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Items: 1 to 20 of 45

1.
Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease
Dominic W. Kolonay, Kristina M. Sattler, Corinne Strawser, Jill Rafael-Fortney, Maria M. Mihaylova, Katherine E. Miller, Christoph Lepper, Kedryn K. Baskin
Front Cell Dev Biol. 2024; 12: 1331563. Published online 2024 Apr 16. doi: 10.3389/fcell.2024.1331563
PMCID:
PMC11058648
AbstractArticlePDF–3.8M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium
Susana Prieto, Geronimo Dubra, Alain Camasses, Ana Bella Aznar, Christina Begon‐Pescia, Elisabeth Simboeck, Nelly Pirot, François Gerbe, Lucie Angevin, Philippe Jay, Liliana Krasinska, Daniel Fisher
EMBO Rep. 2023 Feb; 24(2): e54261. Published online 2022 Dec 22. doi: 10.15252/embr.202154261
PMCID:
PMC10549226
AbstractArticlePDF–11M
4.
CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF
Marius V. Dannappel, Danxi Zhu, Xin Sun, Hui Kheng Chua, Marle Poppelaars, Monica Suehiro, Subash Khadka, Terry C.C. Lim Kam Sian, Dhanya Sooraj, Melissa Loi, Hugh Gao, Daniel Croagh, Roger J. Daly, Pouya Faridi, Thomas G. Boyer, Ron Firestein
J Clin Invest. 2022 Oct 17; 132(20): e158593. Published online 2022 Oct 17. doi: 10.1172/JCI158593
PMCID:
PMC9566890
AbstractArticlePDF–9.1M
5.
The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis
Takanori Yamada, Kazuya Fukasawa, Tetsuhiro Horie, Takuya Kadota, Jiajun Lyu, Kazuya Tokumura, Shinsuke Ochiai, Sayuki Iwahashi, Akane Suzuki, Gyujin Park, Rie Ueda, Megumi Yamamoto, Tatsuya Kitao, Hiroaki Shirahase, Hiroki Ochi, Shingo Sato, Takashi Iezaki, Eiichi Hinoi
Stem Cell Reports. 2022 Jul 12; 17(7): 1576–1588. Published online 2022 Jun 30. doi: 10.1016/j.stemcr.2022.06.001
PMCID:
PMC9287674
AbstractArticlePDF–3.6M
6.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
7.
The Role of CDKs and CDKIs in Murine Development
Grace Jean Campbell, Emma Langdale Hands, Mathew Van de Pette
Int J Mol Sci. 2020 Aug; 21(15): 5343. Published online 2020 Jul 28. doi: 10.3390/ijms21155343
PMCID:
PMC7432401
AbstractArticlePDF–613K
8.
Stress‐Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics
Jessica M. Ponce, Grace Coen, Kathryn M. Spitler, Nikola Dragisic, Ines Martins, Antentor Hinton, Jr, Margaret Mungai, Satya Murthy Tadinada, Hao Zhang, Gavin Y. Oudit, Long‐Sheng Song, Na Li, Peter Sicinski, Stefan Strack, E. Dale Abel, Colleen Mitchell, Duane D. Hall, Chad E. Grueter
J Am Heart Assoc. 2020 Apr 7; 9(7): e014366. Published online 2020 Apr 4. doi: 10.1161/JAHA.119.014366
PMCID:
PMC7428645
AbstractArticlePDF–1.9M
9.
Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development
Andreas Postlmayr, Charles Etienne Dumeau, Anton Wutz
Development. 2020 Jun 1; 147(11): dev175141. Published online 2020 Jun 11. doi: 10.1242/dev.175141
PMCID:
PMC7295591
AbstractArticle
10.
CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions
Angelika Feldmann, Emilia Dimitrova, Alexander Kenney, Anna Lastuvkova, Robert J Klose
Nucleic Acids Res. 2020 Apr 6; 48(6): 2942–2955. Published online 2020 Jan 30. doi: 10.1093/nar/gkaa064
PMCID:
PMC7102981
AbstractArticlePDF–1.3M
11.
Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer
Anne Serrao, Laura M. Jenkins, Alexander A. Chumanevich, Ben Horst, Jiaxin Liang, Michael L. Gatza, Nam Y. Lee, Igor B. Roninson, Eugenia V. Broude, Karthikeyan Mythreye
Oncogene. Author manuscript; available in PMC 2020 Feb 13.
Published in final edited form as: Oncogene. 2018 Aug; 37(35): 4792–4808. Published online 2018 May 21. doi: 10.1038/s41388-018-0316-y
PMCID:
PMC7018387
AbstractArticlePDF–2.6M
12.
Transcriptional responses to IFN-γ require Mediator kinase-dependent pause release and mechanistically distinct functions of CDK8 and CDK19
Iris Steinparzer, Vitaly Sedlyarov, Jonathan D. Rubin, Kevin Eislmayr, Matthew D. Galbraith, Cecilia B. Levandowski, Terezia Vcelkova, Lucy Sneezum, Florian Wascher, Fabian Amman, Renata Kleinova, Heather Bender, Zdenek Andrysik, Joaquin M. Espinosa, Giulio Superti-Furga, Robin D. Dowell, Dylan J. Taatjes, Pavel Kovarik
Mol Cell. Author manuscript; available in PMC 2020 Nov 7.
Published in final edited form as: Mol Cell. 2019 Nov 7; 76(3): 485–499.e8. Published online 2019 Sep 5. doi: 10.1016/j.molcel.2019.07.034
PMCID:
PMC6842433
AbstractArticlePDF–1.9M
13.
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
Ingeborg Menzl, Tinghu Zhang, Angelika Berger-Becvar, Reinhard Grausenburger, Gerwin Heller, Michaela Prchal-Murphy, Leo Edlinger, Vanessa M. Knab, Iris Z. Uras, Eva Grundschober, Karin Bauer, Mareike Roth, Anna Skucha, Yao Liu, John M. Hatcher, Yanke Liang, Nicholas P. Kwiatkowski, Daniela Fux, Andrea Hoelbl-Kovacic, Stefan Kubicek, Junia V. Melo, Peter Valent, Thomas Weichhart, Florian Grebien, Johannes Zuber, Nathanael S. Gray, Veronika Sexl
Nat Commun. 2019; 10: 4741. Published online 2019 Oct 18. doi: 10.1038/s41467-019-12656-x
PMCID:
PMC6802219
AbstractArticlePDF–3.2M
14.
Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation
Jiuli Zhou, Yongji Zeng, Lian Cui, Xingcheng Chen, Seth Stauffer, Zhan Wang, Fang Yu, Subodh M. Lele, Geoffrey A. Talmon, Adrian R. Black, Yuanhong Chen, Jixin Dong
Proc Natl Acad Sci U S A. 2018 Jul 17; 115(29): E6760–E6769. Published online 2018 Jul 2. doi: 10.1073/pnas.1800621115
PMCID:
PMC6055133
AbstractArticlePDF–1.9M
15.
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells
Liv Johannessen, Thomas B Sundberg, Daniel J O’Connell, Raivo Kolde, James Berstler, Katelyn J Billings, Bernard Khor, Brinton Seashore-Ludlow, Anne Fassl, Caitlin N Russell, Isabel J Latorre, Baishan Jiang, Daniel B Graham, Jose R Perez, Piotr Sicinski, Andrew J Phillips, Stuart L Schreiber, Nathanael S Gray, Alykhan F Shamji, Ramnik J Xavier
Nat Chem Biol. Author manuscript; available in PMC 2018 Oct 1.
Published in final edited form as: Nat Chem Biol. 2017 Oct; 13(10): 1102–1108. Published online 2017 Aug 14. doi: 10.1038/nchembio.2458
PMCID:
PMC5693369
AbstractArticlePDF–750K
16.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
17.
MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis
Beatriz Aranda-Orgilles, Ricardo Saldaña-Meyer, Eric Wang, Eirini Trompouki, Anne Fassl, Stephanie Lau, Jasper Mullenders, Pedro P. Rocha, Ramya Raviram, María Guillamot, María Sánchez-Díaz, Kun Wang, Clarisse Kayembe, Nan Zhang, Leonela Amoasii, Avik Choudhuri, Jane A. Skok, Markus Schober, Danny Reinberg, Piotr Sicinski, Heinrich Schrewe, Aristotelis Tsirigos, Leonard I. Zon, Iannis Aifantis
Cell Stem Cell. Author manuscript; available in PMC 2017 Jan 26.
Published in final edited form as: Cell Stem Cell. 2016 Dec 1; 19(6): 784–799. Published online 2016 Aug 25. doi: 10.1016/j.stem.2016.08.004
PMCID:
PMC5268820
AbstractArticlePDF–1.7M
18.
Skp2-MacroH2A1-CDK8 axis orchestrates G2/M transition, polyploidy and tumourigenesis
Dazhi Xu, Chien-Feng Li, Xian Zhang, Zhaohui Gong, Chia-Hsin Chan, Szu-Wei Lee, Guoxiang Jin, Abdol-Hossein Rezaeian, Fei Han, Jing Wang, Wei-Lei Yang, Zi-Zhen Feng, Wei Chen, Ching-Yuan Wu, Ying-Jan Wang, Lu-Ping Chow, Xiao-Feng Zhu, Yi-Xin Zeng, Hui-Kuan Lin
Nat Commun. Author manuscript; available in PMC 2015 Sep 30.
Published in final edited form as: Nat Commun. 2015; 6: 6641. Published online 2015 Mar 30. doi: 10.1038/ncomms7641
PMCID:
PMC4500169
AbstractArticlePDF–1.3M
19.
mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC)
Daorong Feng, Dou Yeon Youn, Xiaoping Zhao, Yanguang Gao, William J. Quinn, 3rd, Alus M. Xiaoli, Yan Sun, Morris J. Birnbaum, Jeffrey E. Pessin, Fajun Yang
PLoS One. 2015; 10(6): e0126240. Published online 2015 Jun 4. doi: 10.1371/journal.pone.0126240
PMCID:
PMC4456374
AbstractArticlePDF–5.0M
20.
Cyclin C is a haploinsufficient tumor suppressor
Na Li, Anne Fassl, Joel Chick, Hiroyuki Inuzuka, Xiaoyu Li, Marc R. Mansour, Lijun Liu, Haizhen Wang, Bryan King, Shavali Shaik, Alejandro Gutierrez, Alban Ordureau, Tobias Otto, Taras Kreslavsky, Lukas Baitsch, Leah Bury, Clifford A. Meyer, Nan Ke, Kristin A. Mulry, Michael J. Kluk, Moni Roy, Sunkyu Kim, Xiaowu Zhang, Yan Geng, Agnieszka Zagozdzon, Sarah Jenkinson, Rosemary E. Gale, David C. Linch, Jean J. Zhao, Charles G. Mullighan, J. Wade Harper, Jon C. Aster, Iannis Aifantis, Harald von Boehmer, Steven P. Gygi, Wenyi Wei, A. Thomas Look, Piotr Sicinski
Nat Cell Biol. Author manuscript; available in PMC 2015 May 1.
Published in final edited form as: Nat Cell Biol. 2014 Nov; 16(11): 1080–1091. Published online 2014 Oct 26. doi: 10.1038/ncb3046
PMCID:
PMC4235773
AbstractArticlePDF–4.3M

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