lei Duan, Hongyu Wang, Yunji Yan, Hang Yin, Liang Niu, He Zhang, Bo wang, Guoqiang Yuan, Yawen Pan

J Cancer Res Clin Oncol. 2022; 148(3): 599–608. Published online 2021 Nov 22. doi: 10.1007/s00432-021-03843-9

PMCID:: PMC8607410

Abstract Article PDF–5.7M

Select item 855290710.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 853366711.

Upregulation of cathepsin L gene under mild cold conditions in young Japanese male adults

Yoshiki Yasukochi, Sora Shin, Hitoshi Wakabayashi, Takafumi Maeda

J Physiol Anthropol. 2021; 40: 16. Published online 2021 Oct 22. doi: 10.1186/s40101-021-00267-9

PMCID:: PMC8533667

Abstract Article PDF–1.1M

Select item 851885612.

The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle‐down characterization of antibodies

Tomislav Čaval, Elizabeth Sara Hecht, Wilfred Tang, Maelia Uy‐Gomez, Andrew Nichols, Yong J. Kil, Wendy Sandoval, Marshall Bern, Albert J. R. Heck

FEBS J. 2021 Sep; 288(18): 5389–5405. Published online 2021 Mar 27. doi: 10.1111/febs.15813

PMCID:: PMC8518856

Abstract Article PDF–2.3M

Select item 837289613.

Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L

Kartikay Prasad, Suliman Yousef AlOmar, Eman Abdullah Almuqri, Hassan Ahmed Rudayni, Vijay Kumar

PLoS One. 2021; 16(8): e0256141. Published online 2021 Aug 18. doi: 10.1371/journal.pone.0256141

PMCID:: PMC8372896

Abstract Article PDF–2.6M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 813852315.

Multiple sites on SARS‐CoV‐2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V

Keval Bollavaram, Tiffanie H. Leeman, Maggie W. Lee, Akhil Kulkarni, Sophia G. Upshaw, Jiabei Yang, Hannah Song, Manu O. Platt

Protein Sci. 2021 Jun; 30(6): 1131–1143. Published online 2021 Apr 15. doi: 10.1002/pro.4073

PMCID:: PMC8138523

Abstract Article PDF–6.0M

Select item 811470316.

Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion

Narendra V. Sankpal, Taylor C. Brown, Timothy P. Fleming, John M. Herndon, Anusha A. Amaravati, Allison N. Loynd, William E. Gillanders

BMC Cancer. 2021; 21: 541. Published online 2021 May 12. doi: 10.1186/s12885-021-08239-z

PMCID:: PMC8114703

Abstract Article PDF–1.3M

Select item 808864817.

The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis

Xinjing Wang, Xiaoduan Li, Feikai Lin, Huizhen Sun, Yingying Lin, Ziliang Wang, Xipeng Wang

J Exp Clin Cancer Res. 2021; 40: 151. Published online 2021 May 1. doi: 10.1186/s13046-021-01957-z

PMCID:: PMC8088648

Abstract Article PDF–16M

Select item 801016818.

SARS Coronavirus, but Not Human Coronavirus NL63, Utilizes Cathepsin L to Infect ACE2-expressing Cells

I-Chueh Huang, Berend Jan Bosch, Fang Li, Wenhui Li, Kyoung Hoa Lee, Sorina Ghiran, Natalya Vasilieva, Terence S. Dermody, Stephen C. Harrison, Philip R. Dormitzer, Michael Farzan, Peter J.M. Rottier, Hyeryun Choe

J Biol Chem. 2006 Feb 10; 281(6): 3198–3203. Published online 2021 Jan 4. doi: 10.1074/jbc.M508381200

PMCID:: PMC8010168

Abstract Article PDF–470K

Select item 799780019.

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

Miao-Miao Zhao, Wei-Li Yang, Fang-Yuan Yang, Li Zhang, Wei-Jin Huang, Wei Hou, Chang-Fa Fan, Rong-Hua Jin, Ying-Mei Feng, You-Chun Wang, Jin-Kui Yang

Signal Transduct Target Ther. 2021; 6: 134. Published online 2021 Mar 27. doi: 10.1038/s41392-021-00558-8

PMCID:: PMC7997800

Abstract Article PDF–4.6M

Select item 783503820.

Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy

Rui Niu, Jindan Wang, Chao Geng, Yahong Li, Lijie Dong, Lin Liu, Yuwen Chang, Jianqun Shen, Zetong Nie, Yan Zhang, Bojie Hu

Aging (Albany NY) 2021 Jan 15; 13(1): 973–990. Published online 2020 Dec 3. doi: 10.18632/aging.202217

PMCID:: PMC7835038

Abstract Article PDF–2.8M

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